Abstract:
Background:Many patients with colorectal cancer are elderly with competing comorbidities. When constructing nomogram for assessing survival, we should consider the influence of competing risk. A competing-risks nomogram was developed to estimate the probability of death due to colorectal cancer for patients after curative surgery. Methods:A total of 2442 patients with non-metastatic colorectal cancer were included to develop competing-risks nomogram. Competing-risks nomogram were established based on the results of Fine and Gray competing-risks proportional hazards model. To maximize the accuracy of prediction, model selection was not carried out, and non-linear continuous variables were flexibly modeled with restricted cubic splines. The nomogram was internal-validated by bootstrapping, and externally validated with a separate database of 299 patients from The Cancer Genome Atlas. The performance of this model was assessed by concordance index and a calibration curve. Results:There were 332 patients died of colorectal cancer and 46 died of other causes during the follow-up period. Age, T stage, N stage, histological type, tumor location, adjuvant chemotherapy, preoperative carcinoembryonic antigen, lymph vascular invasion, lymph node ratio and sample lymph nodes were integrated into competing-risks nomogram. The competing-risks nomogram for predicting probability of death due to colorectal cancer with a concordance index of 0.768, ameliorating the stratification provided by the seventh edition tumor-node-metastasis staging system of the American Joint Committee on Cancer (AJCC). The concordance index for validation dataset was 0.783. Conclusion:We developed and externally validated a competing-risks nomogram for Chinese Han patients with non-metastatic colorectal cancer, which could provide probability of death from colorectal cancer in the presence of competing risks.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Li J,Li X,Gu J,Ma X,Xue Fdoi
10.1093/jjco/hyy136subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1088-1095issue
12eissn
0368-2811issn
1465-3621pii
5106900journal_volume
48pub_type
杂志文章abstract:Backgrounds:Stereotactic ablative radiotherapy (SABR) is one of the newly developed innovative radiotherapy and of which optimal dose prescription needs to be standardized. We aimed to investigate the dose-response relationship for patients with SABR. Methods:Fifty-three patients with Stage I non-small cell lung cance...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx172
更新日期:2018-02-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyi106
更新日期:2005-07-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyn100
更新日期:2008-11-01 00:00:00
abstract::Most terminally ill cancer patients in our hospice ward are referred from hospitals for anticancer treatment. For identical terminally ill cancer patients referred from other hospitals, differences in the accuracy and characteristics of the prognostic prediction of survival by oncologists and palliative care physician...
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更新日期:2018-07-01 00:00:00
abstract::Chemoradiation is potentially curative for esophageal cancer in various stages, but local failure is a major problem. The present case was a 49-year-old male diagnosed with advanced esophageal cancer with an esophago-bronchial fistula and lymph node metastasis. Histological diagnosis by biopsy was adenosquamous cell c...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
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doi:
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更新日期:2003-09-01 00:00:00
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更新日期:2013-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym032
更新日期:2007-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyaa162
更新日期:2021-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyw016
更新日期:2016-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyq227
更新日期:2011-02-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/28.3.182
更新日期:1998-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyw087
更新日期:2016-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu096
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/jjco/hyn061
更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/jjco/hym135
更新日期:2008-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hye113
更新日期:2001-11-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2011-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr030
更新日期:2011-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/28.1.36
更新日期:1998-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyh079
更新日期:2004-08-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2020-05-05 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyd072
更新日期:2000-06-01 00:00:00