Cell-mediated cytotoxicity of murine cytomegalovirus-infected target cells allows for release of residual infectious virus.

Abstract:

:Although cell-mediated cytotoxicity effectively kills target virus-infected cells, no careful consideration has been given to the fate of infectious progeny virus contained within target cells following the cytolytic event. To address this issue with respect to murine cytomegalovirus (MCMV) pathogenesis, we developed a rapid semiquantitative assay for infectious MCMV based on expression of beta-galactosidase using a LacZ-expressing recombinant MCMV. Simultaneous use of this assay in combination with a modified cell-mediated cytotoxicity assay revealed that cytotoxicity of MCMV-infected target cells mediated by MCMV-immune splenic cells does not lead to inactivation of intracellular infectious virus.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Dix RD,Cousins SW

doi

10.1007/s00705-004-0459-8

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

797-803

issue

4

eissn

0304-8608

issn

1432-8798

journal_volume

150

pub_type

杂志文章
  • HIV-1 infection of in vitro cultured human monocytes: early events and influence of anti HIV-1 antibodies.

    abstract::To characterize the role of the humoral immune response on HIV-1 infection of monocytes and macrophages (M phi s) we examined the susceptibility of in vitro cultured monocyte/M phi s to various HIV-1 isolates and the influence of heterologous and particularly autologous anti HIV-1 sera on this infection. Depending on ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01538815

    authors: Arendrup M,Olofsson S,Nielsen JO,Hansen JE

    更新日期:1994-01-01 00:00:00

  • Analysis of the preS1 gene of hepatitis B virus (HBV) to define epidemiologically linked and un-linked infections in South Africa.

    abstract::Analysis of the preS1 gene of hepatitis B virus was used to define two nosocomial outbreaks of HBV infection. In an outbreak in an oncology unit we had previously shown by single stranded conformational polymorphism (SSCP) analysis of a 189 bp fragment of the preS1 gene, that 52 children were infected with HBV strains...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050200

    authors: Hardie DR,Williamson C

    更新日期:1997-01-01 00:00:00

  • Molecular detection and genetic diversity of norovirus in hospitalized young adults with acute gastroenteritis in Bahia, Brazil.

    abstract::The molecular epidemiology of a recent norovirus (NoV) outbreak in Brazil performed by comparative analysis with Genebank NoV sequences showed that the GII.4 strain was responsible for 72.5% of all NoV-positive cases (58/80). Other detected NoV strains included GII.3 (7/80; 8.8%) and GII.9 (8/80; 10%). This is the fir...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-008-0078-x

    authors: Campos GS,Moreau VH,Bandeira A,Barberino G,Almeida PF,Amador DM,de Lima MO,Sardi SI

    更新日期:2008-01-01 00:00:00

  • Analysis of vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) after oral rabies vaccination campaigns in Germany and Austria.

    abstract::To eradicate rabies in foxes, almost 97 million oral rabies vaccine baits have been distributed in Germany and Austria since 1983 and 1986, respectively. Since 2007, no terrestrial cases have been reported in either country. The most widely used oral rabies vaccine viruses in these countries were SAD (Street Alabama D...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-009-0408-7

    authors: Müller T,Bätza HJ,Beckert A,Bunzenthal C,Cox JH,Freuling CM,Fooks AR,Frost J,Geue L,Hoeflechner A,Marston D,Neubert A,Neubert L,Revilla-Fernández S,Vanek E,Vos A,Wodak E,Zimmer K,Mettenleiter TC

    更新日期:2009-01-01 00:00:00

  • Abortive infection with human cytomegalovirus induces an alteration of growth pattern: morphological changes with cytocidal effect in rabbit kidney epithelial cells. Brief report.

    abstract::Rabbit kidney epithelial cells (RK13) exhibited a cytopathic effect (CPE) characterized by cell rounding after infection with human cytomegalovirus (HCMV). Although HCMV-specific immediate early and early antigens were detected by indirect immunofluorescence techniques, neither late antigens nor infectious progeny vir...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01314121

    authors: Kamiya S,Tanaka J,Ogura T,Sato H,Ogura H,Yoshie T,Hatano M

    更新日期:1985-01-01 00:00:00

  • Effect of virazole (ribavirin) on tomato spotted wilt virus in two systemic hosts, tomato and tobacco.

    abstract::Virazole (1, beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide = Ribavirin), a synthetic nucleoside analogue, has been successfully used against tomato spotted wilt virus (TSWV) in tomato and tobacco plants. In tomato, the most efficient concentration to control TSWW was 500 mg/l while in tobacco, concentrations of 10...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01315037

    authors: De Fazio G,Caner J,Vicente M

    更新日期:1980-01-01 00:00:00

  • Infected cell specific protein and viral DNA synthesis in productive and abortive infections of Spodoptera frugiperda nuclear polyhedrosis virus.

    abstract::This study examines viral protein and DNA synthesis in Spodoptera frugiperda multicapsid nuclear polyhedrosis virus (SfMNPV) infections of S. frugiperda and Trichoplusia ni cells. A total of 28 infected cell specific polypeptides (ICSPs) were detected in the productive S. frugiperda cells. Of these, 14 were identified...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01310626

    authors: Liu HS,Bilimoria SL

    更新日期:1990-01-01 00:00:00

  • Hepatitis C virus genotype 3A in a population of injecting drug users in Montenegro: Bayesian and evolutionary analysis.

    abstract::Few reports are available on HCV molecular epidemiology among IDUs in Eastern Europe, and none in Montenegro. The aim of this study was to investigate the HCV genotype distribution in Montenegro among IDUs and to perform Bayesian and evolutionary analysis of the most prevalent HCV genotype circulating in this populati...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-017-3224-5

    authors: Mugosa B,Cella E,Lai A,Lo Presti A,Blasi A,Vratnica Z,Vujoševic D,Ebranati E,Lauševic D,Guarino M,Zehender G,Milano T,Pascarella S,Spoto S,Angeletti S,Ciccozzi M

    更新日期:2017-06-01 00:00:00

  • Mechanism of entry of a xenotropic MMuLV-derived recombinant retrovirus into porcine cells using the expression of the reporter nlslacZ gene.

    abstract::A xenotropic Moloney murine leukemia virus-derived recombinant retrovirus (MMuLVSVnlslacZ) has been utilized to study the mechanism of virus entry into endothelial and epithelial porcine cells. In the genome of this recombinant retrovirus, the nlslacZ reporter gene is under the transcriptional control of both LTR and ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01314625

    authors: Gilbert MA,Charreau B,Vicart P,Paulin D,Nandi PK

    更新日期:1992-01-01 00:00:00

  • A physical map of Spodoptera littoralis B-type nuclear polyhedrosis virus genome.

    abstract::A physical map for the genome of Spodoptera littoralis (Egyptian cottonworm) nuclear polyhedrosis virus of B-type (S1MNPV-B) [Cherry CL, Summers MD (1985) J Invertebr Pathol 46: 289-295] was prepared using the restriction endonucleases SmaI, SfiI, NotI, ApaI, KpnI, BstEII, PstI, SacI, and HindIII. The size of the geno...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01313815

    authors: Croizier G,Boukhoudmi-Amiri K,Croizier L

    更新日期:1989-01-01 00:00:00

  • Roles of the polypyrimidine tract and 3' noncoding region of hepatitis C virus RNA in the internal ribosome entry site-mediated translation.

    abstract::Hepatitis C virus (HCV) genome contains a 3'noncoding region (3'NCR) consisting of a variable region, a polypyrimidine tract (polyU/UC) and the X region. To examine the roles of 3'NCR and polyU/UC tract in the internal ribosome entry site (IRES)-mediated translation process, a variety of 3'NCRs containing different le...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-005-0491-3

    authors: Wang H,Shen XT,Ye R,Lan SY,Xiang L,Yuan ZH

    更新日期:2005-06-01 00:00:00

  • Development of a multiplex real-time RT-PCR assay for simultaneous detection of dengue and chikungunya viruses.

    abstract::Dengue and chikungunya viruses co-circulate and cause infections that start with similar symptoms but progress to radically different outcomes. Therefore, an early diagnostic test that can differentiate between the two is needed. A single-step multiplex real-time RT-PCR assay was developed that can simultaneously dete...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-014-2217-x

    authors: Cecilia D,Kakade M,Alagarasu K,Patil J,Salunke A,Parashar D,Shah PS

    更新日期:2015-01-01 00:00:00

  • VP1, the RNA-dependent RNA polymerase and genome-linked protein of infectious bursal disease virus, interacts with the carboxy-terminal domain of translational eukaryotic initiation factor 4AII.

    abstract::Infectious bursal disease virus (IBDV), a member of the family Birnaviridae, is a non-enveloped, double-stranded RNA virus. Viral protein 1 (VP1), the putative RNA-dependent RNA polymerase, occurs in virions both as a free polypeptide and as a genome-linked protein, called VPg. To gain more insight in its function, we...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-004-0365-0

    authors: Tacken MG,Thomas AA,Peeters BP,Rottier PJ,Boot HJ

    更新日期:2004-11-01 00:00:00

  • Evidence for the presence of a genome-linked protein in infectious flacherie virus.

    abstract::The genomic RNA of infectious flacherie virus (IFV), an insect picornavirus, was shown to contain a covalently attached substance which can be labeled with 125I-Bolton and Hunter reagent. This substance was found to be a protein covalently linked to the virus genome, because it cosedimented and was copurified with the...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01317378

    authors: Hashimoto Y,Watanabe A,Kawase S

    更新日期:1986-01-01 00:00:00

  • Cell-free translation of Drosophila C virus RNA: identification of a virus protease activity involved in capsid protein synthesis and further studies on in vitro processing of cricket paralysis virus specified proteins.

    abstract::Drosophila C virus RNA acted as mRNA in rabbit reticulocyte lysates and directed the synthesis of at least one capsid protein and a number of higher molecular weight proteins. Kinetic analysis by pulse-chase experiments showed that a number of high molecular weight products acted as precursors to the capsid protein(s)...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01311694

    authors: Reavy B,Moore NF

    更新日期:1983-01-01 00:00:00

  • A two-tube multiplex real-time RT-PCR assay for the detection of four hemorrhagic fever viruses: severe fever with thrombocytopenia syndrome virus, Hantaan virus, Seoul virus, and dengue virus.

    abstract::The aim of this study was to develop and evaluate a two-tube multiplex real-time RT-PCR assay for the detection and identification of four viral hemorrhagic fever (VHF) pathogens, severe fever with thrombocytopenia syndrome virus (SFTSV), Hantaan virus (HTNV), Seoul virus (SEOV), and dengue virus (DENV), from human cl...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-013-1677-8

    authors: Li Z,Qi X,Zhou M,Bao C,Hu J,Wu B,Wang S,Tan Z,Fu J,Shan J,Zhu Y,Tang F

    更新日期:2013-09-01 00:00:00

  • The genome sequence of Brassica campestris chrysovirus 1, a novel putative plant-infecting tripartite chrysovirus.

    abstract::A putative chrysovirus recovered from Brassica campestris var. purpurea and provisionally named "Brassica campestris chrysovirus 1" (BrcCV1) was sequenced. The genome of the putative BrcCV1 consists of three double-stranded RNAs (dsRNAs) comprising 3,639 (dsRNA 1), 3,567 (dsRNA 2) and 3,337 (dsRNA 3) base pairs, respe...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-016-3196-x

    authors: Zhang J,Zhao Z,Hu R,Guo L,Zheng L,Du Z,Wu Z,Fang S,Zhang S,Liu Y

    更新日期:2017-04-01 00:00:00

  • Comparing the effect of Toll-like receptor agonist adjuvants on the efficiency of a DNA vaccine.

    abstract::We have investigated whether poly(I:C) Toll-like receptor 3 (TLR3) and resiquimod Toll-like receptor 7 (TLR7) agonists can serve as vaccine adjuvants and promote the efficiency of therapeutic DNA vaccination against tumors expressing the human papilloma virus 16 (HPV-16) E7 protein. For this purpose, C57BL/6 mice were...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-014-2024-4

    authors: Sajadian A,Tabarraei A,Soleimanjahi H,Fotouhi F,Gorji A,Ghaemi A

    更新日期:2014-08-01 00:00:00

  • Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells.

    abstract::Long terminal repeats (LTRs) of human endogenous retroviruses (HERVs) have been reported to serve as alternative promoters in functional genes. The GSDML (gasdermin-like protein) gene located on human chromosome 17q21 has been found to be an oncogenomic recombination hotspot. Here, we identified the LTR element of HER...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-006-0764-5

    authors: Sin HS,Huh JW,Kim DS,Kang DW,Min DS,Kim TH,Ha HS,Kim HH,Lee SY,Kim HS

    更新日期:2006-10-01 00:00:00

  • Human T-lymphotropic Virus Type II Infection inVietnamese Thalassemic Patients.

    abstract::Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confir...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050170

    authors: Lin MT,Nguyen BT,Binh TV,Be TV,Chiang TY,Tseng LH,Yang YC,Lin KH,Chen Y-

    更新日期:1997-07-01 00:00:00

  • Differences in the effectiveness of delivery of B- and CTL-epitopes incorporated into the hepatitis B core antigen (HBcAg) c/e1-region.

    abstract::Work from a number of laboratories including our own has shown that foreign B-epitopes inserted into the c/e1-region of Hepatitis B core antigen (HBcAg) elicit powerful antibody responses when mice are immunised with the recombinant core particles. In the present study, we wished to take advantage of the immunodominan...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050590

    authors: Street M,Herd K,Londono P,Doan T,Dougan G,Kast WM,Tindle RW

    更新日期:1999-01-01 00:00:00

  • Characterization of neutralizing antibodies to bovine enterovirus elicited by synthetic peptides.

    abstract::Six synthetic peptides corresponding to regions of bovine enterovirus (BEV), strain VG-5-27, elicited antibodies in mice which reacted with the virus in various assays. These antibodies have been characterised on the basis of their ability to (1) neutralize the virus, (2) bind to the intact virus particle in an immuno...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01309681

    authors: Smyth MS,Trudgett A,Hoey EM,Martin SJ,Brown F

    更新日期:1992-01-01 00:00:00

  • Rotavirus infection in children of Nizhny Novgorod, Russia: the gradual change of the virus allele from P[8]-1 to P[8]-3 in the period 1984-2010.

    abstract::A collection of rotavirus samples collected over a 26-year period was examined to study the dynamics of change in RV strains of genotype P[8] in a geographically defined population (Nizhny Novgorod, Russia; children under 6 years) with no vaccine pressure. Phylogenetic analysis of gene VP4 (subunit VP8*) showed the pr...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-012-1426-4

    authors: Novikova NA,Morozova OV,Fedorova OF,Epifanova NV,Sashina TA,Efimov EI

    更新日期:2012-12-01 00:00:00

  • Electron microscopic study of human immunodeficiency virus type 1 (HIV-1) core structure: two RNA strands in the core of mature and budding particles.

    abstract::The basic structure of human immunodeficiency virus type 1 (HIV-1) has been investigated morphologically; however, the internal structure of HIV-1 core is not well understood. We studied the internal structures by transmission electron microscopy. We modified the method for electron staining of ultrathin sections and ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050083

    authors: Takasaki T,Kurane I,Aihara H,Ohkawa N,Yamaguchi J

    更新日期:1997-01-01 00:00:00

  • Tetracycline and viruses: a possible treatment for COVID-19?

    abstract::Tetracyclines have been used to treat many bacterial infections. The use of these antibiotics for the treatment of viral diseases dates to the 1960s to 1970s. Over the decades, the effect of tetracyclines on the pathogenesis of viral infections has been demonstrated both clinically and experimentally. Tetracyclines ca...

    journal_title:Archives of virology

    pub_type: 杂志文章,评审

    doi:10.1007/s00705-020-04860-8

    authors: Mosquera-Sulbaran JA,Hernández-Fonseca H

    更新日期:2021-01-01 00:00:00

  • In vitro expression and analysis of secreted fowlpox virus CC chemokine-like proteins Fpv060, Fpv061, Fpv116 and Fpv121.

    abstract::The four CC chemokine-like proteins (Fpv060, Fpv061, Fpv116 and Fpv121) of fowlpox virus (FWPV) were over-expressed as His-tagged versions from a T7 promoter/EMCV IRES construct in vitro, by coupled transcription/translation, or in cell culture, by co-infection with two recombinant FWPVs (one expressing the chemokine-...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-005-0560-7

    authors: Jeshtadi A,Henriquet G,Laidlaw SM,Hot D,Zhang Y,Skinner MA

    更新日期:2005-09-01 00:00:00

  • Identification of a novel subtype of South River virus (family Bunyaviridae).

    abstract::We previously reported the isolation of South River virus (SORV) from a pool of mosquitoes collected in the Yucatan Peninsula of Mexico (Farfan-Ale et al. in Vector Borne Zoonotic Dis 10:777-783, 5). The isolate (designated SORV-252) was identified as SORV after a 197-nucleotide region of its small RNA genome segment ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-012-1280-4

    authors: Blitvich BJ,Staley M,Loroño-Pino MA,Garcia-Rejon JE,Farfan-Ale JA,Dorman KS

    更新日期:2012-06-01 00:00:00

  • Expression, cellular localization and antibody responses of the African swine fever virus genes B602L and K205R.

    abstract::Previously, we identified serological immunodeterminants of African swine fever virus (ASFV), including pK205R and pB602L, without homologues in the database. pK205R is expressed as a 33-kD protein from 4 h post-infection onward, initially diffusely distributed throughout cells, and subsequently in viral factories. pK...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-008-0246-z

    authors: Gutiérrez-Castañeda B,Reis AL,Corteyn A,Parkhouse RM,Kollnberger S

    更新日期:2008-01-01 00:00:00

  • Molecular characterization of human respiratory syncytial virus, 2010-2011: identification of genotype ON1 and a new subgroup B genotype in Thailand.

    abstract::This study reports the molecular epidemiology and genetic characterization of human respiratory syncytial virus (RSV) samples collected in Thailand from January 2010 to December 2011. In total, 1,315 clinical samples were collected from Bangkok and Khon Kaen provinces and were screened by semi-nested PCR for RSV infec...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-013-1773-9

    authors: Auksornkitti V,Kamprasert N,Thongkomplew S,Suwannakarn K,Theamboonlers A,Samransamruajkij R,Poovorawan Y

    更新日期:2014-03-01 00:00:00

  • Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase.

    abstract::Scutellaria baicalensis Georgi, a Chinese herbal decoction, has been used for the treatment of the common cold, fever and influenza virus infections. In previous studies, we found that oral administration of baicalein resulted in the inhibition of influenza A virus replication in vivo, which was linked to baicalin in ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-014-2192-2

    authors: Ding Y,Dou J,Teng Z,Yu J,Wang T,Lu N,Wang H,Zhou C

    更新日期:2014-12-01 00:00:00