Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a Chinese hospital system perspective.

abstract：:Measurement of total homocysteine (tHcy) in healthy and diseased children has documented the utility of this marker in pediatric research and diagnostics. This article focuses on novel data obtained in infants, children and adolescents, with emphasis on cobalamin status in infants. In children, determinants of plasma ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ueland PM,Monsen AL

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Post-menopausal osteoporosis (PO) affecting a large fraction of elderly women, is triggered by the decline in 17β-estradiol (E2) level. Experimental studies in animal models and cell cultures have suggested that the fall in E2 might contribute to developing oxidative stress (OS) which in turn is believed to ...

journal_title：Clinical chemistry and laboratory medicine

authors： Cervellati C,Bonaccorsi G,Cremonini E,Bergamini CM,Patella A,Castaldini C,Ferrazzini S,Capatti A,Picarelli V,Pansini FS,Massari L

更新日期：2013-02-01 00:00:00

abstract：:Cytokines are key mediators in cell regulation and communication. The concentration of these proteins can rapidly and importantly increase during severe clinical situations. However, current techniques are not adapted to stat measurement, thus making their clinical use limited. In this context, the commercialization o...

journal_title：Clinical chemistry and laboratory medicine

authors： Berthier F,Lambert C,Genin C,Bienvenu J

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:We verified the analytical performance of strip-based handheld glucose meters (GM) for prescription use, in a comparative split-sample protocol using blood gas samples from a surgical intensive care unit (ICU). METHODS:Freestyle Precision Pro (Abbott), StatStrip Connectivity Meter (Nova), ACCU-CHEK Inform I...

journal_title：Clinical chemistry and laboratory medicine

authors： Claerhout H,De Prins M,Mesotten D,Van den Berghe G,Mathieu C,Van Eldere J,Vanstapel F

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The identification of human mitochondrial DNA (mtDNA) sequence variations, especially single nucleotide polymorphisms (SNPs), is important for many applications. The PCR-ligase detection reaction (LDR) method can reduce false-positives and eliminate the need for both post-PCR and post-ligation purifications ...

journal_title：Clinical chemistry and laboratory medicine

authors： Luo Y,Tang S,Gao W,Chen L,Yang X,Huang T,Gao Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The study endpoint was to analyze the effect of preanalytical (time, temperature, anticoagulant) and analytical (imprecision, correlation between volume and platelet concentration) variables on mean platelet volume (MPV). A further aim was to calculate in an adult population the reference intervals using the...

journal_title：Clinical chemistry and laboratory medicine

authors： Buttarello M,Mezzapelle G,Plebani M

更新日期：2018-04-25 00:00:00

abstract：:In order to investigate possible ethnic differences in genetic and environmental determinants, we investigated several cardiovascular disease-associated genetic variations in successful ageing populations of France (Nancy) and China (Hong Kong). Allelic frequencies of these genetic variations were compared between hea...

journal_title：Clinical chemistry and laboratory medicine

authors： Xia Y,Baum L,Pang CP,Siest G,Visvikis S

更新日期：2005-01-01 00:00:00

abstract：:Until recently, the "human genome" programs were mainly directed towards the development of maps to identify disease genes. The genetic map comprises about 8000 highly informative second generation markers of the microsatellite type. The density of markers is now sufficient to localize a gene for a monogenic disease w...

journal_title：Clinical chemistry and laboratory medicine

authors： Weissenbach J

更新日期：1998-08-01 00:00:00

abstract：:There is evidence that angiogenesis plays an important role in the progression of multiple myeloma (MM). Hepatocyte growth factor (HGF) and tumor necrosis factor-alpha (TNF-alpha) are cytokines that potently stimulate angiogenesis. We evaluated the microvascular density (MVD) of bone marrow biopsies (after immunostain...

journal_title：Clinical chemistry and laboratory medicine

authors： Alexandrakis MG,Passam FJ,Ganotakis E,Dafnis E,Dambaki C,Konsolas J,Kyriakou DS,Stathopoulos E

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:In analogy with other areas of laboratory diagnostics, the pre-analytical phase is the leading source of variability also in urinalysis. We carried out a multicentric study for comparing results obtained from first-voided and mid-stream urine samples. METHODS:Each of the six hospital-based clinical laborato...

journal_title：Clinical chemistry and laboratory medicine

authors： Manoni F,Gessoni G,Alessio MG,Caleffi A,Saccani G,Silvestri MG,Poz D,Ercolin M,Tinello A,Valverde S,Ottomano C,Lippi G

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer's disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI). In the pr...

journal_title：Clinical chemistry and laboratory medicine

authors： Cervellati C,Romani A,Bergamini CM,Bosi C,Sanz JM,Passaro A,Zuliani G

更新日期：2015-06-01 00:00:00

abstract：:Objectives Our recent survey of 44 mass spectrometry laboratories across 17 countries identified variation in internal standard (IS) choice for the measurement of serum/plasma 17α-hydroxyprogesterone (17OHP) by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The choice of IS may contribute to inter-method v...

journal_title：Clinical chemistry and laboratory medicine

authors： Loh TP,Ho CS,Hartmann MF,Zakaria R,Lo CWS,van den Berg S,de Rijke YB,Cooke BR,Hoad K,Graham P,Davies SR,Mackay LG,Wudy SA,Greaves RF

更新日期：2020-09-25 00:00:00

abstract：:Thrombotic risk factors and thrombosis in children has been receiving increased attention. True idiopathic thrombosis is extremely rare in children. Most patients have a significant underlying medical condition and the presence of a central catheter is the most important risk factor. Children are more likely than adul...

journal_title：Clinical chemistry and laboratory medicine

authors： Trampus-Bakija A

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The presence of IgA antibodies to tissue transglutaminase (anti-tTg) is associated with variable risk for celiac disease. The use of common multiples of the upper limit of normal (ULN) has been suggested to optimize diagnostic pathways as well as improve harmonization between assays. METHODS:The characteris...

journal_title：Clinical chemistry and laboratory medicine

authors： Suh-Lailam BB,Davis KW,Tebo AE

更新日期：2016-02-01 00:00:00

abstract：:Three groups of patients have been studied longitudinally for 24 months to analyze the role of hepatitis G virus (HGV) in hepatic disease. Group 1 consisted of 50 patients with non-B, non-C chronic hepatitis, group 2 consisted of 44 hemodialyzed patients, and group 3 consisted of 50 healthy blood donors. The presence ...

journal_title：Clinical chemistry and laboratory medicine

authors： Grassi M,Mammarella A,Sagliaschi G,Granati L,Musca A,Traditi F,Pezzella M

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Procalcitonin (PCT) is increasingly being used for the diagnostic and prognostic work up of patients with suspected infections in the emergency department (ED). Recently, B·R·A·H·M·S PCT direct, the first high sensitive point-of-care test (POCT), has been developed for fast PCT measurement on capillary or ve...

journal_title：Clinical chemistry and laboratory medicine

authors： Kutz A,Hausfater P,Oppert M,Alan M,Grolimund E,Gast C,Alonso C,Wissmann C,Kuehn C,Bernard M,Huber A,Mueller B,Schuetz P

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Cigarette smoking, a cardiovascular risk factor leading to oxygen free radical formation, is involved in the development of serious pathological conditions. On the other hand, a healthy diet and adequate supplementation can help prevent many diseases. The aim of our study was to evaluate in healthy light smo...

journal_title：Clinical chemistry and laboratory medicine

authors： Bamonti F,Novembrino C,Ippolito S,Soresi E,Ciani A,Lonati S,Scurati-Manzoni E,Cighetti G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Pleomorphic adenoma (PA) is a benign tumour of the salivary gland with a tendency to malignancy which creates many diagnostic problems. N-acetyl-beta-hexosaminidase (HEX) is a lysosomal exoglycosidase involved in degradation of oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans, know...

journal_title：Clinical chemistry and laboratory medicine

authors： Borzym-Kluczyk M,Olszewska E,Radziejewska I,Lewszuk A,Zwierz K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Soluble mesothelin-related protein (SMRP) is increased in the sera of patients with malignant mesothelioma (MM), and has been suggested as a diagnostic tool for MM in an asbestos exposed population. However, factors affecting SMRP concentrations in normal subjects and those with other asbestos related disord...

journal_title：Clinical chemistry and laboratory medicine

authors： Park EK,Thomas PS,Creaney J,Johnson AR,Robinson BW,Yates DH

更新日期：2010-06-01 00:00:00

abstract：:In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry (GSCC-CB), following the encouragement of the EC4/RC decided to organize a voluntary Register for specialists in clinical chemistry. The following criteria for regist...

journal_title：Clinical chemistry and laboratory medicine

authors： Rizos D,Karababa P,Nikolou C,Sarandakou A,Panagiotakis O,Ferderigou A,Haliassos A,Makris K,Psarra K,Bairaktari E,Spyropoulou P,Galiatsatos N,Trakas N,Seferiadis K,Greek National Clinical Chemistry Registration Commission.

更新日期：2011-08-30 00:00:00

abstract：:Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced high density lipoprotein (HDL), both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the -93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk an...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferencak G,Pasalić D,Grsković B,Cheng S,Fijal B,Sesto M,Skodlar J,Rukavina AS

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:We evaluated the effect of kidney glomerular function on serum concentrations of human epididymis protein 4 (HE4) using creatinine (Cr), cystatin C (CysC) and related chronic kidney disease epidemiology collaboration (CKD-EPI) equations. METHODS:We enrolled 101 women aged ≤56 years with a glomerular filtrat...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Pasqualetti S,Carnevale A,Panteghini M

更新日期：2016-10-01 00:00:00

abstract：:In our efforts to develop diagnostic tests for complex multifactorial disorders, and to assist the research community in evaluating genetic markers for predisposition to cardiovascular disease, we have developed a prototype assay to genotype up to 35 variable sites among 15 genes. The candidate markers in this panel w...

journal_title：Clinical chemistry and laboratory medicine

authors： Cheng S,Pallaud C,Grow MA,Scharf SJ,Erlich HA,Klitz W,Pullinger CR,Malloy MJ,Kane JP,Siest G,Visvikis S

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine. Urinary exosomes are released from every segment of the nephron, are detectable in urine, constitutively contain RNA (small RNAs and mRNAs) and harbor unique subset of proteins, r...

journal_title：Clinical chemistry and laboratory medicine

authors： Channavajjhala SK,Rossato M,Morandini F,Castagna A,Pizzolo F,Bazzoni F,Olivieri O

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Toldi G,Stenczer B,Molvarec A,Takáts Z,Beko G,Rigó J Jr,Vásárhelyi B

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:alpha-Thalassemia is a worldwide disease and considered to be a major public health problem in countries within the so-called thalassemia belt. The complex genetics of alpha-thalassemias requires diagnostic methods with the capacity to screen rapidly and accurately for common causative mutations. METHODS:We...

journal_title：Clinical chemistry and laboratory medicine

authors： Puehringer H,Najmabadi H,Law HY,Krugluger W,Viprakasit V,Pissard S,Baysal E,Taher A,Farra C,Al-Ali A,Al-Ateeq S,Oberkanins C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Usually, laboratory diagnostics of hereditary hemoglobin disorders is fairly straightforward. Sometimes, however, correct diagnosis can be difficult. In this study, we describe a family with multiple mutations and sequence variations in the alpha- and beta-globin gene clusters. METHODS:Hemocytometry results...

journal_title：Clinical chemistry and laboratory medicine

authors： de Vooght KM,van Wijk R,Rijksen G,van Solinge WW

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Detection of systemic sclerosis-associated autoantibodies (SSc-Ab) is mostly restricted to anti-centromere and anti-topoisomerase-I. However, anti-RNA-polymerase-III and anti-PM/Scl are also important diagnostic markers for the disease supporting their incorporation in the laboratory repertoire. The aim of t...

journal_title：Clinical chemistry and laboratory medicine

authors： Bonroy C,Smith V,Van Steendam K,Van Praet J,Deforce D,Devreese K,De Keyser F

更新日期：2013-11-01 00:00:00

abstract：:Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity. The frequency of these metabolic disorders is approximately 50% an...

journal_title：Clinical chemistry and laboratory medicine

authors： Bonnet E,Genoux A,Bernard J,Fauvel J,Massip P,Perret B

更新日期：2007-01-01 00:00:00

abstract：:Urinary cotinine was measured according to its inhibitory activity on the agglutination of cotinine-coated latex particles by anti-cotinine antibodies, the agglutination being measured by optical counting of the remaining non-agglutinated particles (particle counting, PaC). The detection limit was 0.03 microgram/ml an...

journal_title：Clinical chemistry and laboratory medicine

authors： Galanti LM,Dell'Omo J,Vanbeckbergen D,Dubois P,Masson PL,Cambiaso CL

更新日期：1999-07-01 00:00:00