Influence of glutathione S-transferase M1 and T1 genotypes on larynx cancer risk among Korean smokers.

abstract：:Background uPA and PAI-1 are breast cancer biomarkers that evaluate the benefit of chemotherapy (CT) for HER2-negative, estrogen receptor-positive, low or intermediate grade patients. Our objectives were to observe clinical routine use of uPA/PAI-1 and to build a new therapeutic decision tree integrating uPA/PAI-1. Me...

journal_title：Clinical chemistry and laboratory medicine

authors： Reix N,Lodi M,Jankowski S,Molière S,Luporsi E,Leblanc S,Scheer L,Ibnouhsein I,Benabu JC,Gabriele V,Guggiola A,Lessinger JM,Chenard MP,Alpy F,Bellocq JP,Neuberger K,Tomasetto C,Mathelin C

更新日期：2019-05-27 00:00:00

abstract：:Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced high density lipoprotein (HDL), both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the -93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk an...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferencak G,Pasalić D,Grsković B,Cheng S,Fijal B,Sesto M,Skodlar J,Rukavina AS

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count. METHODS:In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) dif...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim HN,Hur M,Kim H,Kim SW,Moon HW,Yun YM

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:Heparin is the standard drug for anticoagulation treatment and is used in many cardiac surgical interventions to prevent blood clotting. The anticoagulation status is controlled by various clotting tests. However, these tests depend on parameters like temperature, hemodilution etc. and are thus not applicabl...

journal_title：Clinical chemistry and laboratory medicine

authors： Haselbach S,Maurer J,Vogel V,Harder S,Weber CF,Baykut D,Meininger D,Keller H,Moritz A,Mäntele W

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Reference laboratories providing reference services recognized by the Joint Committee for Traceability in Laboratory Medicine (JCTLM) must be accredited as calibration laboratories according to ISO 17025 and ISO 15195. These standards require laboratories to establish an uncertainty budget, in which the unce...

journal_title：Clinical chemistry and laboratory medicine

authors： Rami L,Canalias F

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Although many reports have elucidated pathophysiological characteristics of abnormal bone metabolism in patients with type 2 diabetes mellitus (DT2), determinants of bone mineral density (BMD) in patients with DT2 are still controversial. METHODS:We examined 168 Belarussian men 45-60 years of age. Plasma to...

journal_title：Clinical chemistry and laboratory medicine

authors： Vasilkova O,Mokhort T,Sanec I,Sharshakova T,Hayashida N,Takamura N

更新日期：2011-01-01 00:00:00

abstract：:Background Delta check is widely used for detecting specimen mix-ups. Owing to the inadequate specificity and sparseness of the absolute incidence of mix-ups, the positive predictive value (PPV) of delta check is considerably low as it is labor consuming to identify true mix-up errors among a large number of false ale...

journal_title：Clinical chemistry and laboratory medicine

authors： Mitani T,Doi S,Yokota S,Imai T,Ohe K

更新日期：2020-02-25 00:00:00

abstract：BACKGROUND:Sequencing based mutation screening assays of genes encompassing large numbers of exons could be substantially optimized by multiplex PCR, which enables simultaneous amplification of many targets in one reaction. In the present study, a multiplex PCR protocol originally developed for fragment analysis was ev...

journal_title：Clinical chemistry and laboratory medicine

authors： Horn MP,Mäder-Heinemann G,Andrey G,Largiadèr CR

更新日期：2009-01-01 00:00:00

abstract：:Polymorphisms of the gene encoding apolipoprotein E have been implicated in the pathogenesis of peripheral and coronary artery disease and neurodegenerative disorders such as sporadic and late-onset familial forms of Alzheimer's disease. We have developed TaqMan assay systems for the single nucleotide polymorphisms -2...

journal_title：Clinical chemistry and laboratory medicine

authors： Koch W,Ehrenhaft A,Griesser K,Pfeufer A,Müller J,Schömig A,Kastrati A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Established general risk score models for intensive care patients incorporate several clinical and laboratory data. However, the collection, documentation and classification of clinical data are time-consuming, incur labor-related costs, and are dependent on the experience of the examiner. Therefore, in the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stachon A,Segbers E,Hering S,Kempf R,Holland-Letz T,Krieg M

更新日期：2008-01-01 00:00:00

abstract：:Background This study aimed to investigate the correlation between glucose fluctuation from self-monitored blood glucose (SMBG) and the major adverse cardiac events (MACE) in diabetic patients with acute coronary syndrome (ACS) during a 6-month follow-up period using the WeChat application. Methods From November 2016 ...

journal_title：Clinical chemistry and laboratory medicine

authors： Xia J,Hu S,Xu J,Hao H,Yin C,Xu D

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:Potassium is an important serum ion that is frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate reference method for serum potassium measurements is important. METHODS:An inductively coupled plasma mass spectrometry (ICP-MS) metho...

journal_title：Clinical chemistry and laboratory medicine

authors： Yan Y,Han B,Zeng J,Zhou W,Zhang T,Zhang J,Chen W,Zhang C

更新日期：2017-08-28 00:00:00

abstract：BACKGROUND:The differential diagnosis between bacterial and viral meningitis is not easy in some cases. Cerebrospinal fluid (CSF) analysis is essential for establishing this diagnosis. The objectives were to quantitate lactic acid (LA) concentrations in bacterial and viral meningitis, and other central nervous system (...

journal_title：Clinical chemistry and laboratory medicine

authors： de Almeida SM,Faria FL,de Goes Fontes K,Buczenko GM,Berto DB,Raboni SM,Vidal LR,Nogueira MB

更新日期：2009-01-01 00:00:00

abstract：:Background Intravenous lipid emulsion (ILE) is used to treat drug poisonings. The resultant hyperlipemia may affect laboratory tests but the consequences are poorly characterized. In a clinical trial we therefore investigated the effects of ILE on laboratory tests analyzed on common analytical platforms (Roche® cobas ...

journal_title：Clinical chemistry and laboratory medicine

authors： Petersen KM,Jørgensen NR,Bøgevig S,Petersen TS,Jensen TB,Dalhoff KP,Christensen MB

更新日期：2018-11-27 00:00:00

abstract：:Laboratory Medicine organizations and their professional members have a goal and responsibility to benefit the health and wellbeing of the patients and communities they serve. Newer genetics and biochemical techniques raise significant issues of community concern, impacting on privacy, informed consent, access to and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Burnett L,McQueen MJ,Jonsson JJ,Torricelli F,IFCC Taskforce on Ethics 13.7.

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The oral glucose tolerance test (OGTT) is recommended to screen for diabetes in patients with coronary artery disease. We hypothesized that testing for glycated hemoglobin (HbA1c), in addition to the OGTT, in screening for abnormal glucose regulation may help to reveal patients with β-cell function impairmen...

journal_title：Clinical chemistry and laboratory medicine

authors： Li YH,Sheu WH,Lee WJ,Lee IT,Lin SY,Lee WL,Liang KW,Wang JS

更新日期：2018-07-26 00:00:00

abstract：Objectives:External quality assessment schemes (EQAS) are being established worldwide to support the faecal immunochemical test (FIT) for haemoglobin (Hb). FIT is widely used as a screening test for colorectal cancer and increasingly in assessment of patients presenting with symptoms. EQA for FIT is provided in several...

journal_title：Clinical chemistry and laboratory medicine

authors： O'Driscoll S,Piggott C,Bruce H,Benton SC

更新日期：2020-08-07 00:00:00

abstract：BACKGROUND:Cardiac troponin T (cTnT) has been reported to be a predictor of stroke outcome. We hypothesized that the high-sensitivity cTnT (hs-cTnT) assay is superior to its previous assay generation for stroke outcome prediction. METHODS:cTnT was measured on emergency department admission in 60 consecutive patients (...

journal_title：Clinical chemistry and laboratory medicine

authors： Furtner M,Ploner T,Hammerer-Lercher A,Pechlaner R,Mair J

更新日期：2012-11-01 00:00:00

abstract：:Background Aberrant kallikrein activity is observed in a number of inflammatory dermatoses. Up-regulation of kallikrein-5 (KLK5) activity leads to uncontrolled skin desquamation and cleavage of proteinase-activated receptor-2 (PAR2), causing the release of pro-inflammatory cytokines and disruption of epidermal barrier...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Paolo CT,Filippou PS,Yu Y,Poda G,Diamandis EP,Prassas I

更新日期：2019-10-25 00:00:00

abstract：:Glycosylation is among the most important post-translational modifications for proteins and is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50%-70% of proteins in circulation are glycosylated, and the "sweet attachments" have versatile structural and functional implications. Both ...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang M,Zhu J,Lubman DM,Gao C

更新日期：2019-03-26 00:00:00

abstract：BACKGROUND:We assessed whether glycated albumin (GA) is a useful glycemic indicator in diabetic patients with anemia who did not undergo dialysis. METHODS:Hemoglobin A(1c) (HbA(1c)) and GA were simultaneously measured in 370 diabetic subjects who had not undergone dialysis. The relationship between GA and HbA(1c) was ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim S,Min WK,Chun S,Lee W,Park HI

更新日期：2011-10-01 00:00:00

abstract：:Despite substantial evidence indicating the association of hyperhomocysteinemia (hHcys) and end-stage renal disease (ESRD), the pathogenic role of increased plasma homocysteine (Hcys) levels in the progression of ESRD remains unclear. This review will briefly summarize recent findings regarding the role of hHcys in th...

journal_title：Clinical chemistry and laboratory medicine

authors： Pin-Lan L,Fan Y,Ningjun L

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Improving quality and patient safety in the medical biochemistry laboratory accredited according to the International Standard Organization (ISO 15189:2012) requires the patient-centered evaluation of errors based on the implementation of quality indicators (QIs) across the total testing process. Our main go...

journal_title：Clinical chemistry and laboratory medicine

authors： Flegar-Meštrić Z,Perkov S,Radeljak A,Kardum Paro MM,Prkačin I,Devčić-Jeras A

更新日期：2017-03-01 00:00:00

abstract：:The effects of the time of the day and breakfast on the outcome of interleukin-6 and its soluble receptor in serum were studied on 22 subjectively health volunteers. We collected blood specimens at 8.00 a.m. after an overnight fast, at 9.30 a.m. after usual breakfast, and at 11.30 a.m. A second group of volunteers (n ...

journal_title：Clinical chemistry and laboratory medicine

authors： Dugué B,Leppänen E

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:With patients referred to emergency departments (EDs) for acute dyspnea, emergency physicians should consider all possible diagnoses and assess patients' risk stratification. Copeptin has been shown to have prognostic power for subsequent events, such as death and rehospitalization in patients admitted for d...

journal_title：Clinical chemistry and laboratory medicine

authors： Vetrone F,Santarelli S,Russo V,Lalle I,De Berardinis B,Magrini L,Di Stasio E,Salerno G,Cardelli P,Piccoli A,Codognotto M,Mion MM,Plebani M,Vettore G,Castello LM,Avanzi GC,Di Somma S

更新日期：2014-10-01 00:00:00

abstract：:Individual risk of toxicity or cancer reflects the amount of exposure to environmental agents, combined with one's underlying genetic predisposition. More than six dozen human ecogenetic polymorphisms have been described; whereas some of these have been demonstrated to be associated with altered risks of toxicity or c...

journal_title：Clinical chemistry and laboratory medicine

authors： Nebert DW

更新日期：2000-09-01 00:00:00

abstract：:Background Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers advantages over immunoassay due to its increased specificity and ability to multiplex metabolites within a single run. Wide scale adoption of LC-MS/MS in routine clinical laboratories is restricted in part due to the high level of technical ex...

journal_title：Clinical chemistry and laboratory medicine

authors： Benton SC,Tetteh GK,Needham SJ,Mücke J,Sheppard L,Alderson S,Ruppen C,Curti M,Redondo M,Milan AM

更新日期：2020-06-25 00:00:00

abstract：:The mutant of CYP2D6*3 allele with A2637 deletion in exon 5 and the mutant of CYP2D6*4 allele G1934-->A, splice site defect are among the most common polymorphic alleles of CYP2D6 gene, resulting in a decreased or no activity of CYP isoenzyme. In this study, a reliable polymerase chain reaction-restriction fragment le...

journal_title：Clinical chemistry and laboratory medicine

authors： Topić E,Stefanović M,Nikolić V,Zoricić I,Ivanisević AM,Zuntar I

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) and choline acetyltransferase (ChAT) have been suggested as candidate genes for determining the risk of late-onset Alzheimer's disease. The aim of this study was to simultaneously detect polymorphisms in codons 112 and 158 of APOE and codon 2 of ChAT by hybridization probe multiplexin...

journal_title：Clinical chemistry and laboratory medicine

authors： Park HD,Park KU,Kim KW,Song J,Chang HE,Heo SR,Lee HJ,Kim JQ

更新日期：2007-01-01 00:00:00

abstract：:We compared six routinely employed immunoassay kits: Architect i2000 and AxSYM, Abbott Laboratories; Elecsys 2010, Roche Diagnostics; ELSA, CIS-BioInternational; Immulite 1, Diagnostic Products Corporation; and IRMA-mat, Byk-Sangtec Diagnostica. Using all analytical systems, we measured identical groups of clinical sa...

journal_title：Clinical chemistry and laboratory medicine

authors： Stern P,Friedecky B,Bartos V,Bezdickova D,Vavrova J,Uhrova J,Rozprimova L,Zima T,Palicka V

更新日期：2001-12-01 00:00:00