Abstract:
OBJECTIVE:The aim of this study was to assess clinically the adequacy of vessel-contouring-based pelvic radiotherapy with regard to nodal coverage for uterine cervical cancer. METHODS:Fifty patients with Stages I-III cervical cancer, treated with vessel-contouring-based three-dimensional radiotherapy since August 2002, were entered into the study (median age: 54, 47 received concurrent daily cisplatin). All patients were treated with external beam radiotherapy using a four-field box technique with or without brachytherapy. Pelvic blood vessels were identified and contoured on computed tomography simulation images. A generous margin was set outside these vessels outlined on digitally reconstructed radiograph accounting for normal size lymph nodes, patient's motion and set-up uncertainty. Multi-leaf collimator (MLC) was inserted and adjusted manually. Patterns of recurrence were clinically evaluated. RESULTS:Distance between major vessels and MLC edges varied inter- and intra-individually. Median distance in the mid-iliosacral joint level was 25 mm (left) and 24 mm (right). The maximum and the minimum distances ranged from 25 to 45 mm (median, 32) and 9 to 27 mm (median, 15) for left side and 24 to 41 mm (median, 30) and 7 to 28 mm (median, 15) for right side, respectively. With a median follow-up of 43 months, 10 patients developed recurrence. However, no marginal recurrence was occurred just lateral to the contoured vessels. All three patients who developed regional recurrence had recurred at the internal iliac node or the obturator node medial to contoured vessels. CONCLUSIONS:Contoured vessels can be used as surrogate markers for location of the pelvic lymph nodes.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Uno T,Isobe K,Ueno N,Kobayashi H,Sanayama Y,Mitsuhashi A,Shozu M,Ito Hdoi
10.1093/jjco/hyp029subject
Has Abstractpub_date
2009-06-01 00:00:00pages
376-80issue
6eissn
0368-2811issn
1465-3621pii
hyp029journal_volume
39pub_type
杂志文章abstract::The relations between alcohol consumption and cancers of the breast, corpus uteri and ovary were investigated in a case-control study involving 1,740 cases of breast cancer, 239 cases of cancer of the corpus uteri, 417 cases of ovarian cancer and 8,920 controls with other cancer sites identified from the Aichi Cancer ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:The cell cycle profile test is suggested to be an independent prognostic indicator for breast cancer patients. To further clarify the prognostic value, we applied this to breast cancer patients treated with postoperative 5-fluorouracil-based chemotherapy. METHODS:A total of 153 breast cancer patients, who we...
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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journal_title:Japanese journal of clinical oncology
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pub_type: 杂志文章,评审
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
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journal_title:Japanese journal of clinical oncology
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章
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