Abstract:
:Histone H3 Lys4 (H3K4) is methylated by yeast Set1-COMPASS and its mammalian homolog, the MLL complex. Human JARID1d can demethylate trimethyl-H3K4 (H3K4me3). We identified Drosophila melanogaster little imaginal discs (Lid) as the JARID1d homolog. We report that Lid knockdown using RNA interference results in a specific genome-wide increase in H3K4me3 levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Eissenberg JC,Lee MG,Schneider J,Ilvarsonn A,Shiekhattar R,Shilatifard Adoi
10.1038/nsmb1217subject
Has Abstractpub_date
2007-04-01 00:00:00pages
344-6issue
4eissn
1545-9993issn
1545-9985pii
nsmb1217journal_volume
14pub_type
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