Acid ribonuclease and alkaline ribonuclease isoenzymes in plasma of patients with decreased glomerular filtration rate.

abstract：BACKGROUND:Vitamin B12 deficiency and bone fractures are common in vegetarians. However, a direct relationship between vitamin B12 status and bone metabolism in vegetarians has not been tested sufficiently. METHODS:Our study included 96 vegetarians (23 German vegans, and 54 German and 19 Indian lacto-, lacto-ovo-veget...

journal_title：Clinical chemistry and laboratory medicine

authors： Herrmann W,Obeid R,Schorr H,Hübner U,Geisel J,Sand-Hill M,Ali N,Herrmann M

更新日期：2009-01-01 00:00:00

abstract：:The aim of this multicenter study was to evaluate the technical and clinical performance of the Elecsys S100 electrochemiluminescence immunoassay and to assess its utility as a tumor marker in patients with malignant melanoma. Imprecision studies yielded within-run coefficients of variation (CVs) of 0.7-2.0% and betwe...

journal_title：Clinical chemistry and laboratory medicine

authors： Alber B,Hein R,Garbe C,Caroli U,Luppa PB

更新日期：2005-01-01 00:00:00

abstract：:Increased expression of sialyl Lewis X or A antigens on metastatic cancer cells leads to their selectin-mediated extravasation. Profound fucosylation of the serum microenvironment may be a factor that interrupts adhesion and influences the formation of metastases. In this study we quantitatively analyzed fucosylation ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kossowska B,Ferens-Sieczkowska M,Gancarz R,Passowicz-Muszyńska E,Jankowska R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Paraoxonases (PON) are members of an enzyme family involved in preventing low-density lipoprotein oxidation and therefore protecting against atherosclerotic plaque formation. METHODS:We studied the Met55Leu and Gln192Arg PON1 polymorphisms in 712 patients (437 Caucasian- and 275 African-Brazilians) who unde...

journal_title：Clinical chemistry and laboratory medicine

authors： Rios DL,D'Onofrio LO,Cerqueira CC,Bonfim-Silva R,Carvalho HG,Santos-Filho A,Galvão-Castro B

更新日期：2007-01-01 00:00:00

abstract：:Quantification of serum proteins is useful in the diagnosis and clinical management of many disorders. With the introduction of automated analyzers and standardized reference materials, one of the last barriers to more widespread utilization of these measurements is the lack of availability of reliable and transferabl...

journal_title：Clinical chemistry and laboratory medicine

authors： Palomaki GE,Neveux LM

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Mid-regional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. METHODS:In a prospective...

journal_title：Clinical chemistry and laboratory medicine

authors： Behnes M,Papassotiriou J,Walter T,Fiedler E,Sauer T,Lang S,Elmas E,Hoffmann U,Borggrefe M,Brueckmann M

更新日期：2008-01-01 00:00:00

abstract：:Two reverse transcription-polymerase chain reaction methods to detect the AML1/ETO rearrangement in the M2 subtype of acute myeloid leukaemia those of Downing et al. (Blood 1993; 81: 2860-5) and Satake et al. (Br J Haematol 1995; 91: 892-8) were evaluated. Bone marrow samples, one at diagnosis and two in complete remi...

journal_title：Clinical chemistry and laboratory medicine

authors： Barragán E,Bonanad S,López JA,Bolufer P,Sanz MA

更新日期：1998-03-01 00:00:00

abstract：:Complexity, cost, and content are three important factors that can impede translation of clinical protein mass spectrometry (MS) tests at a larger scale. Complexity stems from the many components/steps involved in bottom-up protein MS workflows, making them significantly more complicated than enzymatic immunoassays (E...

journal_title：Clinical chemistry and laboratory medicine

authors： Nedelkov D,Hu Y

更新日期：2020-06-25 00:00:00

abstract：:The history of prealbumin dates back to the early forties and may be divided into three parts, based on a chronological and functional approach. The first part--the discovery and the identification of prealbumin--was essentially based on classical protein chemistry methods. The second--the demonstration of prealbumin ...

journal_title：Clinical chemistry and laboratory medicine

authors： De Nayer P

更新日期：2002-12-01 00:00:00

abstract：:Circulating blood platelets play a central role in the maintenance of hemostasis. They adhere to subendothelial extracellular matrix proteins that become exposed upon vessel wall damage, which is followed by platelet activation, further platelet recruitment, platelet aggregation and formation of an occlusive, or non-o...

journal_title：Clinical chemistry and laboratory medicine

authors： Provost P

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Knowledge of the fatty acid composition of lipid classes in human plasma is an important factor in the investigation of human metabolism. Therefore, a method for the analysis of neutral lipid (NL), phospholipid (PL) and free fatty acids (FFA) in human plasma has been developed and validated. METHODS:Separat...

journal_title：Clinical chemistry and laboratory medicine

authors： Firl N,Kienberger H,Hauser T,Rychlik M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Blood biomarkers are subject to pre-analytical variability. In many cases, the stability of important new tissue biomarkers during freeze cycles and storage has not been studied sufficiently. METHODS:To test the stability of matrix metalloproteinases-7 (MMP-7) and their tissue inhibitors (TIMP-1), vascular ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kisand K,Kerna I,Kumm J,Jonsson H,Tamm A

更新日期：2011-02-01 00:00:00

abstract：:In every area of science workers are finding increasing difficulty in managing the volume of available data. In medicine, the accelerating pace has the worrisome overtones of our failing to provide up-to-date care for our patients. In other information-intensive areas, we rely heavily on software that manages much of ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ritchie RF

更新日期：2001-11-01 00:00:00

abstract：:Individual risk of toxicity or cancer reflects the amount of exposure to environmental agents, combined with one's underlying genetic predisposition. More than six dozen human ecogenetic polymorphisms have been described; whereas some of these have been demonstrated to be associated with altered risks of toxicity or c...

journal_title：Clinical chemistry and laboratory medicine

authors： Nebert DW

更新日期：2000-09-01 00:00:00

abstract：:Background This study aimed to investigate the correlation between glucose fluctuation from self-monitored blood glucose (SMBG) and the major adverse cardiac events (MACE) in diabetic patients with acute coronary syndrome (ACS) during a 6-month follow-up period using the WeChat application. Methods From November 2016 ...

journal_title：Clinical chemistry and laboratory medicine

authors： Xia J,Hu S,Xu J,Hao H,Yin C,Xu D

更新日期：2018-11-27 00:00:00

abstract：:The term "clinical proteomics" refers to the application of available proteomics technologies to current areas of clinical investigation. The ability to simultaneously and comprehensively examine changes in large numbers of proteins in the context of disease or other changes in physiological conditions holds great pro...

journal_title：Clinical chemistry and laboratory medicine

authors： Clarke W,Zhang Z,Chan DW

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:High-density lipoprotein (HDL) is believed to be protective against coronary heart disease (CHD). HDL is comprised of different subfractions. Of these, HDL 2b is believed to be the most important in preventing CHD. Current methods for HDL subfraction measurements are not standardized and often exhibit poor a...

journal_title：Clinical chemistry and laboratory medicine

authors： Yang DH,Konigshofer Y,Dike J,Chang E,Mueller O

更新日期：2010-06-01 00:00:00

abstract：:On May 28-29, 2009, a number of medical laboratory opinion leaders, pathologists and biochemists met in Sitges, Spain to discuss issues of interest to medical laboratory professionals. The meeting was sponsored by Bio-Rad Laboratories Inc. (Hercules, CA). Over 40 persons representing Austria, Belgium, Czech Republic, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Burnett D,Ceriotti F,Cooper G,Parvin C,Plebani M,Westgard J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative data and secondarily to evaluate the potential utility of GDF-15 in DKD using Roche Diagnostics ele...

journal_title：Clinical chemistry and laboratory medicine

authors： Hamon SM,Griffin TP,Islam MN,Wall D,Griffin MD,O'Shea PM

更新日期：2019-03-26 00:00:00

abstract：:Background The accurate and precise measurement of triglycerides is important due to the adverse effects associated with hypertriglyceridaemia. Most laboratory methods are based on enzymatic hydrolysis of triglycerides with measurement of the total glycerol. An elevated free glycerol concentration may result in overes...

journal_title：Clinical chemistry and laboratory medicine

authors： van Heerden C,Magwete A,Mabuza D

更新日期：2020-07-28 00:00:00

abstract：:Objectives Cerebrospinal fluid (CSF) is a clear, colorless body fluid filling the central nervous system. The determination of the CSF total protein (TP) content represents an important screening test of various pathologies. We aimed to address the effect of sex and age on CSF-TP content and the use of the current upp...

journal_title：Clinical chemistry and laboratory medicine

authors： Castellazzi M,Pizzicotti S,Lombardo I,Alfiero S,Morotti A,Pellegatti P,Negri G,Natali L,Ferri C,Fainardi E,Bellini T,Pugliatti M

更新日期：2020-10-25 00:00:00

abstract：BACKGROUND:alpha-Thalassemia is a worldwide disease and considered to be a major public health problem in countries within the so-called thalassemia belt. The complex genetics of alpha-thalassemias requires diagnostic methods with the capacity to screen rapidly and accurately for common causative mutations. METHODS:We...

journal_title：Clinical chemistry and laboratory medicine

authors： Puehringer H,Najmabadi H,Law HY,Krugluger W,Viprakasit V,Pissard S,Baysal E,Taher A,Farra C,Al-Ali A,Al-Ateeq S,Oberkanins C

更新日期：2007-01-01 00:00:00

abstract：:We compared six routinely employed immunoassay kits: Architect i2000 and AxSYM, Abbott Laboratories; Elecsys 2010, Roche Diagnostics; ELSA, CIS-BioInternational; Immulite 1, Diagnostic Products Corporation; and IRMA-mat, Byk-Sangtec Diagnostica. Using all analytical systems, we measured identical groups of clinical sa...

journal_title：Clinical chemistry and laboratory medicine

authors： Stern P,Friedecky B,Bartos V,Bezdickova D,Vavrova J,Uhrova J,Rozprimova L,Zima T,Palicka V

更新日期：2001-12-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency is present in more than 90% of patients with congenital adrenal hyperplasia, an inherited metabolic disorder of adrenal steroidogenesis. Impaired enzymatic activity leads to the accumulation of metabolic intermediates (progesterone and 17-hydroxyprogesterone), which results in excessi...

journal_title：Clinical chemistry and laboratory medicine

authors： Concolino P,Mello E,Zuppi C,Capoluongo E

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The knowledge of physiological fluctuation and variation of even commonly used biochemical quantities in extreme age groups and during development is sparse. This challenges the clinical interpretation and utility of laboratory tests in these age groups. To explore the utility of hospital laboratory data as ...

journal_title：Clinical chemistry and laboratory medicine

authors： Søeby K,Jensen PB,Werge T,Sørensen S

更新日期：2015-09-01 00:00:00

abstract：Background:Anti-mitochondrial autoantibodies (AMA) detected by indirect immunofluorescence (IIF) on rodent tissues are the diagnostic marker of primary biliary cholangitis (PBC). However, up to 15% of patients with PBC are AMA-negative by IIF. In the effort to close the serological gap and improve the diagnostic sensit...

journal_title：Clinical chemistry and laboratory medicine

authors： Villalta D,Seaman A,Tiongson M,Warren C,Bentow C,Bizzaro N,Alessio MG,Porcelli B,Norman GL,Mahler M

更新日期：2020-04-10 00:00:00

abstract：BACKGROUND:The presence of IgA antibodies to tissue transglutaminase (anti-tTg) is associated with variable risk for celiac disease. The use of common multiples of the upper limit of normal (ULN) has been suggested to optimize diagnostic pathways as well as improve harmonization between assays. METHODS:The characteris...

journal_title：Clinical chemistry and laboratory medicine

authors： Suh-Lailam BB,Davis KW,Tebo AE

更新日期：2016-02-01 00:00:00

abstract：:Method comparisons are indispensable tools for the extensive validation of analytic procedures. Laboratories often only want to know whether an established procedure (x-method) can be replaced by another one (y-method) without interfering with diagnostic purposes. Then split patients' samples are analyzed more or less...

journal_title：Clinical chemistry and laboratory medicine

authors： Haeckel R,Wosniok W,Al Shareef N

更新日期：2011-11-01 00:00:00

abstract：:The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first-line chemotherapy for metastati...

journal_title：Clinical chemistry and laboratory medicine

authors： Sölétormos G,Petersen PH,Dombernowsky P

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Gestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy. METHODS:Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22-40) years; the subjects were followed in order to establish the gestational...

journal_title：Clinical chemistry and laboratory medicine

authors： Kovac MK,Lalic-Cosic SZ,Dmitrovic JM,Djordjevic VJ,Radojkovic DP

更新日期：2015-11-01 00:00:00