Abstract：
:The choice of codons can influence local translation kinetics during protein synthesis. Whether codon preference is linked to cotranslational regulation of polypeptide folding remains unclear. Here, we derive a revised translational efficiency scale that incorporates the competition between tRNA supply and demand. Applying this scale to ten closely related yeast species, we uncover the evolutionary conservation of codon optimality in eukaryotes. This analysis reveals universal patterns of conserved optimal and nonoptimal codons, often in clusters, which associate with the secondary structure of the translated polypeptides independent of the levels of expression. Our analysis suggests an evolved function for codon optimality in regulating the rhythm of elongation to facilitate cotranslational polypeptide folding, beyond its previously proposed role of adapting to the cost of expression. These findings establish how mRNA sequences are generally under selection to optimize the cotranslational folding of corresponding polypeptides.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Pechmann S,Frydman Jdoi
10.1038/nsmb.2466subject
Has Abstractpub_date
2013-02-01 00:00:00pages
237-43issue
2eissn
1545-9993issn
1545-9985pii
nsmb.2466journal_volume
20pub_type
杂志文章abstract：:Messenger RNAs produced by splicing are translated more efficiently than those produced from similar intronless precursor mRNAs (pre-mRNAs). The exon-junction complex (EJC) probably mediates this enhancement; however, the specific link between the EJC and the translation machinery has not been identified. The EJC prot...
journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb1321
更新日期：2007-12-01 00:00:00
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journal_title：Nature structural & molecular biology
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更新日期：2016-11-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.2910
更新日期：2014-11-01 00:00:00
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journal_title：Nature structural & molecular biology
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更新日期：2018-09-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
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journal_title：Nature structural & molecular biology
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更新日期：2013-04-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nsmb.1463
更新日期：2008-08-01 00:00:00
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更新日期：2013-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.1444
更新日期：2008-08-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.3280
更新日期：2016-09-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.1378
更新日期：2008-02-01 00:00:00
abstract：:Domain 5 (D5) is the central core of group II intron ribozymes. Many base and backbone substituents of this highly conserved hairpin participate in catalysis and are crucial for binding to other intron domains. We report the solution structures of the 34-nucleotide D5 hairpin from the group II intron ai5 gamma in the ...
journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb717
更新日期：2004-02-01 00:00:00
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更新日期：2016-02-01 00:00:00
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更新日期：2009-10-01 00:00:00
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更新日期：2015-05-01 00:00:00
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journal_title：Nature structural & molecular biology
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更新日期：2009-11-01 00:00:00
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更新日期：2013-01-01 00:00:00
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更新日期：2014-05-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb803
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