Abstract:
OBJECTIVE:In 2009, the TNM classification of malignant tumors was revised, and the renewal of the T2-4 stage in renal cell carcinoma was adopted. To date, however, the staging of ipsilateral solitary adrenal involvement in renal cell carcinoma has not been sufficiently evaluated. METHODS:We retrospectively reviewed the adrenal involvement in renal cell carcinoma among 1033 patients admitted to the Department of Urology at Hamamatsu University Hospital, Japan, and affiliated hospitals between 1978 and 2007. RESULTS:We identified 23 of the 1033 patients (2.2%) with adrenal involvement in renal cell carcinoma. In renal cell carcinoma patients with adrenal involvement, a tendency for a high histological grade of tumor and lower overall survival (P< 0.0001) was observed. Ipsilateral solitary adrenal involvement was detected in 4 of the 23 patients (15%), whereas 2 of the 23 (9%) had direct invasion of the adrenal gland. All tumors in the 14 patients without ipsilateral solitary adrenal involvement and recurrent adrenal tumors were classified as Stage IV. The TNM classification of the four renal cell carcinoma patients with ipsilateral solitary adrenal involvement was determined to be either pT3N0M0 or pT1-3N0M1. Among the four patients with ipsilateral solitary adrenal involvement, three patients had recurrent tumors, despite complete surgical resection. Two of these patients died of metastatic renal cell carcinoma after 2 and 10 years of radical nephrectomy, respectively, whereas one was still alive with cancer 3 years after the initial radical nephrectomy. The fourth had no recurrence of renal cell carcinoma, but did develop synchronous gall bladder cancer (pT2N0M0) and bile duct cancer (pT2N0M0). CONCLUSIONS:Adrenal involvement in primary renal cell carcinoma was observed more frequently in patients with advanced tumor stages. In the TNM classification system, we propose that ipsilateral solitary adrenal involvement in renal cell carcinoma should be staged as M1.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Takayama T,Sugiyama T,Kai F,Ito T,Furuse H,Mugiya S,Ozono Sdoi
10.1093/jjco/hyr031subject
Has Abstractpub_date
2011-06-01 00:00:00pages
792-6issue
6eissn
0368-2811issn
1465-3621pii
hyr031journal_volume
41pub_type
杂志文章,多中心研究abstract:BACKGROUND:Tumor marker-producing germ cell tumors of the central nervous system are malignant and require radiation and/or chemotherapy. Although serum beta-human chorionic gonadotropin (hCG) has been used to monitor the course of treatment, the levels of beta-hCG in the cerebrospinal fluid (CSF) have not been measure...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyd076
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abstract:OBJECTIVE:Osteosarcoma is the most common primary malignant bone tumor. The long-term outcome is poor for patients with metastatic disease. METHODS:From June 1989 to January 2008, 202 patients (128 males and 74 females) with high-grade osteosarcoma of the extremities were treated at our institution. Patients were divi...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
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doi:10.1093/jjco/hyw135
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abstract:Background:Many patients with colorectal cancer are elderly with competing comorbidities. When constructing nomogram for assessing survival, we should consider the influence of competing risk. A competing-risks nomogram was developed to estimate the probability of death due to colorectal cancer for patients after curat...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:The value of postmastectomy radiation therapy for breast cancer patients with T1-2 tumor and one to three positive nodes remains controversial. The purpose of this retrospective study was to compare the clinical outcomes of breast cancer patients with T1-2 and one to three positive nodes with and without post...
journal_title:Japanese journal of clinical oncology
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abstract::Immunohistochemical studies using antisera to keratin and secretory component (SC) and monoclonal antibody against leukocyte common antigen (LCA) were performed on 92 biopsy and autopsy specimens taken from 65 patients with nasopharyngeal carcinoma. Five biopsy specimens from malignant lymphoma of the nasopharynx and ...
journal_title:Japanese journal of clinical oncology
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abstract::A simple and effective method for concentrating sputum in the preparation of smears for cytodiagnosis of lung cancer was developed. The procedure, which utilizes a fixative consisting of 2,3-dihydroxy-1,4-dithiol-butane, 3,5-ditert-butyl-4-hydroxy-toluene, polyoxyethylene-cetyl-ether, polyethylene glycol 1540, and eth...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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更新日期:2010-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
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更新日期:2015-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jjco.a023171
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyw011
更新日期:2016-05-01 00:00:00
abstract::Cancer causes profound suffering for patients, and previous reports have demonstrated that psychological distress, particularly depression, is frequently observed in advanced and/or terminally ill cancer patients. Such depression can lead to serious and far-reaching negative consequences in patients with advanced canc...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:In Japan, population-based cancer incidence data are reported several years behind the latest year of cancer mortality data. To bridge this gap, we aimed to determine a short-term projection method for cancer incidence. METHODS:Data between 1985 and 2007 were obtained from the population-based cancer registr...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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更新日期:2012-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00