Abstract:
:Thrombophilia can be identified in about half of all patients presenting with venous thromboembolism (VTE). Thrombophilia screening for various indications has increased tremendously, but whether the results of such tests help in the clinical management of patients is uncertain. Here, current recommendations for thrombophilia screening in selected groups of patients, and considerations whether other high-risk subjects should be tested are reviewed. The methods for determination of the most common thrombophilic defects (antithrombin, protein C, protein S deficiencies, Factor V Leiden and prothrombin G20210A) associated with strong to moderate risk of VTE are described, indicating the timing and location of thrombophilia screening. Circumstances when a positive result of thrombophilia screening helps clinicians decide if adjustments of the anticoagulant regime are needed are discussed. Finally, psychological, social and ethical dilemmas associated with thrombophilia screening are indicated.
journal_name
Clin Chem Lab Medjournal_title
Clinical chemistry and laboratory medicineauthors
Stegnar Mdoi
10.1515/CCLM.2010.367subject
Has Abstractpub_date
2010-12-01 00:00:00pages
S105-13eissn
1434-6621issn
1437-4331journal_volume
48 Suppl 1pub_type
杂志文章,评审abstract::Laboratory Medicine organizations and their professional members have a goal and responsibility to benefit the health and wellbeing of the patients and communities they serve. Newer genetics and biochemical techniques raise significant issues of community concern, impacting on privacy, informed consent, access to and ...
journal_title:Clinical chemistry and laboratory medicine
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doi:10.1515/CCLM.2007.199
更新日期:2007-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
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journal_title:Clinical chemistry and laboratory medicine
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pub_type: 杂志文章
doi:10.1515/cclm-2017-0034
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2011-12-23 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
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journal_title:Clinical chemistry and laboratory medicine
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更新日期:2004-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
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更新日期:2015-08-01 00:00:00
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更新日期:2007-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2011.164
更新日期:2011-06-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
doi:10.1515/CCLM.2007.351
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1515/cclm-2016-0947
更新日期:2017-08-28 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2019-11-26 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2002.009
更新日期:2002-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,多中心研究
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更新日期:2017-03-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/cclm-2013-0044
更新日期:2013-09-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2008.323
更新日期:2008-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2006.205
更新日期:2006-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2010.322
更新日期:2010-11-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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更新日期:2019-09-25 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/cclm-2014-0546
更新日期:2015-02-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
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doi:10.1515/CCLM.2004.230
更新日期:2004-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/cclm-2019-0034
更新日期:2019-09-25 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
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doi:10.1515/CCLM.2005.212
更新日期:2005-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/cclm-2017-0349
更新日期:2018-01-26 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
doi:10.1515/cclm-2013-0405
更新日期:2013-12-01 00:00:00