Abstract:
:The CagA protein of Helicobacter pylori interacts with numerous cellular factors and is associated with increased virulence and risk of gastric carcinoma. We present here the cocrystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrates of this kinase family, resembling eukaryotic protein kinase inhibitors. Mutagenesis of conserved residues central to this interaction renders CagA inactive as an inhibitor of MARK2.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Nesić D,Miller MC,Quinkert ZT,Stein M,Chait BT,Stebbins CEdoi
10.1038/nsmb.1705subject
Has Abstractpub_date
2010-01-01 00:00:00pages
130-2issue
1eissn
1545-9993issn
1545-9985pii
nsmb.1705journal_volume
17pub_type
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