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Transcription promotes contraction of CAG repeat tracts in human cells.

Abstract：

:Induced transcription through CAG repeats in human cells increases repeat contraction approximately 15-fold in both confluent and proliferating cells. Repeats are stabilized against contraction by siRNA knockdown of MSH2, MSH3 or XPA, but not by knockdown of MSH6, XPC or FEN1. These results define a pathway for CAG.CTG repeat contraction that is initiated by transcription, depends on elements of mismatch and nucleotide-excision repair and does not require DNA replication.

journal_name

Nat Struct Mol Biol

journal_title

Nature structural & molecular biology

authors

Lin Y,Dion V,Wilson JH

doi

10.1038/nsmb1042

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

179-80

issue

2

eissn

1545-9993

issn

1545-9985

pii

nsmb1042

journal_volume

13

pub_type

杂志文章

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