Laboratory performance of sweat conductivity for the screening of cystic fibrosis.

abstract：:Cryoglobulins are proteins that precipitate at temperatures below 37 degrees C. Cold-induced precipitation of proteins may occur in vivo secondary to several important diseases, and lead to pathological manifestations involving different organs. Cryoprecipitation may be observed in vitro by exposing serum samples, sup...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Stasio E,Bizzarri P,Bove M,Casato M,Giardina B,Fiorilli M,Galtieri A,Pucillo LP

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Investigation of a 61-year-old Caucasian male suffering from fatigue and weight loss led to the finding of a carbohydrate antigen 19-9 (CA 19-9) concentration of 80 kU/L using an ADVIA Centaur analyser. Determination of CA 19-9 on Vidas, AxSYM and Architect i2000 systems gave normal results. His rheumatoid f...

journal_title：Clinical chemistry and laboratory medicine

authors： Berth M,Bosmans E,Everaert J,Dierick J,Schiettecatte J,Anckaert E,Delanghe J

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Genes correlated with nicotine may be important in obesity because of the role of nicotine in food intake. METHODS:To determine if single nucleotide polymorphisms (SNPs) in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) are associated with overweight/obesity, 156 non-obese and 20...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim J

更新日期：2008-01-01 00:00:00

abstract：:Dementia is a growing public health concern because of the lack of effective curative treatment options and a rising global prevalence. Alzheimer's disease (AD) is the most common type of dementia, affecting 60%-70% of all patients with dementia. The main pathological features of Alzheimer's dementia are neurofibrilla...

journal_title：Clinical chemistry and laboratory medicine

authors： Demarin V,Zavoreo I,Kes VB,Simundić AM

更新日期：2011-05-01 00:00:00

abstract：:Biochemical measurements in "special fluids" are complicated with the problem of reference intervals. Reference intervals are difficult to establish for these types of samples since they are usually only collected in patients with clinical suspicion of disease. Determination of neurotransmitter metabolites in cerebros...

journal_title：Clinical chemistry and laboratory medicine

authors： Dhondt JL

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kennard A,Hawley C,Tate J,Klingberg S,Pretorius C,Hutchison C,Mollee P

更新日期：2016-06-01 00:00:00

abstract：:The serum free light chain (FLC) assay has proven to be an important complementary test in the management of patients with monoclonal gammopathies. The serum FLC assay has value for patients with plasma cell disorders in the context of screening and diagnosis, prognostic stratification, and quantitative monitoring. No...

journal_title：Clinical chemistry and laboratory medicine

authors： Jacobs JF,Tate JR,Merlini G

更新日期：2016-06-01 00:00:00

abstract：:Angiogenesis is a crucial process in tissue remodeling during growth, both in the embryo and the adult. In our study we concentrated on the direct effect of beta-carotene on human umbilical cord originating from endothelial progenitor cells (EPCs). beta-Carotene uptake by EPCs was measured using a HPLC method. The det...

journal_title：Clinical chemistry and laboratory medicine

authors： Kieć-Wilk B,Polus A,Grzybowska J,Mikołajczyk M,Hartwich J,Pryjma J,Skrzeczyńska J,Dembińska-Kieć A

更新日期：2005-01-01 00:00:00

abstract：:Since serum and plasma D-dimer concentrations correlate very well, we evaluated the comparability of other haemostasis activation markers in plasma and serum. Prothrombin fragment F1+2, fibrin monomer and D-dimer concentrations were measured with commercially available immunoassays in serum and plasma. Serum to plasma...

journal_title：Clinical chemistry and laboratory medicine

authors： Korte W,Riesen WF

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Mid-regional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. METHODS:In a prospective...

journal_title：Clinical chemistry and laboratory medicine

authors： Behnes M,Papassotiriou J,Walter T,Fiedler E,Sauer T,Lang S,Elmas E,Hoffmann U,Borggrefe M,Brueckmann M

更新日期：2008-01-01 00:00:00

abstract：:Reference intervals for healthy subjects and diseased populations are important benchmarks for the clinical interpretation of laboratory test values. It is important that the testing conditions used to collect the reference data be closely matched with the testing conditions used for patient data. Interlaboratory diff...

journal_title：Clinical chemistry and laboratory medicine

authors： Klee GG

更新日期：2004-01-01 00:00:00

abstract：:The pathogenesis of cobalamin (Cbl)-deficient (Cbl-D) neuropathy and the role of normal prions (PrPcs) in myelin maintenance are both subjects of debate. We have demonstrated that Cbl deficiency damages myelin by increasing tumor necrosis factor (TNF)-α, and decreasing epidermal growth factor (EGF) levels in the rat c...

journal_title：Clinical chemistry and laboratory medicine

authors： Scalabrino G,Veber D

更新日期：2013-03-01 00:00:00

abstract：:Background uPA and PAI-1 are breast cancer biomarkers that evaluate the benefit of chemotherapy (CT) for HER2-negative, estrogen receptor-positive, low or intermediate grade patients. Our objectives were to observe clinical routine use of uPA/PAI-1 and to build a new therapeutic decision tree integrating uPA/PAI-1. Me...

journal_title：Clinical chemistry and laboratory medicine

authors： Reix N,Lodi M,Jankowski S,Molière S,Luporsi E,Leblanc S,Scheer L,Ibnouhsein I,Benabu JC,Gabriele V,Guggiola A,Lessinger JM,Chenard MP,Alpy F,Bellocq JP,Neuberger K,Tomasetto C,Mathelin C

更新日期：2019-05-27 00:00:00

abstract：:A rat model is introduced which enables investigations in anticoagulated blood with continuous measurements by a flow-through electrode system. In the present study, a potentiometric ion-selective electrode (ISE)-system was used for measuring Ca2+, K+, Na+ and pH in rats. The setup was adjusted to an extracorporeal bl...

journal_title：Clinical chemistry and laboratory medicine

authors： Heidrich JP,Niemeier A,Seyfarth M

更新日期：1998-11-01 00:00:00

abstract：:The mutant of CYP2D6*3 allele with A2637 deletion in exon 5 and the mutant of CYP2D6*4 allele G1934-->A, splice site defect are among the most common polymorphic alleles of CYP2D6 gene, resulting in a decreased or no activity of CYP isoenzyme. In this study, a reliable polymerase chain reaction-restriction fragment le...

journal_title：Clinical chemistry and laboratory medicine

authors： Topić E,Stefanović M,Nikolić V,Zoricić I,Ivanisević AM,Zuntar I

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Elevated plasma total homocysteine is a risk factor for cardiovascular disease (CVD), but the randomized trials of dietary supplementation with B-vitamins to lower homocysteine have not yet provided clear evidence of benefit on vascular risk. METHODS:Cumulative meta-analysis of all randomized trials assessi...

journal_title：Clinical chemistry and laboratory medicine

authors： Clarke R,Armitage J,Lewington S,Collins R,B-Vitamin Treatment Trialists' Collaboration.

更新日期：2007-01-01 00:00:00

abstract：:Cardiovascular risk is associated with high lipoprotein(a) (Lp(a)) concentrations and low molecular weight apolipoprotein(a) (apo(a)) isoforms. We studied the relationship between these two biological parameters, particularly in subjects expressing two apo(a) isoforms. Plasma Lp(a) was measured by immunonephelometry i...

journal_title：Clinical chemistry and laboratory medicine

authors： Alaoui M,Merle C,Garnotel R,Jolly D,Durlach V,Gillery P

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The IFCC Task Force on Clinical Applications of Cardiac Biomarkers suggests comparing several contemporary sensitive troponin assays in the same, sufficiently large reference population. METHODS:Three contemporary sensitive assays were used to measure troponin I concentration in samples from a uniquely larg...

journal_title：Clinical chemistry and laboratory medicine

authors： Petersmann A,Ittermann T,Fries C,Lubenow N,Kohlmann T,Kallner A,Greinacher A,Nauck M

更新日期：2013-11-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency is present in more than 90% of patients with congenital adrenal hyperplasia, an inherited metabolic disorder of adrenal steroidogenesis. Impaired enzymatic activity leads to the accumulation of metabolic intermediates (progesterone and 17-hydroxyprogesterone), which results in excessi...

journal_title：Clinical chemistry and laboratory medicine

authors： Concolino P,Mello E,Zuppi C,Capoluongo E

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The European Society for Pediatric Gastroenterology and Nutrition states that if IgA anti-tissue transglutaminase (tTG) exceeds 10 times the upper limit of normal (ULN), there is the possibility to diagnose celiac disease (CD) without duodenal biopsy, if supported by anti-endomysium testing and human leukocy...

journal_title：Clinical chemistry and laboratory medicine

authors： Oyaert M,Vermeersch P,De Hertogh G,Hiele M,Vandeputte N,Hoffman I,Bossuyt X

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Accurate and early diagnosis of tuberculosis (TB) is of major importance in the management and control of TB. Because the conventional bacteriological diagnosis of TB has several limitations, nucleic acid amplification (NAA) tests have emerged as promising alternatives. A potential problem with NAA tests is ...

journal_title：Clinical chemistry and laboratory medicine

authors： Qin L,Zheng R,Fan C,Cai J,Liu Z,Wang J,Lu J,Jin R,Yang H,Cui Z,Feng Y,Hu Z

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Proteogenomics is an emerging field at the intersection of genomics and proteomics. Many variant peptides corresponding to single nucleotide variations (SNVs) are associated with specific diseases. The aim of this study was to demonstrate the feasibility of proteogenomic-based variant peptide detection in di...

journal_title：Clinical chemistry and laboratory medicine

authors： Dimitrakopoulos L,Prassas I,Berns EMJJ,Foekens JA,Diamandis EP,Charames GS

更新日期：2017-08-28 00:00:00

abstract：:Intake of drugs may influence the interpretation of laboratory test results. Knowledge and correct interpretation of possible drug-laboratory test interactions (DLTIs) is important for physicians, pharmacists and laboratory specialists. Laboratory results may be affected by analytical or physiological effects of medic...

journal_title：Clinical chemistry and laboratory medicine

authors： van Balveren JA,Verboeket-van de Venne WPHG,Erdem-Eraslan L,de Graaf AJ,Loot AE,Musson REA,Oosterhuis WP,Schuijt MP,van der Sijs H,Verheul RJ,de Wolf HK,Kusters R,Hoedemakers RMJ,Dutch Society for Clinical Chemistry and Laborat

更新日期：2018-11-27 00:00:00

abstract：:Homocysteine is a risk factor for ischemic heart disease; similarly as is hyperlipidemia or insulin resistance, which frequently occur in women with polycystic ovary syndrome. We examined the relationships between thiols and hormonal status or insulin resistance in 40 women (aged 25.8 +/- 7 years) with polycystic ovar...

journal_title：Clinical chemistry and laboratory medicine

authors： Vrbíková J,Tallová J,Biciková M,Dvoráková K,Hill M,Stárka L

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Transferrin (Tf) glycoform lacking one or two complete or incomplete glycan chains (i.e., asialo-monosialo- and disialo-Tf) typically appear in blood after chronic alcohol consumption, though recently it was reported that monosialo-Tf is associated with trisialo-Tf but not with alcohol consumption. These gly...

journal_title：Clinical chemistry and laboratory medicine

authors： Daves M,Cemin R,Floreani M,Pusceddu I,Cosio G,Lippi G

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The clinical relevance of chromogranin A (CgA) concentrations depends on the analytical performance of the assay. The goal of the present study was to define the clinical involvements in CgA calibration models by evaluating the confidence intervals (CIs) for values from patients who were undergoing monitorin...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Marano G,Ciardi L,Vendramin C,Bongo AS,Bellomo G,Boracchi P,Biganzoli EM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The immunoglobulin superfamily receptor translocation-associated 2 (IRTA2) gene encodes both membrane and secreted forms of the B-cell differentiation antigen (also identified as FcRH5). The membrane form is highly expressed on the surface of hairy cell leukemia (HCL) cells from patients. This study aimed to...

journal_title：Clinical chemistry and laboratory medicine

authors： Ise T,Kreitman RJ,Pastan I,Nagata S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The measurement of serum IgE aids in the diagnosis and management of atopic allergic disease and hyper-IgE immunodeficiency syndromes. The 2nd World Health Organization (WHO) International Reference Reagent (IRR) for serum IgE (75/502; 5000 IU/ampoule), is widely used to calibrate assays for serum IgE. Exhau...

journal_title：Clinical chemistry and laboratory medicine

authors： Thorpe SJ,Heath A,Fox B,Patel D,Egner W

更新日期：2014-09-01 00:00:00

abstract：:The effect of solvent conditions on the aggregation of IgM in serum specimens from patients with macroglobulinemia was studied by a turbidimetric procedure. Aggregation of IgM varied considerably among the samples and was affected by a number of experimental parameters. In general, IgM aggregation was more pronounced ...

journal_title：Clinical chemistry and laboratory medicine

authors： Sharma L,Baker J,Brooks AM,Sharma A

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Genetic predisposition to hemochromatosis involves several different point mutations in the HFE gene. Routine testing for two such mutations (H63D and S65C) using real-time genotyping deserves special care, as these mutations are in close proximity (6 bp) of each other. METHODS:A novel assay was designed fo...

journal_title：Clinical chemistry and laboratory medicine

authors： Klaassen CH,van Aarssen YA,van der Stappen JW

更新日期：2008-01-01 00:00:00