Abstract:
:Advanced esophageal cancer patients with extensive lymph node metastases show extremely poor prognosis and the long-term outcome is poorer with the involvement of more lymph nodes. We report here a long-surviving case of advanced esophageal cancer with histologically 34 lymph node metastases, in which surgical resection with three-field lymphadenectomy followed by adjuvant chemotherapy and radiotherapy was performed. A 53-year-old male was diagnosed as advanced middle esophageal cancer with multiple regional lymph node metastases such as paraesophageal, pretracheal, tracheobronchial and bifurcational lymph nodes and three intramural metastatic lesions. Subtotal esophagectomy with three-field lymphadenectomy was performed for the tumor. Histopathologically, the tumor was poorly differentiated squamous cell carcinoma and 34 lymph nodes including ligamentum arteriosum lymph nodes and pretracheal lymph nodes were proved to be metastatic. Numerous tumor cells were found in the lymphatic vessels near the metastatic lymph nodes. Chemotherapy [3000 mg of 5-fluorouracil (5-FU), 50 mg of cisplatin (CDDP) and 30 mg of methotrexate (MTX)] was administered in two courses, followed by radiation therapy (field size 21 x 20 cm in mediastinum, 10 MV X-rays, 2 Gy/fr, 5 fr/week, total 46 Gy). Subsequently, 1000 mg of 5-FU and 200 mg of CDDP were administered every 3-4 months without any significant toxicities. The patient has been alive and well without recurrence for 5 years following operation. For treatment of advanced esophageal cancer with extensive lymph node metastases, a wide resection of the tumor and regional lymph nodes should be performed, followed by adjuvant chemotherapy and radiotherapy.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Shigemitsu K,Naomoto Y,Shirakawa Y,Haisa M,Gunduz M,Tanaka Ndoi
10.1093/jjco/hyf067keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
310-4issue
8eissn
0368-2811issn
1465-3621journal_volume
32pub_type
杂志文章abstract:BACKGROUND:To describe computed tomographic (CT) features of highly enhanced hepatic masses as seen on CT during arterial portography (CTAP) and to survey the varieties of hepatic lesions associated with such findings. METHODS:CTAP files for 400 patients were reviewed, on the basis of which six patients with highly en...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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pub_type: 临床试验,杂志文章
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更新日期:1999-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
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更新日期:2001-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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doi:10.1093/jjco/hyw016
更新日期:2016-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/29.7.349
更新日期:1999-07-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
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