Abstract:
BACKGROUND:Until 1998 in Japan, very few institutions were treating prostate cancer solely with radiotherapy (RT) >70 Gy and most were using < or =65 Gy in combination with hormone therapy. The present study reports the long-term results of RT combined with hormone therapy for localized and locally advanced prostate cancer. METHODS:We investigated 57 patients who were treated by external beam RT plus hormone therapy (median age 79 years, median prostate-specific antigen concentration 15.0 ng/ml) between 1992 and 1998. Patients received 40 Gy of radiation to the pelvis and an additional 20 Gy as a prostatic boost. Hormone therapy was begun on the first day of irradiation and continued thereafter. RESULTS:The median follow-up was 93.3 months and the 5 and 10 year actual overall survival rates were 67.8 and 32.6%, respectively, with 5 and 10 year cause-specific survival rates of 97.9 and 95.0%, respectively. The expected survival rate was 66.2% at 5 years, and overall survival was above expected survival. Only one patient developed severe proctitis (Grade 3). The 5 year occurrence of Grade 1/2 genitourinary toxicity was 23.2%. CONCLUSIONS:Combined RT and hormone therapy has a good long-term outcome without severe adverse events. The overall survival rate compares well with the expected survival rate.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Hashine K,Numata K,Azuma K,Sumiyoshi Y,Kataoka Mdoi
10.1093/jjco/hyi174keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
655-9issue
11eissn
0368-2811issn
1465-3621pii
hyi174journal_volume
35pub_type
杂志文章abstract:OBJECTIVE:We evaluated the feasibility of combination chemotherapy with paclitaxel, doxorubicin and cisplatin without prophylactic granulocyte colony-stimulating factor injection for intermediate-to-high-risk or recurrent endometrial cancer. METHODS:Women with histologically confirmed FIGO Stages I-II with >1/2 myomet...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:1989-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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更新日期:2018-02-01 00:00:00
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00