Clinical interpretation of reference intervals and reference limits. A plea for assay harmonization.

abstract：:Background This study aimed to investigate the correlation between glucose fluctuation from self-monitored blood glucose (SMBG) and the major adverse cardiac events (MACE) in diabetic patients with acute coronary syndrome (ACS) during a 6-month follow-up period using the WeChat application. Methods From November 2016 ...

journal_title：Clinical chemistry and laboratory medicine

authors： Xia J,Hu S,Xu J,Hao H,Yin C,Xu D

更新日期：2018-11-27 00:00:00

abstract：:Objectives Our recent survey of 44 mass spectrometry laboratories across 17 countries identified variation in internal standard (IS) choice for the measurement of serum/plasma 17α-hydroxyprogesterone (17OHP) by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The choice of IS may contribute to inter-method v...

journal_title：Clinical chemistry and laboratory medicine

authors： Loh TP,Ho CS,Hartmann MF,Zakaria R,Lo CWS,van den Berg S,de Rijke YB,Cooke BR,Hoad K,Graham P,Davies SR,Mackay LG,Wudy SA,Greaves RF

更新日期：2020-09-25 00:00:00

abstract：:Evidence of the acute lack of interchangeable laboratory results and consensus in current practice among clinical laboratories has underpinned greater attention to standardization and harmonization projects. Although the focus is mainly on the standardization of measurement procedures, the scope of harmonization goes ...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M

更新日期：2013-04-01 00:00:00

abstract：:Circulating blood platelets play a central role in the maintenance of hemostasis. They adhere to subendothelial extracellular matrix proteins that become exposed upon vessel wall damage, which is followed by platelet activation, further platelet recruitment, platelet aggregation and formation of an occlusive, or non-o...

journal_title：Clinical chemistry and laboratory medicine

authors： Provost P

更新日期：2017-05-01 00:00:00

abstract：:Complexity, cost, and content are three important factors that can impede translation of clinical protein mass spectrometry (MS) tests at a larger scale. Complexity stems from the many components/steps involved in bottom-up protein MS workflows, making them significantly more complicated than enzymatic immunoassays (E...

journal_title：Clinical chemistry and laboratory medicine

authors： Nedelkov D,Hu Y

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:In large clinical trials, where RNA cannot be extracted immediately after sampling, preserving RNA in whole blood is a crucial initial step in obtaining robust qPCR data. The current golden standard for RNA preservation is costly and designed for time-consuming column-based RNA-extraction. We investigated th...

journal_title：Clinical chemistry and laboratory medicine

authors： Mærkedahl RB,Frøkiær H,Lauritzen L,Metzdorff SB

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Electrospray ionization mass spectrometry (ESI-MS) can be used for the measurement of glycated adult hemoglobin. Here, we describe the evaluation of ESI-MS for measurement of glycated (GHbF) and acetylated (AcHbF) fetal hemoglobin and the identification by mass of different chains of fetal hemoglobin. METHO...

journal_title：Clinical chemistry and laboratory medicine

authors： Davison AS,Green BN,Roberts NB

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The new swine influenza (H1N1) requires fast and accurate diagnosis. Currently, there are few reports about the diagnostic performance of influenza antigen tests with regard to the H1N1 virus infection. We evaluated the reactivity of eight commercially available rapid antigen tests in samples from confirmed ...

journal_title：Clinical chemistry and laboratory medicine

authors： Herzum I,Lutz T,Koch F,Geisel R,Gehrt A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The objective of the study was to find the incidence of hemolysis in samples transported through a pneumatic tube system (PTS) at different speeds. METHODS:This prospective observational study was done in three phases: "short distance and high speed (115 m at 3 m/s)", "long distance and high speed (225 m at...

journal_title：Clinical chemistry and laboratory medicine

authors： Tiwari AK,Pandey P,Dixit S,Raina V

更新日期：2011-11-10 00:00:00

abstract：:Cryoglobulins are proteins that precipitate at temperatures below 37 degrees C. Cold-induced precipitation of proteins may occur in vivo secondary to several important diseases, and lead to pathological manifestations involving different organs. Cryoprecipitation may be observed in vitro by exposing serum samples, sup...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Stasio E,Bizzarri P,Bove M,Casato M,Giardina B,Fiorilli M,Galtieri A,Pucillo LP

更新日期：2003-02-01 00:00:00

abstract：:Quality in diagnostic testing represents a key target of laboratory medicine, for which an assurance around the quality of testing is expected from all involved in the process. Laboratories attempt to assure the quality of their testing by various processes, but especially by performance of internal quality control an...

journal_title：Clinical chemistry and laboratory medicine

authors： Favaloro EJ,Jennings I,Olson J,Van Cott EM,Bonar R,Gosselin R,Meijer P

更新日期：2018-12-19 00:00:00

abstract：:Cancers of the respiratory tract (lung and head and neck) share common aetiologies, risk factors and molecular characteristics. Epigenetic reprogramming is one of the hallmarks of cancer and DNA methylation is currently the best-studied form. There are a number of characteristics of DNA methylation, which seem advanta...

journal_title：Clinical chemistry and laboratory medicine

authors： Markopoulou S,Nikolaidis G,Liloglou T

更新日期：2012-10-01 00:00:00

abstract：:The importance of proper consumption of dietary folate for human health has been highlighted by an extensive number of publications over several decades. Fortification of grain products with folic acid was initiated with the specific intent to prevent neural tube defects, and the scope of this endeavor is unique in th...

journal_title：Clinical chemistry and laboratory medicine

authors： Strickland KC,Krupenko NI,Krupenko SA

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The handling of cerebrospinal fluid (CSF) affects the biomarker quantification used to diagnose Alzheimer's disease (AD). Only specialized centers can test for AD markers. The precise timing and freezing is required to correctly measure these biomarkers. Therefore, the effects of CSF storage temperature and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Klener J,Hofbauerová K,Bartoš A,Ríčný J,Rípová D,Kopecký V

更新日期：2014-05-01 00:00:00

abstract：:The commutability of 13 control materials was evaluated by performing parallel measurements on two different analysers: a Synchron CX-5 Delta from Beckman-Coulter and a Vitros 950 from Ortho-Clinical Diagnostics. Twenty three clinical chemistry analytes (substrates, electrolytes and enzymatic activities) were determin...

journal_title：Clinical chemistry and laboratory medicine

authors： Brion E,Lessinger JM,Gould N,Leyendecker J,Férard G

更新日期：2002-06-01 00:00:00

abstract：:Three groups of patients have been studied longitudinally for 24 months to analyze the role of hepatitis G virus (HGV) in hepatic disease. Group 1 consisted of 50 patients with non-B, non-C chronic hepatitis, group 2 consisted of 44 hemodialyzed patients, and group 3 consisted of 50 healthy blood donors. The presence ...

journal_title：Clinical chemistry and laboratory medicine

authors： Grassi M,Mammarella A,Sagliaschi G,Granati L,Musca A,Traditi F,Pezzella M

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer's disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI). In the pr...

journal_title：Clinical chemistry and laboratory medicine

authors： Cervellati C,Romani A,Bergamini CM,Bosi C,Sanz JM,Passaro A,Zuliani G

更新日期：2015-06-01 00:00:00

abstract：:A rat model is introduced which enables investigations in anticoagulated blood with continuous measurements by a flow-through electrode system. In the present study, a potentiometric ion-selective electrode (ISE)-system was used for measuring Ca2+, K+, Na+ and pH in rats. The setup was adjusted to an extracorporeal bl...

journal_title：Clinical chemistry and laboratory medicine

authors： Heidrich JP,Niemeier A,Seyfarth M

更新日期：1998-11-01 00:00:00

abstract：:Background Evaluating the tumor RAS/BRAF status is important for treatment selection and prognosis assessment in metastatic colorectal cancer (mCRC) patients. Correction of artifacts from library preparation and sequencing is essential for accurately analyzing circulating tumor DNA (ctDNA) mutations. Here, we assessed...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang B,Wu S,Huang F,Shen M,Jiang H,Yu Y,Yu Q,Yang Y,Zhao Y,Zhou Y,Pan B,Liu T,Guo W

更新日期：2019-09-25 00:00:00

abstract：:Background Direct oral anticoagulants (DOACs) may cause false results of activated protein C resistance (APC-R) ratio. DOAC-Remove, a new reagent based on activated carbon, has been designed to eliminate the interference of DOACs on coagulation assays. The aim of the study was to investigate whether the use of DOAC-Re...

journal_title：Clinical chemistry and laboratory medicine

authors： Kopytek M,Ząbczyk M,Malinowski KP,Undas A,Natorska J

更新日期：2020-02-25 00:00:00

abstract：:The methods for detecting and measuring autoantibodies have evolved markedly in recent years, encompassing three generations of analytical technologies. Many different immunoassay methods have been developed and used for research and laboratory practice purposes, from the early conventional (or monoplex) analytical me...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,Bonaguri C,Melegari A,Antico A,Bassetti D,Bizzaro N

更新日期：2013-01-01 00:00:00

abstract：:Technological advances over the past decades have enabled oral fluid to expand its usefulness in the diagnosis of disease, prediction of disease progression, monitoring of therapeutic drug levels and detection of illicit drugs. The easy non-invasive nature of collection and the relationship between oral fluid and plas...

journal_title：Clinical chemistry and laboratory medicine

authors： Choo RE,Huestis MA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:We assessed whether glycated albumin (GA) is a useful glycemic indicator in diabetic patients with anemia who did not undergo dialysis. METHODS:Hemoglobin A(1c) (HbA(1c)) and GA were simultaneously measured in 370 diabetic subjects who had not undergone dialysis. The relationship between GA and HbA(1c) was ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim S,Min WK,Chun S,Lee W,Park HI

更新日期：2011-10-01 00:00:00

abstract：:Background Some clinical chemistry measurement methods are vulnerable to interference if hemolyzed serum samples are used. The aims of this study were: (1) to obtain updated information about how hemolysis affects clinical chemistry test results on different instrument platforms used in Nordic laboratories, and (2) to...

journal_title：Clinical chemistry and laboratory medicine

authors： Gidske G,Aakre KM,Rustad P,Sandberg S,Norling A,Pelanti J,Henriksen G,Thorsteinsdottir I,Kristensen GBB

更新日期：2019-10-25 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is unclear. We and others have reported that homocysteine (Hcy) is inversely correlated with plasma high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apoA-I) in patie...

journal_title：Clinical chemistry and laboratory medicine

authors： Liao D,Yang X,Wang H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Fibrinogen-based clot firmness is reported as the maximum amplitude (MA) when using the citrated functional fibrinogen (CFF) assay in thrombelastography (TEG), and as the maximum clot firmness (MCF) together with several clot amplitude parameters when using the FIBTEM assay in thromboelastometry (ROTEM). Con...

journal_title：Clinical chemistry and laboratory medicine

authors： Prüller F,Münch A,Preininger A,Raggam RB,Grinschgl Y,Krumnikl J,Toller W,Metzler H,Mahla E,Mangge H

更新日期：2016-03-01 00:00:00

abstract：:Winning a Nobel Prize is a great personal achievement. Some Nobel laureates may consider that their award is a certificate of competence in any field. This may prompt them to undertake projects or accept positions which are beyond their capabilities. Since Nobels are awarded when the laureates have usually passed thei...

journal_title：Clinical chemistry and laboratory medicine

authors： Diamandis EP

更新日期：2013-08-01 00:00:00

abstract：:Historical research on the concept of normality, its roots and its development show that this concept has its sources in very different areas of scientific and medical thinking. Of great importance were: (i) a new theory of disease arising early in the 19th century supposing a continuous change from the healthy to the...

journal_title：Clinical chemistry and laboratory medicine

authors： Büttner J

更新日期：1998-01-01 00:00:00

abstract：:Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Met...

journal_title：Clinical chemistry and laboratory medicine

authors： Veenhof H,Koster RA,Alffenaar JC,van den Berg AP,de Groot MR,Verschuuren EAM,Berger SP,Bakker SJL,Touw DJ

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative data and secondarily to evaluate the potential utility of GDF-15 in DKD using Roche Diagnostics ele...

journal_title：Clinical chemistry and laboratory medicine

authors： Hamon SM,Griffin TP,Islam MN,Wall D,Griffin MD,O'Shea PM

更新日期：2019-03-26 00:00:00