The integration of the detection of systemic sclerosis-associated antibodies in a routine laboratory setting: comparison of different strategies.

abstract：BACKGROUND:Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer (CRC) screening. Availability of data on faecal haemoglobin concentrations (f-Hb) in three countries prompted an observational study on sex and age and the transferability of data across geography. METHODS:Single estimates of f-...

journal_title：Clinical chemistry and laboratory medicine

authors： Fraser CG,Rubeca T,Rapi S,Chen LS,Chen HH

更新日期：2014-08-01 00:00:00

abstract：:The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to c...

journal_title：Clinical chemistry and laboratory medicine

authors： Rayana MC,Burnett RW,Covington AK,D'Orazio P,Fogh-Andersen N,Jacobs E,Kataky R,Külpmann WR,Kuwa K,Larsson L,Lewenstam A,Maas AH,Mager G,Naskalski JW,Okorodudu AO,Ritter C,St John A,International Federation of Clinical C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Query fever (Q fever) is a zoonotic infection, caused by the intracellular Gram-negative coccobacillus Coxiella burnetii. From 2007 until 2010, a large Q fever outbreak has occurred in the Netherlands. We studied traditional and less common inflammation markers in seronegative and seropositive patients with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Vissers E,de Jager CP,Hilbink M,Kusters R,van Gageldonk-Lafeber AB,Wever PC

更新日期：2012-02-04 00:00:00

abstract：PURPOSE:The aim of our study was to measure the inter-assay variation and accuracy of serum creatinine assays and to assess the effect of standardized calibration procedures on this variability. METHODS:We analyzed 30 human sera and three reference materials, using 17 creatinine assays (12 colorimetric, 4 enzymatic an...

journal_title：Clinical chemistry and laboratory medicine

authors： Séronie-Vivien S,Galteau MM,Carlier MC,Hadj-Aissa A,Hanser AM,Hym B,Marchal A,Michotey O,Pouteil-Noble C,Sternberg M,Perret-Liaudet A,Creatinine Working Group of the Société Française de Biologie Clinique.

更新日期：2005-01-01 00:00:00

abstract：:Background Direct oral anticoagulants (DOACs) may cause false results of activated protein C resistance (APC-R) ratio. DOAC-Remove, a new reagent based on activated carbon, has been designed to eliminate the interference of DOACs on coagulation assays. The aim of the study was to investigate whether the use of DOAC-Re...

journal_title：Clinical chemistry and laboratory medicine

authors： Kopytek M,Ząbczyk M,Malinowski KP,Undas A,Natorska J

更新日期：2020-02-25 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is a risk factor for ischemic heart disease. Several other mechanisms apply also to dilative types of heart failure of various, non-ischemic etiologies. We hypothesized that hyperhomocysteinemia is associated with left ventricular (LV) dilatation and hypertrophy in dilative cardiomyopath...

journal_title：Clinical chemistry and laboratory medicine

authors： Alter P,Rupp H,Rominger MB,Figiel JH,Renz H,Klose KJ,Maisch B

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Elevated plasma total homocysteine is a risk factor for cardiovascular disease (CVD), but the randomized trials of dietary supplementation with B-vitamins to lower homocysteine have not yet provided clear evidence of benefit on vascular risk. METHODS:Cumulative meta-analysis of all randomized trials assessi...

journal_title：Clinical chemistry and laboratory medicine

authors： Clarke R,Armitage J,Lewington S,Collins R,B-Vitamin Treatment Trialists' Collaboration.

更新日期：2007-01-01 00:00:00

abstract：:Brain natriuretic peptide is proposed as a biochemical marker which could provide a useful screening test to select patients for further cardiac investigations in heart failure. The applicability of such a biochemical test in clinics, hospital wards, and clinical laboratories is dependent on its ease of use and on the...

journal_title：Clinical chemistry and laboratory medicine

authors： Gobinet-Georges A,Valli N,Filliatre H,Dubernet MF,Dedeystere O,Bordenave L

更新日期：2000-06-01 00:00:00

abstract：:Glycosylation is among the most important post-translational modifications for proteins and is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50%-70% of proteins in circulation are glycosylated, and the "sweet attachments" have versatile structural and functional implications. Both ...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang M,Zhu J,Lubman DM,Gao C

更新日期：2019-03-26 00:00:00

abstract：:Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight cytoplasmic protein and present abundantly in the myocardium. When the myocardium is injured, as in the case of myocardial infarction, low molecular weight cytoplasmic proteins including H-FABP are released into the circulation and H-FABP is dete...

journal_title：Clinical chemistry and laboratory medicine

authors： Okamoto F,Sohmiya K,Ohkaru Y,Kawamura K,Asayama K,Kimura H,Nishimura S,Ishii H,Sunahara N,Tanaka T

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Blood alcohol determination plays an important role in laboratory medicine and forensic medicine. Nowadays, many methods are being used for alcohol measurement, but these methods are time-consuming and complex to perform laborious sample pre-treatment. The disposable amperometric biosensor, due to its portab...

journal_title：Clinical chemistry and laboratory medicine

authors： Luo P,Xie G,Liu Y,Xu H,Deng S,Song F

更新日期：2008-01-01 00:00:00

abstract：:Background Biochemical bone turnover markers (BTM) are useful tools to assess bone remodeling at the cellular level. N-terminal propeptide of type I procollagen (PINP) has been recommended as a reference marker for bone formation in research studies. Methods We describe the results of a multicenter study for routine c...

journal_title：Clinical chemistry and laboratory medicine

authors： Cavalier E,Eastell R,Rye Jørgensen N,Makris K,Tournis S,Vasikaran S,Kanis JA,Cooper C,Pottel H,Morris HA,IFCC-IOF Joint Committee for Bone Metabolism (C-BM).

更新日期：2019-09-25 00:00:00

abstract：BACKGROUND:The appearance of nucleated red blood cells (NRBCs) in peripheral blood is associated with a variety of severe diseases. When NRBCs are detected in blood, this is generally associated with increased mortality. METHODS:In a prospective study, NRBCs and other laboratory parameters were measured daily in the p...

journal_title：Clinical chemistry and laboratory medicine

authors： Stachon A,Holland-Letz T,Kempf R,Becker A,Friese J,Krieg M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Anti-cyclic citrullinated peptide (CCP) antibody is emerging as an important diagnostic marker for rheumatoid arthritis (RA). We evaluated the analytical and diagnostic performance of the ARCHITECT anti-CCP (Abbott Diagnostics), a new fully automated chemiluminescent microparticle immunoassay. METHODS:Serum...

journal_title：Clinical chemistry and laboratory medicine

authors： Hwang SM,Kim JO,Yoo YM,Shin S,Kim JQ,Park MH,Song EY

更新日期：2010-02-01 00:00:00

abstract：:Background Evaluating the tumor RAS/BRAF status is important for treatment selection and prognosis assessment in metastatic colorectal cancer (mCRC) patients. Correction of artifacts from library preparation and sequencing is essential for accurately analyzing circulating tumor DNA (ctDNA) mutations. Here, we assessed...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang B,Wu S,Huang F,Shen M,Jiang H,Yu Y,Yu Q,Yang Y,Zhao Y,Zhou Y,Pan B,Liu T,Guo W

更新日期：2019-09-25 00:00:00

abstract：:Background For pregnant women with suspected preeclampsia, the soluble fms-like tyrosine-kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio is a biomarker to aid diagnosis. We performed method comparisons between Elecsys® and Kryptor sFlt-1 and PlGF immunoassays and assessed the diagnostic performance for preeclam...

journal_title：Clinical chemistry and laboratory medicine

authors： Stepan H,Hund M,Dilba P,Sillman J,Schlembach D

更新日期：2019-08-27 00:00:00

abstract：:Quantification of serum proteins is useful in the diagnosis and clinical management of many disorders. With the introduction of automated analyzers and standardized reference materials, one of the last barriers to more widespread utilization of these measurements is the lack of availability of reliable and transferabl...

journal_title：Clinical chemistry and laboratory medicine

authors： Palomaki GE,Neveux LM

更新日期：2001-11-01 00:00:00

abstract：:Experimental and observational studies support a role of plasma homocysteine levels (tHcy) in coronary artery disease (CAD). In the GENICA (Genetic and Environmental factors In Coronary Atherosclerosis) study, we found that high tHcy predicted cardiovascular mortality in hypertensive, but not in normotensive, patients...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossi GP,Seccia TM,Pessina AC

更新日期：2007-01-01 00:00:00

abstract：:Total prostate-specific antigen (PSA) and complexed PSA were determined in venous blood from 12 patients with prostate cancer before and after radical prostatectomy by using Immuno 1 PSA assays. The elimination kinetics of complexed PSA were compared with that of total PSA. Nearly constant concentrations of complexed ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stephan C,Jung K,Brux B,Lein M,Sinha P,Schnorr D,Loening SA

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer's disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI). In the pr...

journal_title：Clinical chemistry and laboratory medicine

authors： Cervellati C,Romani A,Bergamini CM,Bosi C,Sanz JM,Passaro A,Zuliani G

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Cystatin C (CST3), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized, with the remainder then eliminated in urine. In tubular diseases, it seems sensible to postulate that CST3 degradation would be ...

journal_title：Clinical chemistry and laboratory medicine

authors： Conti M,Moutereau S,Zater M,Lallali K,Durrbach A,Manivet P,Eschwège P,Loric S

更新日期：2006-01-01 00:00:00

abstract：:This review presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The discussion focuses on the applicability of the methods for the identification of unknown toxic compounds, which is defined as systematic toxicological analysis (...

journal_title：Clinical chemistry and laboratory medicine

authors： Boone CM,Ensing K

更新日期：2003-06-01 00:00:00

abstract：:An outbreak of the so-called Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has been spreading rapidly nationwide in China since December 2019. Wuhan, Hubei Province, is the hardest-hit region, with a rise in confirmed cases and its hospitals overwhelme...

journal_title：Clinical chemistry and laboratory medicine

authors： Yusong L,Duanliang P,Jia Y,Dunyan C,Hongbing J,Siyuan Y,Huanhuan C,Juan Z,Lyurong L

更新日期：2020-06-25 00:00:00

abstract：:Low-density lipoprotein (LDL) oxidation in vivo depends on lipid composition and on plasma antioxidant status. The aim of our study was to investigate the relationship between plasma lipid composition and LDL oxidation and, in particular, to explore whether LDL-cholesterol/triglycerides ratio (LDL-C/TG) and LDL-choles...

journal_title：Clinical chemistry and laboratory medicine

authors： Brizzi P,Tonolo G,Carusillo F,Malaguarnera M,Maioli M,Musumeci S

更新日期：2003-01-01 00:00:00

abstract：:The history of prealbumin dates back to the early forties and may be divided into three parts, based on a chronological and functional approach. The first part--the discovery and the identification of prealbumin--was essentially based on classical protein chemistry methods. The second--the demonstration of prealbumin ...

journal_title：Clinical chemistry and laboratory medicine

authors： De Nayer P

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Genes correlated with nicotine may be important in obesity because of the role of nicotine in food intake. METHODS:To determine if single nucleotide polymorphisms (SNPs) in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) are associated with overweight/obesity, 156 non-obese and 20...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The handling of cerebrospinal fluid (CSF) affects the biomarker quantification used to diagnose Alzheimer's disease (AD). Only specialized centers can test for AD markers. The precise timing and freezing is required to correctly measure these biomarkers. Therefore, the effects of CSF storage temperature and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Klener J,Hofbauerová K,Bartoš A,Ríčný J,Rípová D,Kopecký V

更新日期：2014-05-01 00:00:00

abstract：:This review evaluates the role of platelets in bleeding risk among patients with hematological disease and thrombocytopenia. Platelets are pivotal in primary hemostasis, and possess non-hemostatic properties involved in angiogenesis, tissue repair, inflammation and metastatis. Also, platelets safeguard vascular integr...

journal_title：Clinical chemistry and laboratory medicine

authors： Vinholt PJ

更新日期：2019-11-26 00:00:00

abstract：:Molecular diagnostics is one of the most rapidly growing areas of laboratory medicine. This rapid growth of clinical molecular tests has outpaced the availability and development of reference methods and reference materials. Such methods and materials are important for the development, validation, and interpretation o...

journal_title：Clinical chemistry and laboratory medicine

authors： Payne DA,Mamotte CD,Gancberg D,Pazzagli M,van Schaik RH,Schimmel H,Rousseau F,IFCC Committee for Molecular Diagnostics (C-MD).

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Insulin-like growth factors (IGFs) are believed to be important in brain development and repair following neuronal damage. It is also speculated that IGFs are involved in the association of foetal and pre-adult growth with schizophrenia (SZ). METHODS:The aim of this study was to assess levels of IGF-I, IGF-...

journal_title：Clinical chemistry and laboratory medicine

authors： Akanji AO,Ohaeri JU,Al-Shammri SA,Fatania HR

更新日期：2007-01-01 00:00:00