Comparison of functional fibrinogen (FF/CFF) and FIBTEM in surgical patients - a retrospective study.

abstract：:Complexity, cost, and content are three important factors that can impede translation of clinical protein mass spectrometry (MS) tests at a larger scale. Complexity stems from the many components/steps involved in bottom-up protein MS workflows, making them significantly more complicated than enzymatic immunoassays (E...

journal_title：Clinical chemistry and laboratory medicine

authors： Nedelkov D,Hu Y

更新日期：2020-06-25 00:00:00

abstract：:Primary hypertension is a very common disorder particularly in the aging population but hypertensive disorders can appear earlier in life, especially when obesity and unhealthy lifestyle are present. Also pregnant women can be at risk of developing gestational hypertension and/or pre-eclampsia, which causes complicati...

journal_title：Clinical chemistry and laboratory medicine

authors： Danese E,Montagnana M,Fava C

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Filamin myopathy is a neuromuscular disorder manifesting with predominantly limb-girdle muscle weakness and in many patients with diaphragm paralysis and cardiomyopathy, caused by mutations in the filamin C (FLNC) gene. Molecular diagnosis of filamin myopathy based on direct DNA sequencing of coding exons is...

journal_title：Clinical chemistry and laboratory medicine

authors： Odgerel Z,van der Ven PF,Fürst DO,Goldfarb LG

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Genetic predisposition to hemochromatosis involves several different point mutations in the HFE gene. Routine testing for two such mutations (H63D and S65C) using real-time genotyping deserves special care, as these mutations are in close proximity (6 bp) of each other. METHODS:A novel assay was designed fo...

journal_title：Clinical chemistry and laboratory medicine

authors： Klaassen CH,van Aarssen YA,van der Stappen JW

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The presence of IgA antibodies to tissue transglutaminase (anti-tTg) is associated with variable risk for celiac disease. The use of common multiples of the upper limit of normal (ULN) has been suggested to optimize diagnostic pathways as well as improve harmonization between assays. METHODS:The characteris...

journal_title：Clinical chemistry and laboratory medicine

authors： Suh-Lailam BB,Davis KW,Tebo AE

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Although many reports have elucidated pathophysiological characteristics of abnormal bone metabolism in patients with type 2 diabetes mellitus (DT2), determinants of bone mineral density (BMD) in patients with DT2 are still controversial. METHODS:We examined 168 Belarussian men 45-60 years of age. Plasma to...

journal_title：Clinical chemistry and laboratory medicine

authors： Vasilkova O,Mokhort T,Sanec I,Sharshakova T,Hayashida N,Takamura N

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Low-density lipoprotein cholesterol (LDL-C) is an established risk factor for cardiovascular disease and is usually estimated by the Friedewald formula (FF) calculated from three parameters, namely, total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). We aimed to devel...

journal_title：Clinical chemistry and laboratory medicine

authors： Hu CY,Lee CL,Sheu WH,Wang JS,Lee IT,Song YM,Fu CP,Ling JT,Li YF,Lin SY

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The oral glucose tolerance test (OGTT) is recommended to screen for diabetes in patients with coronary artery disease. We hypothesized that testing for glycated hemoglobin (HbA1c), in addition to the OGTT, in screening for abnormal glucose regulation may help to reveal patients with β-cell function impairmen...

journal_title：Clinical chemistry and laboratory medicine

authors： Li YH,Sheu WH,Lee WJ,Lee IT,Lin SY,Lee WL,Liang KW,Wang JS

更新日期：2018-07-26 00:00:00

abstract：:Over the past decades, the randomized controlled trial has entered an era of continuous improvement and has gradually become accepted as the most effective way of determining the relative efficacy and toxicity of new therapies because it controls for placebo and time effects. However, even sensitive and properly desig...

journal_title：Clinical chemistry and laboratory medicine

authors： Cleophas TJ

更新日期：1999-11-01 00:00:00

abstract：:Venous blood sampling (phlebotomy) is the most common invasive procedure performed in patient care. Guidelines on the correct practice of phlebotomy are available, including the H3-A6 guideline issued by the Clinical Laboratory Standards Institute (CLSI). As the quality of practices and procedures related to venous bl...

journal_title：Clinical chemistry and laboratory medicine

authors： van Dongen-Lases EC,Cornes MP,Grankvist K,Ibarz M,Kristensen GB,Lippi G,Nybo M,Simundic AM,Working Group for Preanalytical Phase (WG-PRE), European Federation of Clinical Chemistry and Laboratory Medicine (EFLM).

更新日期：2016-07-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a sight threatening eye disease that affects millions of humans over the age of 65 years. It is considered to be the major cause of irreversible blindness in the elderly population in the developed world. The disease is prevalent in Europe and the United States, which has a la...

journal_title：Clinical chemistry and laboratory medicine

authors： Kokotas H,Grigoriadou M,Petersen MB

更新日期：2011-04-01 00:00:00

abstract：:Severe thermal injury causes an immune dysfunction which includes a decrease of monocyte human leukocyte antigen DR (HLA-DR) expression. Interleukin-10 exerts a negative influence on this parameter in vitro. In this study we determined the prognostic value of reduced monocyte HLA-DR expression with regard to infectiou...

journal_title：Clinical chemistry and laboratory medicine

authors： Sachse C,Prigge M,Cramer G,Pallua N,Henkel E

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Blood biomarkers are subject to pre-analytical variability. In many cases, the stability of important new tissue biomarkers during freeze cycles and storage has not been studied sufficiently. METHODS:To test the stability of matrix metalloproteinases-7 (MMP-7) and their tissue inhibitors (TIMP-1), vascular ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kisand K,Kerna I,Kumm J,Jonsson H,Tamm A

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Pneumatic tube transport of blood samples reduces turnaround times and labour. However, the preanalytical effects on new clinical chemistry parameters and instruments are not fully known. The aim of this study was to evaluate the effect of pneumatic tube transport on haematology and coagulation parameters, i...

journal_title：Clinical chemistry and laboratory medicine

authors： Wallin O,Söderberg J,Grankvist K,Jonsson PA,Hultdin J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Linezolid is the first synthetic compound of a new group of antimicrobials, the oxazolidinones, which inhibit protein synthesis. It shows a broad spectrum of activity against Gram positive organisms. With respect to its pharmacokinetics, linezolid shows a relatively high volume of distribution and good penet...

journal_title：Clinical chemistry and laboratory medicine

authors： Guerrero L,Martínez-Olondris P,Rigol M,Esperatti M,Esquinas C,Luque N,Piñer R,Torres A,Soy D

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Knowledge of the fatty acid composition of lipid classes in human plasma is an important factor in the investigation of human metabolism. Therefore, a method for the analysis of neutral lipid (NL), phospholipid (PL) and free fatty acids (FFA) in human plasma has been developed and validated. METHODS:Separat...

journal_title：Clinical chemistry and laboratory medicine

authors： Firl N,Kienberger H,Hauser T,Rychlik M

更新日期：2013-04-01 00:00:00

abstract：:Translational research and translational medicine (referred to hereafter as translational research) are interchangeable terms that underline the pressing need to translate into practical benefits for those affected by disease the extensive investments divested by the private and public sectors in biomedical research. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M,Marincola FM

更新日期：2006-01-01 00:00:00

abstract：:Thrombotic risk factors and thrombosis in children has been receiving increased attention. True idiopathic thrombosis is extremely rare in children. Most patients have a significant underlying medical condition and the presence of a central catheter is the most important risk factor. Children are more likely than adul...

journal_title：Clinical chemistry and laboratory medicine

authors： Trampus-Bakija A

更新日期：2010-12-01 00:00:00

abstract：:Background Biochemical bone turnover markers (BTM) are useful tools to assess bone remodeling at the cellular level. N-terminal propeptide of type I procollagen (PINP) has been recommended as a reference marker for bone formation in research studies. Methods We describe the results of a multicenter study for routine c...

journal_title：Clinical chemistry and laboratory medicine

authors： Cavalier E,Eastell R,Rye Jørgensen N,Makris K,Tournis S,Vasikaran S,Kanis JA,Cooper C,Pottel H,Morris HA,IFCC-IOF Joint Committee for Bone Metabolism (C-BM).

更新日期：2019-09-25 00:00:00

abstract：:Automation is considered one of the most important breakthroughs in the recent history of laboratory diagnostics. In a model of total laboratory automation (TLA), many analyzers performing different types of tests on different sample matrices are physically integrated as modular systems or physically connected by asse...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Da Rin G

更新日期：2019-05-27 00:00:00

abstract：:Circulating blood platelets play a central role in the maintenance of hemostasis. They adhere to subendothelial extracellular matrix proteins that become exposed upon vessel wall damage, which is followed by platelet activation, further platelet recruitment, platelet aggregation and formation of an occlusive, or non-o...

journal_title：Clinical chemistry and laboratory medicine

authors： Provost P

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Celiac disease (CD) is an immune-mediated disorder of the small bowel in which gluten and related cereal ingestion leads to chronic inflammation and damage to the small bowel mucosa in genetically susceptible individuals. The presence of IgA type tissue-transglutaminase antibodies (IgA-anti-tTG) in individua...

journal_title：Clinical chemistry and laboratory medicine

authors： Ress K,Harro J,Uibo O,Uibo R

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:While thyroglobulin autoantibodies (TgAb) can result in false low serum thyroglobulin (Tg) immunoassay (IA) measurements, they might also be indicators of disease persistence/recurrence. Hence, accurate TgAb measurement, in addition to Tg quantification, is crucial for thyroid cancer monitoring. We compared ...

journal_title：Clinical chemistry and laboratory medicine

authors： Katrangi W,Grebe SKG,Algeciras-Schimnich A

更新日期：2017-10-26 00:00:00

abstract：:Clinical Proteomics biomarker discovery programs lead to the selection of putative new biomarkers of human pathologies. Following an initial discovery phase, validation of these candidates in larger populations is a major task that recently started relying upon the use of mass spectrometry approaches, especially in ca...

journal_title：Clinical chemistry and laboratory medicine

authors： Lehmann S,Poinot P,Tiers L,Junot C,Becher F,Hirtz C

更新日期：2011-10-08 00:00:00

abstract：:Urinary cotinine was measured according to its inhibitory activity on the agglutination of cotinine-coated latex particles by anti-cotinine antibodies, the agglutination being measured by optical counting of the remaining non-agglutinated particles (particle counting, PaC). The detection limit was 0.03 microgram/ml an...

journal_title：Clinical chemistry and laboratory medicine

authors： Galanti LM,Dell'Omo J,Vanbeckbergen D,Dubois P,Masson PL,Cambiaso CL

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Automated systems have been broadly used in the counting of particles in urine, while manual microscopic analyses are still required for confirming components of urine sediments, especially pathologic casts and other unknown particles. Good review rules can reduce the number of manual urine microscopy examin...

journal_title：Clinical chemistry and laboratory medicine

authors： Cao Y,Cheng M,Hu C

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Sequencing based mutation screening assays of genes encompassing large numbers of exons could be substantially optimized by multiplex PCR, which enables simultaneous amplification of many targets in one reaction. In the present study, a multiplex PCR protocol originally developed for fragment analysis was ev...

journal_title：Clinical chemistry and laboratory medicine

authors： Horn MP,Mäder-Heinemann G,Andrey G,Largiadèr CR

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration in a large group prompted an observational study on gender and age. METHODS:A single estimate of faecal haemoglobin concentration was made using quantitative automated im...

journal_title：Clinical chemistry and laboratory medicine

authors： McDonald PJ,Strachan JA,Digby J,Steele RJ,Fraser CG

更新日期：2011-12-07 00:00:00

abstract：:Background Quantification of plasma amino acids is key to the diagnosis of inherited defects of amino acid synthesis, catabolism and transport, many of which present as clinical emergencies. The utility of this test is limited by the long analysis time and subsequent inability of laboratories to provide results in rea...

journal_title：Clinical chemistry and laboratory medicine

authors： Carling RS,John K,Churchus R,Turner C,Dalton RN

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:When certain inflammatory processes occur, toxic granulation neutrophils (TGNs) appear in the blood showing prominent cytoplasmic granules. Currently, the granularity of TGNs is analyzed by manual microscopy of blood smears. The SYSMEX XE-5000 is an automated hematology analyzer, which can measure toxic gran...

journal_title：Clinical chemistry and laboratory medicine

authors： Zimmermann M,Cremer M,Hoffmann C,Weimann K,Weimann A

更新日期：2011-07-01 00:00:00