Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line.

abstract：PURPOSE:Mechanical manipulation of the prostate is a generally accepted interfering factor for the measurement of prostate-specific antigen (PSA). However, only few studies have focused on common daily mechanical manipulations, such as bicycle riding. Furthermore, physical exercise is also supposed to modulate PSA seru...

journal_title：Clinical chemistry and laboratory medicine

authors： Herrmann M,Scharhag J,Sand-Hill M,Kindermann W,Herrmann W

更新日期：2004-03-01 00:00:00

abstract：:In our efforts to develop diagnostic tests for complex multifactorial disorders, and to assist the research community in evaluating genetic markers for predisposition to cardiovascular disease, we have developed a prototype assay to genotype up to 35 variable sites among 15 genes. The candidate markers in this panel w...

journal_title：Clinical chemistry and laboratory medicine

authors： Cheng S,Pallaud C,Grow MA,Scharf SJ,Erlich HA,Klitz W,Pullinger CR,Malloy MJ,Kane JP,Siest G,Visvikis S

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer's disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI). In the pr...

journal_title：Clinical chemistry and laboratory medicine

authors： Cervellati C,Romani A,Bergamini CM,Bosi C,Sanz JM,Passaro A,Zuliani G

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The timely detection of severe inflammatory conditions is of great importance for early therapy initiation and the patient's prognosis. The complex humoral and cellular processes involved in inflammation offer many opportunities for diagnostic testing, which are still unused in clinical practice. We investig...

journal_title：Clinical chemistry and laboratory medicine

authors： Hoffmann C,Hoffmann P,Zimmermann M

更新日期：2015-03-01 00:00:00

abstract：:Biochemical measurements in "special fluids" are complicated with the problem of reference intervals. Reference intervals are difficult to establish for these types of samples since they are usually only collected in patients with clinical suspicion of disease. Determination of neurotransmitter metabolites in cerebros...

journal_title：Clinical chemistry and laboratory medicine

authors： Dhondt JL

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:CD4+CD25+ forkhead box P3 (FOXP3)+ regulatory T cells (Tregs) accumulate in malignant tumors and negatively regulate antitumor immunity. However, the clinical significance of Tregs in HCC remains unclear. To determine the prognostic value of Tregs, we conducted a retrospective study on 264 patients with Barc...

journal_title：Clinical chemistry and laboratory medicine

authors： Li F,Guo Z,Lizée G,Yu H,Wang H,Si T

更新日期：2014-09-01 00:00:00

abstract：:The discovery and development of new biomarkers continues to be an exciting and promising field. Improvement in prediction of risk of developing disease is one of the key motivations in these pursuits. Appropriate statistical measures are necessary for drawing meaningful conclusions about the clinical usefulness of th...

journal_title：Clinical chemistry and laboratory medicine

authors： Pencina MJ,D'Agostino RB,Vasan RS

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration in a large group prompted an observational study on gender and age. METHODS:A single estimate of faecal haemoglobin concentration was made using quantitative automated im...

journal_title：Clinical chemistry and laboratory medicine

authors： McDonald PJ,Strachan JA,Digby J,Steele RJ,Fraser CG

更新日期：2011-12-07 00:00:00

abstract：BACKGROUND:Decreased brain-derived neurotrophic factor (BDNF) has been demonstrated in animal models and patients with depression. However, little is known about changes in BDNF in post-stroke depression (PSD). This study investigated the changes in serum BDNF in patients with PSD, and evaluated whether serum concentra...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhou Z,Lu T,Xu G,Yue X,Zhu W,Ma M,Liu W,Zhu S,Liu X

更新日期：2011-02-01 00:00:00

abstract：:Background Many of the mobile applications (apps) used for delivering health interventions involve laboratory medicine data. This survey was conducted to search the online market for health apps that manage laboratory medicine data. The aim was to review them and perform a quality evaluation. Methods Apps search crite...

journal_title：Clinical chemistry and laboratory medicine

authors： Jovičić S,Siodmiak J,Watson ID,European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Patient Focused Laboratory Medicine.

更新日期：2019-02-25 00:00:00

abstract：:Diabesity, that is to say, obesity-dependent diabetes, has emerged as a major public health problem. Though diabesity is basically explained by insulin resistance and pancreatic beta cell dysfunction, new paradigms have evolved to explain these alterations in the context of the modern epidemics of obesity and diabetes...

journal_title：Clinical chemistry and laboratory medicine

authors： Schmidt MI,Duncan BB

更新日期：2003-09-01 00:00:00

abstract：:Individual risk of toxicity or cancer reflects the amount of exposure to environmental agents, combined with one's underlying genetic predisposition. More than six dozen human ecogenetic polymorphisms have been described; whereas some of these have been demonstrated to be associated with altered risks of toxicity or c...

journal_title：Clinical chemistry and laboratory medicine

authors： Nebert DW

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Increased homocysteine (Hcy) blood levels are correlated with vascular and neurological problems. AIM:The aim of the present study was to investigate erythrocyte membrane acetylcholinesterase (AChE) activity in subjects with the MTHFR C677T genotype in relation to Hcy. METHODS:Blood was obtained from 22 in...

journal_title：Clinical chemistry and laboratory medicine

authors： Tsakiris S,Schulpis KH,Papaconstantinou ED,Tsakiris T,Tjamouranis I,Giannoulia-Karantana A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Although many reports have elucidated pathophysiological characteristics of abnormal bone metabolism in patients with type 2 diabetes mellitus (DT2), determinants of bone mineral density (BMD) in patients with DT2 are still controversial. METHODS:We examined 168 Belarussian men 45-60 years of age. Plasma to...

journal_title：Clinical chemistry and laboratory medicine

authors： Vasilkova O,Mokhort T,Sanec I,Sharshakova T,Hayashida N,Takamura N

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Gestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy. METHODS:Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22-40) years; the subjects were followed in order to establish the gestational...

journal_title：Clinical chemistry and laboratory medicine

authors： Kovac MK,Lalic-Cosic SZ,Dmitrovic JM,Djordjevic VJ,Radojkovic DP

更新日期：2015-11-01 00:00:00

abstract：:The pathogenesis of cobalamin (Cbl)-deficient (Cbl-D) neuropathy and the role of normal prions (PrPcs) in myelin maintenance are both subjects of debate. We have demonstrated that Cbl deficiency damages myelin by increasing tumor necrosis factor (TNF)-α, and decreasing epidermal growth factor (EGF) levels in the rat c...

journal_title：Clinical chemistry and laboratory medicine

authors： Scalabrino G,Veber D

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The Schwartz 2009 creatinine-based revised formula is the only pediatric GFR estimating formula, which is compatible with the recent global creatinine standardization. This formula is only applicable if enzymatic creatinine methods are used. We propose an equation, taking into account the relative bias cause...

journal_title：Clinical chemistry and laboratory medicine

authors： Speeckaert MM,Wuyts B,Stove V,Walle JV,Delanghe JR

更新日期：2012-03-09 00:00:00

abstract：BACKGROUND:When certain inflammatory processes occur, toxic granulation neutrophils (TGNs) appear in the blood showing prominent cytoplasmic granules. Currently, the granularity of TGNs is analyzed by manual microscopy of blood smears. The SYSMEX XE-5000 is an automated hematology analyzer, which can measure toxic gran...

journal_title：Clinical chemistry and laboratory medicine

authors： Zimmermann M,Cremer M,Hoffmann C,Weimann K,Weimann A

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Antinuclear autoantibody determination relies on an initial screening step using immunofluorescence on HEp2 cells. This may be followed by anti-deoxyribonucleic acid (DNA) determination, if the fluorescence of nuclei is homogeneous. We assessed the validity of a restricted algorithm and compared this to a mo...

journal_title：Clinical chemistry and laboratory medicine

authors： Servais G,Karmali R,Guillaume MP,Badot V,Duchateau J,Corazza F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The calibration of Jaffe method for serum creatinine using one serum-based standard complemented with artificial matrix compensating standard's Jaffe-interfering substances allows two-point calibration with results well comparable with enzymatic methods. METHOD:Spectrophotometry was used. RESULTS:Jaffe pro...

journal_title：Clinical chemistry and laboratory medicine

authors： Chromý V,Rozkosná K,Sedlák P

更新日期：2008-01-01 00:00:00

abstract：:Adequate volume loading may be the most important step in the treatment of patients with septic shock. Techniques allowing us to achieve and tightly control volume loading and regional perfusion are considered to be helpful. An elevated oxygen delivery may be beneficial in some patients but the increase of oxygen deli...

journal_title：Clinical chemistry and laboratory medicine

authors： Meier-Hellmann A,Sakka S,Reinhart K

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Toldi G,Stenczer B,Molvarec A,Takáts Z,Beko G,Rigó J Jr,Vásárhelyi B

更新日期：2010-10-01 00:00:00

abstract：:Two reverse transcription-polymerase chain reaction methods to detect the AML1/ETO rearrangement in the M2 subtype of acute myeloid leukaemia those of Downing et al. (Blood 1993; 81: 2860-5) and Satake et al. (Br J Haematol 1995; 91: 892-8) were evaluated. Bone marrow samples, one at diagnosis and two in complete remi...

journal_title：Clinical chemistry and laboratory medicine

authors： Barragán E,Bonanad S,López JA,Bolufer P,Sanz MA

更新日期：1998-03-01 00:00:00

abstract：:The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first-line chemotherapy for metastati...

journal_title：Clinical chemistry and laboratory medicine

authors： Sölétormos G,Petersen PH,Dombernowsky P

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:An E670G polymorphism of the exon 12 of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene was recently found to be associated with increased plasma low-density lipoprotein cholesterol (LDL-C) levels and severity of coronary atherosclerosis. This case-control study tested for a possible link betw...

journal_title：Clinical chemistry and laboratory medicine

authors： Hsu LA,Teng MS,Ko YL,Chang CJ,Wu S,Wang CL,Hu CF

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:There is a certain difference in opinion regarding the optimal choice of housekeeping genes used as normalization factors in gene expression analysis. We have therefore examined the suitability of three housekeeping genes, hypoxanthine phosphoribosyl transferase, beta-glucuronidase and beta2-micro-globulin, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kågedal B,Farnebäck M,Håkansson A,Gustafsson B,Håkansson L

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Serum immunoglobulin free light chains (FLC) are secreted into circulation by plasma cells as a by-product of immunoglobulin production. In a healthy individual the population of FLC is polyclonal as no single cell is secreting more FLC than the total immunoglobulin secreting cell population. In a person wit...

journal_title：Clinical chemistry and laboratory medicine

authors： Barnidge DR,Dispenzieri A,Merlini G,Katzmann JA,Murray DL

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:There is a need for reference materials (RMs) in the field of genetic testing for verification of test results obtained in patients and probands. For the frequent genetic variation G20210A in the prothrombin gene, it has been shown that purified plasmids containing the gene fragment harbouring the mutation c...

journal_title：Clinical chemistry and laboratory medicine

authors： Gancberg D,Corbisier P,Meeus N,Marki-Zay J,Mannhalter C,Schimmel H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Ebola virus, an enveloped virus, is the cause of the largest and most complex Ebola virus disease (EVD) outbreak in West Africa. Blood or body fluids of an infected person may represent a biohazard to laboratory workers. Laboratory tests of virus containing specimens should be conducted in referral centres a...

journal_title：Clinical chemistry and laboratory medicine

authors： Tempestilli M,Pucci L,Notari S,Di Caro A,Castilletti C,Rivelli MR,Agrati C,Pucillo LP

更新日期：2015-11-01 00:00:00

abstract：:The annual inter- and intra-individual biological variation, including the circannual rhythmic variation, of the serum concentrations of magnesium and ionized calcium has been investigated in a group of 51 apparently healthy volunteers. Venous blood specimens were collected on intervals of once a month within a one-ye...

journal_title：Clinical chemistry and laboratory medicine

authors： Valero-Politi J,Ginard-Salvá M,González-Alba JM

更新日期：2001-01-01 00:00:00