Current status of PD-1/PD-L1 blockade immunotherapy in breast cancer.

abstract：BACKGROUND:There is at present no consensus on the policy for the treatment of patients with low-grade gliomas (LGGs). METHODS:This report is a retrospective multi-institutional study of 100 patients (ages 16-65 years) with astrocytoma (grade II), oligodendroglioma, anaplastic oligodendroglioma and anaplastic oligoast...

journal_title：Japanese journal of clinical oncology

authors： Sakata K,Hareyama M,Komae T,Shirato H,Watanabe O,Watarai J,Takai K,Yamada S,Tsuchida E,Sakai K

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:It has been reported that prognosis is less favorable in poorly (G3) differentiated endometrioid adenocarcinoma than in well (G1) or moderately (G2) differentiated endometrioid adenocarcinoma. The goal of this study is therefore to analyze the prognosis of G3 endometrioid adenocarcinoma and various factors t...

journal_title：Japanese journal of clinical oncology

authors： Kuwabara Y,Susumu N,Banno K,Hirao T,Kawaguchi M,Yamagami W,Suzuki N,Aoki D,Nozawa S

更新日期：2005-01-01 00:00:00

abstract：:Human lymphoblastoid interferon-alpha was administered intramuscularly at a dose of 5 x 10(6) units/day to 20 metastatic renal cell carcinoma patients. For potentiating the antitumor effect of interferon, cimetidine was also given to them orally at a dose of 800 mg/day. The combination therapy obtained a complete resp...

journal_title：Japanese journal of clinical oncology

authors： Kotake T,Kinouchi T,Saiki S,Kuroda M,Miki T,Kiyohara H,Usami M

更新日期：1991-02-01 00:00:00

abstract：:The techniques of aseptic procedures in the laminar airflow room (LAF) were evaluated in 110 adult patients undergoing antileukemic chemotherapy for remission induction. The patients were divided into three groups according to the regimens: Group A, consisting of 20 patients who stayed in the LAF and received the gown...

journal_title：Japanese journal of clinical oncology

authors： Takeo H,Sakurai T,Amaki I

更新日期：1983-01-01 00:00:00

abstract：Background:Many patients with colorectal cancer are elderly with competing comorbidities. When constructing nomogram for assessing survival, we should consider the influence of competing risk. A competing-risks nomogram was developed to estimate the probability of death due to colorectal cancer for patients after curat...

journal_title：Japanese journal of clinical oncology

authors： Li J,Li X,Gu J,Ma X,Xue F

更新日期：2018-12-01 00:00:00

abstract：:Many psychosocial factors have been reported to influence the duration of survival of breast cancer patients. We have studied how family members, hobbies and habits of the patients may alter their psychosocial status. Female patients with surgically treated breast cancer diagnosed between 1986 and 1995 at the Tochigi ...

journal_title：Japanese journal of clinical oncology

authors： Tominaga K,Andow J,Koyama Y,Numao S,Kurokawa E,Ojima M,Nagai M

更新日期：1998-01-01 00:00:00

abstract：:In the present nationwide survey, 1,040 new cases of lymphoid malignancy, in most of which expression of cell surface markers had been determined, and 243 controls for a case-control study on adult T-cell leukemia/lymphoma (ATL) and other types of lymphoid malignancies were enrolled during the two years (1982-84) from...

journal_title：Japanese journal of clinical oncology

authors：

更新日期：1985-09-01 00:00:00

abstract：:Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-type lymphoma) is a rare thymic tumor, with only seven previous cases described worldwide to date. We describe the only case to have presented with pulmonary amyloid nodules. A 63-year-old Japanese female was found to have an anterior mediastinal tum...

journal_title：Japanese journal of clinical oncology

authors： Moriyama E,Yokose T,Kodama T,Matsuno Y,Hojo F,Takahashi K,Nagai K,Nishiwaki Y,Ochiai A

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the correlations between the changes in the quality-of-life scores and the dose-volume histogram parameters in patients receiving high-dose-rate brachytherapy combined with hypofractionated external beam radiation therapy for localized prostate cancer. METHODS:Among the patients who were treated ...

journal_title：Japanese journal of clinical oncology

authors： Hashimoto Y,Akimoto T,Iizuka J,Tanabe K,Mitsuhashi N

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To report the results of radiotherapy for patients with failure, adverse reactions or relative contraindications to the use of steroids or immunosuppressants, by using newly developed quantitative indexes. METHODS:Fourteen female and six male patients with Graves' ophthalmopathy were treated with radiothera...

journal_title：Japanese journal of clinical oncology

authors： Sakata K,Hareyama M,Oouchi A,Shidou M,Nagakura H,Morita K,Osanai H,Ohtsuka K,Hinoda Y

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVES:Perinephric fat invasion (PFI) of renal cell carcinoma (RCC) is known to be associated with adverse pathological features and poor prognosis. We analyzed these associations using a sub-group of the RCC registry of The Cancer Registration Committee of the Japanese Urological Association. METHODS:The study co...

journal_title：Japanese journal of clinical oncology

authors： Kume H,Homma Y,Shinohara N,Obara W,Kondo T,Kimura G,Fujimoto H,Nonomura N,Hongo F,Sugiyama T,Takahashi M,Kanayama HO,Fukumori T,Eto M

更新日期：2019-08-01 00:00:00

abstract：:Morphometrical analysis was performed on cells of bladder carcinomas taken from patients who had undergone surgery at the National Cancer Center Hospital. Ten cases each of the following groups were compared as to the nuclear area, standard deviation of nuclear areas, cytoplasmic area, and nuclear/cytoplasmic ratio: n...

journal_title：Japanese journal of clinical oncology

authors： Hanai S,Kishi K,Watanabe S,Shimosato Y

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:The majority of patients with localized and some cases of locally advanced prostate cancer undergo radical prostatectomy. However, radical prostatectomy cannot always be selected for those patients. In this situation, primary hormone therapy is an alternative treatment option. We have designed a prospective ...

journal_title：Japanese journal of clinical oncology

authors： Akaza H,Homma Y,Okada K,Yokoyama M,Moriyama N,Usami M,Hirao Y,Tsushima T,Ohashi Y,Aso Y

更新日期：2000-03-01 00:00:00

abstract：:Sixty-six patients with carcinoma of the hypopharynx or cervical esophagus received esophageal extraction and primary reconstruction. The methods of reconstruction were free forearm skin tube grafting, free jejunal transplantation and immediate pharyngo-gastrostomy after pull-through esophagectomy. Considering the pos...

journal_title：Japanese journal of clinical oncology

authors： Kato H,Watanabe H,Iizuka T,Ebihara S,Ono I,Terui S,Harii K

更新日期：1987-09-01 00:00:00

abstract：Background:Advanced gastric cancer (AGC) and systemic chemotherapy are some of the risk factors for venous thromboembolism (VTE). However, the cumulative incidence, risk factors and prognostic impact of VTE have not been evaluated in Japanese patients with AGC. Methods:This retrospective study included patients who re...

journal_title：Japanese journal of clinical oncology

authors： Arai H,Hironaka S,Minashi K,Denda T,Shimokawa M,Yamaguchi T

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Benefits of chemotherapy have generally been modest in gastric cancer, although those regimens developed more recently have produced higher response rates. Paclitaxel plus cisplatin is one such regimen and divided administration of paclitaxel has been suggested to be associated with lower neurological and he...

journal_title：Japanese journal of clinical oncology

authors： Kim YH,Yamaguchi K,Bang YJ,Takiuchi H,Kang WK,Sato A,Kang YK,Sakamoto J,Abe C,Sakata Y

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Although radiotherapy in combination with endocrinal manipulation has been identified as an effective treatment for patients with high-risk prostate cancer, the optimal dose for locoregional control of prostate cancer in combination with hormonal therapy has not yet been determined. METHODS:The efficacy of ...

journal_title：Japanese journal of clinical oncology

authors： Sasaki T,Nakamura K,Shioyama Y,Ohga S,Urashima Y,Terashima H,Koga H,Naito S,Noma H,Komatsu K,Yamaguchi A,Honda H

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Triplet antiemetic therapy with neurokinin 1 receptor blocker, 5-hydroxytryptamine receptor blocker and steroids is commonly used in patients who are highly emetic after chemotherapy. However, an alternative antiemetic therapy for patients who are resistant to triplet antiemetic therapy is not established. Ol...

journal_title：Japanese journal of clinical oncology

authors： Sato J,Kashiwaba M,Komatsu H,Ishida K,Nihei S,Kudo K

更新日期：2016-05-01 00:00:00

abstract：:Cases of hyperfractionated radiotherapy and adjuvant chemotherapy for nasopharyngeal cancer are reported. Seven patients received hyperfractionated radiotherapy (76.8-81.6 Gy/64-68 fractions to primary tumor) and two cycles of cisplatin (80 mg/m2 i.v. on day 1) plus 5-FU (800 mg/m2 continuous infusion on days 2-6). Mu...

journal_title：Japanese journal of clinical oncology

authors： Toita T,Ogawa K,Kamata M,Kojya S,Itokazu T,Kakinohana Y,Iraha S,Yoshinaga M,Zukeran Y,Sawada S

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:We investigated the expression of PyNPase both in cancer cells and in stroma cells to clarify the correlation between PyNPase expression and the prognosis of patients with colorectal cancer. METHODS:Using immunohistochemical staining with an anti-PyNPase antibody, the PyNPase expression in tissues from 114 ...

journal_title：Japanese journal of clinical oncology

authors： Osanai T,Ichikawa W,Takagi Y,Uetake H,Nihei Z,Sugihara K

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Docetaxel plus cisplatin (DP) is a combination chemotherapy regimen that is active against untreated advanced gastric cancer. We evaluated the feasibility of DP treatment in patients with recurring or metastatic gastric cancer who had been previously treated with other chemotherapy regimens. PATIENTS AND ME...

journal_title：Japanese journal of clinical oncology

authors： Kim H,Park JH,Bang SJ,Kim DH,Cho HR,Kim GY,Min YJ

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the prognostic importance of the sequencing of radiation therapy and chemotherapy after mastectomy in high-risk premenopausal women with breast cancer in addition to other known prognostic factors in the literature. METHODS:In this retrospective study, 176 premenopau...

journal_title：Japanese journal of clinical oncology

authors： Cakir S,Gursel B,Meydan D,Yildiz L

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:The study objective was to evaluate the efficacy and toxicity of chemoradiotherapy with 5-fluorouracil (5-FU) plus cisplatin in patients with Stage I esophageal squamous cell carcinoma (ESCC). The primary endpoint was proportion of complete response (%CR). METHODS:Patients with Stage I (T1N0M0) ESCC, aged 20...

journal_title：Japanese journal of clinical oncology

authors： Kato H,Sato A,Fukuda H,Kagami Y,Udagawa H,Togo A,Ando N,Tanaka O,Shinoda M,Yamana H,Ishikura S

更新日期：2009-10-01 00:00:00

abstract：:The prognosis of multiple myeloma was quite poor in the last century, but it has significantly improved with the incorporation of novel agents, immunomodulatory drugs (IMiDs) and proteasome inhibitors. Thalidomide was first developed as a sedative in 1950s, but it was withdrawn from the market because of teratogenicit...

journal_title：Japanese journal of clinical oncology

authors： Abe Y,Ishida T

更新日期：2019-08-01 00:00:00

abstract：:Hepatobiliary and pancreatic cancers have poor outcomes. Clinical staging is useful for predicting survival and selecting treatment options. The 8th edition of tumor-node metastasis (TNM) was published in 2016 and came into effect from 2018. Regarding liver cancer (hepatocellular carcinoma), tumour size and vascular i...

journal_title：Japanese journal of clinical oncology

authors： Ueno M,Morizane C,Ikeda M,Okusaka T,Ishii H,Furuse J

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:No risk factor has been confirmed for para-aortic lymph node (PAN) metastasis from gastric cancer. To identify the risk factors and the most frequent route of metastasis to PAN, we analyzed the prospective data from a phase III trial. METHODS:In JCOG9501 comparing D2 and D2 + PAN dissection, 260 patients wi...

journal_title：Japanese journal of clinical oncology

authors： Nomura E,Sasako M,Yamamoto S,Sano T,Tsujinaka T,Kinoshita T,Furukawa H,Shimizu T,Hiratsuka M,Kobayashi O,Kurokawa Y,Tanigawa N,Gastric Cancer Surgical Study Group of the Japan Clinical Oncology Group.

更新日期：2007-06-01 00:00:00

abstract：:We found deletions of both alleles of the retinoblastoma gene (Rb) and the candidate Wilms' tumor gene (WT33) in a surgically resected human insulinoma by blot hybridization. Rearrangement of Krev-1, a transformation suppressor gene, was also detected in this case. The clinical and histological findings suggested that...

journal_title：Japanese journal of clinical oncology

authors： Iwamura Y,Futagawa T,Kaneko M,Nakagawa K,Kawai K,Yamashita K,Nakamura T,Hayashi H

更新日期：1992-02-01 00:00:00

abstract：:Alendronate, a bisphosphonate compound, lowers serum calcium in patients with cancer-associated hypercalcemia through its inhibitory effect on bone resorption and as a result symptoms associated with hypercalcemia improve. This study was carried out to investigate the effects of alendronate in patients with hypercalce...

journal_title：Japanese journal of clinical oncology

authors： Ohnishi T,Takeda E,Yogita S,Miyake H,Kinoshita T,Terashima Y,Matsumoto T,Tashiro S

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Although adjuvant analgesics are used to treat opioid-refractory cancer pain, there is insufficient evidence to support this practice and limited data to guide the choice depending on cancer pain pathophysiology, dose titration and starting dose. This survey aimed to clarify the current use of adjuvant analg...

journal_title：Japanese journal of clinical oncology

authors： Tagami K,Matsuoka H,Ariyoshi K,Oyamada S,Hiratsuka Y,Kizawa Y,Koyama A,Inoue A

更新日期：2020-12-16 00:00:00

abstract：OBJECTIVE:A Phase I/II study of S-1 combined radiation therapy was conducted in patients with Stage II (T2N0) glottic cancer. The purpose of the Phase I study was to identify the maximum tolerated dose, the recommended dose and the dose limiting toxicity. The objectives in the phase II study were to estimate the local ...

journal_title：Japanese journal of clinical oncology

authors： Nakayama M,Hayakawa K,Okamoto M,Niibe Y,Ishiyama H,Kotani S

更新日期：2010-10-01 00:00:00