Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP).

abstract：BACKGROUND:The measurement of serum IgE aids in the diagnosis and management of atopic allergic disease and hyper-IgE immunodeficiency syndromes. The 2nd World Health Organization (WHO) International Reference Reagent (IRR) for serum IgE (75/502; 5000 IU/ampoule), is widely used to calibrate assays for serum IgE. Exhau...

journal_title：Clinical chemistry and laboratory medicine

authors： Thorpe SJ,Heath A,Fox B,Patel D,Egner W

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The presence of IgA antibodies to tissue transglutaminase (anti-tTg) is associated with variable risk for celiac disease. The use of common multiples of the upper limit of normal (ULN) has been suggested to optimize diagnostic pathways as well as improve harmonization between assays. METHODS:The characteris...

journal_title：Clinical chemistry and laboratory medicine

authors： Suh-Lailam BB,Davis KW,Tebo AE

更新日期：2016-02-01 00:00:00

abstract：:Biochemical reactions in cells which involve oxalic acid are described. It is shown that this compound is required for the formation of uracil and orotic acid. The former is a component of RNA which is common to all cells in the human metabolism. On the basis of the biochemical reactions described a possible treatment...

journal_title：Clinical chemistry and laboratory medicine

authors： Robertson DS

更新日期：2011-09-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is a potent inhibitor of nitric oxide synthase and is regarded as a novel risk factor for cardiovascular disease. The metabolic pathways of ADMA and homocysteine are strongly intertwined. First, during synthesis of ADMA, two equivalents of homocysteine are formed. Second, homocystein...

journal_title：Clinical chemistry and laboratory medicine

authors： Teerlink T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:An effective quality control (QC) program requires the establishment of control limits within which the results of the QC sample is expected to fall. Traditionally, the mean plus/minus two standard deviations calculated for a set of QC sample results is used to establish control limits. Allowable total error...

journal_title：Clinical chemistry and laboratory medicine

authors： Dimech W,Vincini G,Karakaltsas M

更新日期：2015-02-01 00:00:00

abstract：:Given the lack of information about Y haplotypes for Campania (southern Italy), we analyzed eight Y short tandem repeats in a sample of males from this region with the aim of establishing a Y-haplotype database that can be used for forensic purposes. The eight Y short tandem repeats were amplified by two PCR multiplex...

journal_title：Clinical chemistry and laboratory medicine

authors： Calcagno G,Labruna G,Sacchetti L

更新日期：2005-01-01 00:00:00

abstract：:The formation of superoxide partially accounts for the well-known oxygen enhancement of radiation-induced biochemical changes and cell damage. Radioprotective effects of copper (II), manganese (IV) or vanadium (IV) complexes, of superoxide dismutase-mimetic activity, on body weight, survival rate and some biochemical ...

journal_title：Clinical chemistry and laboratory medicine

authors： Abou-Seif MA,El-Naggar MM,El-Far M,Ramadan M,Salah N

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) measurements are important for the assessment of liver damage. The aim of this study was to define the reference intervals (RIs) for these enzymes in adults, paying attention to standardization of the methods us...

journal_title：Clinical chemistry and laboratory medicine

authors： Ceriotti F,Henny J,Queraltó J,Ziyu S,Özarda Y,Chen B,Boyd JC,Panteghini M,IFCC Committee on Reference Intervals and Decision Limits (C-RIDL).,Committee on Reference Systems for Enzymes (C-RSE).

更新日期：2010-11-01 00:00:00

abstract：:Remarkably elevated levels of phospholipase A2 (PLA2) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two isoenzymes--the pancreatic PLA2, group I, and the extrapancreatic PLA2, group ...

journal_title：Clinical chemistry and laboratory medicine

authors： Aufenanger J,Samman M,Quintel M,Fassbender K,Zimmer W,Bertsch T

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Standardization of parathyroid hormone (PTH) assays is a major issue, especially in hemodialyzed (HD) patients. Two automated third generation PTH assays (Roche Elecsys and DiaSorin Liaison) are now available. These assays are specific for the (1-84) PTH and do not cross-react with the (7-84) fragment, contr...

journal_title：Clinical chemistry and laboratory medicine

authors： Cavalier E,Delanaye P,Lukas P,Carlisi A,Gadisseur R,Souberbielle JC

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The few available External Quality Assessment (EQA) programs on urinary sediment rarely include an evaluation of clinical cases. The present paper provides a descriptive analysis of clinical cases included in the Italian EQA program on urinary sediment. METHODS:Ten cases were presented over a 5-year period ...

journal_title：Clinical chemistry and laboratory medicine

authors： Fogazzi GB,Secchiero S,Garigali G,Plebani M

更新日期：2014-06-01 00:00:00

abstract：:Choroid plexus has the highest concentration of transthyretin (TTR) mRNA in the body, 4.4 microg TTR mRNA/g wet weight tissue, compared with 0.39 microg in the liver. The proportion of TTR to total protein synthesis in choroid plexus is 12%. All newly synthesized TTR is secreted towards the ventricles. Net transfer of...

journal_title：Clinical chemistry and laboratory medicine

authors： Schreiber G

更新日期：2002-12-01 00:00:00

abstract：:Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Andersson A,Ankerst J,Lindgren A,Larsson K,Hultberg B

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Point of care (POC) assays for cardiac troponins I or T (cTnI or cTnT) may accelerate the diagnosis of patients with suspected acute coronary syndrome (ACS). However, their clinical utility according to the 0 h/3 h algorithm recommended by the European Society of Cardiology (ESC) for non-ST elevation myocard...

journal_title：Clinical chemistry and laboratory medicine

authors： Suh D,Keller DI,Hof D,von Eckardstein A,Gawinecka J

更新日期：2018-03-28 00:00:00

abstract：BACKGROUND:With patients referred to emergency departments (EDs) for acute dyspnea, emergency physicians should consider all possible diagnoses and assess patients' risk stratification. Copeptin has been shown to have prognostic power for subsequent events, such as death and rehospitalization in patients admitted for d...

journal_title：Clinical chemistry and laboratory medicine

authors： Vetrone F,Santarelli S,Russo V,Lalle I,De Berardinis B,Magrini L,Di Stasio E,Salerno G,Cardelli P,Piccoli A,Codognotto M,Mion MM,Plebani M,Vettore G,Castello LM,Avanzi GC,Di Somma S

更新日期：2014-10-01 00:00:00

abstract：:The detection and quantification of amyloidogenic monoclonal light chains are necessary for the diagnosis and evaluation of response to treatment in AL amyloidosis. However, the amyloid clone is often small and difficult to detect. We report the case of a 68-year-old man who was referred to our Center in April 2013 af...

journal_title：Clinical chemistry and laboratory medicine

authors： Milani P,Valentini V,Ferraro G,Basset M,Russo F,Foli A,Palladini G,Merlini G

更新日期：2016-06-01 00:00:00

abstract：:Successful reduction of the risk of viral transmission via blood components has focused attention on the risk of transfusion-associated bacterial sepsis. The incidence of transfusion reactions due to bacteria is currently estimated at between 1 per 100,000 and 1 per 1,000,000 units in the case of packed red blood cell...

journal_title：Clinical chemistry and laboratory medicine

authors： Walther-Wenke G

更新日期：2008-01-01 00:00:00

abstract：:Protein-coding genes comprise only 3% of the human genome, while the genes that are transcribed into RNAs but do not code for proteins occupy majority of the genome. Once considered as biological darker matter, non-coding RNAs are now being recognized as critical regulators in cancer genome. Among the many types of no...

journal_title：Clinical chemistry and laboratory medicine

authors： Ling H,Girnita L,Buda O,Calin GA

更新日期：2017-05-01 00:00:00

abstract：:Microsatellite typing is frequently used in disease diagnosis and in genetic association studies. Inter-study consistency and comparability is essential in both applications. In this study, we show that the interlaboratory comparison of microsatellite sizes is often discrepant and misleading. This is a matter of great...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossouw M,Warren R,Hoal EG

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Potassium is an important serum ion that is frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate reference method for serum potassium measurements is important. METHODS:An inductively coupled plasma mass spectrometry (ICP-MS) metho...

journal_title：Clinical chemistry and laboratory medicine

authors： Yan Y,Han B,Zeng J,Zhou W,Zhang T,Zhang J,Chen W,Zhang C

更新日期：2017-08-28 00:00:00

abstract：BACKGROUND:Heparin is the standard drug for anticoagulation treatment and is used in many cardiac surgical interventions to prevent blood clotting. The anticoagulation status is controlled by various clotting tests. However, these tests depend on parameters like temperature, hemodilution etc. and are thus not applicabl...

journal_title：Clinical chemistry and laboratory medicine

authors： Haselbach S,Maurer J,Vogel V,Harder S,Weber CF,Baykut D,Meininger D,Keller H,Moritz A,Mäntele W

更新日期：2013-10-01 00:00:00

abstract：:A rat model is introduced which enables investigations in anticoagulated blood with continuous measurements by a flow-through electrode system. In the present study, a potentiometric ion-selective electrode (ISE)-system was used for measuring Ca2+, K+, Na+ and pH in rats. The setup was adjusted to an extracorporeal bl...

journal_title：Clinical chemistry and laboratory medicine

authors： Heidrich JP,Niemeier A,Seyfarth M

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Accurate reference intervals (RIs) based on a healthy pediatric population are essential for pediatric test result interpretation. The CALIPER project has recruited a large healthy cohort and completed a series of a priori studies to address gaps in pediatric RIs. As immunoassays from different manufacturers...

journal_title：Clinical chemistry and laboratory medicine

authors： Higgins V,Fung AWS,Chan MK,Macri J,Adeli K

更新日期：2018-01-26 00:00:00

abstract：BACKGROUND:The objective of this study was to examine the diagnostic accuracy of high-sensitivity cardiac troponin T (hs-cTnT) for acute myocardial infarction (AMI) in patients with renal insufficiency, since this population has a high incidence of non-AMI elevations of hs-cTnT. METHODS:In this prospective study, we e...

journal_title：Clinical chemistry and laboratory medicine

authors： Huang H,Zhu S,Wang W,Yi H,Du X,Nie X,He Y,Song H,Miao Q,Wang L,Li G

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Lactase persistence is an inherited autosomal dominant trait that confers the ability to digest lactose after weaning. Lactose persistence is caused by single nucleotide variants in a regulatory element for the lactase gene (LCT). In Europeans, lactase persistence is associated with the nucleotide variant LC...

journal_title：Clinical chemistry and laboratory medicine

authors： Strand H,Sørensen LK,Ingebretsen OC

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Thyroid stimulating hormone (TSH) receptor autoantibodies (TRAb) are pathogenetic and diagnostic hallmarks of Graves' disease (GD). Three varieties of TRAb have been described: stimulating (S-TRAb), blocking (B-TRAb), and apoptotic (A-TRAb) autoantibodies. Very recently, the first immunoassay method (Immulit...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,D'Aurizio F,Villalta D,Giovanella L

更新日期：2017-01-01 00:00:00

abstract：:The soluble transferrin receptor (sTfR) distinguishes iron deficiency anemia from other types of anemia. Refractory iron deficiency anemia is often the onset symptom in malabsorption-induced celiac disease. We evaluated whether sTfR levels distinguish celiac disease-associated iron deficiency anemia from iron deficien...

journal_title：Clinical chemistry and laboratory medicine

authors： De Caterina M,Grimaldi E,Di Pascale G,Salerno G,Rosiello A,Passaretti M,Scopacasa F

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to provide inter-laboratory imprecision comparisons of different groups of diagnostic systems as well as a comparison of professional laboratories with medical offices performance on the basis of 88,429 glucose results obtained in external quality assessment (EQA) schemes organized ...

journal_title：Clinical chemistry and laboratory medicine

authors： Morandi PA,Deom A,Kesseler D,Cohen R

更新日期：2010-09-01 00:00:00

abstract：:Low-density lipoprotein (LDL) oxidation in vivo depends on lipid composition and on plasma antioxidant status. The aim of our study was to investigate the relationship between plasma lipid composition and LDL oxidation and, in particular, to explore whether LDL-cholesterol/triglycerides ratio (LDL-C/TG) and LDL-choles...

journal_title：Clinical chemistry and laboratory medicine

authors： Brizzi P,Tonolo G,Carusillo F,Malaguarnera M,Maioli M,Musumeci S

更新日期：2003-01-01 00:00:00

abstract：:Congenital disorders of glycosylation (CDG) are genetic multisystemic diseases due to various defects in the biosynthesis or processing of glycoproteins. Our aim is to present our experience in the selective screening of CDG syndrome in a paediatric population (421 patients) with clinical suspicion of the disease, ana...

journal_title：Clinical chemistry and laboratory medicine

authors： Colomé C,Ferrer I,Artuch R,Vilaseca MA,Pineda M,Briones P

更新日期：2000-10-01 00:00:00