Abstract:
:Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). Recently, a new RAMP, ERj1p, has been identified that recruits BiP to ribosomes and regulates translational activity. Here we present the cryo-EM structure of a ribosome-ERj1p complex, revealing how ERj1p coordinates the ribosome at the membrane and how allosteric effects may mediate ERj1p's regulatory activity.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Blau M,Mullapudi S,Becker T,Dudek J,Zimmermann R,Penczek PA,Beckmann Rdoi
10.1038/nsmb998keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1015-6issue
11eissn
1545-9993issn
1545-9985pii
nsmb998journal_volume
12pub_type
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