How useful are housekeeping genes? Variable expression in melanoma metastases.

abstract：:Until recently, the "human genome" programs were mainly directed towards the development of maps to identify disease genes. The genetic map comprises about 8000 highly informative second generation markers of the microsatellite type. The density of markers is now sufficient to localize a gene for a monogenic disease w...

journal_title：Clinical chemistry and laboratory medicine

authors： Weissenbach J

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Mutations in the retina-specific ABC transporter (ABCA4) gene are associated with different types of macular degeneration, including Stargardt disease, cone-rod dystrophy, Fundus flavimaculatus, Retinitis pigmentosa and probably age-related macular degeneration. METHODS:Screening for mutations in the ABCA4 ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stenirri S,Battistella S,Fermo I,Manitto MP,Martina E,Brancato R,Ferrari M,Cremonesi L

更新日期：2006-01-01 00:00:00

abstract：:The results of several recent experimental studies using animal models and clinical trials suggested that obesity is not merely an epiphenomenon or a prominent comorbidity in patients with heart failure (HF). Indeed, recent studies suggest that obesity is intimately involved in the pathogenesis of HF with preserved ej...

journal_title：Clinical chemistry and laboratory medicine

authors： Clerico A,Zaninotto M,Passino C,Plebani M

更新日期：2018-06-27 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, play an important role in tumor invasion and metastasis. This study aimed to determine the serum levels of MMP-2, MMP-9, 130- and 225-kDa gelatinolytic bands and conventional tumor markers, carcinoembryonic antigen (CEA) and cancer antigen (CA) 19...

journal_title：Clinical chemistry and laboratory medicine

authors： Emara M,Cheung PY,Grabowski K,Sawicki G,Wozniak M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Query fever (Q fever) is a zoonotic infection, caused by the intracellular Gram-negative coccobacillus Coxiella burnetii. From 2007 until 2010, a large Q fever outbreak has occurred in the Netherlands. We studied traditional and less common inflammation markers in seronegative and seropositive patients with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Vissers E,de Jager CP,Hilbink M,Kusters R,van Gageldonk-Lafeber AB,Wever PC

更新日期：2012-02-04 00:00:00

abstract：:The importance of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well known. Moreover, bone health is positively influenced by certain elements (e.g., zinc, copper, fluorine, manganese, magnesium, iron and boron). Deficiency of these elements slows down the increase of ...

journal_title：Clinical chemistry and laboratory medicine

authors： Zofková I,Nemcikova P,Matucha P

更新日期：2013-08-01 00:00:00

abstract：:Technological advances over the past decades have enabled oral fluid to expand its usefulness in the diagnosis of disease, prediction of disease progression, monitoring of therapeutic drug levels and detection of illicit drugs. The easy non-invasive nature of collection and the relationship between oral fluid and plas...

journal_title：Clinical chemistry and laboratory medicine

authors： Choo RE,Huestis MA

更新日期：2004-01-01 00:00:00

abstract：:This paper reports on a pilot external quality assessment scheme for bone markers including serum bone alkaline phosphatase and procollagen 1-carboxy terminal propeptide together with urine deoxypyridinoline, N- and C-telopeptides. The data shows poor numerical agreement between commercial assays, between-laboratory i...

journal_title：Clinical chemistry and laboratory medicine

authors： Whitham KM,Milford-Ward A

更新日期：2000-11-01 00:00:00

abstract：:Background Brevican, neurocan, tenascin-C and tenascin-R are extracellular matrix proteins present in brain that show increased expression in experimental animal models of brain injury. However, little is known about the dynamics of these proteins in human body fluids, such as cerebrospinal fluid (CSF) and serum, afte...

journal_title：Clinical chemistry and laboratory medicine

authors： Minta K,Cullen NC,Nimer FA,Thelin EP,Piehl F,Clarin M,Tullberg M,Jeppsson A,Portelius E,Zetterberg H,Blennow K,Andreasson U

更新日期：2019-09-25 00:00:00

abstract：BACKGROUND:The Intermountain Mortality Risk Score (IMRS), a sex-specific mortality-prediction metric, has proven to be effective in various populations. IMRS is comprised of the complete blood count (CBC), basic metabolic panel (BMP), and age. Whether the addition of factors from the comprehensive metabolic panel (CMP)...

journal_title：Clinical chemistry and laboratory medicine

authors： May HT,Anderson JL,Muhlestein JB,Lappé DL,Ronnow BS,Horne BD

更新日期：2016-10-01 00:00:00

abstract：:Cryoglobulins are proteins that precipitate at temperatures below 37 degrees C. Cold-induced precipitation of proteins may occur in vivo secondary to several important diseases, and lead to pathological manifestations involving different organs. Cryoprecipitation may be observed in vitro by exposing serum samples, sup...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Stasio E,Bizzarri P,Bove M,Casato M,Giardina B,Fiorilli M,Galtieri A,Pucillo LP

更新日期：2003-02-01 00:00:00

abstract：:The formation of superoxide partially accounts for the well-known oxygen enhancement of radiation-induced biochemical changes and cell damage. Radioprotective effects of copper (II), manganese (IV) or vanadium (IV) complexes, of superoxide dismutase-mimetic activity, on body weight, survival rate and some biochemical ...

journal_title：Clinical chemistry and laboratory medicine

authors： Abou-Seif MA,El-Naggar MM,El-Far M,Ramadan M,Salah N

更新日期：2003-07-01 00:00:00

abstract：:Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Andersson A,Ankerst J,Lindgren A,Larsson K,Hultberg B

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Electrospray ionization mass spectrometry (ESI-MS) can be used for the measurement of glycated adult hemoglobin. Here, we describe the evaluation of ESI-MS for measurement of glycated (GHbF) and acetylated (AcHbF) fetal hemoglobin and the identification by mass of different chains of fetal hemoglobin. METHO...

journal_title：Clinical chemistry and laboratory medicine

authors： Davison AS,Green BN,Roberts NB

更新日期：2008-01-01 00:00:00

abstract：:A rat model is introduced which enables investigations in anticoagulated blood with continuous measurements by a flow-through electrode system. In the present study, a potentiometric ion-selective electrode (ISE)-system was used for measuring Ca2+, K+, Na+ and pH in rats. The setup was adjusted to an extracorporeal bl...

journal_title：Clinical chemistry and laboratory medicine

authors： Heidrich JP,Niemeier A,Seyfarth M

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Cystatin C (CST3), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized, with the remainder then eliminated in urine. In tubular diseases, it seems sensible to postulate that CST3 degradation would be ...

journal_title：Clinical chemistry and laboratory medicine

authors： Conti M,Moutereau S,Zater M,Lallali K,Durrbach A,Manivet P,Eschwège P,Loric S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Automated systems for antinuclear antibody analysis are being introduced. The aim was to evaluate whether automated quantitative reading of fluorescence intensity is clinically relevant and allows for value-added reporting of test results. METHODS:Consecutive samples (n=260) were used to correlate fluoresce...

journal_title：Clinical chemistry and laboratory medicine

authors： Schouwers S,Bonnet M,Verschueren P,Westhovens R,Blockmans D,Mariën G,Bossuyt X

更新日期：2014-04-01 00:00:00

abstract：:Complexity, cost, and content are three important factors that can impede translation of clinical protein mass spectrometry (MS) tests at a larger scale. Complexity stems from the many components/steps involved in bottom-up protein MS workflows, making them significantly more complicated than enzymatic immunoassays (E...

journal_title：Clinical chemistry and laboratory medicine

authors： Nedelkov D,Hu Y

更新日期：2020-06-25 00:00:00

abstract：:The Institute of Medicine (IOM) report, To err is human, galvanized a dramatically increased level of concern about adverse events and patient safety in healthcare, including errors in laboratory medicine. While a significant decrease in the error rates of clinical laboratories has been achieved and documented in rece...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M

更新日期：2007-01-01 00:00:00

abstract：:Thrombophilia can be identified in about half of all patients presenting with venous thromboembolism (VTE). Thrombophilia screening for various indications has increased tremendously, but whether the results of such tests help in the clinical management of patients is uncertain. Here, current recommendations for throm...

journal_title：Clinical chemistry and laboratory medicine

authors： Stegnar M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Point of care (POC) assays for cardiac troponins I or T (cTnI or cTnT) may accelerate the diagnosis of patients with suspected acute coronary syndrome (ACS). However, their clinical utility according to the 0 h/3 h algorithm recommended by the European Society of Cardiology (ESC) for non-ST elevation myocard...

journal_title：Clinical chemistry and laboratory medicine

authors： Suh D,Keller DI,Hof D,von Eckardstein A,Gawinecka J

更新日期：2018-03-28 00:00:00

abstract：:Age-related macular degeneration (AMD) is a sight threatening eye disease that affects millions of humans over the age of 65 years. It is considered to be the major cause of irreversible blindness in the elderly population in the developed world. The disease is prevalent in Europe and the United States, which has a la...

journal_title：Clinical chemistry and laboratory medicine

authors： Kokotas H,Grigoriadou M,Petersen MB

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:An effective quality control (QC) program requires the establishment of control limits within which the results of the QC sample is expected to fall. Traditionally, the mean plus/minus two standard deviations calculated for a set of QC sample results is used to establish control limits. Allowable total error...

journal_title：Clinical chemistry and laboratory medicine

authors： Dimech W,Vincini G,Karakaltsas M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Filamin myopathy is a neuromuscular disorder manifesting with predominantly limb-girdle muscle weakness and in many patients with diaphragm paralysis and cardiomyopathy, caused by mutations in the filamin C (FLNC) gene. Molecular diagnosis of filamin myopathy based on direct DNA sequencing of coding exons is...

journal_title：Clinical chemistry and laboratory medicine

authors： Odgerel Z,van der Ven PF,Fürst DO,Goldfarb LG

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:As ABO blood type influences the plasma level of coagulation factor VIII (FVIII), it likely also affects activated partial thromboplastin time (aPTT) and thrombin generation assay (TGA) values. Here, we aimed to investigate the effect of ABO type on the normal values of three global coagulation assays: proth...

journal_title：Clinical chemistry and laboratory medicine

authors： Choi Q,Kim JE,Kim SY,Han KS,Kim HK

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Soluble mesothelin-related protein (SMRP) is increased in the sera of patients with malignant mesothelioma (MM), and has been suggested as a diagnostic tool for MM in an asbestos exposed population. However, factors affecting SMRP concentrations in normal subjects and those with other asbestos related disord...

journal_title：Clinical chemistry and laboratory medicine

authors： Park EK,Thomas PS,Creaney J,Johnson AR,Robinson BW,Yates DH

更新日期：2010-06-01 00:00:00

abstract：:The aim of this study was to clarify the effects of anti-dsDNA antibodies on the titer and the nuclear staining pattern(s) in a fluorescent antinuclear antibody (FANA) assay using HEp-2 cells. Anti-dsDNA derived from 14 patients with systemic lupus erythematosus (SLE) was individually affinity-purified. The anti-dsDNA...

journal_title：Clinical chemistry and laboratory medicine

authors： Suzuki K,Kawamura M,Mineo M,Shinohara T,Kataharada K,Okada M,Takada K,Miyawaki S,Ohsuzu F

更新日期：2002-01-01 00:00:00

abstract：:The soluble transferrin receptor (sTfR) distinguishes iron deficiency anemia from other types of anemia. Refractory iron deficiency anemia is often the onset symptom in malabsorption-induced celiac disease. We evaluated whether sTfR levels distinguish celiac disease-associated iron deficiency anemia from iron deficien...

journal_title：Clinical chemistry and laboratory medicine

authors： De Caterina M,Grimaldi E,Di Pascale G,Salerno G,Rosiello A,Passaretti M,Scopacasa F

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Cigarette smoking, a cardiovascular risk factor leading to oxygen free radical formation, is involved in the development of serious pathological conditions. On the other hand, a healthy diet and adequate supplementation can help prevent many diseases. The aim of our study was to evaluate in healthy light smo...

journal_title：Clinical chemistry and laboratory medicine

authors： Bamonti F,Novembrino C,Ippolito S,Soresi E,Ciani A,Lonati S,Scurati-Manzoni E,Cighetti G

更新日期：2006-01-01 00:00:00

abstract：:This document summarizes the steps in development of a new IFCC Master Program and outlines some of the ways the IFCC would assist in setting up such a regional Program. This is intended to be of assistance to those who wish to embark on such an endeavour. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Fink NE,Allen LC,International Federation of Clinical Chemistry and Laboratory Medicine.,IFCC Committee on Education and Curriculum Development, Education and Management Division.

更新日期：2003-10-01 00:00:00