Expression of pyrimidine nucleoside phosphorylase (PyNPase) in colorectal cancer.

Abstract:

BACKGROUND:We investigated the expression of PyNPase both in cancer cells and in stroma cells to clarify the correlation between PyNPase expression and the prognosis of patients with colorectal cancer. METHODS:Using immunohistochemical staining with an anti-PyNPase antibody, the PyNPase expression in tissues from 114 patients with stage II or III colorectal cancer was examined. From the correlation between PyNPase expression and the clinicopathological findings, the prognosis for survival was analyzed. RESULTS:The expression of PyNPase was classified as negative or positive on the basis of staining. No relationship between PyNPase expression and any of the clinicopathological findings was identified. However, a relationship was observed regarding positive staining between cancer cells and stroma cells. The prognosis of patients with positive staining in both cancer cells and stroma was worse than that of other patients. In multivariate analyses, expression in cancer cells was the strongest predictor of prognosis. CONCLUSIONS:PyNPase expression appears to be a relevant factor for predicting the prognosis of colorectal cancer.

journal_name

Jpn J Clin Oncol

authors

Osanai T,Ichikawa W,Takagi Y,Uetake H,Nihei Z,Sugihara K

doi

10.1093/jjco/hye108

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

500-5

issue

10

eissn

0368-2811

issn

1465-3621

journal_volume

31

pub_type

杂志文章
  • Cyclophosphamide, adriamycin, 5-fluorouracil and high-dose toremifene for patients with advanced/recurrent breast cancer. The Japan Toremifene Cooperative Study Group.

    abstract:BACKGROUND:Multi-combination chemotherapy consisting of anthracyclines has been effective but has not invariably prolonged the survival period in advanced/recurrent breast cancer. The possibility has been discussed that chemoendocrine therapy combined with endocrine agents is more effective. METHODS:In order to evalua...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.4.250

    authors: Tominaga T,Nomura Y,Uchino J,Hirata K,Kimura M,Yoshida M,Aoyama H,Kinoshita H,Koyama H,Monden Y,Takashima S,Ogawa M

    更新日期:1998-04-01 00:00:00

  • Population pharmacokinetic analysis of cisplatin and its metabolites in cancer patients: possible misinterpretation of covariates for pharmacokinetic parameters calculated from the concentrations of unchanged cisplatin, ultrafiltered platinum and total pl

    abstract:BACKGROUND:Usually, total and filtered platinum concentrations in plasma are monitored after cisplatin administration. However, these concentrations represent a mixture of unchanged cisplatin and metabolites. In this work, we studied population pharmacokinetic analysis based on these platinum concentrations. METHODS:T...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hye040

    authors: Hanada K,Nishijima K,Ogata H,Atagi S,Kawahara M

    更新日期:2001-05-01 00:00:00

  • The predictors of local recurrence after radical cystectomy in patients with invasive bladder cancer.

    abstract:OBJECTIVES:To examine the association between local recurrence and distant metastasis or disease-specific survival and identify independent factor predictors for local recurrence. METHODS:We identified a study population of 146 consecutive patients treated surgically for invasive bladder cancer at our institution betw...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyn036

    authors: Ide H,Kikuchi E,Miyajima A,Nakagawa K,Ohigashi T,Nakashima J,Oya M

    更新日期:2008-05-01 00:00:00

  • Triple carcinomas in Cronkhite-Canada syndrome.

    abstract::The present report describes a 69-year-old man displaying the clinical features of the Cronkhite-Canada syndrome. After taking medicine for the common cold, he suffered hypogeusia and watery diarrhea, eruptions on the lower extremities and an 8 kg loss in body weight. All his finger and toenails began to fall out. He ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Kaneko Y,Kato H,Tachimori Y,Watanabe H,Ushio K,Yamaguchi H,Itabashi M,Noguchi M

    更新日期:1991-06-01 00:00:00

  • Chemoradiotherapy for esophageal squamous cell cancer.

    abstract::Chemoradiotherapy has been clinically indicated for patients with resectable esophageal squamous cell carcinoma who refuse surgical resection and in locally advanced unresectable esophageal squamous cell carcinoma patients. Concurrent chemoradiotherapy prolongs survival than radiation therapy alone when given as defin...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyw082

    authors: Sasaki Y,Kato K

    更新日期:2016-09-01 00:00:00

  • Castleman's disease in the left upper retroperitoneal space mimicking an adrenal neoplasm: report of a case and literature review.

    abstract::Castleman's disease is a rare disorder characterized by benign proliferation of lymphoid tissue. Most cases occur as a mediastinal mass, although extrathoracic involvement including nodal and extranodal locations has been reported. The left suprarenal location of this localized disease may be mistaken for an adrenal t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi092

    authors: Chen JH,Yu CY,Pai CY,Chan DC,Chen CJ,Yu JC,Liu YC

    更新日期:2005-06-01 00:00:00

  • A phase I/II study of cisplatin and vinorelbine chemotherapy in patients with advanced non-small cell lung cancer.

    abstract:BACKGROUND:A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1093/jjco/hye129

    authors: Hotta K,Sekine I,Tamura T,Sawada M,Watanabe H,Kusaba H,Akiyama Y,Inoue A,Shimoyama T,Nokihara H,Ueda Y,Yamamoto N,Kunitoh H,Ohe Y,Kodama T,Saijo N

    更新日期:2001-12-01 00:00:00

  • A new method of preparing specimens for cytodiagnosis of lung cancer.

    abstract::A simple and effective method for concentrating sputum in the preparation of smears for cytodiagnosis of lung cancer was developed. The procedure, which utilizes a fixative consisting of 2,3-dihydroxy-1,4-dithiol-butane, 3,5-ditert-butyl-4-hydroxy-toluene, polyoxyethylene-cetyl-ether, polyethylene glycol 1540, and eth...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Yamagishi K,Koketsu H,Tajima M,Suemasu K

    更新日期:1985-06-01 00:00:00

  • Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women.

    abstract:OBJECTIVE:Human papillomavirus vaccines are being introduced worldwide and are expected to reduce the incidence of cervical cancer. Here we report a cross-sectional study using a validated human papillomavirus genotyping method to reveal the human papillomavirus prevalence and genotype distribution in Japanese women wi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu112

    authors: Azuma Y,Kusumoto-Matsuo R,Takeuchi F,Uenoyama A,Kondo K,Tsunoda H,Nagasaka K,Kawana K,Morisada T,Iwata T,Aoki D,Kukimoto I

    更新日期:2014-10-01 00:00:00

  • Blue nodes left behind after vital blue dye-guided axillary sentinel node biopsy in breast cancer patients.

    abstract:BACKGROUND:Vital dye-guided sentinel node biopsy is affordable in most hospitals, but may be of limited accuracy in identifying all sentinel nodes. Leaving sentinel nodes in the axilla may result in a false nodal staging of breast carcinomas. METHODS:From a series of 112 successful sentinel lymph node biopsies with Pa...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd072

    authors: Cserni G,Rajtár M,Boross G

    更新日期:2000-06-01 00:00:00

  • The current clinical use of adjuvant analgesics for refractory cancer pain in Japan: a nationwide cross-sectional survey.

    abstract:BACKGROUND:Although adjuvant analgesics are used to treat opioid-refractory cancer pain, there is insufficient evidence to support this practice and limited data to guide the choice depending on cancer pain pathophysiology, dose titration and starting dose. This survey aimed to clarify the current use of adjuvant analg...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa147

    authors: Tagami K,Matsuoka H,Ariyoshi K,Oyamada S,Hiratsuka Y,Kizawa Y,Koyama A,Inoue A

    更新日期:2020-12-16 00:00:00

  • The possibility of clinical sequencing in the management of cancer.

    abstract::Comprehensive genomic profiling using next-generation sequencing technologies provides insights into understanding the genomic architecture of human cancer. This new understanding of the cancer genome allows us to identify many more genomic alterations occurring within tumors than before, some of which could be potent...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyw018

    authors: Kou T,Kanai M,Matsumoto S,Okuno Y,Muto M

    更新日期:2016-05-01 00:00:00

  • A case of resected huge ileocolonic mesenteric liposarcoma which responded to pre-operative chemotherapy using doxorubicin, cisplatin and ifosfamide.

    abstract::Primary mesenteric liposarcoma is a rare entity that has been reported only 14 times in English literature. The treatment strategy for mesenteric liposarcoma is, if no distant metastases are detected, surgical resection with a wide surgical margin, often followed by radiation and/or adjuvant chemotherapy for high-risk...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyl087

    authors: Ishiguro S,Yamamoto S,Chuman H,Moriya Y

    更新日期:2006-11-01 00:00:00

  • Attitudes toward participating in Phase I clinical trials: an investigation with patient-family-physician triads.

    abstract:OBJECTIVE:Phase I oncology trials have raised concerns that patients' 'unrealistic' optimism could compromise the validity of informed consent, and that patients often participate in trials to conform to physicians' or family members' recommendations. We aimed to determine whether patients or families-given the same in...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyw135

    authors: Shin DW,Cho J,Kim SY,Yang HK,Cho B,Shin DB,Chun MS,Min YJ,Kim YW,Park JH

    更新日期:2016-12-01 00:00:00

  • The variation of cell type distribution in lung cancer: a study of 10,910 cases at a medical center in Taiwan between 1970 and 1993.

    abstract::The rise in the incidence of lung cancer has been associated with shifts in histologic distribution. A study was conducted to investigate changes in the cell type distribution in lung cancer in relation to age, sex, and smoking history, based on a retrospective analysis of 10,910 proven cases of lung cancer at the Vet...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.jjco.a023219

    authors: Perng DW,Perng RP,Kuo BI,Chiang SC

    更新日期:1996-08-01 00:00:00

  • Epididymis metastasis from colon carcinoma: a case report and a review of the Japanese literature.

    abstract::A 56-year-old Japanese man in whom a descending colon carcinoma had been resected underwent a high orchitectomy for metastatic epididymis from the colon. Metastatic carcinoma from the digestive organs to the spermatic cord (SC) and/or the intrascrotal contents (ISC) is rare. Fifty-four Japanese patients with metastasi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Kanno K,Ohwada S,Nakamura S,Ohya T,Iino Y,Morishita Y,Hayashi M,Yamanaka H,Fukusato T,Koyama T

    更新日期:1994-12-01 00:00:00

  • Stainability of lung cancer cells with Leu-7 and OKT-9 monoclonal antibodies.

    abstract::One hundred and one cases of lung cancer were immunohistochemically studied for stainability with Leu-7 (anti-myelin fiber associated glycoprotein) and OKT-9 (anti-transferrin receptor) monoclonal antibodies. All small cell carcinomas and carcinoid tumors were positively stained by Leu-7, and 22 of 41 differentiated a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Sato Y,Watanabe S,Kodama T,Goto M,Shimosato Y

    更新日期:1985-09-01 00:00:00

  • Successful treatment of pulmonary artery sarcoma by a two-drug combination chemotherapy consisting of ifosfamide and epirubicin.

    abstract::We describe a case of 63-year-old woman with pulmonary artery sarcoma successfully treated with chemotherapy. She developed acute shortness of breath, and left chest and shoulder pain. Although a diagnosis of acute pulmonary embolism was made at a local hospital and she received anticoagulation and thrombolysis therap...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi106

    authors: Uchida A,Tabata M,Kiura K,Tanimoto Y,Kanehiro A,Aoe M,Ohohara N,Ueoka H,Tanimoto M

    更新日期:2005-07-01 00:00:00

  • Phase II study of chemoradiotherapy for advanced squamous cell carcinoma of the thoracic esophagus: nine Japanese institutions trial.

    abstract::A phase II study of chemoradiotherapy for advanced squamous cell carcinoma of the thoracic esophagus was carried out cooperatively by nine Japanese institutions. Forty-five patients with thoracic advanced squamous cell carcinoma, who had T4 tumor or distant lymph node metastasis (M1(LYM)), were enrolled in the study f...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1093/oxfordjournals.jjco.a023238

    authors: Ishida K,Iizuka T,Ando N,Ide H

    更新日期:1996-10-01 00:00:00

  • Psychiatric disorders in patients who lost family members to cancer and asked for medical help: descriptive analysis of outpatient services for bereaved families at Japanese cancer center hospital.

    abstract:OBJECTIVE:There have been no previous studies about consultation of the bereaved who have lost a loved one to cancer and ask for medical help. The aim of this study was to investigate their basic characteristics and their psychiatric disorders. METHODS:A retrospective study using clinical and background data obtained ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq213

    authors: Ishida M,Onishi H,Wada M,Tada Y,Ito H,Narabayashi M,Sasaki Y,Nomura S,Uchitomi Y

    更新日期:2011-03-01 00:00:00

  • Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma.

    abstract:OBJECTIVE:The aim of this study was to identify clinicopathological variables associated with the clinical outcomes of patients with lymph node metastasis-positive urothelial bladder carcinoma after radical cystectomy. METHODS:Forty-six patients who underwent radical cystectomy without preoperative chemotherapy and ha...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys136

    authors: Nakagawa T,Kanai Y,Nakanishi H,Komiyama M,Fujimoto H

    更新日期:2012-11-01 00:00:00

  • MicroRNAs in Cancer: the 22nd Hiroshima Cancer Seminar/the 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima.

    abstract::The joint international symposium of the 22nd Hiroshima Cancer Seminar and the 4th Japanese Association for RNA Interference focused on a pivotal role of microRNAs in carcinogenesis, progression and therapy of human cancer. Mammalian immune regulator MCPIP1 (Zc3h12a) RNase acts as a novel suppressor of microRNA activi...

    journal_title:Japanese journal of clinical oncology

    pub_type:

    doi:10.1093/jjco/hyt037

    authors: Tahara H,Kay MA,Yasui W,Tahara E

    更新日期:2013-05-01 00:00:00

  • Genetic alterations of androgen receptor gene in Japanese human prostate cancer.

    abstract::In order to determine the significance of androgen receptor (AR) gene mutations for Japanese prostate cancers, we examined the entire coding region, from exon A to H, in 36 primary lesions. Five in stage A, 12 in stage B, six in stage C and 13 in stage D were subjected to PCR-SSCP analysis for genomic DNA and nucleoti...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/27.6.389

    authors: Watanabe M,Ushijima T,Shiraishi T,Yatani R,Shimazaki J,Kotake T,Sugimura T,Nagao M

    更新日期:1997-12-01 00:00:00

  • Trousseau's syndrome: cancer-associated thrombosis.

    abstract::Trousseau's syndrome (cancer-associated thrombosis) is the second leading cause of death in cancer patients, after death from cancer itself. The risk of a venous thromboembolism is 4- to 7-fold higher in patients with cancer than in those without cancer. The causes of this impaired coagulation are associated with gene...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyv165

    authors: Ikushima S,Ono R,Fukuda K,Sakayori M,Awano N,Kondo K

    更新日期:2016-03-01 00:00:00

  • Preoperative level of depression is a predictor of postoperative levels of depression in patients with head and neck cancer.

    abstract:OBJECTIVE:Emotional distress is considered to be higher in patients with head and neck cancer than other types of cancer. The present study aimed to identify predictors of the postoperative levels of depression in patients with head and neck cancer who have undergone surgery. METHODS:Postoperative levels of depression...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu002

    authors: Adachi Y,Kimura H,Sato N,Nagashima W,Nakamura K,Aleksic B,Yoshida K,Fujimoto Y,Nakashima T,Ozaki N

    更新日期:2014-04-01 00:00:00

  • Clinical features and prognosis of a unilateral fibroadenoma of the breast in a 16-month-old female.

    abstract::Fibroadenoma of the breast is a common benign disease, occurring mainly in females younger than 30 years of age. Infant fibroadenoma is extremely rare. Here, we report on a 16-month-old female with a 6 month history of unilateral progressive breast enlargement. Upon clinical evaluation, a palpable mass was observed in...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq181

    authors: Shi A,Li S,Xu N,Nie G,Li X,Zhang T,Fan Z

    更新日期:2011-02-01 00:00:00

  • Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma.

    abstract:OBJECTIVE:Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. Therefore, we explor...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyw046

    authors: Si Y,Lan G,Deng Z,Wang Y,Lu Y,Qin Y,Huang B,Yang Y,Weng J,Han X,Zhang B,Qin Y,Xiong W,Li B,Wu S

    更新日期:2016-07-01 00:00:00

  • Cumulative incidence, risk factors and prognostic impact of venous thromboembolism in Japanese patients with advanced gastric cancer.

    abstract:Background:Advanced gastric cancer (AGC) and systemic chemotherapy are some of the risk factors for venous thromboembolism (VTE). However, the cumulative incidence, risk factors and prognostic impact of VTE have not been evaluated in Japanese patients with AGC. Methods:This retrospective study included patients who re...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx107

    authors: Arai H,Hironaka S,Minashi K,Denda T,Shimokawa M,Yamaguchi T

    更新日期:2017-10-01 00:00:00

  • Prognostic factors and therapeutic options of radiotherapy in pediatric brain stem gliomas.

    abstract:BACKGROUND:A retrospective analysis was made to clarify the relationship between prognosis, radiation dose and survival of brain stem gliomas. METHODS:From 1983 to 1995, 22 children with brain stem tumors were treated by radiotherapy in the Veterans General Hospital-Taipei. Twelve patients had pathology proof and the ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.8.474

    authors: Liu YM,Shiau CY,Wong TT,Wang LW,Wu LJ,Chi KH,Chen KY,Yen SH

    更新日期:1998-08-01 00:00:00

  • Locally recurrent rectal cancer successfully treated by total pelvic exenteration with combined ischiopubic rami resection: report of a case.

    abstract::A combined ischiopubic rami resection is extremely rare in the field of gastroenterologic surgery. We report a case of a locally recurrent rectal cancer that was successfully treated by total pelvic exenteration with combined ischiopubic rami resection. A 58-year-old male with locally recurrent rectal cancer and liver...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr169

    authors: Uehara K,Yoshioka Y,Taguchi Y,Igami T,Ebata T,Yokoyama Y,Sugawara G,Tsukushi S,Nishida Y,Yoshino Y,Nagino M

    更新日期:2012-01-01 00:00:00