Antibodies to citrullinated peptides: a significant step forward in the early diagnosis of rheumatoid arthritis.

abstract：:Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The i...

journal_title：Clinical chemistry and laboratory medicine

authors： Hong YJ,Lee JK,Lee GH,Hong SI

更新日期：2000-09-01 00:00:00

abstract：:Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight cytoplasmic protein and present abundantly in the myocardium. When the myocardium is injured, as in the case of myocardial infarction, low molecular weight cytoplasmic proteins including H-FABP are released into the circulation and H-FABP is dete...

journal_title：Clinical chemistry and laboratory medicine

authors： Okamoto F,Sohmiya K,Ohkaru Y,Kawamura K,Asayama K,Kimura H,Nishimura S,Ishii H,Sunahara N,Tanaka T

更新日期：2000-03-01 00:00:00

abstract：:A body of evidence has been accumulated to demonstrate that current practice is not sufficiently safe for several stages of central laboratory testing. In particular, while analytical and perianalytical steps that take place within the laboratory are subjected to quality control procedures, this is not the case for se...

journal_title：Clinical chemistry and laboratory medicine

authors： Kay J

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of pre-eclampsia (PE) is incompletely understood. The placenta is considered to play a key role in this disease. Recent research showed that many microRNAs (miRNAs) are expressed in human placenta. Our aim in this study was to determine differential expression of miRNAs in placenta with seve...

journal_title：Clinical chemistry and laboratory medicine

authors： Hu Y,Li P,Hao S,Liu L,Zhao J,Hou Y

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:An effective quality control (QC) program requires the establishment of control limits within which the results of the QC sample is expected to fall. Traditionally, the mean plus/minus two standard deviations calculated for a set of QC sample results is used to establish control limits. Allowable total error...

journal_title：Clinical chemistry and laboratory medicine

authors： Dimech W,Vincini G,Karakaltsas M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:We evaluated the effect of kidney glomerular function on serum concentrations of human epididymis protein 4 (HE4) using creatinine (Cr), cystatin C (CysC) and related chronic kidney disease epidemiology collaboration (CKD-EPI) equations. METHODS:We enrolled 101 women aged ≤56 years with a glomerular filtrat...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Pasqualetti S,Carnevale A,Panteghini M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Previous genomic linkage studies have produced evidence linking sodium-lithium countertransport activity (Na/Li CT) with various chromosomal regions including loci harbouring glutathione S transferase (GST) genes. The aim of this study was to examine the putative association of erythrocyte Na/Li CT activity ...

journal_title：Clinical chemistry and laboratory medicine

authors： Goulas A,Kosmidou M,Hatzitolios AI,Raikos N,Molyva D,Savopoulos C,Giannopoulos S,Fidani L

更新日期：2008-01-01 00:00:00

abstract：:In the Emergency Department it is mandatory to establish the diagnosis and the prognosis of acute pancreatitis as soon as possible. To evaluate whether the association of serum lipase either with serum beta2-microglobulin or with C-reactive protein allows simultaneously to establish the diagnosis and the prognosis of ...

journal_title：Clinical chemistry and laboratory medicine

authors： Pezzilli R,Morselli-Labate AM,Barakat B,Fiocchi M,Cappelletti O

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:The aim of the study was to develop a method for sweat chloride (Cl) quantification using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to present to the Joint Committee for Traceability in Laboratory Medicine (JCTLM) as a candidate reference method for the diagnosis of cystic fibrosis (CF). METHODS...

journal_title：Clinical chemistry and laboratory medicine

authors： Collie JT,Massie RJ,Jones OA,Morrison PD,Greaves RF

更新日期：2016-04-01 00:00:00

abstract：:We evaluated the analytical performance of the Immulite 2000 immunoassay analyzer (Diagnostic Products Corporation, Los Angeles, USA) based on a new detection technology, electrochemical luminescence. The evaluated analytes were thyrotropin, triiodothyronine, free thyroxine, follitropin, lutropin, prolactin, cortisol,...

journal_title：Clinical chemistry and laboratory medicine

authors： Tello FL,Hernández DM

更新日期：2000-10-01 00:00:00

abstract：:Human protein 1/Clara cell Mr 10,000 protein consists of two identical subunits of seventy amino acid residues each. In the present study, eight clones of monoclonal antibodies against native protein 1 were prepared and their respective epitopes were immunochemically and immunohistochemically characterized using nativ...

journal_title：Clinical chemistry and laboratory medicine

authors： Yamaguchi T,Yamada T,Okutani R,Shijubo N,Singh G,Itoh Y

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Haemoglobin (Hb) variants are well-known factors interfering with accurate HbA1c testing. This report describes two novel Hb variants leading to inappropriate quantification of HbA1c by ion-exchange chromatography. METHODS:Glycated forms of novel Hb variants were recognised in the blood of two patients with...

journal_title：Clinical chemistry and laboratory medicine

authors： Bots M,Stroobants AK,Delzenne B,Soeters MR,de Vries JE,Weykamp CW,Norg RJ,Veldthuis M,Zwieten Rv

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:In large clinical trials, where RNA cannot be extracted immediately after sampling, preserving RNA in whole blood is a crucial initial step in obtaining robust qPCR data. The current golden standard for RNA preservation is costly and designed for time-consuming column-based RNA-extraction. We investigated th...

journal_title：Clinical chemistry and laboratory medicine

authors： Mærkedahl RB,Frøkiær H,Lauritzen L,Metzdorff SB

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:With patients referred to emergency departments (EDs) for acute dyspnea, emergency physicians should consider all possible diagnoses and assess patients' risk stratification. Copeptin has been shown to have prognostic power for subsequent events, such as death and rehospitalization in patients admitted for d...

journal_title：Clinical chemistry and laboratory medicine

authors： Vetrone F,Santarelli S,Russo V,Lalle I,De Berardinis B,Magrini L,Di Stasio E,Salerno G,Cardelli P,Piccoli A,Codognotto M,Mion MM,Plebani M,Vettore G,Castello LM,Avanzi GC,Di Somma S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Adult-type hypolactasia is characterized by the inability to digest lactose during adulthood, due to lactase (LCT) deficiency. It is usually diagnosed by the measurement of breath hydrogen increase after a lactose load (breath hydrogen test, BHT). A substitution of C to T at position -13910 bp upstream the L...

journal_title：Clinical chemistry and laboratory medicine

authors： Mottes M,Belpinati F,Milani M,Saccomandi D,Petrelli E,Calacoci M,Chierici R,Pignatti PF,Borgna-Pignatti C

更新日期：2008-01-01 00:00:00

abstract：:In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry (GSCC-CB), following the encouragement of the EC4/RC decided to organize a voluntary Register for specialists in clinical chemistry. The following criteria for regist...

journal_title：Clinical chemistry and laboratory medicine

authors： Rizos D,Karababa P,Nikolou C,Sarandakou A,Panagiotakis O,Ferderigou A,Haliassos A,Makris K,Psarra K,Bairaktari E,Spyropoulou P,Galiatsatos N,Trakas N,Seferiadis K,Greek National Clinical Chemistry Registration Commission.

更新日期：2011-08-30 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) and choline acetyltransferase (ChAT) have been suggested as candidate genes for determining the risk of late-onset Alzheimer's disease. The aim of this study was to simultaneously detect polymorphisms in codons 112 and 158 of APOE and codon 2 of ChAT by hybridization probe multiplexin...

journal_title：Clinical chemistry and laboratory medicine

authors： Park HD,Park KU,Kim KW,Song J,Chang HE,Heo SR,Lee HJ,Kim JQ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The use of laboratory tests has been increasing in recent years due to various factors affecting laboratories, physicians, legal aspects, or patients themselves. METHODS:The efficacy of laboratory tests must be evaluated on the basis of the clinical benefits that they provide in terms of prevention, diagnos...

journal_title：Clinical chemistry and laboratory medicine

authors： Alonso-Cerezo MC,Martín JS,García Montes MA,de la Iglesia VM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Aging is the result of several mechanisms which operate simultaneously. Among them, glycation is of particular interest because it is a reaction which affects slowly renewing tissues and macromolecules with elevated half-life, like the dermis, a skin compartment highly affected by aging. Glycation produces c...

journal_title：Clinical chemistry and laboratory medicine

authors： Pageon H,Zucchi H,Rousset F,Monnier VM,Asselineau D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The improvement of the consistency of gamma-glutamyltransferase (GGT) activity results among different assays after calibration with a common material was estimated. We evaluated if this harmonization could lead to reference limits common to different routine methods. METHODS:Seven laboratories measured GGT...

journal_title：Clinical chemistry and laboratory medicine

authors： Steinmetz J,Schiele F,Gueguen R,Férard G,Henny J,Periodic Health Examination Centers Laboratory Working Group.

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Measurement of late-night salivary cortisol concentrations is increasingly used as a screening test in suspected Cushing's syndrome. Cortisol concentrations are typically extremely low in late-night samples and discordant assay-specific reference ranges have been reported. Therefore, the aim of our study was...

journal_title：Clinical chemistry and laboratory medicine

authors： Vogeser M,Durner J,Seliger E,Auernhammer C

更新日期：2006-01-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is a potent inhibitor of nitric oxide synthase and is regarded as a novel risk factor for cardiovascular disease. The metabolic pathways of ADMA and homocysteine are strongly intertwined. First, during synthesis of ADMA, two equivalents of homocysteine are formed. Second, homocystein...

journal_title：Clinical chemistry and laboratory medicine

authors： Teerlink T

更新日期：2005-01-01 00:00:00

abstract：:In the relatively short time frame since the introduction of next generation sequencing, it has become a method of choice for complex genomic research studies. As a paradigm shifting technology, we are now witnessing its translation into clinical diagnostic laboratories for patient care. Multi-gene panels for a variet...

journal_title：Clinical chemistry and laboratory medicine

authors： Coonrod EM,Margraf RL,Voelkerding KV

更新日期：2011-12-23 00:00:00

abstract：BACKGROUND:The identification of human mitochondrial DNA (mtDNA) sequence variations, especially single nucleotide polymorphisms (SNPs), is important for many applications. The PCR-ligase detection reaction (LDR) method can reduce false-positives and eliminate the need for both post-PCR and post-ligation purifications ...

journal_title：Clinical chemistry and laboratory medicine

authors： Luo Y,Tang S,Gao W,Chen L,Yang X,Huang T,Gao Y

更新日期：2010-04-01 00:00:00

abstract：:The etiology of cardiovascular diseases is known to be multi-factorial. Some forms of cardiovascular disease are influenced by unclear genetic factors but are predominantly affected by factors such as diet, obesity, cigarette smoking, diabetes mellitus and dyslipidaemia. Some are caused by specific gene defects, with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Pang CP

更新日期：1998-08-01 00:00:00

abstract：:The formation of superoxide partially accounts for the well-known oxygen enhancement of radiation-induced biochemical changes and cell damage. Radioprotective effects of copper (II), manganese (IV) or vanadium (IV) complexes, of superoxide dismutase-mimetic activity, on body weight, survival rate and some biochemical ...

journal_title：Clinical chemistry and laboratory medicine

authors： Abou-Seif MA,El-Naggar MM,El-Far M,Ramadan M,Salah N

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:alpha-Thalassemia is a worldwide disease and considered to be a major public health problem in countries within the so-called thalassemia belt. The complex genetics of alpha-thalassemias requires diagnostic methods with the capacity to screen rapidly and accurately for common causative mutations. METHODS:We...

journal_title：Clinical chemistry and laboratory medicine

authors： Puehringer H,Najmabadi H,Law HY,Krugluger W,Viprakasit V,Pissard S,Baysal E,Taher A,Farra C,Al-Ali A,Al-Ateeq S,Oberkanins C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:We assessed whether glycated albumin (GA) is a useful glycemic indicator in diabetic patients with anemia who did not undergo dialysis. METHODS:Hemoglobin A(1c) (HbA(1c)) and GA were simultaneously measured in 370 diabetic subjects who had not undergone dialysis. The relationship between GA and HbA(1c) was ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim S,Min WK,Chun S,Lee W,Park HI

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The dogma of establishing intra-laboratory reference limits (RLs) and their periodic review cannot be fulfilled by most laboratories due to the expenses involved. Thus, most laboratories adopt external sources for their RLs, often neglecting the problems of transferability. This is particularly problematic f...

journal_title：Clinical chemistry and laboratory medicine

authors： Arzideh F,Wosniok W,Haeckel R

更新日期：2011-04-01 00:00:00

abstract：:The aim of this study was to clarify the effects of anti-dsDNA antibodies on the titer and the nuclear staining pattern(s) in a fluorescent antinuclear antibody (FANA) assay using HEp-2 cells. Anti-dsDNA derived from 14 patients with systemic lupus erythematosus (SLE) was individually affinity-purified. The anti-dsDNA...

journal_title：Clinical chemistry and laboratory medicine

authors： Suzuki K,Kawamura M,Mineo M,Shinohara T,Kataharada K,Okada M,Takada K,Miyawaki S,Ohsuzu F

更新日期：2002-01-01 00:00:00