Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease.

abstract：:Abstract Lipoprotein-related risk of cardiovascular disease (CVD) can be adequately predicted in subjects with elevated total cholesterol and low-density lipoprotein (LDL-)cholesterol using the available guidelines. However, individuals with dyslipidemia can have normal total- and LDL-cholesterol concentrations. Many ...

journal_title：Clinical chemistry and laboratory medicine

authors： Langlois MR

更新日期：2012-04-10 00:00:00

abstract：:Reference intervals in clinical chemistry are commonly based on results of measurements in reference populations or are taken from the literature. A reference population should represent a defined group of individuals and be as similar as possible to the patients under investigation. Frequently, reference populations ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kallner A,Gustavsson E,Hendig E

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:alpha-Thalassemia is a worldwide disease and considered to be a major public health problem in countries within the so-called thalassemia belt. The complex genetics of alpha-thalassemias requires diagnostic methods with the capacity to screen rapidly and accurately for common causative mutations. METHODS:We...

journal_title：Clinical chemistry and laboratory medicine

authors： Puehringer H,Najmabadi H,Law HY,Krugluger W,Viprakasit V,Pissard S,Baysal E,Taher A,Farra C,Al-Ali A,Al-Ateeq S,Oberkanins C

更新日期：2007-01-01 00:00:00

abstract：:An increasing incidence of male infertility has been noted over the past few decades. This adds urgency to the need to develop immunohistochemical markers for better evaluation of testicular biopsies. We provide evidence that a histopathological evaluation performed according to morphological criteria and assisted by ...

journal_title：Clinical chemistry and laboratory medicine

authors： Bar-Shira Maymon B,Yavetz H,Schreiber L,Paz G

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Pertussis has been increasing in frequency and can cause protean manifestation in infants, often resulting in extensive laboratory evaluation. METHODS:We examined the prevalence of cerebrospinal fluid (CSF) anomalies in infants with pertussis and parapertussis over a 5-year period. RESULTS:In total, 239 of...

journal_title：Clinical chemistry and laboratory medicine

authors： Chu TT,Groh J,Cruz AT

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Haptoglobin (Hp) is an abundant serum protein which binds extracorpuscular hemoglobin (Hb). Two alleles exist in humans for the Hp gene, denoted 1 and 2. Diabetic individuals with the Hp 2-2 genotype are at increased risk of developing vascular complications including heart attack, stroke, and kidney disease...

journal_title：Clinical chemistry and laboratory medicine

authors： Levy NS,Vardi M,Blum S,Miller-Lotan R,Afinbinder Y,Cleary PA,Paterson AD,Bharaj B,Snell-Bergeon JK,Rewers MJ,Lache O,Levy AP

更新日期：2013-08-01 00:00:00

abstract：:It is now undeniable that laboratory testing is vital for the diagnosis, prognostication and therapeutic monitoring of human disease. Despite the many advances made for achieving a high degree of quality and safety in the analytical part of diagnostic testing, many hurdles in the total testing process remain, especial...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Baird GS,Banfi G,Bölenius K,Cadamuro J,Church S,Cornes MP,Dacey A,Guillon A,Hoffmann G,Nybo M,Premawardhana LD,Salinas M,Sandberg S,Slingerland R,Stankovic A,Sverresdotter SM,Vermeersch P,Simundic AM

更新日期：2017-03-01 00:00:00

abstract：:We developed sensitive assay methods for autoantibodies recognizing the citrullinated synthetic peptides derived from type I and type II collagens in patients with rheumatoid arthritis (RA). These peptides were tested with the chemiluminescence method (Nichols Advantage System). In 44 RA patients out of 120, the sera ...

journal_title：Clinical chemistry and laboratory medicine

authors： Koivula MK,Ramberg J,Aman S,Karjalainen A,Hakala M,Risteli J

更新日期：2005-01-01 00:00:00

abstract：UNLABELLED:Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse detection and monitoring of therapy response are crucial for efficient treatment of advanced melanoma. Thus, there is a need for blood-based biomarker...

journal_title：Clinical chemistry and laboratory medicine

authors： Kuhlmann JD,Wimberger P,Wilsch K,Fluck M,Suter L,Brunner G

更新日期：2015-03-01 00:00:00

abstract：:Despite many years of study, clinical trials of new drugs to prevent thrombosis have often been disappointing. Part of the problem lies in our incomplete understanding of the regulation of plasminogen activation and/or inhibition in vivo. We have previously shown that in vitro nitration of plasminogen in plasma by per...

journal_title：Clinical chemistry and laboratory medicine

authors： Hathuc C,Hermo R,Schulze J,Gugliucci A

更新日期：2006-01-01 00:00:00

abstract：:It has been well reported over recent years that most errors within the total testing process occur in the pre-analytical phase (46%-68.2%), an area that is usually outside of the direct control of the laboratory and which includes sample collection (phlebotomy). National and international (WHO, CLSI) guidelines recom...

journal_title：Clinical chemistry and laboratory medicine

authors： Cornes M,van Dongen-Lases E,Grankvist K,Ibarz M,Kristensen G,Lippi G,Nybo M,Simundic AM,Working Group for Preanalytical Phase (WG-PRE), European Federation of Clinical Chemistry and Laboratory Medicine (EFLM).

更新日期：2017-01-01 00:00:00

abstract：:In blood, the exopeptidase dipeptidyl-peptidase IV (DPPIV; EC 3.4.14.5) is predominantly present in a soluble form in plasma/serum and as an activation antigen on the membrane of lymphocytes (CD26). It modifies some important biologically active peptides (neuropeptides, chemokines), and a regulatory role for DPPIV/CD2...

journal_title：Clinical chemistry and laboratory medicine

authors： Durinx C,Neels H,Van der Auwera JC,Naelaerts K,Scharpe S,De Meester I

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:The presence of fibronectin fragments has been observed in some inflammatory diseases and is believed to reflect tissue breakdown. In this study, possible fibronectin fragmentation and alterations in its domain and sialyl and fucosyl glycotope expressions were analyzed in amniotic fluids in relation to intra...

journal_title：Clinical chemistry and laboratory medicine

authors： Hirnle L,Katnik-Prastowska I

更新日期：2007-01-01 00:00:00

abstract：:In our efforts to develop diagnostic tests for complex multifactorial disorders, and to assist the research community in evaluating genetic markers for predisposition to cardiovascular disease, we have developed a prototype assay to genotype up to 35 variable sites among 15 genes. The candidate markers in this panel w...

journal_title：Clinical chemistry and laboratory medicine

authors： Cheng S,Pallaud C,Grow MA,Scharf SJ,Erlich HA,Klitz W,Pullinger CR,Malloy MJ,Kane JP,Siest G,Visvikis S

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Gilbert's syndrome is a common metabolic dysfunction characterized by elevated levels of unconjugated bilirubin in the bloodstream. This condition is usually caused by additional (TA) insertions in a promoter region of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene, which instead of the se...

journal_title：Clinical chemistry and laboratory medicine

authors： Fesenko EE,Heydarov RN,Stepanova EV,Abramov ME,Chudinov AV,Zasedatelev AS,Mikhailovich VM

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:When performed erroneously, the venous blood specimen collection (VBSC) practice steps patient identification, test request management and test tube labeling are at high risk to jeopardize patient safety. VBSC educational programs with the intention to minimize risk of harm to patients are therefore needed. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Willman B,Grankvist K,Bölenius K

更新日期：2018-10-25 00:00:00

abstract：:Point-of-care testing (POCT) is traditionally defined as laboratory diagnostics performed at or near the site where clinical care is delivered. POCT thereby combines sample collection, analysis, and reporting of results into a robust integrated testing structure, with a simple user interface. The availability of relia...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Plebani M,Favaloro EJ,Trenti T

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Pleomorphic adenoma (PA) is a benign tumour of the salivary gland with a tendency to malignancy which creates many diagnostic problems. N-acetyl-beta-hexosaminidase (HEX) is a lysosomal exoglycosidase involved in degradation of oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans, know...

journal_title：Clinical chemistry and laboratory medicine

authors： Borzym-Kluczyk M,Olszewska E,Radziejewska I,Lewszuk A,Zwierz K

更新日期：2008-01-01 00:00:00

abstract：:The effects of the time of the day and breakfast on the outcome of interleukin-6 and its soluble receptor in serum were studied on 22 subjectively health volunteers. We collected blood specimens at 8.00 a.m. after an overnight fast, at 9.30 a.m. after usual breakfast, and at 11.30 a.m. A second group of volunteers (n ...

journal_title：Clinical chemistry and laboratory medicine

authors： Dugué B,Leppänen E

更新日期：1998-05-01 00:00:00

abstract：:Background Evaluating the tumor RAS/BRAF status is important for treatment selection and prognosis assessment in metastatic colorectal cancer (mCRC) patients. Correction of artifacts from library preparation and sequencing is essential for accurately analyzing circulating tumor DNA (ctDNA) mutations. Here, we assessed...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang B,Wu S,Huang F,Shen M,Jiang H,Yu Y,Yu Q,Yang Y,Zhao Y,Zhou Y,Pan B,Liu T,Guo W

更新日期：2019-09-25 00:00:00

abstract：:Cancers of the respiratory tract (lung and head and neck) share common aetiologies, risk factors and molecular characteristics. Epigenetic reprogramming is one of the hallmarks of cancer and DNA methylation is currently the best-studied form. There are a number of characteristics of DNA methylation, which seem advanta...

journal_title：Clinical chemistry and laboratory medicine

authors： Markopoulou S,Nikolaidis G,Liloglou T

更新日期：2012-10-01 00:00:00

abstract：:Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced high density lipoprotein (HDL), both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the -93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk an...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferencak G,Pasalić D,Grsković B,Cheng S,Fijal B,Sesto M,Skodlar J,Rukavina AS

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:The European Directive 98/79/EC on in-vitro diagnostic medical devices (IVDs) regulates IVD marketing practices and post-market surveillance. IVD manufacturers have to inform the responsible Competent Authorities of any issues. In Germany, the Federal Institute for Drugs and Medical Devices (BfArM) is respon...

journal_title：Clinical chemistry and laboratory medicine

authors： Siekmeier R,Lütz J

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Transferrin (Tf) glycoform lacking one or two complete or incomplete glycan chains (i.e., asialo-monosialo- and disialo-Tf) typically appear in blood after chronic alcohol consumption, though recently it was reported that monosialo-Tf is associated with trisialo-Tf but not with alcohol consumption. These gly...

journal_title：Clinical chemistry and laboratory medicine

authors： Daves M,Cemin R,Floreani M,Pusceddu I,Cosio G,Lippi G

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole. METHODS:Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers. RESUL...

journal_title：Clinical chemistry and laboratory medicine

authors： Engin-Ustün Y,Ustün Y,Karabulut AB,Doğan K,Meydanli MM,Sezgin B

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The dogma of establishing intra-laboratory reference limits (RLs) and their periodic review cannot be fulfilled by most laboratories due to the expenses involved. Thus, most laboratories adopt external sources for their RLs, often neglecting the problems of transferability. This is particularly problematic f...

journal_title：Clinical chemistry and laboratory medicine

authors： Arzideh F,Wosniok W,Haeckel R

更新日期：2011-04-01 00:00:00

abstract：:Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic...

journal_title：Clinical chemistry and laboratory medicine

authors： Hultberg B,Jensen E,Dehlin O,Hagberg B,Samuelsson G,Svensson T

更新日期：1999-10-01 00:00:00

abstract：:The importance of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well known. Moreover, bone health is positively influenced by certain elements (e.g., zinc, copper, fluorine, manganese, magnesium, iron and boron). Deficiency of these elements slows down the increase of ...

journal_title：Clinical chemistry and laboratory medicine

authors： Zofková I,Nemcikova P,Matucha P

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer (CRC) screening. Availability of data on faecal haemoglobin concentrations (f-Hb) in three countries prompted an observational study on sex and age and the transferability of data across geography. METHODS:Single estimates of f-...

journal_title：Clinical chemistry and laboratory medicine

authors： Fraser CG,Rubeca T,Rapi S,Chen LS,Chen HH

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Cigarette smoking, a cardiovascular risk factor leading to oxygen free radical formation, is involved in the development of serious pathological conditions. On the other hand, a healthy diet and adequate supplementation can help prevent many diseases. The aim of our study was to evaluate in healthy light smo...

journal_title：Clinical chemistry and laboratory medicine

authors： Bamonti F,Novembrino C,Ippolito S,Soresi E,Ciani A,Lonati S,Scurati-Manzoni E,Cighetti G

更新日期：2006-01-01 00:00:00