Diagnostic testing for a high-grade inflammation: parameter dynamics and novel markers.

abstract：BACKGROUND:The clinical relevance of chromogranin A (CgA) concentrations depends on the analytical performance of the assay. The goal of the present study was to define the clinical involvements in CgA calibration models by evaluating the confidence intervals (CIs) for values from patients who were undergoing monitorin...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Marano G,Ciardi L,Vendramin C,Bongo AS,Bellomo G,Boracchi P,Biganzoli EM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Placental protein-13 (PP13) is involved in placental invasion and has been suggested as a maternal serum marker of preeclampsia (PE) development. However, the discriminatory ability of PP13 in first trimester has not been completely clarified. METHODS:PP13 was measured in first trimester (week 10+3-13+6) ma...

journal_title：Clinical chemistry and laboratory medicine

authors： De Villiers CP,Hedley PL,Placing S,Wøjdemann KR,Shalmi AC,Carlsen AL,Rode L,Sundberg K,Tabor A,Christiansen M

更新日期：2017-11-27 00:00:00

abstract：:Elevated plasma levels of angiotensin converting enzyme (ACE) are associated with granulomatous diseases. However, several families of autosomal dominant hyper-ACE-emia without disease association have already been reported. Recently, the ACE mutation c.3705C>T (Pro1199Leu) was identified as the genetic correlate in E...

journal_title：Clinical chemistry and laboratory medicine

authors： Semmler A,Stein RW,Caplan L,Danilov SM,Klockgether T,Linnebank M

更新日期：2006-01-01 00:00:00

abstract：:There is no comprehensive study on the stability of coagulation analytes in plasma. We therefore determined the influence of storage time and temperature on prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, factors V and VIII, antithrombin III, protein C and S in plasma from 20 health...

journal_title：Clinical chemistry and laboratory medicine

authors： Heil W,Grunewald R,Amend M,Heins M

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) and choline acetyltransferase (ChAT) have been suggested as candidate genes for determining the risk of late-onset Alzheimer's disease. The aim of this study was to simultaneously detect polymorphisms in codons 112 and 158 of APOE and codon 2 of ChAT by hybridization probe multiplexin...

journal_title：Clinical chemistry and laboratory medicine

authors： Park HD,Park KU,Kim KW,Song J,Chang HE,Heo SR,Lee HJ,Kim JQ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Biological variation (BV) data enable assessment of the significance of changes in serial measurements observed within a subject and are used to set analytical quality specifications. This data is available in a database held in Westgard website (http://www.westgard.com/biodatabase1.htm). Some limitations of...

journal_title：Clinical chemistry and laboratory medicine

authors： Carobene A

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Thyroid stimulating hormone (TSH) receptor autoantibodies (TRAb) are pathogenetic and diagnostic hallmarks of Graves' disease (GD). Three varieties of TRAb have been described: stimulating (S-TRAb), blocking (B-TRAb), and apoptotic (A-TRAb) autoantibodies. Very recently, the first immunoassay method (Immulit...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,D'Aurizio F,Villalta D,Giovanella L

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:When performed erroneously, the venous blood specimen collection (VBSC) practice steps patient identification, test request management and test tube labeling are at high risk to jeopardize patient safety. VBSC educational programs with the intention to minimize risk of harm to patients are therefore needed. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Willman B,Grankvist K,Bölenius K

更新日期：2018-10-25 00:00:00

abstract：:Winning a Nobel Prize is a great personal achievement. Some Nobel laureates may consider that their award is a certificate of competence in any field. This may prompt them to undertake projects or accept positions which are beyond their capabilities. Since Nobels are awarded when the laureates have usually passed thei...

journal_title：Clinical chemistry and laboratory medicine

authors： Diamandis EP

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The goal of this study was to detect modification in the expression of plasma proteins and/or post-translational modifications of their structure in patients with end stage renal disease. METHODS:Serum samples from 19 adult patients treated by maintenance hemodialysis (MHD) were analyzed in comparison to se...

journal_title：Clinical chemistry and laboratory medicine

authors： Donadio E,Piccolomini F,Dimuccio V,Felicioli A,Balestreri E,Cianti R,Armini A,Bini L,Felicioli R,Donadio C

更新日期：2009-01-01 00:00:00

abstract：:Drug-induced cardiotoxicity is a major clinical problem; cardiotoxic drugs may induce both cardiac dysfunction and myocardial injury. Several recent studies reported that cardiac troponins measured with high-sensitivity methods (hs-cTn) can enable the early detection of myocardial injury related to chemotherapy or abu...

journal_title：Clinical chemistry and laboratory medicine

authors： Cardinale DM,Zaninotto M,Cipolla CM,Passino C,Plebani M,Clerico A

更新日期：2020-08-26 00:00:00

abstract：:The serum free light chain (FLC) assay has proven to be an important complementary test in the management of patients with monoclonal gammopathies. The serum FLC assay has value for patients with plasma cell disorders in the context of screening and diagnosis, prognostic stratification, and quantitative monitoring. No...

journal_title：Clinical chemistry and laboratory medicine

authors： Jacobs JF,Tate JR,Merlini G

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:High-dose biotin therapy is beneficial in progressive multiple sclerosis (MS) and is expected to be adopted by a large number of patients. Biotin therapy leads to analytical interference in many immunoassays that utilize streptavidin-biotin capture techniques, yielding skewed results that can mimic various e...

journal_title：Clinical chemistry and laboratory medicine

authors： Piketty ML,Prie D,Sedel F,Bernard D,Hercend C,Chanson P,Souberbielle JC

更新日期：2017-05-01 00:00:00

abstract：:In view of the role of pharmacotherapy in medicine, on the one hand, and the powerful technical possibilities that are now available on the other hand, therapeutic drug monitoring is a surprisingly neglected area of laboratory medicine. In this viewpoint article, an "omics approach" to pharmacovigilance and drug monit...

journal_title：Clinical chemistry and laboratory medicine

authors： Vogeser M

更新日期：2020-05-05 00:00:00

abstract：:In every area of science workers are finding increasing difficulty in managing the volume of available data. In medicine, the accelerating pace has the worrisome overtones of our failing to provide up-to-date care for our patients. In other information-intensive areas, we rely heavily on software that manages much of ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ritchie RF

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Investigation of a 61-year-old Caucasian male suffering from fatigue and weight loss led to the finding of a carbohydrate antigen 19-9 (CA 19-9) concentration of 80 kU/L using an ADVIA Centaur analyser. Determination of CA 19-9 on Vidas, AxSYM and Architect i2000 systems gave normal results. His rheumatoid f...

journal_title：Clinical chemistry and laboratory medicine

authors： Berth M,Bosmans E,Everaert J,Dierick J,Schiettecatte J,Anckaert E,Delanghe J

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Risk prediction algorithms for coronary heart disease (CHD) are recommended for clinical use. However, their predictive ability remains modest and the inclusion of genetic risk may improve their performance. METHODS:QRISK2 was used to assess CHD risk using conventional risk factors (CRFs). The performance o...

journal_title：Clinical chemistry and laboratory medicine

authors： Beaney KE,Cooper JA,Drenos F,Humphries SE

更新日期：2017-08-28 00:00:00

abstract：BACKGROUND:Autoantibodies against β1-adrenergic receptors (β1AR) that stimulate cardiac cAMP-production play a causal role in the pathogenesis of human heart failure. Patients can be subjected to specific therapies, if the presence of potentially cardio-noxious β1AR-autoantibodies is reliably diagnosed. This requires a...

journal_title：Clinical chemistry and laboratory medicine

authors： Bornholz B,Benninghaus T,Reinke Y,Felix SB,Roggenbuck D,Jahns-Boivin V,Jahns R,Boege F

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:DNA strand breaks are believed to induce carcinogenesis. This study was conducted to analyze induction and repair of irradiation- and chemotherapy-related strand breaks in vitro. METHODS:Friend Leukemia cells were exposed to irradiation and various chemotherapeutic agents at different doses and concentrations....

journal_title：Clinical chemistry and laboratory medicine

authors： Froelich JJ,Schneller FR,Zahn RK

更新日期：1999-04-01 00:00:00

abstract：:It is now undeniable that laboratory testing is vital for the diagnosis, prognostication and therapeutic monitoring of human disease. Despite the many advances made for achieving a high degree of quality and safety in the analytical part of diagnostic testing, many hurdles in the total testing process remain, especial...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Baird GS,Banfi G,Bölenius K,Cadamuro J,Church S,Cornes MP,Dacey A,Guillon A,Hoffmann G,Nybo M,Premawardhana LD,Salinas M,Sandberg S,Slingerland R,Stankovic A,Sverresdotter SM,Vermeersch P,Simundic AM

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The improvement of the consistency of gamma-glutamyltransferase (GGT) activity results among different assays after calibration with a common material was estimated. We evaluated if this harmonization could lead to reference limits common to different routine methods. METHODS:Seven laboratories measured GGT...

journal_title：Clinical chemistry and laboratory medicine

authors： Steinmetz J,Schiele F,Gueguen R,Férard G,Henny J,Periodic Health Examination Centers Laboratory Working Group.

更新日期：2007-01-01 00:00:00

abstract：:An alcohol-associated change in the serum transferrin glycoform pattern, carbohydrate-deficient transferrin (CDT), is used as a biomarker of chronic moderate to heavy alcohol consumption. A current limitation in CDT analysis is the lack of standardization, which hampers clinical and analytical comparison between studi...

journal_title：Clinical chemistry and laboratory medicine

authors： Jeppsson JO,Arndt T,Schellenberg F,Wielders JP,Anton RF,Whitfield JB,Helander A,International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardization of Carbohydrate-deficient Transferin (IFCC-WG-CDT).

更新日期：2007-01-01 00:00:00

abstract：:Betaine serves as a methyl donor in a reaction converting homocysteine to methionine, catalysed by the enzyme betaine-homocysteine methyltransferase. It has been used for years to lower the concentration of plasma total homocysteine (tHcy) in patients with homocystinuria, and has recently been shown to reduce fasting ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ueland PM,Holm PI,Hustad S

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Toldi G,Stenczer B,Molvarec A,Takáts Z,Beko G,Rigó J Jr,Vásárhelyi B

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Efficient laboratory service is the cornerstone of modern health care systems. Scientific innovations have contributed to substantial improvements in the field of laboratory science, but errors still prevail. These errors are classified as preanalytical, analytical and postanalytical, depending upon the time...

journal_title：Clinical chemistry and laboratory medicine

authors： Goswami B,Singh B,Chawla R,Mallika V

更新日期：2010-01-01 00:00:00

abstract：:We have previously reported two novel mutations in the 5'-untranslated region (UTR) of the gene for folate receptor-alpha (FOLR1). In our search for additional mutations, 92 patient samples with elevated levels of homocysteine were screened by single-strand conformation polymorphism (SSCP) between nt -425 and -782, an...

journal_title：Clinical chemistry and laboratory medicine

authors： Börjel AK,Yngve A,Sjöström M,Nilsson TK

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The purpose of an external quality assessment (EQA) is to evaluate the analytical capability of clinical laboratories, identify differences among the laboratories and improve analytical quality. Our EQA results show that the rates of unsatisfactory performance for thyroid hormone tests were the highest in al...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhou Q,Li S,Li X,Wang W,Wang Z

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Accurate outcome prediction in gastroesophageal malignancies is challenging. Acute-phase response proteins (APRPs) have been claimed to be independent prognosticators, although the basis for their association with prognosis remains unexplained. We hypothesized that, similarly to pancreatic and lung cancers, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Krzystek-Korpacka M,Matusiewicz M,Diakowska D,Grabowski K,Blachut K,Kustrzeba-Wojcicka I,Terlecki G,Gamian A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The Intermountain Mortality Risk Score (IMRS), a sex-specific mortality-prediction metric, has proven to be effective in various populations. IMRS is comprised of the complete blood count (CBC), basic metabolic panel (BMP), and age. Whether the addition of factors from the comprehensive metabolic panel (CMP)...

journal_title：Clinical chemistry and laboratory medicine

authors： May HT,Anderson JL,Muhlestein JB,Lappé DL,Ronnow BS,Horne BD

更新日期：2016-10-01 00:00:00

abstract：:A questionnaire to assess knowledge of the expected elevation in serum K measurement with different grades of hemolysis was administered to medical technologists working in biochemistry laboratories, hospital physicians and nurses. The questions involved different grades of hemolysis (mild, 1.0, moderate, 2.5 and seve...

journal_title：Clinical chemistry and laboratory medicine

authors： Hawkins RC

更新日期：2005-01-01 00:00:00