Analytical and clinical validation of a novel amplicon-based NGS assay for the evaluation of circulating tumor DNA in metastatic colorectal cancer patients.

abstract：:Primary hypertension is a very common disorder particularly in the aging population but hypertensive disorders can appear earlier in life, especially when obesity and unhealthy lifestyle are present. Also pregnant women can be at risk of developing gestational hypertension and/or pre-eclampsia, which causes complicati...

journal_title：Clinical chemistry and laboratory medicine

authors： Danese E,Montagnana M,Fava C

更新日期：2013-12-01 00:00:00

abstract：:Homocysteine is a risk factor for ischemic heart disease; similarly as is hyperlipidemia or insulin resistance, which frequently occur in women with polycystic ovary syndrome. We examined the relationships between thiols and hormonal status or insulin resistance in 40 women (aged 25.8 +/- 7 years) with polycystic ovar...

journal_title：Clinical chemistry and laboratory medicine

authors： Vrbíková J,Tallová J,Biciková M,Dvoráková K,Hill M,Stárka L

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Chagas disease is endemic in Latin America, affecting 16-18 million people with more than 100 million exposed to risk of infection. Its etiological agent is Trypanosoma cruzi. To date, benznidazole is the only treatment of Chagas disease available in Europe. METHODS:A high-performance reversed-phase isocrat...

journal_title：Clinical chemistry and laboratory medicine

authors： Guerrero L,Pinazo MJ,Posada E,Gascón J,Ribas J,Soy D

更新日期：2011-01-01 00:00:00

abstract：:Background Intravenous lipid emulsion (ILE) is used to treat drug poisonings. The resultant hyperlipemia may affect laboratory tests but the consequences are poorly characterized. In a clinical trial we therefore investigated the effects of ILE on laboratory tests analyzed on common analytical platforms (Roche® cobas ...

journal_title：Clinical chemistry and laboratory medicine

authors： Petersen KM,Jørgensen NR,Bøgevig S,Petersen TS,Jensen TB,Dalhoff KP,Christensen MB

更新日期：2018-11-27 00:00:00

abstract：:The non-forage feeding of dairy cows rich in fast absorption carbohydrates, the low value of their euglycemic-hyperinsulinemic clamp suggest a dysregulation of carbohydrate metabolism able to produce neurodegenerative disorders. Comparisons between Alzheimer's disease developed in diabetes mellitus and bovine spongifo...

journal_title：Clinical chemistry and laboratory medicine

authors： Frey J

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Soluble mesothelin-related protein (SMRP) is increased in the sera of patients with malignant mesothelioma (MM), and has been suggested as a diagnostic tool for MM in an asbestos exposed population. However, factors affecting SMRP concentrations in normal subjects and those with other asbestos related disord...

journal_title：Clinical chemistry and laboratory medicine

authors： Park EK,Thomas PS,Creaney J,Johnson AR,Robinson BW,Yates DH

更新日期：2010-06-01 00:00:00

abstract：:Diabesity, that is to say, obesity-dependent diabetes, has emerged as a major public health problem. Though diabesity is basically explained by insulin resistance and pancreatic beta cell dysfunction, new paradigms have evolved to explain these alterations in the context of the modern epidemics of obesity and diabetes...

journal_title：Clinical chemistry and laboratory medicine

authors： Schmidt MI,Duncan BB

更新日期：2003-09-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency is present in more than 90% of patients with congenital adrenal hyperplasia, an inherited metabolic disorder of adrenal steroidogenesis. Impaired enzymatic activity leads to the accumulation of metabolic intermediates (progesterone and 17-hydroxyprogesterone), which results in excessi...

journal_title：Clinical chemistry and laboratory medicine

authors： Concolino P,Mello E,Zuppi C,Capoluongo E

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Whereas N-terminal pro-brain natriuretic peptide (NT-proBNP) is approved for risk stratification of patients with acute coronary syndromes (ACS), short-term temporal changes in NT-proBNP concentrations and the optimal time points for sampling are not clear. The purpose of this study was to better define the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Buchner S,Debl K,Barlage S,Griese D,Fredersdorf S,Jeron A,Lubnow M,Müller T,Muders F,Holmer S,Riegger GA,Luchner A

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Given the role of folate in many disorders, intracellular distribution of folate vitamers is of potential clinical importance. In particular, accumulation of non-methyltetrahydrofolates due to altered partitioning of folate metabolism at the level of methylenetetrahydrofolate is of interest. METHODS:We desc...

journal_title：Clinical chemistry and laboratory medicine

authors： Smith DE,Kok RM,Teerlink T,Jakobs C,Smulders YM

更新日期：2006-01-01 00:00:00

abstract：:Overcrowding of the emergency department (ED) is rapidly becoming a global challenge and a major source of concern for emergency physicians. The evaluation of cardiac biomarkers is critical for confirming diagnoses and expediting treatment decisions to reduce overcrowding, however, physicians currently face the dilemm...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Somma S,Zampini G,Vetrone F,Soto-Ruiz KM,Magrini L,Cardelli P,Ronco C,Maisel A,Peacock FW

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The study aim was to evaluate and compare the analytical performance of the new chemiluminescent immunoassay for cardiac troponin I (cTnI), called Access hs-TnI using DxI platform, with those of Access AccuTnI+3 method, and high-sensitivity (hs) cTnI method for ARCHITECT platform. METHODS:The limits of blan...

journal_title：Clinical chemistry and laboratory medicine

authors： Masotti S,Prontera C,Musetti V,Storti S,Ndreu R,Zucchelli GC,Passino C,Clerico A

更新日期：2018-02-23 00:00:00

abstract：:Severe thermal injury causes an immune dysfunction which includes a decrease of monocyte human leukocyte antigen DR (HLA-DR) expression. Interleukin-10 exerts a negative influence on this parameter in vitro. In this study we determined the prognostic value of reduced monocyte HLA-DR expression with regard to infectiou...

journal_title：Clinical chemistry and laboratory medicine

authors： Sachse C,Prigge M,Cramer G,Pallua N,Henkel E

更新日期：1999-03-01 00:00:00

abstract：:The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first-line chemotherapy for metastati...

journal_title：Clinical chemistry and laboratory medicine

authors： Sölétormos G,Petersen PH,Dombernowsky P

更新日期：2000-05-01 00:00:00

abstract：:Although prostate-specific antigen (PSA), or human kallikrein 3, is the most valuable tool available for the diagnosis and management of prostate cancer, as currently used it is insufficiently sensitive and specific for early detection or staging of the malignancy. Many new concepts have been introduced in order to op...

journal_title：Clinical chemistry and laboratory medicine

authors： Daher R,Beaini M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Procalcitonin (PCT) is increasingly being used for the diagnostic and prognostic work up of patients with suspected infections in the emergency department (ED). Recently, B·R·A·H·M·S PCT direct, the first high sensitive point-of-care test (POCT), has been developed for fast PCT measurement on capillary or ve...

journal_title：Clinical chemistry and laboratory medicine

authors： Kutz A,Hausfater P,Oppert M,Alan M,Grolimund E,Gast C,Alonso C,Wissmann C,Kuehn C,Bernard M,Huber A,Mueller B,Schuetz P

更新日期：2016-04-01 00:00:00

abstract：:Both technological advances and economic drivers have led to major changes in clinical laboratories across the world, with vastly improved testing productivity. However, the production process capability advances have far outpaced the clinical pathologists' success in assuring optimal test utilization and interpretati...

journal_title：Clinical chemistry and laboratory medicine

authors： Blanckaert N

更新日期：2010-07-01 00:00:00

abstract：UNLABELLED:Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse detection and monitoring of therapy response are crucial for efficient treatment of advanced melanoma. Thus, there is a need for blood-based biomarker...

journal_title：Clinical chemistry and laboratory medicine

authors： Kuhlmann JD,Wimberger P,Wilsch K,Fluck M,Suter L,Brunner G

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Transferrin (Tf) glycoform lacking one or two complete or incomplete glycan chains (i.e., asialo-monosialo- and disialo-Tf) typically appear in blood after chronic alcohol consumption, though recently it was reported that monosialo-Tf is associated with trisialo-Tf but not with alcohol consumption. These gly...

journal_title：Clinical chemistry and laboratory medicine

authors： Daves M,Cemin R,Floreani M,Pusceddu I,Cosio G,Lippi G

更新日期：2011-10-01 00:00:00

abstract：:Remarkably elevated levels of phospholipase A2 (PLA2) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two isoenzymes--the pancreatic PLA2, group I, and the extrapancreatic PLA2, group ...

journal_title：Clinical chemistry and laboratory medicine

authors： Aufenanger J,Samman M,Quintel M,Fassbender K,Zimmer W,Bertsch T

更新日期：2002-03-01 00:00:00

abstract：:Background Many of the mobile applications (apps) used for delivering health interventions involve laboratory medicine data. This survey was conducted to search the online market for health apps that manage laboratory medicine data. The aim was to review them and perform a quality evaluation. Methods Apps search crite...

journal_title：Clinical chemistry and laboratory medicine

authors： Jovičić S,Siodmiak J,Watson ID,European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Patient Focused Laboratory Medicine.

更新日期：2019-02-25 00:00:00

abstract：BACKGROUND:The aim of the study was to develop a method for sweat chloride (Cl) quantification using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to present to the Joint Committee for Traceability in Laboratory Medicine (JCTLM) as a candidate reference method for the diagnosis of cystic fibrosis (CF). METHODS...

journal_title：Clinical chemistry and laboratory medicine

authors： Collie JT,Massie RJ,Jones OA,Morrison PD,Greaves RF

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The European Society for Pediatric Gastroenterology and Nutrition states that if IgA anti-tissue transglutaminase (tTG) exceeds 10 times the upper limit of normal (ULN), there is the possibility to diagnose celiac disease (CD) without duodenal biopsy, if supported by anti-endomysium testing and human leukocy...

journal_title：Clinical chemistry and laboratory medicine

authors： Oyaert M,Vermeersch P,De Hertogh G,Hiele M,Vandeputte N,Hoffman I,Bossuyt X

更新日期：2015-09-01 00:00:00

abstract：:The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) formed a Task Force on the Application of Cardiac Bio-markers (TF-CB) in 2008, re-designated in 2018 as a committee (C-CB), to produce educational materials on cardiac biomarkers. Established in June 2017, definitive tables covering the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Collinson PO,Saenger AK,Apple FS,IFCC C-CB.

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:The long noncoding RNAs (lncRNAs) have gradually been reported to be an important class of RNAs with pivotal roles in regulation of gene expression, and thus are involved in multitudinous human complex diseases. However, the biological functions and precise mechanisms of the majority of lncRNAs are still poo...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhuo Y,Zeng Q,Zhang P,Li G,Xie Q,Cheng Y

更新日期：2017-01-01 00:00:00

abstract：:Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The i...

journal_title：Clinical chemistry and laboratory medicine

authors： Hong YJ,Lee JK,Lee GH,Hong SI

更新日期：2000-09-01 00:00:00

abstract：:The aim of the study was to evaluate the clinical efficiency of soluble transferrin receptor and transferrin receptor-ferritin index (sTfR/logF) in the diagnosis of iron deficiency anemia, as well as the differential diagnosis of iron deficiency anemia and anemia in rheumatoid arthritis. The study included 96 patients...

journal_title：Clinical chemistry and laboratory medicine

authors： Margetic S,Topic E,Ruzic DF,Kvaternik M

更新日期：2005-01-01 00:00:00

abstract：:Undiagnosed thyroid disease is a common problem with significant public health implications. This is especially true during pregnancy, when the health of both the mother and the developing child can be adversely affected by abnormal maternal thyroid function. Measurement of serum thyroid stimulating hormone (TSH) and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Quinn FA,Gridasov GN,Vdovenko SA,Krasnova NA,Vodopianova NV,Epiphanova MA,Schulten M

更新日期：2005-01-01 00:00:00

abstract：:Measurement of total homocysteine (tHcy) in healthy and diseased children has documented the utility of this marker in pediatric research and diagnostics. This article focuses on novel data obtained in infants, children and adolescents, with emphasis on cobalamin status in infants. In children, determinants of plasma ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ueland PM,Monsen AL

更新日期：2003-11-01 00:00:00

abstract：:The detection and quantification of amyloidogenic monoclonal light chains are necessary for the diagnosis and evaluation of response to treatment in AL amyloidosis. However, the amyloid clone is often small and difficult to detect. We report the case of a 68-year-old man who was referred to our Center in April 2013 af...

journal_title：Clinical chemistry and laboratory medicine

authors： Milani P,Valentini V,Ferraro G,Basset M,Russo F,Foli A,Palladini G,Merlini G

更新日期：2016-06-01 00:00:00