Correlation between the changes in the EPIC QOL scores and the dose-volume histogram parameters in high-dose-rate brachytherapy combined with hypofractionated external beam radiation therapy for prostate cancer.

Abstract:

OBJECTIVE:To evaluate the correlations between the changes in the quality-of-life scores and the dose-volume histogram parameters in patients receiving high-dose-rate brachytherapy combined with hypofractionated external beam radiation therapy for localized prostate cancer. METHODS:Among the patients who were treated with high-dose-rate brachytherapy (18 Gy in two fractions) combined with hypofractionated external beam radiation therapy (45 Gy in 15 fractions), the data of 118 consecutive patients followed up for >24 months were prospectively analyzed. The disease-specific quality of life was assessed using the expanded prostate cancer index composite, and the acute genitourinary toxicities were graded based on the Radiation Therapy Oncology Group and European Organization for Research and Treatment of Cancer Toxicity criteria. RESULTS:The median follow-up duration was 58 months (42-84 months). Thirteen patients (11%) developed Grade 2 or more severe acute genitourinary toxicities. The score for the general urinary domain of the expanded prostate cancer index composite quality-of-life scores dropped significantly at 1 month after high-dose-rate brachytherapy, and then returned to the baseline level by 3 months. Among the dose-volume histogram parameters, the reduction of the expanded prostate cancer index composite quality-of-life scores for the general urinary domain and its subscales at 12 months after high-dose-rate brachytherapy was significantly greater in the patients for whom the V150 or urethral D10 was within the upper 20% of the range than in those in whom the values of these dosimetric parameters were within the lower 20% of the range. CONCLUSION:The high-dose area of the prostate gland (V150) or urethra (D10) might influence the quality-of-life scores for the urinary domain and its subscales over the long term.

journal_name

Jpn J Clin Oncol

authors

Hashimoto Y,Akimoto T,Iizuka J,Tanabe K,Mitsuhashi N

doi

10.1093/jjco/hyu173

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

81-7

issue

1

eissn

0368-2811

issn

1465-3621

pii

hyu173

journal_volume

45

pub_type

杂志文章
  • A preliminary study of preoperative chemotherapy combining irinotecan and cisplatin in patients with gastric cancer with unresectable para-aortic lymph node metastases.

    abstract:BACKGROUND:A high response rate has been reported for chemotherapy combining irinotecan (CPT-11) and cisplatin (CDDP) against advanced gastric cancer. The strong anti-tumor activity of this regimen makes it very attractive as a preoperative chemotherapy. We conducted a preliminary study on preoperative chemotherapy wit...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh046

    authors: Yamao T,Ohta K,Ohyama S,Ishihara S,Chin K,Maruyama M,Takahashi T,Nakajima T

    更新日期:2004-05-01 00:00:00

  • Rapid reconstruction of three dimensional images from ultrasonography using a linearly moving mirror.

    abstract::A system for reconstructing three dimensional (3-D) images from ultrasonography using a linearly moving mirror was modified. The device could display the 3-D structure of objects in real time by employing an on-line system. In a case of hepatocellular carcinoma, structures of the tumor and blood vessels were selective...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kawabata M,Mochida S,Fujiwara K,Yamanaka R,Yamamoto K,Yoshikura H

    更新日期:1992-02-01 00:00:00

  • Biochemical recurrence after radical prostatectomy with or without pelvic lymphadenectomy in Korean men with high-risk prostate cancer.

    abstract:OBJECTIVE:To identify predictors of biochemical recurrence (BCR) after radical prostatectomy with or without standard pelvic lymphadenectomy in Korean men with high-risk prostate cancer. METHODS:The clinical and pathologic data of 199 patients with high-risk features were reviewed retrospectively. High-risk features w...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr030

    authors: Ku JH,Jeong CW,Park YH,Cho MC,Kwak C,Kim HH

    更新日期:2011-05-01 00:00:00

  • Hepatic arterial infusion of oxaliplatin for a patient with hepatic metastases from colon cancer undergoing hemodialysis.

    abstract::There has been no previous report of oxaliplatin administration in patients undergoing hemodialysis. A 65-year-old female with end-stage renal disease who was undergoing hemodialysis presented with anemia in August 2005. She was diagnosed with colon cancer with multiple liver metastases. After colectomy, hepatic arter...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym044

    authors: Shitara K,Munakata M,Muto O,Okada R,Mitobe S,Mino M,Ikami I,Sakata Y

    更新日期:2007-07-01 00:00:00

  • Multiple primary cancers of the esophagus and thyroid gland.

    abstract::The occurrence of multiple primary cancers in the aerodigestive tract is a well known phenomenon that has been explained by the concept of 'field carcinogenesis'. Metachronous or synchronous esophageal cancer has usually been identified in patients with head and neck cancer, gastric cancer or colon cancer. The inciden...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/29.7.349

    authors: Naomoto Y,Haisa M,Yamatsuji T,Shirakawa Y,Muramatsu T,Isozaki H,Kamikawa Y,Tanaka N

    更新日期:1999-07-01 00:00:00

  • Adenocarcinoma arising at a colostomy site with inguinal lymph node metastasis: report of a case.

    abstract::Inguinal lymph node metastasis from adenocarcinoma arising at a colostomy site is extremely rare, and the significance of surgical resection for metastatic inguinal lymph nodes has not been established. An 82-year-old woman who had undergone abdominoperineal resection 27 years earlier was admitted to our hospital comp...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu192

    authors: Iwamoto M,Kawada K,Hida K,Hasegawa S,Sakai Y

    更新日期:2015-02-01 00:00:00

  • A newly introduced comprehensive consultation fee in the national health insurance system in Japan: a promotive effect of multidisciplinary medical care in the field of radiation oncology--results from a questionnaire survey.

    abstract:OBJECTIVE:The consultation fee for outpatient radiotherapy was newly introduced in the national health insurance system in Japan in April 2012. We conducted a survey on the use of this consultation fee and its effect on clinical practices. METHODS:The health insurance committee of the Japanese Society of Therapeutic R...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt147

    authors: Igaki H,Onishi H,Nakagawa K,Dokiya T,Nemoto K,Shigematsu N,Nishimura Y,Hiraoka M,Japanese Society for Therapeutic Radiology and Oncology Health Insurance Committee.

    更新日期:2013-12-01 00:00:00

  • Psychological distress experienced by families of cancer patients: preliminary findings from psychiatric consultation of a Cancer Center Hospital.

    abstract:OBJECTIVE:The purpose of the present study was to obtain preliminary findings regarding psychiatric disorders and background characteristics among Japanese family members of cancer patients. METHODS:We investigated the psychiatric diagnosis and background factors of family members of cancer patients by analyzing the c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyl029

    authors: Akechi T,Akizuki N,Okamura M,Shimizu K,Oba A,Ito T,Yoshikawa E,Nakano T,Inagaki M,Uchitomi Y

    更新日期:2006-05-01 00:00:00

  • A double blind comparative study of tegafur (FT) and UFT (a combination of Tegafur and uracil) in advanced breast cancer.

    abstract::A double blind study to compare the efficacy of oral UFT (400 mg Tegafur (FT) plus 896 mg uracil/day) with that of oral FT (800 mg/day) on advanced breast cancer was performed between November, 1986, and November, 1989. Sixty patients were registered for the trial and fifty-six cases were evaluated (28 for UFT and 28 ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Tashiro H,Nomura Y,Ohsaki A

    更新日期:1994-08-01 00:00:00

  • Identification of a Japanese Lynch syndrome patient with large deletion in the 3' region of the EPCAM gene.

    abstract::Germline deletion of the 3' portion of the Epithelial Cell Adhesion Molecule (EPCAM) gene located 5' upstream of MutS Homolog 2 (MSH2) is a novel mechanism for its inactivation in Lynch syndrome. However, its contribution in Japanese Lynch syndrome patients is poorly understood. Moreover, somatic events inactivating t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv172

    authors: Eguchi H,Kumamoto K,Suzuki O,Kohda M,Tada Y,Okazaki Y,Ishida H

    更新日期:2016-02-01 00:00:00

  • Contactin-1 (CNTN-1) overexpression is correlated with advanced clinical stage and lymph node metastasis in oesophageal squamous cell carcinomas.

    abstract:OBJECTIVE:Oesophageal squamous cell carcinoma is one of the deadliest malignancies worldwide. Contactin-1, a neural adhesion molecule, is implicated in tumour invasion and metastasis. The purpose of this study was to investigate the expression of CNTN-1 in normal and cancerous oesophageal tissue, and the potential rele...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys066

    authors: Liu P,Chen S,Wu W,Liu B,Shen W,Wang F,He X,Zhang S

    更新日期:2012-07-01 00:00:00

  • Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patients with malignant germ cell tumor can be used to detect early recurrence and monitor the response to treatment.

    abstract:BACKGROUND:Tumor marker-producing germ cell tumors of the central nervous system are malignant and require radiation and/or chemotherapy. Although serum beta-human chorionic gonadotropin (hCG) has been used to monitor the course of treatment, the levels of beta-hCG in the cerebrospinal fluid (CSF) have not been measure...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd076

    authors: Fujimaki T,Mishima K,Asai A,Tabuchi K,Kobayashi M,Suzuki I,Kirino T

    更新日期:2000-07-01 00:00:00

  • Techniques and clinical effect of aseptic procedures on patients with acute leukemia in laminar airflow rooms.

    abstract::The techniques of aseptic procedures in the laminar airflow room (LAF) were evaluated in 110 adult patients undergoing antileukemic chemotherapy for remission induction. The patients were divided into three groups according to the regimens: Group A, consisting of 20 patients who stayed in the LAF and received the gown...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Takeo H,Sakurai T,Amaki I

    更新日期:1983-01-01 00:00:00

  • Evaluation of feedback interventions for improving the quality assurance of cancer screening in Japan: study design and report of the baseline survey.

    abstract:OBJECTIVE:The importance of quality assurance in cancer screening has recently gained increasing attention in Japan. To evaluate and improve quality, checklists and process indicators have been developed. To explore effective methods of enhancing quality in cancer screening, we started a randomized control study of the...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hyr185

    authors: Machii R,Saika K,Higashi T,Aoki A,Hamashima C,Saito H

    更新日期:2012-02-01 00:00:00

  • A case of subglottic carcinoma effectively treated with intraluminal irradiation using low dose rate iridium-192 thin wires combined with external beam irradiation.

    abstract::Subglottic carcinoma is rare and has a poor prognosis. It is usually treated with surgical resection, external beam irradiation (EBR) and/or a combination of both. Intraluminal irradiation (IR) as a curative treatment for subglottic carcinoma has never been reported. We report a case of subglottic carcinoma in a 66-ye...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyg016

    authors: Wakisaka M,Fuwa N,Matsumoto A,Tachibana H,Kodaira T,Furutani K,Kamata M,Mori H

    更新日期:2003-02-01 00:00:00

  • Multiple (multicentric and multifocal) cancers in the ipsilateral breast with different histologies: profiles of chromosomal numerical abnormality.

    abstract:BACKGROUND:Chromosomal numerical abnormality (CNA) is a characteristic of breast cancer as with other common solid cancers. Multiple mammary carcinomas are also sometimes encountered in the ipsilateral breast. Deciding whether they are multicentric (arising independently) or multifocal (of the same origin) has been a c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyg089

    authors: Nakamura R,Song JP,Isogaki J,Kitayama Y,Sugimura H

    更新日期:2003-09-01 00:00:00

  • A pooled analysis of primary hepatic angiosarcoma.

    abstract:BACKGROUND:Angiosarcoma is an aggressive and malignant neoplasm. Primary hepatic angiosarcoma is extremely rare and accounts for only approximately 5% of all angiosarcomas. Therefore, many doctors do not know enough about this disease; this lack of knowledge motivated us to perform this study. METHODS:We carried out a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa017

    authors: Zeng D,Cheng J,Gong Z,Chen J,Long H,Zhu B

    更新日期:2020-05-05 00:00:00

  • Detection of microsatellite alterations in bronchial washings in squamous cell lung cancer: the first study from India.

    abstract:BACKGROUND:In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh079

    authors: Malhotra P,Behera D,Srinivasan R,Majumdar S,Wali A,Mir S,Kaur R

    更新日期:2004-08-01 00:00:00

  • Proposal for the breakdown of increased cancer healthcare cost and its improvement.

    abstract::Technological progress in the field of cancer treatment can be expected to accelerate in the future, giving hope to such patients. At the same time, there is concern that cancer care will become more expensive. It is indispensable to minimize the economic burden of patients to deliver technological advances in treatme...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyt015

    authors: Koinuma N

    更新日期:2013-04-01 00:00:00

  • A Phase I/II trial of chemoradiotherapy concurrent with S-1 plus mitomycin C in patients with clinical Stage II/III squamous cell carcinoma of anal canal (JCOG0903: SMART-AC).

    abstract::A Phase I/II trial of chemoradiotherapy concurrent with S-1 plus mitomycin C in patients with clinical Stage II/III squamous cell carcinoma of the anal canal was started in Japan. The aim of this trial is to determine the recommended dose of S-1 combined with a fixed dose of mitomycin C plus radiotherapy in Phase I an...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyr028

    authors: Takashima A,Shimada Y,Hamaguchi T,Ito Y,Nakano A,Nakamura K,Shibata T,Fukuda H,Moriya Y,Colorectal Cancer Study Group of the Japan Clinical Oncology Group.

    更新日期:2011-05-01 00:00:00

  • Successful treatment of pulmonary artery sarcoma by a two-drug combination chemotherapy consisting of ifosfamide and epirubicin.

    abstract::We describe a case of 63-year-old woman with pulmonary artery sarcoma successfully treated with chemotherapy. She developed acute shortness of breath, and left chest and shoulder pain. Although a diagnosis of acute pulmonary embolism was made at a local hospital and she received anticoagulation and thrombolysis therap...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi106

    authors: Uchida A,Tabata M,Kiura K,Tanimoto Y,Kanehiro A,Aoe M,Ohohara N,Ueoka H,Tanimoto M

    更新日期:2005-07-01 00:00:00

  • Second primary osteosarcomas in patients with retinoblastoma.

    abstract:OBJECTIVE:Second primary malignancies have become the leading cause of death in retinoblastoma survivors. Although osteosarcoma is the most common second malignancy, little is known about its clinical and therapeutic features. METHODS:We retrospectively reviewed a database of patients with retinoblastoma and osteosarc...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv140

    authors: Fujiwara T,Fujiwara M,Numoto K,Ogura K,Yoshida A,Yonemoto T,Suzuki S,Kawai A

    更新日期:2015-12-01 00:00:00

  • Natural history and prognosis of adenomatous hyperplasia and early hepatocellular carcinoma: multi-institutional analysis of 53 nodules followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical rese

    abstract:BACKGROUND:The natural history and posttherapeutic outcome of adenomatous hyperplasia and early hepatocellular carcinoma have rarely been analyzed. METHODS:Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or early hepatocellular carcinoma and followed up for more than 6 months and 141 patients with sing...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.10.604

    authors: Sakamoto M,Hirohashi S

    更新日期:1998-10-01 00:00:00

  • Stereotactic body radiation therapy in patients with pelvic recurrence from rectal carcinoma.

    abstract:OBJECTIVE:To investigate the clinical applications of stereotactic body radiation therapy (SBRT) using the CyberKnife system for pelvic recurrence from rectal cancer with a focus on survival and toxicity. METHODS:Between 2002 and 2006, 23 patients with recurrent rectal cancer were treated with SBRT at our institution....

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyn083

    authors: Kim MS,Choi C,Yoo S,Cho C,Seo Y,Ji Y,Lee D,Hwang D,Moon S,Kim MS,Kang H

    更新日期:2008-10-01 00:00:00

  • Establishment and analysis of biological characteristics of a human duodenal carcinoma cell line, WDC-1.

    abstract:BACKGROUND:Duodenal carcinoma is very rare and its culture cell lines have rarely been established. METHODS:Tumor cells separated from a surgically resected primary tumor of duodenal carcinoma were put into culture. The patient was an 81-year-old female and had metastatic lymph nodes. We investigated the biological ch...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/29.12.596

    authors: Tani M,Tanimura H,Terasawa H,Yamade N,Shono Y,Yamaue H

    更新日期:1999-12-01 00:00:00

  • Modified and bilateral retroperitoneal lymph node dissection for testicular cancer: peri- and postoperative complications and therapeutic outcome.

    abstract:OBJECTIVE:To characterize surgical invasiveness and morbidity and to verify therapeutic efficacy, we reviewed perioperative and postoperative courses and therapeutic outcomes of patients who underwent retroperitoneal lymph node dissection (RPLND) for testicular germ cell cancers. METHODS:The study included 31 patients...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyl026

    authors: Tanaka T,Kitamura H,Kunishima Y,Takahashi S,Takahashi A,Masumori N,Itoh N,Tsukamoto T

    更新日期:2006-06-01 00:00:00

  • Survival in patients with glioblastoma at a first progression does not correlate with isocitrate dehydrogenase (IDH)1 gene mutation status.

    abstract:BACKGROUNDS:Mutations in the isocitrate dehydrogenase (IDH)1 gene are favourable prognostic factors in newly diagnosed diffuse gliomas, whereas it remains controversial in the recurrent glioblastoma setting. METHODS:A total of 171 patients with newly diagnosed glioblastoma, either 'primary' glioblastoma or 'secondary'...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa162

    authors: Tabei Y,Kobayashi K,Saito K,Shimizu S,Suzuki K,Sasaki N,Shiokawa Y,Nagane M

    更新日期:2021-01-01 00:00:00

  • CD10-positive stromal cells in gastric carcinoma: correlation with invasion and metastasis.

    abstract:BACKGROUND:CD10 is a cell surface metalloproteinase expressed by a variety of normal cell types, including lymphoid precursor cells, germinal center B lymphocytes and some epithelial cells. Although accumulating data indicate that CD10 expression by stromal cells is involved in colorectal carcinogenesis and it is a nov...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi076

    authors: Huang WB,Zhou XJ,Chen JY,Zhang LH,Meng K,Ma HH,Lu ZF

    更新日期:2005-05-01 00:00:00

  • The association between malignancy and end-stage renal disease in Taiwan.

    abstract:OBJECTIVE:Patients with end-stage renal disease are suggestive to have a higher risk for the development of some kinds of cancer. The aim of this study is to evaluate the possible association between malignancy and end-stage renal disease in Taiwan. METHODS:We used the data of the National Health Insurance system of T...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr051

    authors: Liang JA,Sun LM,Yeh JJ,Sung FC,Chang SN,Kao CH

    更新日期:2011-06-01 00:00:00

  • Current status of PD-1/PD-L1 blockade immunotherapy in breast cancer.

    abstract::Over the past 10 years, immunotherapy with immune checkpoint inhibitors has revolutionized the management of various cancers. However, immunotherapy in breast cancer has not been successful. Breast cancer has long been recognized as an immunologically 'cold' tumor, although a higher frequency of tumor-infiltrating lym...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa230

    authors: Noguchi E,Shien T,Iwata H

    更新日期:2020-12-15 00:00:00