Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.

Abstract:

BACKGROUND:In a tumor, increased deubiquitination of cyclins by a protein gene product gene, PGP9.5, could contribute to the uncontrolled growth of somatic cells that is a hallmark of cancer. We hypothesized that PGP9.5 may be expressed in tumors of patients with non-small cell lung cancer (NSCLC). METHODS:Expression of PGP9.5 messenger RNA was evaluated by reverse transcription polymerase chain reaction (RT-PCR) in 95 non-small cell lung carcinomas and adjacent histological normal lung samples. The data were analyzed with reference to clinicopathological factors. RESULTS:PGP9.5 transcripts were detected in 18 (12.8%) of the tumor samples, although some of paired normal lung samples showed very weak expression. There was no relationship between PGP9.5 gene expression and age, gender, N-status or pathological subtype. PGP9.5 gene was preferentially expressed in T3/T4 NSCLC (12/41, 29.3%) compared with T1/T2 NSCLC (6/54, 11.1%) (p = 0.0482). CONCLUSIONS:Although the PGP9.5 gene was not expressed in a majority of NSCLC tumors, we suggest that PGP9.5 may correlate with tumor invasion or progression of NSCLC.

journal_name

Jpn J Clin Oncol

authors

Sasaki H,Yukiue H,Moriyama S,Kobayashi Y,Nakashima Y,Kaji M,Fukai I,Kiriyama M,Yamakawa Y,Fujii Y

doi

10.1093/jjco/hye113

keywords:

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

532-5

issue

11

eissn

0368-2811

issn

1465-3621

journal_volume

31

pub_type

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