Placental protein-13 (PP13) in combination with PAPP-A and free leptin index (fLI) in first trimester maternal serum screening for severe and early preeclampsia.

abstract：BACKGROUND:Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine. Urinary exosomes are released from every segment of the nephron, are detectable in urine, constitutively contain RNA (small RNAs and mRNAs) and harbor unique subset of proteins, r...

journal_title：Clinical chemistry and laboratory medicine

authors： Channavajjhala SK,Rossato M,Morandini F,Castagna A,Pizzolo F,Bazzoni F,Olivieri O

更新日期：2014-03-01 00:00:00

abstract：:Low-density lipoprotein (LDL) oxidation in vivo depends on lipid composition and on plasma antioxidant status. The aim of our study was to investigate the relationship between plasma lipid composition and LDL oxidation and, in particular, to explore whether LDL-cholesterol/triglycerides ratio (LDL-C/TG) and LDL-choles...

journal_title：Clinical chemistry and laboratory medicine

authors： Brizzi P,Tonolo G,Carusillo F,Malaguarnera M,Maioli M,Musumeci S

更新日期：2003-01-01 00:00:00

abstract：:The recent revision of ISO15189 has further strengthened its position as the standard for accreditation for medical laboratories. Both for laboratories and their customers it is important that the scope of such accreditation is clear. Therefore the European co-operation for accreditation (EA) demands that the national...

journal_title：Clinical chemistry and laboratory medicine

authors： Thelen MH,Vanstapel FJ,Kroupis C,Vukasovic I,Boursier G,Barrett E,Bernabeu Andreu F,Brguljan PM,Brugnoni D,Lohmander M,Sprongl L,Vodnik T,Ghita I,Vaubourdolle M,Huisman W,Working Group Accreditation ISO\/CEN standards (WG-A

更新日期：2015-07-01 00:00:00

abstract：:The concentration of leukocyte elastase/alpha1-proteinase inhibitor complexes in plasma and polymorphonuclear neutrophil extracts, and plasma trypsin inhibitory capacity were determined in 88 patients with type 2 diabetes and 47 control subjects. Higher values of these variables were found in patients as compared to c...

journal_title：Clinical chemistry and laboratory medicine

authors： Piwowar A,Knapik-Kordecka M,Warwas M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The presence of fibronectin fragments has been observed in some inflammatory diseases and is believed to reflect tissue breakdown. In this study, possible fibronectin fragmentation and alterations in its domain and sialyl and fucosyl glycotope expressions were analyzed in amniotic fluids in relation to intra...

journal_title：Clinical chemistry and laboratory medicine

authors： Hirnle L,Katnik-Prastowska I

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Investigation of a 61-year-old Caucasian male suffering from fatigue and weight loss led to the finding of a carbohydrate antigen 19-9 (CA 19-9) concentration of 80 kU/L using an ADVIA Centaur analyser. Determination of CA 19-9 on Vidas, AxSYM and Architect i2000 systems gave normal results. His rheumatoid f...

journal_title：Clinical chemistry and laboratory medicine

authors： Berth M,Bosmans E,Everaert J,Dierick J,Schiettecatte J,Anckaert E,Delanghe J

更新日期：2006-01-01 00:00:00

abstract：:Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Met...

journal_title：Clinical chemistry and laboratory medicine

authors： Veenhof H,Koster RA,Alffenaar JC,van den Berg AP,de Groot MR,Verschuuren EAM,Berger SP,Bakker SJL,Touw DJ

更新日期：2019-11-26 00:00:00

abstract：:We evaluated the analytical performance of the Immulite 2000 immunoassay analyzer (Diagnostic Products Corporation, Los Angeles, USA) based on a new detection technology, electrochemical luminescence. The evaluated analytes were thyrotropin, triiodothyronine, free thyroxine, follitropin, lutropin, prolactin, cortisol,...

journal_title：Clinical chemistry and laboratory medicine

authors： Tello FL,Hernández DM

更新日期：2000-10-01 00:00:00

abstract：:Biochemical measurements in "special fluids" are complicated with the problem of reference intervals. Reference intervals are difficult to establish for these types of samples since they are usually only collected in patients with clinical suspicion of disease. Determination of neurotransmitter metabolites in cerebros...

journal_title：Clinical chemistry and laboratory medicine

authors： Dhondt JL

更新日期：2004-01-01 00:00:00

abstract：:Measurement of S-100B protein in serum or cerebrospinal fluid is increasingly used as a molecular marker of brain damage. However, there is no information about the pre-analytical in vitro stability of S-100B. We have investigated whether storing blood samples at different time periods and conditions affected the meas...

journal_title：Clinical chemistry and laboratory medicine

authors： Raabe A,Kopetsch O,Gross U,Zimmermann M,Gebhart P

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The basic helix-loop-helix transcription factor HAND1 is essential for cardiac development and structural remodeling, and mutations in HAND1 have been causally linked to various congenital heart diseases. However, whether genetically compromised HAND1 predisposes to dilated cardiomyopathy (DCM) in humans rem...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhou YM,Dai XY,Qiu XB,Yuan F,Li RG,Xu YJ,Qu XK,Huang RT,Xue S,Yang YQ

更新日期：2016-07-01 00:00:00

abstract：:Removal of low molecular weight proteins from plasma by kidneys depends on glomerular filtration rate (GFR), protein-glomerular membrane electric charge, steric interactions and a number of functionally active nephrons present in the kidneys. There is a well documented relationship between the concentration of low mol...

journal_title：Clinical chemistry and laboratory medicine

authors： Naskalski J,Anyszek T,Surdacka E,Hoyer B,Sulowicz W

更新日期：2004-03-01 00:00:00

abstract：:Automation is considered one of the most important breakthroughs in the recent history of laboratory diagnostics. In a model of total laboratory automation (TLA), many analyzers performing different types of tests on different sample matrices are physically integrated as modular systems or physically connected by asse...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Da Rin G

更新日期：2019-05-27 00:00:00

abstract：:Despite substantial evidence indicating the association of hyperhomocysteinemia (hHcys) and end-stage renal disease (ESRD), the pathogenic role of increased plasma homocysteine (Hcys) levels in the progression of ESRD remains unclear. This review will briefly summarize recent findings regarding the role of hHcys in th...

journal_title：Clinical chemistry and laboratory medicine

authors： Pin-Lan L,Fan Y,Ningjun L

更新日期：2007-01-01 00:00:00

abstract：:Background Systemic sclerosis (SSc) and primary biliary cholangitis (PBC) are autoimmune diseases that may occur concomitantly and are both strongly associated with disease-specific autoantibodies. This study investigated the prevalence and fine specificity of PBC-specific serology (PBC-Ab) and associations with the S...

journal_title：Clinical chemistry and laboratory medicine

authors： Florin L,Rubben K,Vanhaecke A,Devreese K,De Keyser F,Smith V,Bonroy C

更新日期：2020-02-25 00:00:00

abstract：BACKGROUND:Serum amino acids, part of a pool of free amino acids, are influenced by metabolism and disease. Few reports exist describing their function and concentrations in serum. Our study aimed to determine age- and gender-related differences in serum amino acid concentrations in healthy Japanese patients, focusing ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kouchiwa T,Wada K,Uchiyama M,Kasezawa N,Niisato M,Murakami H,Fukuyama K,Yokogoshi H

更新日期：2012-01-04 00:00:00

abstract：:Angiogenesis is a crucial process in tissue remodeling during growth, both in the embryo and the adult. In our study we concentrated on the direct effect of beta-carotene on human umbilical cord originating from endothelial progenitor cells (EPCs). beta-Carotene uptake by EPCs was measured using a HPLC method. The det...

journal_title：Clinical chemistry and laboratory medicine

authors： Kieć-Wilk B,Polus A,Grzybowska J,Mikołajczyk M,Hartwich J,Pryjma J,Skrzeczyńska J,Dembińska-Kieć A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as the most promising biomarker of acute kidney injury. However, there are no reliable data on analytical sensitivity and reference limits of urinary NGAL (uNGAL) assay in pediatric age. The aim of the present study is to evaluate the analy...

journal_title：Clinical chemistry and laboratory medicine

authors： Cangemi G,Storti S,Cantinotti M,Fortunato A,Emdin M,Bruschettini M,Bugnone D,Melioli G,Clerico A

更新日期：2013-05-01 00:00:00

abstract：Objectives:Matrix differences among serum samples from non-pregnant and pregnant patients could bias measurements. Standard Reference Material 1949, Frozen Human Prenatal Serum, was developed to provide a quality assurance material for the measurement of hormones and nutritional elements throughout pregnancy. Methods:...

journal_title：Clinical chemistry and laboratory medicine

authors： Boggs ASP,Kilpatrick LE,Burdette CQ,Tevis DS,Fultz ZA,Nelson MA,Jarrett JM,Kemp JV,Singh RJ,Grebe SKG,Wise SA,Kassim BL,Long SE

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:Recently published data identified bone-specific alkaline phosphatase (BALP) as a good marker of bone formation in different bone diseases and osteoporosis. Two methods are available for BALP determination: one measures enzyme activity, the other its mass concentration. We compared results for BALP activity ...

journal_title：Clinical chemistry and laboratory medicine

authors： Avbersek-Luznik I,Gmeiner Stopar T,Marc J

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Blood alcohol determination plays an important role in laboratory medicine and forensic medicine. Nowadays, many methods are being used for alcohol measurement, but these methods are time-consuming and complex to perform laborious sample pre-treatment. The disposable amperometric biosensor, due to its portab...

journal_title：Clinical chemistry and laboratory medicine

authors： Luo P,Xie G,Liu Y,Xu H,Deng S,Song F

更新日期：2008-01-01 00:00:00

abstract：:Gastric juice is known to have phospholipase A2 catalytic activity. Helicobacter pylori (H. pylori) has been reported to produce phospholipase A2, which is believed to hydrolyse the protective layer of gastric mucosal phospholipids and to promote mucosal damage. The current study aimed at identifying secretory phospho...

journal_title：Clinical chemistry and laboratory medicine

authors： Huhtinen HT,Grönroos JM,Haapamäki MM,Nevalainen TJ

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Increased homocysteine (Hcy) blood levels are correlated with vascular and neurological problems. AIM:The aim of the present study was to investigate erythrocyte membrane acetylcholinesterase (AChE) activity in subjects with the MTHFR C677T genotype in relation to Hcy. METHODS:Blood was obtained from 22 in...

journal_title：Clinical chemistry and laboratory medicine

authors： Tsakiris S,Schulpis KH,Papaconstantinou ED,Tsakiris T,Tjamouranis I,Giannoulia-Karantana A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:External quality assessment/proficiency test (EQA/PT) organizers play an important role in monitoring the performance of HbA1c measurements. With increasing quality of the assays, HbA1c is increasingly used for diagnosis of diabetes and the demands on EQA/PT organizers themselves are rising constantly. EQA o...

journal_title：Clinical chemistry and laboratory medicine

authors： Kaiser P,Spannagl M,van Campenhout C,Lenga Y,Siebelder C,Weykamp C

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Celiac disease (CD) is an immune-mediated disorder of the small bowel in which gluten and related cereal ingestion leads to chronic inflammation and damage to the small bowel mucosa in genetically susceptible individuals. The presence of IgA type tissue-transglutaminase antibodies (IgA-anti-tTG) in individua...

journal_title：Clinical chemistry and laboratory medicine

authors： Ress K,Harro J,Uibo O,Uibo R

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:We report a Dutch-Belgian multicentre evaluation of the Tosoh HLC-723G8 glycohaemoglobin analyser, an ion-exchange HPLC instrument for the separation and quantification of haemoglobin A1c (HbA1c) in whole blood. METHODS:We evaluated the analytical performances of the Tosoh G8 analyser and compared the resul...

journal_title：Clinical chemistry and laboratory medicine

authors： Chapelle JP,Teixeira J,Maisin D,Assink H,Barla G,Stroobants AK,Delzenne B,van den Eshof W

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to calculate age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) concentrations using quantile regression. METHODS:From the Study of Health in Pomerania (SHIP), 1798 men and...

journal_title：Clinical chemistry and laboratory medicine

authors： Friedrich N,Krebs A,Nauck M,Wallaschofski H

更新日期：2010-01-01 00:00:00

abstract：:The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to c...

journal_title：Clinical chemistry and laboratory medicine

authors： Rayana MC,Burnett RW,Covington AK,D'Orazio P,Fogh-Andersen N,Jacobs E,Kataky R,Külpmann WR,Kuwa K,Larsson L,Lewenstam A,Maas AH,Mager G,Naskalski JW,Okorodudu AO,Ritter C,St John A,International Federation of Clinical C

更新日期：2006-01-01 00:00:00

abstract：:Authors are usually invited to follow the instructions to authors in scientific journals, because this section is likely to contain unique requirements, such as the references style requested. Authors not only must accurately check the instructions, but are also expected to verify references against the original docum...

journal_title：Clinical chemistry and laboratory medicine

authors： Salvagno GL,Lippi G,Montagnana M,Guidi GC

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) and choline acetyltransferase (ChAT) have been suggested as candidate genes for determining the risk of late-onset Alzheimer's disease. The aim of this study was to simultaneously detect polymorphisms in codons 112 and 158 of APOE and codon 2 of ChAT by hybridization probe multiplexin...

journal_title：Clinical chemistry and laboratory medicine

authors： Park HD,Park KU,Kim KW,Song J,Chang HE,Heo SR,Lee HJ,Kim JQ

更新日期：2007-01-01 00:00:00