Abstract:
:Cytotoxic effects of mannosamine and free fatty acids on human malignant T-lymphoid cell lines derived from patients with T-cell leukemia were investigated. The combination of mannosamine and an unsaturated fatty acid (oleate or linoleate) produced more striking cytotoxic effects on malignant lymphoid cells than on normal human lymphocytes. The amino sugars glucosamine or mannosamine in the combination caused a synergistic cytotoxic effect, while the other carbohydrates (N-acetylmannosamine, N-acetylglucosamine, or mannose) had little effect. On the other hand, the effect of saturated fatty acids (palmitate or stearate) in the same system was nil. An unsaturated fatty acid (oleate) caused an increase in lipid fluidity of the surface membrane in MOLT-4 lymphoid cells, which possess higher lipid fluidity in combination with mannosamine, while saturated fatty acids had no effect on the fluidity properties of the membrane lipids (even in the presence of mannosamine). The relationship between mannosamine and unsaturated fatty acids in cytolysis was discussed.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Onoda T,Morikawa S,Harada T,Morikawa Ksubject
Has Abstractpub_date
1985-09-01 00:00:00pages
545-52issue
3eissn
0368-2811issn
1465-3621journal_volume
15pub_type
杂志文章abstract:BACKGROUND:To improve palliative care practice, the need for patients-reported outcome measures is increasing globally. The Integrated Palliative care Outcome Scale (IPOS) is a streamlined outcome scale developed to comprehensively evaluate patients' distress. The goal of this study is to assess the reliability and val...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1093/jjco/hyy203
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:There are few reports of the outcomes of external beam radiotherapy in Asian males with localized prostate cancer. The aim of this study is to evaluate the long-term outcomes of external beam irradiation using three-dimensional two-dynamic conformal arc therapy, combined with neoadjuvant hormonal therapy, in ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyt197
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Angiosarcoma is an aggressive and malignant neoplasm. Primary hepatic angiosarcoma is extremely rare and accounts for only approximately 5% of all angiosarcomas. Therefore, many doctors do not know enough about this disease; this lack of knowledge motivated us to perform this study. METHODS:We carried out a...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyaa017
更新日期:2020-05-05 00:00:00
abstract:OBJECTIVE:A Phase I/II study of S-1 combined radiation therapy was conducted in patients with Stage II (T2N0) glottic cancer. The purpose of the Phase I study was to identify the maximum tolerated dose, the recommended dose and the dose limiting toxicity. The objectives in the phase II study were to estimate the local ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyq077
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:Suboptimal treatment of chemotherapy-induced nausea and vomiting and unsatisfactory response to antiemetic drugs cause impairment of cancer patient's daily functioning. This study was aimed to investigate the association of selected germline polymorphisms with ondansetron and metoclopramide response in Indone...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr117
更新日期:2011-10-01 00:00:00
abstract:Background:Gliomas are highly malignant brain tumors. Aberrant activation of NF-κB plays a crucial role in tumor progression. Method:ELISA assay was used to detect NF-κB activity in glimoas cells with different treatments. PPP3CC expression was evaluated by qRT-PCR and western blot assay. Kaplan-Meier analysis estimat...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx182
更新日期:2018-02-01 00:00:00
abstract:Introduction:Since June 2005, the University Hospital Medical Information Network-Clinical Trial Registry (UMIN-CTR) has been an International Committee of Medical Journal Editors (ICMJE)-approved clinical trial registry in Japan. The number of clinical trials registered in the UMIN-CTR has increased annually. To date,...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyy131
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Anatomical segmentectomy has the potential to replace lobectomy as the standard procedure for early stage non-small cell lung cancer. We investigated the safety and feasibility of robotic anatomical segmentectomy for non-small cell lung cancer. METHODS:Overall 20 patients underwent robotic anatomical segment...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyz199
更新日期:2020-04-07 00:00:00
abstract::BAT-25 is a DNA marker, intragenic to the c-kit protooncogene, assigned to 4q12, containing a polythymine tract, mostly repeats of 25 poly(T) (T25). The BAT-25 locus is frequently used in the analysis of microsatellite instability (MSI) in cancer tissues. The number of poly(T) repeats at BAT-25 is reported to be quasi...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hye066
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:The prognosis of breast cancer-derived brain metastasis is poor, but new drugs and recent therapeutic strategies have helped extend survival in patients. Prediction of therapeutic responses and outcomes is not yet possible, however. In a retrospective study, we examined prognostic factors in patients with bre...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyv067
更新日期:2015-08-01 00:00:00
abstract::Following a simple cholecystectomy, a 63-year-old woman with gallstones was histologically diagnosed as having minute squamous cell carcinoma of the gallbladder. A laparotomy revealed a small, firm nodule that appeared to be an adenoma, which was palpated in the fundus of the gallbladder. The resected gallbladder cont...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyd010
更新日期:2000-01-01 00:00:00
abstract::Squamous cell carcinoma of the head and neck is characterized by an immunosuppressive environment and evades immune responses through multiple resistance mechanisms. A breakthrough in cancer immunotherapy employing immune checkpoint inhibitors has evolved into a number of clinical trials with antibodies against progra...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/hyaa139
更新日期:2020-09-28 00:00:00
abstract:BACKGROUND:A Patterns of Care Study (PCS) has been conducted to evaluate the standards of practice for prostate cancer patients treated with radiotherapy in Japan. This study examines the influence of institutional stratification on the process of care for patients receiving radical external beam radiotherapy for prost...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1093/jjco/hyh002
更新日期:2004-01-01 00:00:00
abstract::Mucin-producing carcinoma of the thyroid is rare and its histogenesis has been debated. The first case was reported by Diaz-Perez et al. (1976). We herein report the sixth case of mucin-producing carcinoma of the thyroid which was discovered in a 72-year-old Japanese woman. This patient was admitted with a 10-year his...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::The concepts of lifetime and age-conditional probabilities of developing and dying of cancer are introduced as indexes to understand the risk of cancer. In this paper, we estimated the lifetime and age-conditional probabilities of developing and dying of cancer in 2001 and 2005, respectively, in Japan. It is estimated...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyn061
更新日期:2008-08-01 00:00:00
abstract::A clinical review with analysis of prognostic factors, including the impact of the initial management modality, was conducted on 137 patients with superior vena cava syndrome (SVCS) seen at the Veterans General Hospital-Taipei between 1989 and 1993. Malignant diseases account for most of the SVCS in our Chinese patien...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::A 21-year-old man had undergone central bisegmentectomy of the liver due to fibrolamellar carcinoma (FLC). Twice, 24 and 30 months after the first operation, lymph node metastases were removed. We have reported this case previously and this is the second report of the same case. Forty-two months after the second opera...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.9.445
更新日期:1999-09-01 00:00:00
abstract::Chemoradiation is potentially curative for esophageal cancer in various stages, but local failure is a major problem. The present case was a 49-year-old male diagnosed with advanced esophageal cancer with an esophago-bronchial fistula and lymph node metastasis. Histological diagnosis by biopsy was adenosquamous cell c...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyf016
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:The disease status of axillary lymph nodes at diagnosis is the most powerful predictor of prognosis for patients with breast cancer. Axillary lymph node dissection (ALND) has been the standard treatment. Recently, lymphatic mapping and sentinel lymph node biopsy (SNB) have been suggested as alternatives to A...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyf105
更新日期:2002-12-01 00:00:00
abstract::The development of PD-1 pathway inhibitors has dramatically altered the treatment of advanced/recurrent non-small-cell lung cancer patients. However, the prognostic significance of their ongoing usage is controversial, especially for patients who have not progressed for a period of time. If discontinuation has no nega...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1093/jjco/hyaa054
更新日期:2020-07-09 00:00:00
abstract:OBJECTIVE:We evaluated the feasibility of combination chemotherapy with paclitaxel, doxorubicin and cisplatin without prophylactic granulocyte colony-stimulating factor injection for intermediate-to-high-risk or recurrent endometrial cancer. METHODS:Women with histologically confirmed FIGO Stages I-II with >1/2 myomet...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1093/jjco/hyu124
更新日期:2014-11-01 00:00:00
abstract::In order to study the characteristics of lung cancer in smokers and nonsmokers, clinico-epidemiological features of 943 lung cancer patients treated in the Aichi Cancer Center Hospital from 1964-77 were analyzed according to their smoking histories. About 70% of both male and female patients who smoked fell in Group I...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:After approval of bevacizumab in Japan, post-marketing surveillance studies reported on safety. However, few reports have shown the efficacy of bevacizumab as used in daily practice. We evaluated the efficacy and safety of bevacizumab for metastatic colorectal cancer patients in daily practice. METHODS:All u...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr008
更新日期:2011-04-01 00:00:00
abstract::This study was performed to assess the prognostic factors and the predictors of long-term (3-year) survival in patients with small cell carcinoma of the lung, accrued in one randomized trial, and to define patient subgroups showing significantly different survivals using recursive partitioning and amalgamation analysi...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/jjco/27.3.158
更新日期:1997-06-01 00:00:00
abstract::Human gastrin-releasing peptide (GRP) mRNA was detected in the tumor tissues of medullary thyroid carcinomas and small cell lung carcinomas using synthetic oligodeoxyribonucleotides as hybridization probes. The amount of GRP mRNA was estimated by radiodensitometric hybridization assay. A good correlation was found bet...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::The positive correlation between smoking and cancer risk is well estimated in sporadic colorectal cancer, whereas little is known with regard to Lynch syndrome-associated colorectal cancer. A total of 118 familial colorectal cancer patients from the Hereditary Nonpolyposis Colorectal Cancer Registry and Genetic Testin...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu218
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:The importance of quality assurance in cancer screening has recently gained increasing attention in Japan. To evaluate and improve quality, checklists and process indicators have been developed. To explore effective methods of enhancing quality in cancer screening, we started a randomized control study of the...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1093/jjco/hyr185
更新日期:2012-02-01 00:00:00
abstract::Cancer causes profound suffering for patients, and previous reports have demonstrated that psychological distress, particularly depression, is frequently observed in advanced and/or terminally ill cancer patients. Such depression can lead to serious and far-reaching negative consequences in patients with advanced canc...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/hys152
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Adrenocortical carcinoma (ACC) is a rare tumor usually diagnosed at an advanced stage on invasion of or adherence to adjacent organs. We report surgical outcome of stage III and IV ACCs. METHODS:ACCs from seven patients at clinical stage II (n = 1), III (n = 4), or IV (n = 2) were resected. Combined resecti...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyl127
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to evaluate the liver metastasis risk among colorectal cancer patients with liver cirrhosis. METHODS:This was a nationwide population-based cohort study of 2973 newly diagnosed colorectal cancer patients with liver cirrhosis and 11 892 age-sex matched controls enrolled in Taiwan betw...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu178
更新日期:2015-02-01 00:00:00