Abstract:
:Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent polypeptides arising from interrupted translation.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Brandman O,Hegde RSdoi
10.1038/nsmb.3147subject
Has Abstractpub_date
2016-01-01 00:00:00pages
7-15issue
1eissn
1545-9993issn
1545-9985pii
nsmb.3147journal_volume
23pub_type
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journal_title:Nature structural & molecular biology
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journal_title:Nature structural & molecular biology
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更新日期:2016-12-01 00:00:00
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journal_title:Nature structural & molecular biology
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更新日期:2004-09-01 00:00:00
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journal_title:Nature structural & molecular biology
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/s41594-017-0008-2
更新日期:2018-01-01 00:00:00
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journal_title:Nature structural & molecular biology
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更新日期:2016-03-01 00:00:00
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journal_title:Nature structural & molecular biology
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更新日期:2015-08-01 00:00:00
abstract::The noncoding RNA Xist recruits silencing factors to the inactive X chromosome (Xi) and facilitates re-organization of Xi structure. Here, we examine the mouse epigenomic landscape of Xi and assess how Xist alters chromatin accessibility. Xist deletion triggers a gain of accessibility of select chromatin regions that ...
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journal_title:Nature structural & molecular biology
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doi:10.1038/nsmb.3451
更新日期:2017-09-01 00:00:00
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journal_title:Nature structural & molecular biology
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更新日期:2012-01-08 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
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pub_type: 已发布勘误
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更新日期:2019-06-01 00:00:00
abstract::We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA. The bound RNA forms a newly discovered G-quadruplex separated from the flanking duplex stem by a mixed...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.2064
更新日期:2011-06-05 00:00:00
abstract::Heterochromatin causes epigenetic repression that can be transmitted through multiple cell divisions. However, the mechanisms underlying silencing and stability of heterochromatin are not fully understood. We show that heterochromatin differs from euchromatin in histone turnover and identify histone deacetylase (HDAC)...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.2565
更新日期:2013-05-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/s41594-020-0475-8
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.2794
更新日期:2014-04-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.1667
更新日期:2009-10-01 00:00:00
abstract::DNA methylation is an epigenetic modification that is generally associated with repression of transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent high-throughput genomic and proteomic screenings, DNA methylation can also have different outcomes, including activation of transcri...
journal_title:Nature structural & molecular biology
pub_type: 杂志文章
doi:10.1038/nsmb.2910
更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/nsmb.1878
更新日期:2010-09-01 00:00:00
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journal_title:Nature structural & molecular biology
pub_type: 杂志文章,评审
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journal_title:Nature structural & molecular biology
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更新日期:2005-08-01 00:00:00
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journal_title:Nature structural & molecular biology
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abstract::Mosquito-based malaria transmission-blocking vaccines (mTBVs) target midgut-surface antigens of the Plasmodium parasite's obligate vector, the Anopheles mosquito. The alanyl aminopeptidase N (AnAPN1) is the leading mTBV immunogen; however, AnAPN1's role in Plasmodium infection of the mosquito and how anti-AnAPN1 antib...
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更新日期:2015-07-01 00:00:00
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journal_title:Nature structural & molecular biology
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abstract::Multiple Argonaute proteins are implicated in gene silencing by RNA interference (RNAi), but only one is known to be an endonuclease that can cleave target mRNAs. Chimeric Argonaute proteins now reveal an unexpected mechanism by which mutations distal to the catalytic center can unmask intrinsic catalytic activity, re...
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pub_type: 评论,新闻
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journal_title:Nature structural & molecular biology
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更新日期:2020-02-01 00:00:00
abstract::Domain 5 (D5) is the central core of group II intron ribozymes. Many base and backbone substituents of this highly conserved hairpin participate in catalysis and are crucial for binding to other intron domains. We report the solution structures of the 34-nucleotide D5 hairpin from the group II intron ai5 gamma in the ...
journal_title:Nature structural & molecular biology
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