Abstract:
BACKGROUND:Patients suffering from hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) generally have a poor prognosis. We therefore conducted a prospective pilot trial of combined transcatheter arterial chemoembolization (TACE) and local radiotherapy (RT) for PVTT in unresectable HCC. The aim of the study was to investigate the efficacy and toxicity of this preliminary trial regime and to explore RT guidelines for cirrhosis. METHODS:Eight patients with unresectable HCC accompanied by first branch PVTT were entered into the study from February 1998 to December 1999. TACE was performed using Lipiodol, epirubicin hydrochloride and mytomycin followed by gelatin sponge cubes. RT was started 10-14 days following TACE. A total delivered dose of 60 Gy was given as daily 2 Gy fractions, with the clinical target volume defined as PVTT only. We observed a relationship between deterioration of liver function and the percent volume of the total liver receiving a dose exceeding 30 Gy (V30). RESULTS:An objective response was observed in three of the eight patients. However, on follow-up angiograms the protrusion of PVTT into the main portal trunk was decreased in all cases. Deterioration of liver function was observed in all patients with V30 >40%. CONCLUSION:It is possible that this combined therapy prevents PVTT from spreading to the main trunk and that indicates a further benefit of TACE. Our results indicate that V30 constitutes a predictive test for the development of liver failure. More detailed evaluations of liver function and determination of the safe irradiation volume are necessary.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Yamada K,Soejima T,Sugimoto K,Mayahara H,Izaki K,Sasaki R,Maruta T,Matsumoto S,Hirota S,Sugimura Kdoi
10.1093/jjco/hye029keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
147-52issue
4eissn
0368-2811issn
1465-3621journal_volume
31pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to evaluate patient-related parameters that determine ovarian cyst formation in women using tamoxifen for breast cancer. METHODS:A retrospective review of tamoxifen-treated women with breast cancer who were followed up in the outpatient clinic at Ankara Oncology Hospital between...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyz081
更新日期:2019-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 历史文章,杂志文章,评审
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abstract::Cancer is the leading cause of mortality in Singapore. The age-standardized incidence rates continue to increase as the population grows and ages, and the influence of environmental and lifestyle choices bear their consequences. The increase is most marked in colorectal, breast and prostate cancers, mirroring the most...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:1999-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2016-04-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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更新日期:2015-01-01 00:00:00
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更新日期:1983-12-01 00:00:00