Abstract:
:Recent reports of cancers that produce colony-stimulating factors (CSF) and which are associated with leukocytosis indicate that most are granulocyte CSF-producing tumors. A 71-year-old man with metastatic chest wall tumors from large cell lung cancer with marked leukocytosis and eosinophilia was reported. His maximal leukocyte count was 48300/microliter with 37.5% eosinophils. Granulocyte-macrophage CSF (GM-CSF) activity detected by enzyme-linked immunosorbent assay (ELISA) in serum was 112 pg/ml (normal range < 2.0 pg/ml), but G-CSF was normal. Immunohistochemical detection of GM-CSF protein on a chest wall tumor sample was positive. Irradiation of the chest wall tumor was performed and the leukocyte count decreased temporally. However, he died of respiratory failure due to progressive tumor growth 56 days after admission. Based on these results it appears that autocrine production of GM-CSF is a possible cause of this leukemoid reaction.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Watanabe M,Ono K,Ozeki Y,Tanaka S,Aida S,Okuno Ydoi
10.1093/jjco/28.9.559subject
Has Abstractpub_date
1998-09-01 00:00:00pages
559-62issue
9eissn
0368-2811issn
1465-3621journal_volume
28pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the extent of informed decision-making and treatment preference of Korean patients receiving palliative chemotherapy. METHODS:We assessed 138 patients (median age: 58 years; 73% male) with advanced cancer who had received at least one cycle of chemotherapy. General demographic information, the e...
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pub_type: 临床试验,杂志文章
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更新日期:2018-01-01 00:00:00
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更新日期:2005-07-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/28.11.709
更新日期:1998-11-01 00:00:00
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更新日期:2020-09-28 00:00:00
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