Using multiples of the median to normalize serum protein measurements.

abstract：BACKGROUND:Stone composition has changed substantially over the past decades in developed countries. We studied urinary stone composition in Tunisian children. METHODS:We studied 205 children ranging from 3 months to 16 years old age and who were diagnosed as having urinary stones (122 boys and 83 girls). Stone analys...

journal_title：Clinical chemistry and laboratory medicine

authors： Alaya A,Nouri A,Najjar MF

更新日期：2011-02-01 00:00:00

abstract：:Iron status in man is influenced by environmental and genetic factors. The molecular variation of haptoglobin is one of the genetic factors influencing iron status in Caucasians. Differences in iron metabolism between blacks and whites have been reported. We wanted to investigate the effect of haptoglobin polymorphism...

journal_title：Clinical chemistry and laboratory medicine

authors： Kasvosve I,Gordeuk VR,Delanghe JR,Gomo ZA,Gangaidzo IT,Khumalo H,Moyo VM,Saungweme T,Mvundura E,Boelaert JR

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:We verified the analytical performance of strip-based handheld glucose meters (GM) for prescription use, in a comparative split-sample protocol using blood gas samples from a surgical intensive care unit (ICU). METHODS:Freestyle Precision Pro (Abbott), StatStrip Connectivity Meter (Nova), ACCU-CHEK Inform I...

journal_title：Clinical chemistry and laboratory medicine

authors： Claerhout H,De Prins M,Mesotten D,Van den Berghe G,Mathieu C,Van Eldere J,Vanstapel F

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Antinuclear autoantibody determination relies on an initial screening step using immunofluorescence on HEp2 cells. This may be followed by anti-deoxyribonucleic acid (DNA) determination, if the fluorescence of nuclei is homogeneous. We assessed the validity of a restricted algorithm and compared this to a mo...

journal_title：Clinical chemistry and laboratory medicine

authors： Servais G,Karmali R,Guillaume MP,Badot V,Duchateau J,Corazza F

更新日期：2009-01-01 00:00:00

abstract：:Soluble transferrin receptor (sTfR) is reported to be a reliable marker for the diagnosis of iron deficiency, especially when iron metabolism is influenced by inflammatory disorders such as infection, chronic inflammation and cancer-related anemia. In the present multicenter study the analytical performance of a recen...

journal_title：Clinical chemistry and laboratory medicine

authors： Kolbe-Busch S,Lotz J,Hafner G,Blanckaert NJ,Claeys G,Togni G,Carlsen J,Röddiger R,Thomas L

更新日期：2002-05-01 00:00:00

abstract：:There are large differences in the use of laboratory tests between hospitals in Sweden. These differences are not only due to differences between the patients treated but also to differences in practice. Use of laboratory test seems to reflect local traditions to a large extent. These large variations in practice are ...

journal_title：Clinical chemistry and laboratory medicine

authors： Larsson A,Palmer M,Hultén G,Tryding N

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF/MS), a laboratory-friendly technique, is used to identify biomarkers for cancer. The aim of the present study was to explore the application of SELDI proteomic patterns in serum for distinguishing between cases of pa...

journal_title：Clinical chemistry and laboratory medicine

authors： Navaglia F,Fogar P,Basso D,Greco E,Padoan A,Tonidandel L,Fadi E,Zambon CF,Bozzato D,Moz S,Seraglia R,Pedrazzoli S,Plebani M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is a risk factor for ischemic heart disease. Several other mechanisms apply also to dilative types of heart failure of various, non-ischemic etiologies. We hypothesized that hyperhomocysteinemia is associated with left ventricular (LV) dilatation and hypertrophy in dilative cardiomyopath...

journal_title：Clinical chemistry and laboratory medicine

authors： Alter P,Rupp H,Rominger MB,Figiel JH,Renz H,Klose KJ,Maisch B

更新日期：2010-04-01 00:00:00

abstract：:It is well-established that more than 8% of patients examined for vitamin B12 deficiency unexpectedly have increased plasma levels of the vitamin, but so far there are no guidelines for the clinical interpretation of such findings. In this review, we summarise known associations between high plasma cobalamin and disea...

journal_title：Clinical chemistry and laboratory medicine

authors： Arendt JF,Nexo E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Transition from communications (abstracts) of an Argentinean congress and their publication as full papers was analyzed. No similar report was found for clinical laboratory in Latin America. METHODS:A total of 388 communications from five congresses were identified, and searches were performed on the intern...

journal_title：Clinical chemistry and laboratory medicine

authors： Martínez AM,Fink NE

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:We evaluated the effect of kidney glomerular function on serum concentrations of human epididymis protein 4 (HE4) using creatinine (Cr), cystatin C (CysC) and related chronic kidney disease epidemiology collaboration (CKD-EPI) equations. METHODS:We enrolled 101 women aged ≤56 years with a glomerular filtrat...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Pasqualetti S,Carnevale A,Panteghini M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Serum amino acids, part of a pool of free amino acids, are influenced by metabolism and disease. Few reports exist describing their function and concentrations in serum. Our study aimed to determine age- and gender-related differences in serum amino acid concentrations in healthy Japanese patients, focusing ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kouchiwa T,Wada K,Uchiyama M,Kasezawa N,Niisato M,Murakami H,Fukuyama K,Yokogoshi H

更新日期：2012-01-04 00:00:00

abstract：:The present paper describes an evaluation of the interferences found with an immunochemical drug test performed during a workplace control. During the period 1993-2003 more than 200,000 urine samples from workers were examined by the Italian Air Force. Samples were screened for drugs of abuse (opiates, cocaine, cannab...

journal_title：Clinical chemistry and laboratory medicine

authors： De Giovanni N,Fucci N

更新日期：2006-01-01 00:00:00

abstract：:Congenital disorders of glycosylation (CDG) are genetic multisystemic diseases due to various defects in the biosynthesis or processing of glycoproteins. Our aim is to present our experience in the selective screening of CDG syndrome in a paediatric population (421 patients) with clinical suspicion of the disease, ana...

journal_title：Clinical chemistry and laboratory medicine

authors： Colomé C,Ferrer I,Artuch R,Vilaseca MA,Pineda M,Briones P

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:There are several methods for calculating serum osmolality, and their accordance with measured osmolality is the subject of controversy. METHODS:The concentrations of sodium, potassium, glucose, blood urea nitrogen (BUN) and osmolalities of 210 serum samples were measured. Two empirical equations were deduc...

journal_title：Clinical chemistry and laboratory medicine

authors： Rasouli M,Kalantari KR

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Aging is the result of several mechanisms which operate simultaneously. Among them, glycation is of particular interest because it is a reaction which affects slowly renewing tissues and macromolecules with elevated half-life, like the dermis, a skin compartment highly affected by aging. Glycation produces c...

journal_title：Clinical chemistry and laboratory medicine

authors： Pageon H,Zucchi H,Rousset F,Monnier VM,Asselineau D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:EML4-ALK fusion oncogene has emerged as a novel molecular target in non-small cell lung cancer (NSCLC). Although break-apart fluorescent in situ hybridization (FISH) is the standard method for diagnosis, it is expensive, not readily available and sometimes difficult to interpret. In addition, ALK immunohisto...

journal_title：Clinical chemistry and laboratory medicine

authors： Rho JK,Lee H,Park CS,Choi CM,Lee JC

更新日期：2013-09-01 00:00:00

abstract：:Individual risk of toxicity or cancer reflects the amount of exposure to environmental agents, combined with one's underlying genetic predisposition. More than six dozen human ecogenetic polymorphisms have been described; whereas some of these have been demonstrated to be associated with altered risks of toxicity or c...

journal_title：Clinical chemistry and laboratory medicine

authors： Nebert DW

更新日期：2000-09-01 00:00:00

abstract：Background:Anti-mitochondrial autoantibodies (AMA) detected by indirect immunofluorescence (IIF) on rodent tissues are the diagnostic marker of primary biliary cholangitis (PBC). However, up to 15% of patients with PBC are AMA-negative by IIF. In the effort to close the serological gap and improve the diagnostic sensit...

journal_title：Clinical chemistry and laboratory medicine

authors： Villalta D,Seaman A,Tiongson M,Warren C,Bentow C,Bizzaro N,Alessio MG,Porcelli B,Norman GL,Mahler M

更新日期：2020-04-10 00:00:00

abstract：:The soluble transferrin receptor (sTfR) distinguishes iron deficiency anemia from other types of anemia. Refractory iron deficiency anemia is often the onset symptom in malabsorption-induced celiac disease. We evaluated whether sTfR levels distinguish celiac disease-associated iron deficiency anemia from iron deficien...

journal_title：Clinical chemistry and laboratory medicine

authors： De Caterina M,Grimaldi E,Di Pascale G,Salerno G,Rosiello A,Passaretti M,Scopacasa F

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Iodine requirements increase during pregnancy and previous studies have reported the inadequate iodine status of pregnant women in areas that have achieved iodine sufficiency in the general population. We examined the urinary iodine (UI) concentrations of pregnant women in Ukraine, where the iodine status is...

journal_title：Clinical chemistry and laboratory medicine

authors： Sekitani Y,Hayashida N,Takahashi J,Kozlovsky AA,Rudnitskiy S,Petrova A,Gutevych OK,Chorniy SA,Yamashita S,Takamura N

更新日期：2013-04-01 00:00:00

abstract：:This article provides an overview of the role of metabolite toxicity, low-grade inflammation and disturbed cellular signaling in obesity, glucose intolerance and diabetes. It also highlights links between this continuum of deteriorating glucose tolerance and atherosclerosis. Obesity, diabetes mellitus, and cardiovascu...

journal_title：Clinical chemistry and laboratory medicine

authors： Dominiczak MH

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The Schwartz 2009 creatinine-based revised formula is the only pediatric GFR estimating formula, which is compatible with the recent global creatinine standardization. This formula is only applicable if enzymatic creatinine methods are used. We propose an equation, taking into account the relative bias cause...

journal_title：Clinical chemistry and laboratory medicine

authors： Speeckaert MM,Wuyts B,Stove V,Walle JV,Delanghe JR

更新日期：2012-03-09 00:00:00

abstract：:ISO 15189's particular requirements for quality management in medical laboratories provide guidance for (a) relating performance specifications to the intended use of a test or examination procedure, (b) designing internal quality control (IQC) procedures to verify the attainment of the intended quality of test result...

journal_title：Clinical chemistry and laboratory medicine

authors： Westgard JO

更新日期：2010-01-01 00:00:00

abstract：:Proteomics analysis has been heralded as a novel tool for identifying new and specific biomarkers that may improve diagnosis and monitoring of various disease states. Recent years have brought a number of proteomics profiling technologies. Although proteomics profiling has resulted in the detection of disease-associat...

journal_title：Clinical chemistry and laboratory medicine

authors： Findeisen P,Neumaier M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Chronic atrophic gastritis (CAG) is a precursor of the intestinal type of gastric cancer, the second leading cause of cancer-related death worldwide. GastroPanel is a recently marketed serological kit for the non-invasive diagnosis of CAG, defined by some authors "even more reliable than biopsy histology". T...

journal_title：Clinical chemistry and laboratory medicine

authors： Lombardo L,Leto R,Molinaro G,Migliardi M,Ravarino N,Rocca R,Torchio B

更新日期：2010-09-01 00:00:00

abstract：:Since PSA is supposed to play an active role in the progression of prostate cancer, we applied a quantitative RT-PCR to measure the absolute levels of prostate-specific antigen (PSA) mRNA expression in benign and malignant prostatic tissue. Consecutive fine needle prostate biopsy material from 59 patients (43 with pro...

journal_title：Clinical chemistry and laboratory medicine

authors： Gelmini S,Tricarico C,Petrone L,Forti G,Amorosi A,Dedola GL,Serio M,Pazzagli M,Orlando C

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incide...

journal_title：Clinical chemistry and laboratory medicine

authors： Nikolopoulos GK,Bagos PG,Tsangaris I,Tsiara CG,Kopterides P,Vaiopoulos A,Kapsimali V,Bonovas S,Tsantes AE

更新日期：2014-07-01 00:00:00

abstract：:Polymorphisms of the gene encoding apolipoprotein E have been implicated in the pathogenesis of peripheral and coronary artery disease and neurodegenerative disorders such as sporadic and late-onset familial forms of Alzheimer's disease. We have developed TaqMan assay systems for the single nucleotide polymorphisms -2...

journal_title：Clinical chemistry and laboratory medicine

authors： Koch W,Ehrenhaft A,Griesser K,Pfeufer A,Müller J,Schömig A,Kastrati A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Over the last few decades, new synthetic insulin analogues have been developed. Their measurement is of prime importance in the investigation of hypoglycaemia, but their quantification is hampered by variable cross-reactivity with many insulin assays. For clinical analysis, it has now become essential to kno...

journal_title：Clinical chemistry and laboratory medicine

authors： Heurtault B,Reix N,Meyer N,Gasser F,Wendling MJ,Ratomponirina C,Jeandidier N,Sapin R,Agin A

更新日期：2014-03-01 00:00:00