Medical treatment for inoperable insulinoma: clinical usefulness of diphenylhydantoin and diltiazem.

Abstract:

:This report describes a 78-year-old woman with insulinoma, treated with a combination of diphenylhydantoin and a calcium antagonist. The effectiveness of 200 mg of diphenylhydantoin and 180 mg of diltiazem was evaluated by measuring the levels of plasma glucose, immunoreactive insulin and immunoreactive insulin/plasma glucose after fasting or by the oral glucose tolerance test, and by the appearance of hypoglycemic symptoms. The mean concentration of fasting plasma glucose increased significantly during the treatment. The levels of immunoreactive insulin/plasma glucose and C-peptide immunoreactivity/plasma glucose significantly decreased. Symptomatically, no episode of hypoglycemia was noted during the combined treatment.

journal_name

Jpn J Clin Oncol

authors

Imanaka S,Matsuda S,Ito K,Matsuoka T,Okada Y

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

65-71

issue

1

eissn

0368-2811

issn

1465-3621

journal_volume

16

pub_type

杂志文章
  • Trends and projections of cancer mortality in Osaka, Japan from 1977 to 2032.

    abstract::Projecting cancer mortality is fundamental to the process of planning cancer control. Although the prefecture is one of the main units for the implementation and evaluation of cancer control in Japan, a long-term detailed future projection of cancer mortality has not been conducted by prefecture. The main objective of...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy204

    authors: Fukui K,Ito Y,Nakayama T

    更新日期:2019-04-01 00:00:00

  • Changes and current state of diagnosis of lung cancer after development of the flexible bronchofiberscope.

    abstract::The flexible bronchofiberscope developed by Ikeda et al. has brought about revolutionary changes in the diagnosis and treatment of lung cancer. Advances in this device are continuing to emerge and lesions even smaller than those visible to the naked eye can now be visualized. In addition, the use of ultrasound now ena...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq136

    authors: Kaneko M

    更新日期:2010-09-01 00:00:00

  • Patterns of care study: comparison of process of post-mastectomy radiotherapy (PMRT) in Japan and the USA.

    abstract:BACKGROUND:The Patterns of Care Study (USPCS) by the American College of Radiology (ACR) has made significant contributions to improvements in the procedures of care for patients with breast cancer in the USA. The purpose of this study was to identify problems associated with the process of care for patients undergoing...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyg095

    authors: Shikama N,Nishikawa A,Mitsumori M,Hiraoka M,Yamamoto T,Teshima T,Inoue T,Wilson F,Owen J

    更新日期:2003-10-01 00:00:00

  • Recurrent cervical cancer in the pelvis--intra-arterial infusion of oncostatics.

    abstract::Five cases of recurrent cervical carcinoma with sites of recurrence restricted to the pelvis were treated by intra-arterial infusion of oncostatics via the bilateral internal iliac arteries. One tip of the catheter was positioned in the internal iliac artery, proximal and close to the superior glutea artery, through t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kawagoe K,Iijima S,Sasaki J

    更新日期:1983-12-01 00:00:00

  • Highly enhanced hepatic masses seen on CT during arterial portography: early hepatocellular carcinoma and adenomatous hyperplasia.

    abstract:BACKGROUND:To describe computed tomographic (CT) features of highly enhanced hepatic masses as seen on CT during arterial portography (CTAP) and to survey the varieties of hepatic lesions associated with such findings. METHODS:CTAP files for 400 patients were reviewed, on the basis of which six patients with highly en...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd113

    authors: Onaya H,Itai Y,Satake M,Luo T,Saida Y,Haruno M,Hasebe T,Moriyama N

    更新日期:2000-10-01 00:00:00

  • ATAD2 overexpression is associated with progression and prognosis in colorectal cancer.

    abstract:OBJECTIVES:ATPase family AAA domain-containing 2 plays an important role in tumor progression including cell cycle, proliferation, apoptosis and chemoresistance. However, the expression of ATPase family AAA domain-containing 2 in colorectal cancer and its significance are still unclear. The aim of this study was to exa...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv195

    authors: Hou M,Huang R,Song Y,Feng D,Jiang Y,Liu M

    更新日期:2016-03-01 00:00:00

  • Prediction of renal function after nephroureterectomy in patients with upper tract urothelial carcinoma.

    abstract:OBJECTIVE:The estimated glomerular filtration rate is significantly decreased after nephroureterectomy. Deteriorating renal function likely affects the eligibility for cisplatin-based chemotherapy in patients with upper tract urothelial carcinoma. The present study was undertaken to identify preoperative factors for th...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv136

    authors: Hashimoto T,Ohno Y,Nakashima J,Gondo T,Nakagami Y,Namiki K,Horiguchi Y,Yoshioka K,Ohori M,Tachibana M

    更新日期:2015-11-01 00:00:00

  • Prognostic impact of incisional or excisional biopsy of cervical lymph node metastases of solid tumors.

    abstract:Objectives:In performing an open biopsy of a neck mass, an incisional biopsy may increase the risk of cancer cell seeding and dissemination that, ultimately, worsens a patient's survival. The aim of this study was to compare the impact of incisional and excisional biopsies of cervical lymph node metastases of solid tum...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy056

    authors: Shinohara S,Takebayashi S,Kikuchi M,Michida T,Hayashi K,Yamamoto R,Saida K,Mizuno K,Fujiwara K,Naito Y

    更新日期:2018-06-01 00:00:00

  • Continuous intravenous administration of 1-(2-tetrahydrofuryl)-5-fluorouracil [FT] by intravenous hyperalimentation (IVH)--stability of FT in IVH solution and tumor levels of 5-fluorouracil (5-FU).

    abstract::The continuous intravenous administration of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) to colorectal cancer patients was studied in regard to the stability of FT in intravenous hyperalimentation (IVH) solutions and tumor levels of 5-fluorouracil (5-FU). FT was very compatible with IVH solutions, because the decomposit...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Moriya Y,Koyama Y,Hojo K,Tsunematsu R

    更新日期:1983-03-01 00:00:00

  • Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patients with malignant germ cell tumor can be used to detect early recurrence and monitor the response to treatment.

    abstract:BACKGROUND:Tumor marker-producing germ cell tumors of the central nervous system are malignant and require radiation and/or chemotherapy. Although serum beta-human chorionic gonadotropin (hCG) has been used to monitor the course of treatment, the levels of beta-hCG in the cerebrospinal fluid (CSF) have not been measure...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd076

    authors: Fujimaki T,Mishima K,Asai A,Tabuchi K,Kobayashi M,Suzuki I,Kirino T

    更新日期:2000-07-01 00:00:00

  • Identification of a Japanese Lynch syndrome patient with large deletion in the 3' region of the EPCAM gene.

    abstract::Germline deletion of the 3' portion of the Epithelial Cell Adhesion Molecule (EPCAM) gene located 5' upstream of MutS Homolog 2 (MSH2) is a novel mechanism for its inactivation in Lynch syndrome. However, its contribution in Japanese Lynch syndrome patients is poorly understood. Moreover, somatic events inactivating t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv172

    authors: Eguchi H,Kumamoto K,Suzuki O,Kohda M,Tada Y,Okazaki Y,Ishida H

    更新日期:2016-02-01 00:00:00

  • Safety, tolerability and pharmacokinetics of shorter duration of infusion of obinutuzumab in Japanese patients with B-cell non-Hodgkin lymphoma: final results of the phase II GATS study.

    abstract:Background:Shorter duration of infusion of monoclonal antibody treatments may reduce treatment burden and improve healthcare resource utilization. Methods:This phase II study recruited Japanese patients with previously untreated CD20+ B-cell non-Hodgkin lymphoma. Patients received intravenous obinutuzumab 1000 mg by r...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyy087

    authors: Ohmachi K,Ando K,Kinoshita T,Kumagai K,Hatake K,Ishikawa T,Teshima T,Kato K,Izutsu K,Ueda E,Nakai K,Kuriki H,Tobinai K

    更新日期:2018-08-01 00:00:00

  • Phase II study of cisplatin and 5-fluorouracil with concurrent radiotherapy in advanced squamous cell carcinoma of the esophagus: a Japan Esophageal Oncology Group (JEOG)/Japan Clinical Oncology Group trial (JCOG9516).

    abstract:BACKGROUND:In Japan, concurrent chemoradiotherapy is the standard treatment for unresectable esophageal cancer. The optimal combination of chemotherapeutic agents and radiotherapy dose remains controversial. The present study consists of a phase II trial of a cisplatin (CDDP)/5-fluorouracil (5-FU) infusion with concurr...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/jjco/hyh107

    authors: Ishida K,Ando N,Yamamoto S,Ide H,Shinoda M

    更新日期:2004-10-01 00:00:00

  • Factors affecting enrollment in randomized controlled trials conducted for patients with metastatic breast cancer.

    abstract:BACKGROUND:It is critical to obtain informed consent from eligible patients to complete clinical trials. We investigated the factors that affect the participation rates of eligible patients. PATIENTS AND METHODS:Patients with metastatic breast cancer who were eligible for SELECT BC or SELECT BC-CONFIRM trials, randomi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa065

    authors: Ohsumi S,Mukai H,Takahashi M,Hozumi Y,Akabane H,Park Y,Tokunaga E,Takashima T,Watanabe T,Sagara Y,Kaneko T,Ohashi Y

    更新日期:2020-08-04 00:00:00

  • Pseudoaneurysm of the external carotid artery branch following radiotherapy for nasopharyngeal carcinoma.

    abstract::Rupture of irradiated arteries in patients with head and neck cancer is an uncommon complication. We present the first case of a pseudoaneurysm of the external carotid artery branch that developed after irradiation of nasopharyngeal carcinoma and was successfully treated by microcoil embolization therapy. Clinicians s...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym019

    authors: Li SH,Hsu SW,Wang SL,Chen HC,Huang CH

    更新日期:2007-04-01 00:00:00

  • Efficacy of CDDP and AGM-1470 chemotherapy against lung metastasis in rat osteosarcoma depends on the timing of combined administration.

    abstract::The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. Tumor-bearing male Fischer 3...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/27.4.236

    authors: Morishita T,Mii Y,Miyauchi Y,Miura S,Honoki K,Aoki M,Kido A,Tamai S,Tsutsumi M,Konishi Y

    更新日期:1997-08-01 00:00:00

  • The national database of hospital-based cancer registries: a nationwide infrastructure to support evidence-based cancer care and cancer control policy in Japan.

    abstract::Monitoring the current status of cancer care is essential for effective cancer control and high-quality cancer care. To address the information needs of patients and physicians in Japan, hospital-based cancer registries are operated in 397 hospitals designated as cancer care hospitals by the national government. These...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyt013

    authors: Higashi T,Nakamura F,Shibata A,Emori Y,Nishimoto H

    更新日期:2014-01-01 00:00:00

  • Stereotactic body radiation therapy in patients with pelvic recurrence from rectal carcinoma.

    abstract:OBJECTIVE:To investigate the clinical applications of stereotactic body radiation therapy (SBRT) using the CyberKnife system for pelvic recurrence from rectal cancer with a focus on survival and toxicity. METHODS:Between 2002 and 2006, 23 patients with recurrent rectal cancer were treated with SBRT at our institution....

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyn083

    authors: Kim MS,Choi C,Yoo S,Cho C,Seo Y,Ji Y,Lee D,Hwang D,Moon S,Kim MS,Kang H

    更新日期:2008-10-01 00:00:00

  • Prognostic factors and prognostic staging system for small cell lung cancer.

    abstract::This study was performed to assess the prognostic factors and the predictors of long-term (3-year) survival in patients with small cell carcinoma of the lung, accrued in one randomized trial, and to define patient subgroups showing significantly different survivals using recursive partitioning and amalgamation analysi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/jjco/27.3.158

    authors: Kawahara M,Fukuoka M,Saijo N,Nishiwaki Y,Ikegami H,Tamura T,Shimoyama M,Suemasu K,Furuse K

    更新日期:1997-06-01 00:00:00

  • Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum.

    abstract::The positive correlation between smoking and cancer risk is well estimated in sporadic colorectal cancer, whereas little is known with regard to Lynch syndrome-associated colorectal cancer. A total of 118 familial colorectal cancer patients from the Hereditary Nonpolyposis Colorectal Cancer Registry and Genetic Testin...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu218

    authors: Tanakaya K,Furukawa Y,Nakamura Y,Hirata K,Tomita N,Tamura K,Sugano K,Ishioka C,Yoshida T,Ishida H,Watanabe T,Sugihara K,HNPCC registry and genetic testing project of the Japanese Society for Cancer of the Colon and Rectum.,Yama

    更新日期:2015-03-01 00:00:00

  • Reduced-intensity hematopoietic stem cell transplantation (RIST) for solid malignancies.

    abstract::Reduced intensity stem cell transplantation (RIST) is a new approach of stem cell transplantation, which has shown promising features as reported in multiple phase I and II studies. Elderly patients, who are not eligible for conventional myeloablative hematopoietic stem cell transplantation (HSCT), are now treatable w...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyh139

    authors: Kami M,Makimoto A,Heike Y,Takaue Y

    更新日期:2004-12-01 00:00:00

  • Long-term outcomes of 60 Gy conventional radiotherapy combined with androgen deprivation for localized or locally advanced prostate cancer.

    abstract:BACKGROUND:Until 1998 in Japan, very few institutions were treating prostate cancer solely with radiotherapy (RT) >70 Gy and most were using < or =65 Gy in combination with hormone therapy. The present study reports the long-term results of RT combined with hormone therapy for localized and locally advanced prostate ca...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi174

    authors: Hashine K,Numata K,Azuma K,Sumiyoshi Y,Kataoka M

    更新日期:2005-11-01 00:00:00

  • Retroperitoneal schwannoma mimicking hepatic tumor in the caudate lobe.

    abstract::We report a 41-year-old woman with a retroperitoneal schwannoma mimicking hepatic tumor in the caudate lobe. Dynamic computed tomography in the early phase showed an enhanced tumor (2.7 cm in diameter) in the Spiegel lobe of the liver, which compressed the inferior vena cava (IVC). We also performed left hepatic angio...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/27.4.282

    authors: Nakamura M,Takayama T,Takayasu K,Shimada K,Yamamoto J,Kosuge T,Sakamoto M,Yamasaki S,Shimizu S,Makuuchi M

    更新日期:1997-08-01 00:00:00

  • The first case of primary testicular germ cell tumor containing nephroblastoma as the only one non-germ cell component.

    abstract::Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is ve...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr080

    authors: Keskin S,Ekenel M,Başaran M,Aksu C,Kiliçaslan I,Tunç M,Bavbek S

    更新日期:2011-08-01 00:00:00

  • Multiple resections for hepatic and pulmonary metastases of colorectal carcinoma.

    abstract:BACKGROUND:Resections are effective for some patients with both hepatic and pulmonary metastases of colorectal cancer, but the best selection criteria for the resections and effective treatment for recurrence after the resections have not been determined. METHODS:A retrospective analysis was performed for 30 consecuti...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym006

    authors: Takahashi S,Nagai K,Saito N,Konishi M,Nakagohri T,Gotohda N,Nishimura M,Yoshida J,Kinoshita T

    更新日期:2007-03-01 00:00:00

  • Treatment outcomes of the patients with early glottic cancer treated with initial radiotherapy and salvaged by conservative surgery.

    abstract:OBJECTIVE:This retrospective study analyzed the oncological and treatment outcomes of the patients with T1-T2N0 glottic cancer, who were treated with radiotherapy as initial treatment and salvaged by conservative surgery for radiation failure. METHODS:Between May 1999 and December 2010, 115 patients with glottic laryn...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu203

    authors: Harada A,Sasaki R,Miyawaki D,Yoshida K,Nishimura H,Ejima Y,Kitajima K,Saito M,Otsuki N,Nibu K

    更新日期:2015-03-01 00:00:00

  • Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer.

    abstract:BACKGROUND:Angiogenesis is required for growth and metastasis of colorectal cancer (CRC), and several positive regulators of tumor angiogenesis have been identified. Cyclooxygenase-2 (COX-2), known to be elevated in several human cancers, regulates angiogenesis by inducing angiogenic factors. The aim of this study was ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym080

    authors: Nakamoto RH,Uetake H,Iida S,Kolev YV,Soumaoro LT,Takagi Y,Yasuno M,Sugihara K

    更新日期:2007-09-01 00:00:00

  • A double blind comparative study of tegafur (FT) and UFT (a combination of Tegafur and uracil) in advanced breast cancer.

    abstract::A double blind study to compare the efficacy of oral UFT (400 mg Tegafur (FT) plus 896 mg uracil/day) with that of oral FT (800 mg/day) on advanced breast cancer was performed between November, 1986, and November, 1989. Sixty patients were registered for the trial and fifty-six cases were evaluated (28 for UFT and 28 ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Tashiro H,Nomura Y,Ohsaki A

    更新日期:1994-08-01 00:00:00

  • Cancer epidemiology and control in Taiwan: a brief review.

    abstract::Malignant neoplasm has become the leading cause of death in Taiwan since 1982. There has been a decreasing trend for cancers of the stomach and cervix uteri, while an increasing trend has been observed for cancers of the lung, liver, oral cavity, colon and rectum, breast and prostate. International comparison and migr...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hye138

    authors: Chen CJ,You SL,Lin LH,Hsu WL,Yang YW

    更新日期:2002-03-01 00:00:00

  • The localization of human keratin proteins at cytological and histological levels in carcinomatous and sarcomatous lesions.

    abstract::Immunoperoxidase staining for human keratin proteins was performed cytologically on samples from 90 patients with malignant tumors, and histologically on samples from 164 patients with malignant tumors. At the cytological level, almost all tumor cells not only in squamous cell carcinoma but also in nonsquamous cell ca...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Yagi Y,Imamura Y,Saku T,Shimotsu T,Hatae M,Yagi S

    更新日期:1986-03-01 00:00:00