Abstract:
:Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Murphy FV 4th,Ramakrishnan Vdoi
10.1038/nsmb866keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1251-2issue
12eissn
1545-9993issn
1545-9985pii
nsmb866journal_volume
11pub_type
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journal_title:Nature structural & molecular biology
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doi:10.1038/nsmb.2067
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb1302
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abstract::The N-end rule pathway is a regulated proteolytic system that targets proteins containing destabilizing N-terminal residues (N-degrons) for ubiquitination and proteasomal degradation in eukaryotes. The N-degrons of type 1 substrates contain an N-terminal basic residue that is recognized by the UBR box domain of the E3...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.1907
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.3033
更新日期:2015-06-01 00:00:00
abstract::The CagA protein of Helicobacter pylori interacts with numerous cellular factors and is associated with increased virulence and risk of gastric carcinoma. We present here the cocrystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrates of this kinase fam...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.1705
更新日期:2010-01-01 00:00:00
abstract::Although the two B-family human DNA polymerases, pol δ and pol ε, are responsible for the bulk of nuclear genome replication, at least 14 additional polymerases have roles in nuclear DNA repair and replication. In this issue, newly reported crystal structures of two specialized A-family polymerases, pol δ and pol ε, e...
journal_title:Nature structural & molecular biology
pub_type: 评论,杂志文章
doi:10.1038/nsmb.3006
更新日期:2015-04-01 00:00:00
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journal_title:Nature structural & molecular biology
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Nature structural & molecular biology
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更新日期:2008-08-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.3395
更新日期:2017-05-04 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章,评审
doi:10.1038/nsmb.3147
更新日期:2016-01-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.1738
更新日期:2010-01-01 00:00:00
abstract::When targeting promoter regions, small interfering RNAs (siRNAs) trigger a previously proposed pathway known as transcriptional gene silencing by promoting heterochromatin formation. Here we show that siRNAs targeting intronic or exonic sequences close to an alternative exon regulate the splicing of that exon. The eff...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.1620
更新日期:2009-07-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/s41594-017-0008-2
更新日期:2018-01-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.2466
更新日期:2013-02-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.2033
更新日期:2011-04-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
abstract::Processing of transcribed precursor ribosomal RNA (pre-rRNA) to a mature state is a conserved aspect of ribosome biogenesis in vivo. We developed an affinity-purification system to isolate and analyze in vivo-formed pre-rRNA-containing ribonucleoprotein (RNP) particles (rRNPs) from wild-type E. coli. We observed that ...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.2887
更新日期:2014-10-01 00:00:00
abstract::Messenger RNAs produced by splicing are translated more efficiently than those produced from similar intronless precursor mRNAs (pre-mRNAs). The exon-junction complex (EJC) probably mediates this enhancement; however, the specific link between the EJC and the translation machinery has not been identified. The EJC prot...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
abstract::We have isolated a soluble cytochrome from Shewanella oneidensis that contains eight covalently attached heme groups and determined its crystal structure. One of these hemes exhibits novel ligation of the iron atom by the epsilon-amino group of a lysine residue, despite its attachment via a typical CXXCH motif. This h...
journal_title:Nature structural & molecular biology
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
abstract::Bacteriophages express proteins that inactivate the CRISPR-Cas bacterial immune system. Here we report the crystal structure of the anti-CRISPR protein AcrF3 in complex with Pseudomonas aeruginosa Cas3 (PaCas3). AcrF3 forms a homodimer that locks PaCas3 in an ADP-bound form, blocks the entrance of the DNA-binding tunn...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.3269
更新日期:2016-09-01 00:00:00