abstract：BACKGROUNDS:Mutations in the isocitrate dehydrogenase (IDH)1 gene are favourable prognostic factors in newly diagnosed diffuse gliomas, whereas it remains controversial in the recurrent glioblastoma setting. METHODS:A total of 171 patients with newly diagnosed glioblastoma, either 'primary' glioblastoma or 'secondary'...

journal_title：Japanese journal of clinical oncology

authors： Tabei Y,Kobayashi K,Saito K,Shimizu S,Suzuki K,Sasaki N,Shiokawa Y,Nagane M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Although adjuvant analgesics are used to treat opioid-refractory cancer pain, there is insufficient evidence to support this practice and limited data to guide the choice depending on cancer pain pathophysiology, dose titration and starting dose. This survey aimed to clarify the current use of adjuvant analg...

journal_title：Japanese journal of clinical oncology

authors： Tagami K,Matsuoka H,Ariyoshi K,Oyamada S,Hiratsuka Y,Kizawa Y,Koyama A,Inoue A

更新日期：2020-12-16 00:00:00

abstract：OBJECTIVES:Immune checkpoint inhibitors offer longer survival than chemotherapy in several clinical trials for advanced non-small cell lung cancer. In subset analyses of clinical trials, immune checkpoint inhibitors extended survival in patients aged ≥65 years, but the effects in patients aged ≥75 years are controversi...

journal_title：Japanese journal of clinical oncology

authors： Kubo T,Watanabe H,Ninomiya K,Kudo K,Minami D,Murakami E,Ochi N,Ninomiya T,Harada D,Yasugi M,Ichihara E,Ohashi K,Rai K,Fujiwara K,Hotta K,Tabata M,Maeda Y,Kiura K

更新日期：2020-12-16 00:00:00

abstract：:Cancer originating in the biliary tract can be classified as bile duct cancer (cholangiocarcinoma), gallbladder cancer, or ampullary cancer. Bile duct cancer is further divided to intrahepatic, perihilar and distal bile duct subtypes according to the anatomical location of the tumor. The biological characteristics of ...

journal_title：Japanese journal of clinical oncology

authors： Nara S,Esaki M,Ban D,Takamoto T,Shimada K,Ioka T,Okusaka T,Ishii H,Furuse J

更新日期：2020-12-16 00:00:00

abstract：OBJECTIVE:To clarify the clinical outcomes of stereotactic body radiotherapy for colorectal cancer-derived bone metastases and identify factors predicting treatment failure. METHODS:Patients treated with stereotactic body radiotherapy for bone metastases from colorectal cancer between September 2013 and June 2019 were...

journal_title：Japanese journal of clinical oncology

authors： Ito K,Yamaguchi T,Ogawa H,Nakajima Y,Karasawa K

更新日期：2020-12-16 00:00:00

abstract：:Over the past 10 years, immunotherapy with immune checkpoint inhibitors has revolutionized the management of various cancers. However, immunotherapy in breast cancer has not been successful. Breast cancer has long been recognized as an immunologically 'cold' tumor, although a higher frequency of tumor-infiltrating lym...

journal_title：Japanese journal of clinical oncology

authors： Noguchi E,Shien T,Iwata H

更新日期：2020-12-15 00:00:00

abstract：:Squamous cell carcinoma of the head and neck is characterized by an immunosuppressive environment and evades immune responses through multiple resistance mechanisms. A breakthrough in cancer immunotherapy employing immune checkpoint inhibitors has evolved into a number of clinical trials with antibodies against progra...

journal_title：Japanese journal of clinical oncology

authors： Yokota T,Homma A,Kiyota N,Tahara M,Hanai N,Asakage T,Matsuura K,Ogawa T,Saito Y,Sano D,Kodaira T,Motegi A,Yasuda K,Takahashi S,Tanaka K,Onoe T,Okano S,Imamura Y,Ariizumi Y,Hayashi R,Japan Clinical Oncology Group (

更新日期：2020-09-28 00:00:00

abstract：OBJECTIVES:To evaluate computed tomography findings and assess the clinical course of patients with pulmonary epithelioid hemangioendothelioma. METHODS:Patients diagnosed with pulmonary epithelioid hemangioendothelioma at our institution between 2000 and 2019 were retrospectively analyzed. Patients with pleural involv...

journal_title：Japanese journal of clinical oncology

authors： Onishi Y,Kusumoto M,Goto Y,Kaku S,Motoi N

更新日期：2020-09-28 00:00:00

abstract：BACKGROUND:Second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma adversely affect patients' outcomes and the quality of life; however, an adequate surveillance schedule remains unclear. METHODS:We analyzed 330 patients with early esophageal squamous cell carcinoma who un...

journal_title：Japanese journal of clinical oncology

authors： Shinozaki T,Katada C,Shiga K,Asakage T,Yokoyama T,Yano T,Oda I,Shimizu Y,Takemura K,Ishikawa H,Yokoyama A,Muto M

更新日期：2020-09-28 00:00:00

abstract：OBJECTIVE:Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as advanced and inoperable due to the lack of effective biomarkers and poor sensitivity of clinical diagnosis. Here, we aimed to identify the genomic profile of CCA and provided molecular evidence for further biomarker development. ME...

journal_title：Japanese journal of clinical oncology

authors： Jiang G,Zhang W,Wang T,Ding S,Shi X,Zhang S,Shi W,Liu A,Zheng S

更新日期：2020-09-28 00:00:00

abstract：OBJECTIVE:We conducted a questionnaire survey of oncology specialists to investigate the frequency of administration of different drugs for the management of chemotherapy-induced peripheral neuropathy in Japan in 2015. Our group published Clinical Guidelines for the Management of Chemotherapy-Induced Peripheral Neuropa...

journal_title：Japanese journal of clinical oncology

authors： Hirayama Y,Yoshida Y,Mori M,Tamura K

更新日期：2020-08-04 00:00:00

abstract：:A randomized phase III trial was initiated in Japan in August 2019 to confirm the superiority of preoperative chemoradiotherapy followed by surgery plus adjuvant chemotherapy compared to the standard treatment, i.e. surgery plus adjuvant chemotherapy, for locally recurrent rectal cancer in local relapse-free survival....

journal_title：Japanese journal of clinical oncology

authors： Kadota T,Tsukada Y,Ito M,Katayama H,Mizusawa J,Nakamura N,Ito Y,Bando H,Ando M,Onaya H,Fukuda H,Kanemitsu Y

更新日期：2020-08-04 00:00:00

abstract：OBJECTIVES:Tepotinib (MSC2156119J) is an oral, potent and highly selective small molecule mesenchymal-epithelial transition factor (MET) inhibitor for which the recommended Phase II dose of 500 mg once daily has been defined, based on the first-in-man trial conducted in the USA and Europe. We carried out a multicenter ...

journal_title：Japanese journal of clinical oncology

authors： Shitara K,Yamazaki K,Tsushima T,Naito T,Matsubara N,Watanabe M,Sarholz B,Johne A,Doi T

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:It is critical to obtain informed consent from eligible patients to complete clinical trials. We investigated the factors that affect the participation rates of eligible patients. PATIENTS AND METHODS:Patients with metastatic breast cancer who were eligible for SELECT BC or SELECT BC-CONFIRM trials, randomi...

journal_title：Japanese journal of clinical oncology

authors： Ohsumi S,Mukai H,Takahashi M,Hozumi Y,Akabane H,Park Y,Tokunaga E,Takashima T,Watanabe T,Sagara Y,Kaneko T,Ohashi Y

更新日期：2020-08-04 00:00:00

abstract：:The development of PD-1 pathway inhibitors has dramatically altered the treatment of advanced/recurrent non-small-cell lung cancer patients. However, the prognostic significance of their ongoing usage is controversial, especially for patients who have not progressed for a period of time. If discontinuation has no nega...

journal_title：Japanese journal of clinical oncology

authors： Nomura S,Goto Y,Mizutani T,Kataoka T,Kawai S,Okuma Y,Murakami H,Tanaka K,Ohe Y

更新日期：2020-07-09 00:00:00

abstract：BACKGROUND:Regular endoscopic surveillance for Lynch syndrome is reported to reduce colorectal cancer (CRC)-related mortality. However, the appropriate surveillance intervals are still unclear. We evaluated the adequacy of annual colonoscopy and investigated the differences in tumor occurrence rates between individual ...

journal_title：Japanese journal of clinical oncology

authors： Taniguchi F,Tanakaya K,Sugano K,Akagi K,Ishida H,Nagahisa S,Nishimura S,Une Y,Kimura Y,Watanabe M,Utsumi M,Aoki H

更新日期：2020-06-10 00:00:00

abstract：BACKGROUND:Angiosarcoma is an aggressive and malignant neoplasm. Primary hepatic angiosarcoma is extremely rare and accounts for only approximately 5% of all angiosarcomas. Therefore, many doctors do not know enough about this disease; this lack of knowledge motivated us to perform this study. METHODS:We carried out a...

journal_title：Japanese journal of clinical oncology

authors： Zeng D,Cheng J,Gong Z,Chen J,Long H,Zhu B

更新日期：2020-05-05 00:00:00

abstract：:The prognosis of pancreatic adenocarcinoma is dismal. Hence, advances in multidisciplinary treatment strategies, including surgery, are urgently needed. Early recurrence of distant organ metastases suggests that there are occult metastases even in cases with resectable disease. Several randomized controlled trials on ...

journal_title：Japanese journal of clinical oncology

authors： Motoi F,Unno M

更新日期：2020-05-05 00:00:00

abstract：:Brachytherapy is an invasive therapy with placement of radiation source into or near the tumor. The difference between planning target volume and clinical target volume is minimal, and the dose out of the tumor reduces rapidly due to the inverse-square law. High-dose-rate brachytherapy enables three-dimensional image ...

journal_title：Japanese journal of clinical oncology

authors： Itami J

更新日期：2020-05-05 00:00:00

abstract：OBJECTIVE:Anatomical segmentectomy has the potential to replace lobectomy as the standard procedure for early stage non-small cell lung cancer. We investigated the safety and feasibility of robotic anatomical segmentectomy for non-small cell lung cancer. METHODS:Overall 20 patients underwent robotic anatomical segment...

journal_title：Japanese journal of clinical oncology

authors： Kagimoto A,Tsutani Y,Izaki Y,Handa Y,Mimae T,Miyata Y,Okada M

更新日期：2020-04-07 00:00:00

abstract：OBJECTIVE:The treatment modality for desmoid-type fibromatosis has shifted from surgery to conservative treatment. This systematic review aims to evaluate the efficacy of low-dose chemotherapy with methotrexate and vinblastine for patients with extra-abdominal desmoid-type fibromatosis. METHODS:We searched the pertine...

journal_title：Japanese journal of clinical oncology

authors： Shimizu K,Hamada S,Sakai T,Koike H,Yoshida M,Nishida Y

更新日期：2020-04-07 00:00:00

abstract：OBJECTIVE:To describe changes in Japanese clinical trial regulations after the implementation of the Clinical Trials Act in April 2018. METHODS:First, how to apply multiple regulations after the enforcement of Clinical Trials Act was described. Second, the changes in the number of clinical trials in the National Cance...

journal_title：Japanese journal of clinical oncology

authors： Nakamura K,Shibata T

更新日期：2020-04-07 00:00:00

abstract：INTRODUCTION:Thymic epithelial tumors are a rare type of neoplasm. Accordingly, it is difficult to perform phase III trials in patients with thymic epithelial tumors, and thus, no standard treatment has been established for these tumors. In this study, we aimed to investigate the current status of thymic epithelial tum...

journal_title：Japanese journal of clinical oncology

authors： Kanemura H,Tamura T,Nishimura N,Kobayashi D,Higashi T

更新日期：2020-03-09 00:00:00

abstract：:Hepatobiliary and pancreatic cancers have poor outcomes. Clinical staging is useful for predicting survival and selecting treatment options. The 8th edition of tumor-node metastasis (TNM) was published in 2016 and came into effect from 2018. Regarding liver cancer (hepatocellular carcinoma), tumour size and vascular i...

journal_title：Japanese journal of clinical oncology

authors： Ueno M,Morizane C,Ikeda M,Okusaka T,Ishii H,Furuse J

更新日期：2019-12-27 00:00:00

abstract：OBJECTIVE:Limited by sample size, angiosarcoma was rarely studied. We aimed to investigate the characteristics and prognosis of angiosarcoma in the National Cancer Institute's Surveillance, Epidemiology and End Results database. METHODS:Patients who were diagnosed with primary angiosarcoma from 1973 to 2014 were extra...

journal_title：Japanese journal of clinical oncology

authors： Zhang C,Xu G,Liu Z,Xu Y,Lin F,Baklaushev VP,Chekhonin VP,Peltzer K,Mao M,Wang X,Wang G,Zhang C

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Patterns of cancer incidence and radiotherapy use are similar in Korea and Japan, with differences in radiotherapy infrastructure. METHODS:The authors surveyed the megavoltage machines in 91 radiotherapy centers in Korea and published data in Japan. The number of megavoltage machines per center was used as ...

journal_title：Japanese journal of clinical oncology

authors： Huh SJ,Nishimura T,Park W,Nakamura K

更新日期：2019-12-18 00:00:00

abstract：:Some cancer patients suddenly develop severe, excruciating pain that requires rapid management using opioid medication. This study aimed to evaluate the effectiveness of rapid titration using oxycodone injection. Study subjects were advanced cancer patients who experienced severe pain (numeric rating scale ≥7) and nee...

journal_title：Japanese journal of clinical oncology

authors： Nakajima N

更新日期：2019-12-18 00:00:00

abstract：OBJECTIVE:To confirm the safety and efficacy of everolimus in patients with unresectable or metastatic RCC. METHODS:Patients with unresectable or metastatic RCC were included and were followed for up to 1 year from the start of everolimus. The study was conducted at 618 investigational sites in Japan from March 2010 t...

journal_title：Japanese journal of clinical oncology

authors： Akaza H,Kurihara R,Katsura A,Harumiya M,Ushida N

更新日期：2019-10-01 00:00:00

abstract：:Due to the rapid aging of Japan's population, clinical research focusing on older patients with cancer is urgently needed. The Japan Clinical Oncology Group (JCOG) has conducted several such clinical trials, but there has been no formal policy for geriatric research. We have therefore established a JCOG policy for ger...

journal_title：Japanese journal of clinical oncology

authors： Mizutani T,Nakamura K,Fukuda H,Ogawa A,Hamaguchi T,Nagashima F,Geriatric Study Committee\/Japan Clinical Oncology Group.

更新日期：2019-10-01 00:00:00

abstract：:The Lugano classification was published in 2014 to form the basis for revising the recommendations regarding anatomic staging and evaluation of disease before and after therapy. This staging system was adopted by the eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer. In this review,...

journal_title：Japanese journal of clinical oncology

authors： Munakata W,Terauchi T,Maruyama D,Nagai H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:S-1 plus cisplatin is a standard chemotherapy regimen for advanced non-small cell lung cancer (NSCLC). The addition of bevacizumab has been shown to significantly improve overall survival (OS) in patients with advanced non-squamous (NSq) NSCLC who received carboplatin plus paclitaxel, however, failed to show...

journal_title：Japanese journal of clinical oncology

authors： Miyanaga A,Kubota K,Hosomi Y,Okuma Y,Minato K,Fujimoto S,Okamoto H,Satouchi M,Isobe H,Aono H,Takiguchi Y,Gemma A,Tokyo Cooperative Oncology Group.

更新日期：2019-08-01 00:00:00

abstract：:The prognosis of multiple myeloma was quite poor in the last century, but it has significantly improved with the incorporation of novel agents, immunomodulatory drugs (IMiDs) and proteasome inhibitors. Thalidomide was first developed as a sedative in 1950s, but it was withdrawn from the market because of teratogenicit...

journal_title：Japanese journal of clinical oncology

authors： Abe Y,Ishida T

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Perinephric fat invasion (PFI) of renal cell carcinoma (RCC) is known to be associated with adverse pathological features and poor prognosis. We analyzed these associations using a sub-group of the RCC registry of The Cancer Registration Committee of the Japanese Urological Association. METHODS:The study co...

journal_title：Japanese journal of clinical oncology

authors： Kume H,Homma Y,Shinohara N,Obara W,Kondo T,Kimura G,Fujimoto H,Nonomura N,Hongo F,Sugiyama T,Takahashi M,Kanayama HO,Fukumori T,Eto M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma is a malignant bone tumor mainly affecting teenagers and young adults. Its main driver mutation, the EWS-FLI1 fusion gene, has been identified more than 20 years ago, whereas its other somatic mutations have been just recently reported. METHODS:In this study, we organized the somatic mutations...

journal_title：Japanese journal of clinical oncology

authors： Zhang Y,Song J,Shi Q,Song X,Shen L,Zhou J,Shao J

更新日期：2019-07-01 00:00:00

abstract：:Pelvic lymphadenectomy is generally performed to treat early-stage cervical cancer, and pelvic ± para-aortic lymphadenectomy is performed in patients with endometrial cancer confined to the uterus. However, systematic lymphadenectomy is frequently associated with sequelae including lymphocele, lymphedema and celluliti...

journal_title：Japanese journal of clinical oncology

authors： Niikura H,Tsuji K,Tokunaga H,Shimada M,Ishikawa M,Yaegashi N

更新日期：2019-06-01 00:00:00

abstract：:Information of prefectural cancer incidence in Japan is an important resource to plan an effective regional cancer control program. In order to obtain accurate prefectural cancer incidence, we have to adjust for both of completeness of regional cancer registries and regional dispersion, simultaneously, Then, we develo...

journal_title：Japanese journal of clinical oncology

authors： Tanabe R,Kamo KI,Fukui K,Imori S

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:We aimed to clarify the suitable surgical management around the paratracheal area of patients who undergo total pharyngolaryngectomy based on the pathological results of hypopharyngeal cancer. METHODS:The study was conducted under a multicenter, retrospective observational design in Japan. We analyzed histop...

journal_title：Japanese journal of clinical oncology

authors： Tomioka T,Beppu T,Fujii T,Ozawa T,Asakage T,Onitsuka T,Fujimoto Y,Matsuura K,Kawabata K,Hayashi R

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:In an interim analysis of a Phase II trial in Japanese patients with pancreatic neuroendocrine tumors (panNETs), sunitinib demonstrated antitumor activity with an objective response rate (ORR) of 50% (95% confidence interval [CI], 21-79) and a median progression-free survival (PFS) of 16.8 months (95% CI, 9....

journal_title：Japanese journal of clinical oncology

authors： Ito T,Tori M,Hashigaki S,Kimura N,Sato K,Ohki E,Sawaki A,Okusaka T

更新日期：2019-04-01 00:00:00

abstract：:Projecting cancer mortality is fundamental to the process of planning cancer control. Although the prefecture is one of the main units for the implementation and evaluation of cancer control in Japan, a long-term detailed future projection of cancer mortality has not been conducted by prefecture. The main objective of...

journal_title：Japanese journal of clinical oncology

authors： Fukui K,Ito Y,Nakayama T

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:To improve palliative care practice, the need for patients-reported outcome measures is increasing globally. The Integrated Palliative care Outcome Scale (IPOS) is a streamlined outcome scale developed to comprehensively evaluate patients' distress. The goal of this study is to assess the reliability and val...

journal_title：Japanese journal of clinical oncology

authors： Sakurai H,Miyashita M,Imai K,Miyamoto S,Otani H,Oishi A,Kizawa Y,Matsushima E

更新日期：2019-03-01 00:00:00