Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?

abstract：BACKGROUND:Certain genetic polymorphisms can lead to differences in immunity function, resulting in different clinical outcomes for hepatitis B virus (HBV) patients. The aim of this study was to investigate the association between apolipoprotein E (ApoE) gene polymorphisms and HBV infection status in northern Chinese i...

journal_title：Clinical chemistry and laboratory medicine

authors： Yin Z,Xiong C,Wang Y,Zhou X,Yan SK

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:CDC25 phosphatases control cell cycle progression by activating cyclin dependent kinases. The three CDC25 isoforms encoding genes are submitted to alternative splicing events which generate at least two variants for CDC25A and five for both CDC25B and CDC25C. An over-expression of CDC25 was reported in sever...

journal_title：Clinical chemistry and laboratory medicine

authors： Albert H,Santos S,Battaglia E,Brito M,Monteiro C,Bagrel D

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The aim was to investigate whether first trimester glycodelin and angiopoietin-2 can predict small-for-gestational age (SGA) at delivery, individually or in combination. METHODS:In this case-control study we measured glycodelin and angiopoietin-2 on serum from 170 singleton pregnant women delivering SGA neo...

journal_title：Clinical chemistry and laboratory medicine

authors： Hansen YB,Myrhøj V,Jørgensen FS,Sørensen S

更新日期：2016-09-01 00:00:00

abstract：:The non-forage feeding of dairy cows rich in fast absorption carbohydrates, the low value of their euglycemic-hyperinsulinemic clamp suggest a dysregulation of carbohydrate metabolism able to produce neurodegenerative disorders. Comparisons between Alzheimer's disease developed in diabetes mellitus and bovine spongifo...

journal_title：Clinical chemistry and laboratory medicine

authors： Frey J

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Toldi G,Stenczer B,Molvarec A,Takáts Z,Beko G,Rigó J Jr,Vásárhelyi B

更新日期：2010-10-01 00:00:00

abstract：:We developed a time-resolved-fluoro-immunoassay to measure cortisol binding globulin (CBG) in serum. It is a microtitre plate, solid phase, reagent excess, sandwich assay in which the same polyclonal antiserum is used as a source of capture and labeled antibodies. The results of this assay were shown to be reliable an...

journal_title：Clinical chemistry and laboratory medicine

authors： Bonte HA,van den Hoven RJ,van der Sluijs Veer G,Vermes I

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Query fever (Q fever) is a zoonotic infection, caused by the intracellular Gram-negative coccobacillus Coxiella burnetii. From 2007 until 2010, a large Q fever outbreak has occurred in the Netherlands. We studied traditional and less common inflammation markers in seronegative and seropositive patients with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Vissers E,de Jager CP,Hilbink M,Kusters R,van Gageldonk-Lafeber AB,Wever PC

更新日期：2012-02-04 00:00:00

abstract：BACKGROUND:The aim of the study was to develop a method for sweat chloride (Cl) quantification using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to present to the Joint Committee for Traceability in Laboratory Medicine (JCTLM) as a candidate reference method for the diagnosis of cystic fibrosis (CF). METHODS...

journal_title：Clinical chemistry and laboratory medicine

authors： Collie JT,Massie RJ,Jones OA,Morrison PD,Greaves RF

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Fatty acid metabolites play a key role in numerous physiological and pathological processes. A rapid liquid chromatography-mass spectrometry assay for the simultaneous determination of prostanoids, isoprostane and lipoxygenase (LOX) derived fatty acid metabolites in a small biological sample of only 20 micro...

journal_title：Clinical chemistry and laboratory medicine

authors： Unterwurzacher I,Koal T,Bonn GK,Weinberger KM,Ramsay SL

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The discovery of mutations in the epidermal growth factor receptor gene (EGFR) related to the clinical response to tyrosine kinase inhibitors, has transformed the management of non-small cell lung cancer (NSCLC). Several methods have been developed for determination of mutations in EGFR, with different sensi...

journal_title：Clinical chemistry and laboratory medicine

authors： Martínez-Carretero C,Pascual FI,Rus A,Bernardo I

更新日期：2017-10-26 00:00:00

abstract：BACKGROUND:Efficient laboratory service is the cornerstone of modern health care systems. Scientific innovations have contributed to substantial improvements in the field of laboratory science, but errors still prevail. These errors are classified as preanalytical, analytical and postanalytical, depending upon the time...

journal_title：Clinical chemistry and laboratory medicine

authors： Goswami B,Singh B,Chawla R,Mallika V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kennard A,Hawley C,Tate J,Klingberg S,Pretorius C,Hutchison C,Mollee P

更新日期：2016-06-01 00:00:00

abstract：:Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Met...

journal_title：Clinical chemistry and laboratory medicine

authors： Veenhof H,Koster RA,Alffenaar JC,van den Berg AP,de Groot MR,Verschuuren EAM,Berger SP,Bakker SJL,Touw DJ

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:Apolipoprotein A-I gene (APOA1) polymorphisms have been associated with variations in serum low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol. We have investigated whether APOA1 common variants are also associated with variations in basal triglyceride serum concentrations and resp...

journal_title：Clinical chemistry and laboratory medicine

authors： Sorkin SC,Forestiero FJ,Hirata MH,Guzmán EC,Cavalli SA,Bertolami MC,Salazar LA,Hirata RD

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The compatibility of immunoassay tests in different sample matrices is extremely important during the assay validation process. In this study, we investigated the interchangeability of some Access (and therefore all the UniCel Family platforms) assays between serum and plasma. METHODS:We tested approximatel...

journal_title：Clinical chemistry and laboratory medicine

authors： Vignati G,Chiecchio A,Osnaghi B,Giovanelli L,Meloncelli C

更新日期：2008-01-01 00:00:00

abstract：:Although the perioperative event rate has declined over the past 30 years, as a consequence of the developments in anesthesiology and surgical techniques, perioperative cardiovascular complications are still a significant clinical problem. At the end of the last century, a pooled analysis of several large studies foun...

journal_title：Clinical chemistry and laboratory medicine

authors： Clerico A,Emdin M,Passino C

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Knowledge of the fatty acid composition of lipid classes in human plasma is an important factor in the investigation of human metabolism. Therefore, a method for the analysis of neutral lipid (NL), phospholipid (PL) and free fatty acids (FFA) in human plasma has been developed and validated. METHODS:Separat...

journal_title：Clinical chemistry and laboratory medicine

authors： Firl N,Kienberger H,Hauser T,Rychlik M

更新日期：2013-04-01 00:00:00

abstract：:The Institute of Medicine (IOM) report, To err is human, galvanized a dramatically increased level of concern about adverse events and patient safety in healthcare, including errors in laboratory medicine. While a significant decrease in the error rates of clinical laboratories has been achieved and documented in rece...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M

更新日期：2007-01-01 00:00:00

abstract：:Neopterin is elevated in infections, autoimmune diseases and post-transplant. Recently neopterin elevation was linked to stress response and malignancy. To determine early changes of serum neopterin caused by surgical stress and to investigate their association with other inflammatory markers and with malignancy, we m...

journal_title：Clinical chemistry and laboratory medicine

authors： Jerin A,Pozar-Lukanovic N,Sojar V,Stanisavljevic D,Paver-Erzen V,Osredkar J

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Premature osteoporosis is a frequent problem in female athletes. Current concepts suggest that a disruption of the hypothalamic-pituitary axis leads to hypoestrogenism, which then causes amenorrhea and osteoporosis. However, the underlying mechanisms have been insufficiently investigated. Osteoprotegerin (OPG) ...

journal_title：Clinical chemistry and laboratory medicine

authors： Herrmann M,Herrmann W

更新日期：2004-01-01 00:00:00

abstract：:The pathogenesis of cobalamin (Cbl)-deficient (Cbl-D) neuropathy and the role of normal prions (PrPcs) in myelin maintenance are both subjects of debate. We have demonstrated that Cbl deficiency damages myelin by increasing tumor necrosis factor (TNF)-α, and decreasing epidermal growth factor (EGF) levels in the rat c...

journal_title：Clinical chemistry and laboratory medicine

authors： Scalabrino G,Veber D

更新日期：2013-03-01 00:00:00

abstract：:The mutant of CYP2D6*3 allele with A2637 deletion in exon 5 and the mutant of CYP2D6*4 allele G1934-->A, splice site defect are among the most common polymorphic alleles of CYP2D6 gene, resulting in a decreased or no activity of CYP isoenzyme. In this study, a reliable polymerase chain reaction-restriction fragment le...

journal_title：Clinical chemistry and laboratory medicine

authors： Topić E,Stefanović M,Nikolić V,Zoricić I,Ivanisević AM,Zuntar I

更新日期：1998-08-01 00:00:00

abstract：:Given the lack of information about Y haplotypes for Campania (southern Italy), we analyzed eight Y short tandem repeats in a sample of males from this region with the aim of establishing a Y-haplotype database that can be used for forensic purposes. The eight Y short tandem repeats were amplified by two PCR multiplex...

journal_title：Clinical chemistry and laboratory medicine

authors： Calcagno G,Labruna G,Sacchetti L

更新日期：2005-01-01 00:00:00

abstract：:Cardiovascular risk is associated with high lipoprotein(a) (Lp(a)) concentrations and low molecular weight apolipoprotein(a) (apo(a)) isoforms. We studied the relationship between these two biological parameters, particularly in subjects expressing two apo(a) isoforms. Plasma Lp(a) was measured by immunonephelometry i...

journal_title：Clinical chemistry and laboratory medicine

authors： Alaoui M,Merle C,Garnotel R,Jolly D,Durlach V,Gillery P

更新日期：2003-05-01 00:00:00

abstract：:Nitric oxide (NO) activates soluble guanylyl cyclase, which results in an increased synthesis of cyclic guanosine 3',5'-cyclic monophosphate (cGMP), smooth muscle relaxation and vasodilation. The heme group in soluble guanylyl cyclase binds NO and allosterically activates the catalytic site. In addition, a second allo...

journal_title：Clinical chemistry and laboratory medicine

authors： Nakane M

更新日期：2003-07-01 00:00:00

abstract：:In the relatively short time frame since the introduction of next generation sequencing, it has become a method of choice for complex genomic research studies. As a paradigm shifting technology, we are now witnessing its translation into clinical diagnostic laboratories for patient care. Multi-gene panels for a variet...

journal_title：Clinical chemistry and laboratory medicine

authors： Coonrod EM,Margraf RL,Voelkerding KV

更新日期：2011-12-23 00:00:00

abstract：:Both technological advances and economic drivers have led to major changes in clinical laboratories across the world, with vastly improved testing productivity. However, the production process capability advances have far outpaced the clinical pathologists' success in assuring optimal test utilization and interpretati...

journal_title：Clinical chemistry and laboratory medicine

authors： Blanckaert N

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The study aim was to evaluate and compare the analytical performance of the new chemiluminescent immunoassay for cardiac troponin I (cTnI), called Access hs-TnI using DxI platform, with those of Access AccuTnI+3 method, and high-sensitivity (hs) cTnI method for ARCHITECT platform. METHODS:The limits of blan...

journal_title：Clinical chemistry and laboratory medicine

authors： Masotti S,Prontera C,Musetti V,Storti S,Ndreu R,Zucchelli GC,Passino C,Clerico A

更新日期：2018-02-23 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) and choline acetyltransferase (ChAT) have been suggested as candidate genes for determining the risk of late-onset Alzheimer's disease. The aim of this study was to simultaneously detect polymorphisms in codons 112 and 158 of APOE and codon 2 of ChAT by hybridization probe multiplexin...

journal_title：Clinical chemistry and laboratory medicine

authors： Park HD,Park KU,Kim KW,Song J,Chang HE,Heo SR,Lee HJ,Kim JQ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Mid-regional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. METHODS:In a prospective...

journal_title：Clinical chemistry and laboratory medicine

authors： Behnes M,Papassotiriou J,Walter T,Fiedler E,Sauer T,Lang S,Elmas E,Hoffmann U,Borggrefe M,Brueckmann M

更新日期：2008-01-01 00:00:00