Abstract:
BACKGROUND:In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a country which contributes significantly to the lung cancer burden of the world. METHODS:Bronchial washings as well as tumor specimens obtained on bronchoscopy were analyzed for the presence of loss of heterozygosity (LOH) and microsatellite instability (MSI) using the D3S1300 microsatellite marker on chromosome 3p and the TP53 marker on chromosome 17p. RESULTS:The sensitivities of the TP53 and D3S1300 loci in bronchial washings were 35% and 45% (combined 50%), respectively, which was significantly better than conventional cytology (positive for malignant cells in 15%). The presence of these microsatellite alterations was not related to the age, cumulative smoking exposure or smoking status (current or former) of patients. CONCLUSION:Microsatellite alterations, particularly LOH, occur in a significant proportion of Indian patients with squamous cell carcinoma of the lung.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Malhotra P,Behera D,Srinivasan R,Majumdar S,Wali A,Mir S,Kaur Rdoi
10.1093/jjco/hyh079keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
439-44issue
8eissn
0368-2811issn
1465-3621pii
34/8/439journal_volume
34pub_type
杂志文章abstract:BACKGROUND:We conducted a dose-finding and feasibility study in which we administered a fixed dose 3-h infusion of paclitaxel and an escalating dose of cisplatin in Japanese patients with advanced non-small cell lung cancer. METHODS:Chemotherapy consisted of fixed dose (210 mg/m(2)) paclitaxel given over 3 h on day 1 ...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
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