Abstract:
:Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain unclear. Emerging evidence indicates that DNA breaks stimulate DNA-RNA hybrid formation. Here, we discuss the possibility that formation of hybrids may be an inevitable risk of DNA breaks that occur within actively transcribed regions. While such hybrids must be removed to permit repair, their potential role as repair intermediates remains to be established.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Aguilera A,Gómez-González Bdoi
10.1038/nsmb.3395subject
Has Abstractpub_date
2017-05-04 00:00:00pages
439-443issue
5eissn
1545-9993issn
1545-9985pii
nsmb.3395journal_volume
24pub_type
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abstract:: ...
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