Urinary stone composition in pediatric patients: a retrospective study of 205 cases.

abstract：BACKGROUND:Sertoli-Leydig cell tumours of the ovary account for only 0.2% of malignant ovarian tumours. Two-thirds of all patients become apparent due to the tumour's hormone production. METHODS:A 41-year-old patient (gravida 4, para 4) presented with dyspnoea, enlarged abdominal girth and melaena. Diagnostic imaging ...

journal_title：Clinical chemistry and laboratory medicine

authors： Lenhard M,Kuemper C,Ditsch N,Diebold J,Stieber P,Friese K,Burges A

更新日期：2007-01-01 00:00:00

abstract：:People are increasingly able to access their laboratory results via patient portals. The potential benefits provided by such access, such as reductions in patient burden and improvements in patient satisfaction, disease management, and medical decision making, also come with potentially valid concerns about such resul...

journal_title：Clinical chemistry and laboratory medicine

authors： Witteman HO,Zikmund-Fisher BJ

更新日期：2019-02-25 00:00:00

abstract：:Background For pregnant women with suspected preeclampsia, the soluble fms-like tyrosine-kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio is a biomarker to aid diagnosis. We performed method comparisons between Elecsys® and Kryptor sFlt-1 and PlGF immunoassays and assessed the diagnostic performance for preeclam...

journal_title：Clinical chemistry and laboratory medicine

authors： Stepan H,Hund M,Dilba P,Sillman J,Schlembach D

更新日期：2019-08-27 00:00:00

abstract：BACKGROUND:Sequencing based mutation screening assays of genes encompassing large numbers of exons could be substantially optimized by multiplex PCR, which enables simultaneous amplification of many targets in one reaction. In the present study, a multiplex PCR protocol originally developed for fragment analysis was ev...

journal_title：Clinical chemistry and laboratory medicine

authors： Horn MP,Mäder-Heinemann G,Andrey G,Largiadèr CR

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The presence of preanalytical mistakes (PM) in samples from primary care centres (PCC) is a widely studied topic. Different correcting strategies have been proposed, with variable success. We planned a series of multidisciplinary sessions for clinical update, with the aim to decrease PM rates in samples from...

journal_title：Clinical chemistry and laboratory medicine

authors： Romero A,Gómez-Salgado J,Gómez-Fernández JA,Cobos A,Ruiz-Frutos C

更新日期：2017-10-26 00:00:00

abstract：:Age-related macular degeneration (AMD) is a sight threatening eye disease that affects millions of humans over the age of 65 years. It is considered to be the major cause of irreversible blindness in the elderly population in the developed world. The disease is prevalent in Europe and the United States, which has a la...

journal_title：Clinical chemistry and laboratory medicine

authors： Kokotas H,Grigoriadou M,Petersen MB

更新日期：2011-04-01 00:00:00

abstract：:Background Intravenous lipid emulsion (ILE) is used to treat drug poisonings. The resultant hyperlipemia may affect laboratory tests but the consequences are poorly characterized. In a clinical trial we therefore investigated the effects of ILE on laboratory tests analyzed on common analytical platforms (Roche® cobas ...

journal_title：Clinical chemistry and laboratory medicine

authors： Petersen KM,Jørgensen NR,Bøgevig S,Petersen TS,Jensen TB,Dalhoff KP,Christensen MB

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:There are several complementary English-language guidelines for the performance of the sweat chloride test. These guidelines also incorporate information for the collection of conductivity samples. However, recommendations for the measurement and reporting of sweat conductivity are less clear than for sweat ...

journal_title：Clinical chemistry and laboratory medicine

authors： Greaves RF,Jolly L,Massie J,Scott S,Wiley VC,Metz MP,Mackay RJ,Australasian Association of Clinical Biochemists Sweat Test Working Party in association with the Royal Australasian College of Pathologists Quality Assurance Programs.

更新日期：2018-03-28 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is unclear. We and others have reported that homocysteine (Hcy) is inversely correlated with plasma high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apoA-I) in patie...

journal_title：Clinical chemistry and laboratory medicine

authors： Liao D,Yang X,Wang H

更新日期：2007-01-01 00:00:00

abstract：:Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced high density lipoprotein (HDL), both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the -93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk an...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferencak G,Pasalić D,Grsković B,Cheng S,Fijal B,Sesto M,Skodlar J,Rukavina AS

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:The European Directive 98/79/EC on in-vitro diagnostic medical devices (IVDs) regulates IVD marketing practices and post-market surveillance. IVD manufacturers have to inform the responsible Competent Authorities of any issues. In Germany, the Federal Institute for Drugs and Medical Devices (BfArM) is respon...

journal_title：Clinical chemistry and laboratory medicine

authors： Siekmeier R,Lütz J

更新日期：2007-01-01 00:00:00

abstract：:Activated protein C (APC), a natural anticoagulant, is formed from protein C by the action of the thrombin-thrombomodulin (TM) complex on the endothelial cell surface. Endothelial protein C receptor augments the activation of protein C by the thrombin/TM system. APC inactivates the activated form of coagulation factor...

journal_title：Clinical chemistry and laboratory medicine

authors： Okajima K

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count. METHODS:In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) dif...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim HN,Hur M,Kim H,Kim SW,Moon HW,Yun YM

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:International recommendations highlight the superior value of cardiac troponins (cTns) for early diagnosis of myocardial infarction along with analytical requirements of improved precision and detectability. In this multicenter study, we investigated the analytical performance of a new high sensitive cardiac...

journal_title：Clinical chemistry and laboratory medicine

authors： Krintus M,Kozinski M,Boudry P,Capell NE,Köller U,Lackner K,Lefèvre G,Lennartz L,Lotz J,Herranz AM,Nybo M,Plebani M,Sandberg MB,Schratzberger W,Shih J,Skadberg Ø,Chargui AT,Zaninotto M,Sypniewska G

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse detection and monitoring of therapy response are crucial for efficient treatment of advanced melanoma. Thus, there is a need for blood-based biomarker...

journal_title：Clinical chemistry and laboratory medicine

authors： Kuhlmann JD,Wimberger P,Wilsch K,Fluck M,Suter L,Brunner G

更新日期：2015-03-01 00:00:00

abstract：:Although affinity and kinetic measurements on their own provide useful information regarding the suitability of antibodies for various immunoassays, a thermodynamic analysis provices additional information that throws light on the molecular forces at work in the antigen-antibody interaction. It may then be possible to...

journal_title：Clinical chemistry and laboratory medicine

authors： Van Regenmortel MH

更新日期：1998-06-01 00:00:00

abstract：:Common genetic variants of coagulation factor genes associated with differences in concentration and/or function of coagulation factors have been studied in search of variability that could explain the individual susceptibility to thrombosis and atherothrombotic diseases. The more outstanding polymorphisms in genes of...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferrer-Antunes C

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:The objective of this study was to examine the diagnostic accuracy of high-sensitivity cardiac troponin T (hs-cTnT) for acute myocardial infarction (AMI) in patients with renal insufficiency, since this population has a high incidence of non-AMI elevations of hs-cTnT. METHODS:In this prospective study, we e...

journal_title：Clinical chemistry and laboratory medicine

authors： Huang H,Zhu S,Wang W,Yi H,Du X,Nie X,He Y,Song H,Miao Q,Wang L,Li G

更新日期：2015-04-01 00:00:00

abstract：:Homocysteine is a risk factor for ischemic heart disease; similarly as is hyperlipidemia or insulin resistance, which frequently occur in women with polycystic ovary syndrome. We examined the relationships between thiols and hormonal status or insulin resistance in 40 women (aged 25.8 +/- 7 years) with polycystic ovar...

journal_title：Clinical chemistry and laboratory medicine

authors： Vrbíková J,Tallová J,Biciková M,Dvoráková K,Hill M,Stárka L

更新日期：2003-02-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is a potent inhibitor of nitric oxide synthase and is regarded as a novel risk factor for cardiovascular disease. The metabolic pathways of ADMA and homocysteine are strongly intertwined. First, during synthesis of ADMA, two equivalents of homocysteine are formed. Second, homocystein...

journal_title：Clinical chemistry and laboratory medicine

authors： Teerlink T

更新日期：2005-01-01 00:00:00

abstract：:Volatile biomarker analysis in exhaled breath is becoming one of the desirable strategies for cancer detection because it may offer a relatively inexpensive, rapid, and non-invasive screening method for early diagnosis. Breath analysis has attracted a considerable amount of scientific and clinical interest over the pa...

journal_title：Clinical chemistry and laboratory medicine

authors： Badjagbo K

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Adult-type hypolactasia is characterized by the inability to digest lactose during adulthood, due to lactase (LCT) deficiency. It is usually diagnosed by the measurement of breath hydrogen increase after a lactose load (breath hydrogen test, BHT). A substitution of C to T at position -13910 bp upstream the L...

journal_title：Clinical chemistry and laboratory medicine

authors： Mottes M,Belpinati F,Milani M,Saccomandi D,Petrelli E,Calacoci M,Chierici R,Pignatti PF,Borgna-Pignatti C

更新日期：2008-01-01 00:00:00

abstract：:Collagenous proteins are especially prone to nonenzymatic glycation, because they contain several dibasic amino acid residues with free amino groups, have a very slow turnover rate, and are exposed to ambient levels of glucose. The aim of this study was to determine the time-dependent course of advanced glycation proc...

journal_title：Clinical chemistry and laboratory medicine

authors： Turk Z,Misur I,Turk N,Benko B

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Potassium is an important serum ion that is frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate reference method for serum potassium measurements is important. METHODS:An inductively coupled plasma mass spectrometry (ICP-MS) metho...

journal_title：Clinical chemistry and laboratory medicine

authors： Yan Y,Han B,Zeng J,Zhou W,Zhang T,Zhang J,Chen W,Zhang C

更新日期：2017-08-28 00:00:00

abstract：:Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The i...

journal_title：Clinical chemistry and laboratory medicine

authors： Hong YJ,Lee JK,Lee GH,Hong SI

更新日期：2000-09-01 00:00:00

abstract：:Introduction Element-tagged immunoassay coupled with inductively coupled plasma-mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis in clinical detection; however, a systematic evaluation with the standard guidelines of the assay is needed to ensure its performance meets the re...

journal_title：Clinical chemistry and laboratory medicine

authors： Jiang W,Sun G,Wen X,Men S,Cui W,Jing M,Jia X,Hu Z,Pu D,Zhang S,Yuan X,Liu X,Zhang X,Wang C

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:The compatibility of immunoassay tests in different sample matrices is extremely important during the assay validation process. In this study, we investigated the interchangeability of some Access (and therefore all the UniCel Family platforms) assays between serum and plasma. METHODS:We tested approximatel...

journal_title：Clinical chemistry and laboratory medicine

authors： Vignati G,Chiecchio A,Osnaghi B,Giovanelli L,Meloncelli C

更新日期：2008-01-01 00:00:00

abstract：:Intake of drugs may influence the interpretation of laboratory test results. Knowledge and correct interpretation of possible drug-laboratory test interactions (DLTIs) is important for physicians, pharmacists and laboratory specialists. Laboratory results may be affected by analytical or physiological effects of medic...

journal_title：Clinical chemistry and laboratory medicine

authors： van Balveren JA,Verboeket-van de Venne WPHG,Erdem-Eraslan L,de Graaf AJ,Loot AE,Musson REA,Oosterhuis WP,Schuijt MP,van der Sijs H,Verheul RJ,de Wolf HK,Kusters R,Hoedemakers RMJ,Dutch Society for Clinical Chemistry and Laborat

更新日期：2018-11-27 00:00:00

abstract：:Background Biochemical bone turnover markers (BTM) are useful tools to assess bone remodeling at the cellular level. N-terminal propeptide of type I procollagen (PINP) has been recommended as a reference marker for bone formation in research studies. Methods We describe the results of a multicenter study for routine c...

journal_title：Clinical chemistry and laboratory medicine

authors： Cavalier E,Eastell R,Rye Jørgensen N,Makris K,Tournis S,Vasikaran S,Kanis JA,Cooper C,Pottel H,Morris HA,IFCC-IOF Joint Committee for Bone Metabolism (C-BM).

更新日期：2019-09-25 00:00:00

abstract：BACKGROUND:Inflammation plays an imperative role in the etiology of cardiovascular diseases (CVD). The role of cytokines in the development and progression of idiopathic dilated cardiomyopathy (IDCM) is still uncertain. The current study was conducted to evaluate the association of tumor necrosis factor-α (TNF-α) -238G...

journal_title：Clinical chemistry and laboratory medicine

authors： Liaquat A,Shauket U,Ahmad W,Javed Q

更新日期：2015-02-01 00:00:00