Abstract:
:Long terminal repeats (LTRs) of human endogenous retroviruses (HERVs) have been reported to serve as alternative promoters in functional genes. The GSDML (gasdermin-like protein) gene located on human chromosome 17q21 has been found to be an oncogenomic recombination hotspot. Here, we identified the LTR element of HERV-H with reverse orientation as an alternative promoter of the GSDML gene and analyzed its expression pattern in human tissues and cancer cells. A reporter gene assay of the promoter activity of the LTR on the GSDML gene in human cancer cell lines (HCT-116 and HeLa) and a kidney cell line (Cos7) of African green monkey indicated that the LTR promoter with reverse orientation had stronger promoter activity than forward one. The transcripts of this LTR-derived promoter were widely distributed in various human tissues and cancer cells, whereas the transcripts of the cellular promoter were found only in stomach tissues and some cancer cells (HCT116, MCF7, U937, C-33A, and PC3). These findings suggest that the LTR element on the GSDML gene was integrated into the hominoid lineage and acquired the role of transcriptional regulation of human tissues and cancer cells.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Sin HS,Huh JW,Kim DS,Kang DW,Min DS,Kim TH,Ha HS,Kim HH,Lee SY,Kim HSdoi
10.1007/s00705-006-0764-5subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1985-94issue
10eissn
0304-8608issn
1432-8798journal_volume
151pub_type
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