Comparison of different immunoassays for CA 19-9.

abstract：BACKGROUND:Whereas N-terminal pro-brain natriuretic peptide (NT-proBNP) is approved for risk stratification of patients with acute coronary syndromes (ACS), short-term temporal changes in NT-proBNP concentrations and the optimal time points for sampling are not clear. The purpose of this study was to better define the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Buchner S,Debl K,Barlage S,Griese D,Fredersdorf S,Jeron A,Lubnow M,Müller T,Muders F,Holmer S,Riegger GA,Luchner A

更新日期：2010-06-01 00:00:00

abstract：:The detection and quantification of amyloidogenic monoclonal light chains are necessary for the diagnosis and evaluation of response to treatment in AL amyloidosis. However, the amyloid clone is often small and difficult to detect. We report the case of a 68-year-old man who was referred to our Center in April 2013 af...

journal_title：Clinical chemistry and laboratory medicine

authors： Milani P,Valentini V,Ferraro G,Basset M,Russo F,Foli A,Palladini G,Merlini G

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Query fever (Q fever) is a zoonotic infection, caused by the intracellular Gram-negative coccobacillus Coxiella burnetii. From 2007 until 2010, a large Q fever outbreak has occurred in the Netherlands. We studied traditional and less common inflammation markers in seronegative and seropositive patients with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Vissers E,de Jager CP,Hilbink M,Kusters R,van Gageldonk-Lafeber AB,Wever PC

更新日期：2012-02-04 00:00:00

abstract：:Background Non-small cell lung cancer (NSCLC) patients benefit from targeted therapies both in first- and second-line treatment. Nevertheless, molecular profiling of lung cancer tumors after first disease progression is seldom performed. The analysis of circulating tumor DNA (ctDNA) enables not only non-invasive bioma...

journal_title：Clinical chemistry and laboratory medicine

authors： Provencio M,Pérez-Barrios C,Barquin M,Calvo V,Franco F,Sánchez E,Sánchez R,Marsden D,Cristóbal Sánchez J,Martin Acosta P,Laza-Briviesca R,Cruz-Bermúdez A,Romero A

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Cystatin C (CST3), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized, with the remainder then eliminated in urine. In tubular diseases, it seems sensible to postulate that CST3 degradation would be ...

journal_title：Clinical chemistry and laboratory medicine

authors： Conti M,Moutereau S,Zater M,Lallali K,Durrbach A,Manivet P,Eschwège P,Loric S

更新日期：2006-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-induced death. Somatic mutation of the p53 gene is the most common genetic abnormality so far described in human cancer and there is evidence that supports a high level of p53 alterations in HCC. The aim of this study was to investigate serum le...

journal_title：Clinical chemistry and laboratory medicine

authors： El Far MA,Atwa MA,Yahya RS,El Basuni MA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Serum immunoglobulin free light chains (FLC) are secreted into circulation by plasma cells as a by-product of immunoglobulin production. In a healthy individual the population of FLC is polyclonal as no single cell is secreting more FLC than the total immunoglobulin secreting cell population. In a person wit...

journal_title：Clinical chemistry and laboratory medicine

authors： Barnidge DR,Dispenzieri A,Merlini G,Katzmann JA,Murray DL

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Adult-type hypolactasia is characterized by the inability to digest lactose during adulthood, due to lactase (LCT) deficiency. It is usually diagnosed by the measurement of breath hydrogen increase after a lactose load (breath hydrogen test, BHT). A substitution of C to T at position -13910 bp upstream the L...

journal_title：Clinical chemistry and laboratory medicine

authors： Mottes M,Belpinati F,Milani M,Saccomandi D,Petrelli E,Calacoci M,Chierici R,Pignatti PF,Borgna-Pignatti C

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to clarify the effects of anti-dsDNA antibodies on the titer and the nuclear staining pattern(s) in a fluorescent antinuclear antibody (FANA) assay using HEp-2 cells. Anti-dsDNA derived from 14 patients with systemic lupus erythematosus (SLE) was individually affinity-purified. The anti-dsDNA...

journal_title：Clinical chemistry and laboratory medicine

authors： Suzuki K,Kawamura M,Mineo M,Shinohara T,Kataharada K,Okada M,Takada K,Miyawaki S,Ohsuzu F

更新日期：2002-01-01 00:00:00

abstract：:Background uPA and PAI-1 are breast cancer biomarkers that evaluate the benefit of chemotherapy (CT) for HER2-negative, estrogen receptor-positive, low or intermediate grade patients. Our objectives were to observe clinical routine use of uPA/PAI-1 and to build a new therapeutic decision tree integrating uPA/PAI-1. Me...

journal_title：Clinical chemistry and laboratory medicine

authors： Reix N,Lodi M,Jankowski S,Molière S,Luporsi E,Leblanc S,Scheer L,Ibnouhsein I,Benabu JC,Gabriele V,Guggiola A,Lessinger JM,Chenard MP,Alpy F,Bellocq JP,Neuberger K,Tomasetto C,Mathelin C

更新日期：2019-05-27 00:00:00

abstract：:Background The increasing number of multi-drug resistant (MDR) bacteria provides enormous challenges for choosing an appropriate antibiotic therapy in the early phase of sepsis. While bacterial identification has been greatly accelerated by the introduction of matrix-assisted laser desorption ionization-time of flight...

journal_title：Clinical chemistry and laboratory medicine

authors： Kittel M,Findeisen P,Ghebremedhin B,Miethke T,Grundt A,Ahmad-Nejad P,Neumaier M

更新日期：2019-07-26 00:00:00

abstract：:Primary hypertension is a very common disorder particularly in the aging population but hypertensive disorders can appear earlier in life, especially when obesity and unhealthy lifestyle are present. Also pregnant women can be at risk of developing gestational hypertension and/or pre-eclampsia, which causes complicati...

journal_title：Clinical chemistry and laboratory medicine

authors： Danese E,Montagnana M,Fava C

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The VU University Medical Center (VUmc) was the first hospital in the Netherlands to introduce the Delfia Xpress for the analysis of free beta-human chorionic gonadotrophin (beta-hCG) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester screening program for Down syndrome. Since then, ot...

journal_title：Clinical chemistry and laboratory medicine

authors： Linskens IH,Levitus M,Frans A,Schielen PC,van Vugt JM,Blankenstein MA,Dijstelbloem HM

更新日期：2009-01-01 00:00:00

abstract：:Testing for the diagnosis of acute myocardial infarction and other diseases included in the spectrum of the "acute coronary syndrome" is rapidly changing from the traditional enzymatic assays to mass measurement of more specific and sensitive markers (cardiac troponins, CK-MB and myoglobin). Several questions have ari...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M,Zaninotto M

更新日期：1999-11-01 00:00:00

abstract：:The aim of the study was to evaluate the clinical efficiency of soluble transferrin receptor and transferrin receptor-ferritin index (sTfR/logF) in the diagnosis of iron deficiency anemia, as well as the differential diagnosis of iron deficiency anemia and anemia in rheumatoid arthritis. The study included 96 patients...

journal_title：Clinical chemistry and laboratory medicine

authors： Margetic S,Topic E,Ruzic DF,Kvaternik M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:We evaluated the effect of kidney glomerular function on serum concentrations of human epididymis protein 4 (HE4) using creatinine (Cr), cystatin C (CysC) and related chronic kidney disease epidemiology collaboration (CKD-EPI) equations. METHODS:We enrolled 101 women aged ≤56 years with a glomerular filtrat...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Pasqualetti S,Carnevale A,Panteghini M

更新日期：2016-10-01 00:00:00

abstract：:Progression of atherosclerosis is currently believed to involve interactions between leukocytes and vascular endothelium. Epidemiological risk factors for atherosclerosis such as hypertension and smoking are known to cause endothelial dysfunction, which is an early event in the atherosclerotic process; they also may b...

journal_title：Clinical chemistry and laboratory medicine

authors： Mazzone A,Cusa C,Mazzucchelli I,Vezzoli M,Ottini E,Ghio S,Tossini G,Pacifici R,Zuccaro P

更新日期：2001-09-01 00:00:00

abstract：:Transferrin concentration and total iron binding capacity (TIBC) are currently used to assess iron status. Although correlation between TIBC and transferrin is generally considered as good, conversion factors between the two analytes found in literature show large differences. Although the price per test is lower for ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kasvosve I,Delanghe J

更新日期：2002-10-01 00:00:00

abstract：:Introduction Element-tagged immunoassay coupled with inductively coupled plasma-mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis in clinical detection; however, a systematic evaluation with the standard guidelines of the assay is needed to ensure its performance meets the re...

journal_title：Clinical chemistry and laboratory medicine

authors： Jiang W,Sun G,Wen X,Men S,Cui W,Jing M,Jia X,Hu Z,Pu D,Zhang S,Yuan X,Liu X,Zhang X,Wang C

更新日期：2020-06-25 00:00:00

abstract：:Advanced age-related macular degeneration (AAMD) is a complex sight-threating disease of public health significance. Micro RNAs (miRNAs) have been proposed as biomarkers for AAMD. The presence of certain single nucleotide polymorphisms (SNPs) may influence the explanatory value of these biomarkers. Here we present fin...

journal_title：Clinical chemistry and laboratory medicine

authors： SanGiovanni JP,SanGiovanni PM,Sapieha P,De Guire V

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Pleomorphic adenoma (PA) is a benign tumour of the salivary gland with a tendency to malignancy which creates many diagnostic problems. N-acetyl-beta-hexosaminidase (HEX) is a lysosomal exoglycosidase involved in degradation of oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans, know...

journal_title：Clinical chemistry and laboratory medicine

authors： Borzym-Kluczyk M,Olszewska E,Radziejewska I,Lewszuk A,Zwierz K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Cigarette smoking, a cardiovascular risk factor leading to oxygen free radical formation, is involved in the development of serious pathological conditions. On the other hand, a healthy diet and adequate supplementation can help prevent many diseases. The aim of our study was to evaluate in healthy light smo...

journal_title：Clinical chemistry and laboratory medicine

authors： Bamonti F,Novembrino C,Ippolito S,Soresi E,Ciani A,Lonati S,Scurati-Manzoni E,Cighetti G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kennard A,Hawley C,Tate J,Klingberg S,Pretorius C,Hutchison C,Mollee P

更新日期：2016-06-01 00:00:00

abstract：:The treatment of tuberculosis usually includes the antibiotic rifampicin, especially in patients with concomitant human immunodeficiency virus infection. Some of these patients are in withdrawal therapy for drug abuse. When opiate screening is carried out in patients receiving rifampicin, false positive results are de...

journal_title：Clinical chemistry and laboratory medicine

authors： de Paula M,Saiz LC,González-Revaldería J,Pascual T,Alberola C,Miravalles E

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Autoantibodies against β1-adrenergic receptors (β1AR) that stimulate cardiac cAMP-production play a causal role in the pathogenesis of human heart failure. Patients can be subjected to specific therapies, if the presence of potentially cardio-noxious β1AR-autoantibodies is reliably diagnosed. This requires a...

journal_title：Clinical chemistry and laboratory medicine

authors： Bornholz B,Benninghaus T,Reinke Y,Felix SB,Roggenbuck D,Jahns-Boivin V,Jahns R,Boege F

更新日期：2016-04-01 00:00:00

abstract：:An increasing incidence of male infertility has been noted over the past few decades. This adds urgency to the need to develop immunohistochemical markers for better evaluation of testicular biopsies. We provide evidence that a histopathological evaluation performed according to morphological criteria and assisted by ...

journal_title：Clinical chemistry and laboratory medicine

authors： Bar-Shira Maymon B,Yavetz H,Schreiber L,Paz G

更新日期：2002-03-01 00:00:00

abstract：:Urinary cotinine was measured according to its inhibitory activity on the agglutination of cotinine-coated latex particles by anti-cotinine antibodies, the agglutination being measured by optical counting of the remaining non-agglutinated particles (particle counting, PaC). The detection limit was 0.03 microgram/ml an...

journal_title：Clinical chemistry and laboratory medicine

authors： Galanti LM,Dell'Omo J,Vanbeckbergen D,Dubois P,Masson PL,Cambiaso CL

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Thyroid stimulating hormone (TSH) receptor autoantibodies (TRAb) are pathogenetic and diagnostic hallmarks of Graves' disease (GD). Three varieties of TRAb have been described: stimulating (S-TRAb), blocking (B-TRAb), and apoptotic (A-TRAb) autoantibodies. Very recently, the first immunoassay method (Immulit...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,D'Aurizio F,Villalta D,Giovanella L

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Lactase persistence is an inherited autosomal dominant trait that confers the ability to digest lactose after weaning. Lactose persistence is caused by single nucleotide variants in a regulatory element for the lactase gene (LCT). In Europeans, lactase persistence is associated with the nucleotide variant LC...

journal_title：Clinical chemistry and laboratory medicine

authors： Strand H,Sørensen LK,Ingebretsen OC

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) in general, and citalopram/escitalopram in particular, are widely used to treat clinical depression. However, SSRI bioavailability and non-compliance represent major issues, especially in the clinical trials setting. In this context, frequent drug-level measure...

journal_title：Clinical chemistry and laboratory medicine

authors： Serebruany V,Malinin A,Dragan V,Atar D,van Zyl L,Dragan A,Lexapro Compliance Task Force.

更新日期：2007-01-01 00:00:00