当前位置： SCI文献检索 > JAPANESE JOURNAL OF CLINICAL ONCOLOGY期刊下所有文献 > Serum total bilirubin as a predictive factor for severe neutropenia in lung cancer patients treated with cisplatin and irinotecan.

Serum total bilirubin as a predictive factor for severe neutropenia in lung cancer patients treated with cisplatin and irinotecan.

Abstract：

OBJECTIVE:To clarify the association between pre-treatment total bilirubin (PTB) level and severe toxicity in patients receiving cisplatin and irinotecan. METHODS:We analyzed retrospectively the relationships of grade 4 neutropenia or grade 3-4 diarrhea and clinical variables including PTB and pre-treatment neutrophil counts (PNC) using a logistic regression model. RESULTS:One hundred and twenty-seven patients (93 men, 34 women; median age: 61 years; range: 24-74 years) received cisplatin (60 or 80 mg/m2) on day 1 and irinotecan (60 mg/m2) on days 1 and 8 every 3 weeks or on days 1, 8 and 15 every 4 weeks. Grade 4 neutropenia occurred in 29 patients (23%) and grade 3-4 diarrhea occurred in 13 patients (10%). Grade 4 neutropenia was associated with a higher PTB level (odds ratio: 4.9; 95% confidence interval: 1.4-17.7), a higher cisplatin dose (2.8, 1.0-7.8) and a lower PNC (1.5, 1.0-2.3). Grade 3-4 diarrhea was associated with liver metastasis (11.2, 2.2-57.4), a higher cisplatin dose (5.0, 1.2-21.3) and a lower PNC (2.0, 1.1-3.6). CONCLUSIONS:PTB level was associated with the severity of neutropenia caused by cisplatin and irinotecan.

journal_name

Jpn J Clin Oncol

journal_title

Japanese journal of clinical oncology

authors

Fujiwara Y,Sekine I,Ohe Y,Kunitoh H,Yamamoto N,Nokihara H,Simmyo Y,Fukui T,Yamada K,Tamura T

doi

10.1093/jjco/hym033

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

358-64

issue

5

eissn

0368-2811

issn

1465-3621

pii

hym033

journal_volume

37

pub_type

杂志文章

相关文献

JAPANESE JOURNAL OF CLINICAL ONCOLOGY文献大全
  • The current clinical use of adjuvant analgesics for refractory cancer pain in Japan: a nationwide cross-sectional survey.

    abstract：BACKGROUND:Although adjuvant analgesics are used to treat opioid-refractory cancer pain, there is insufficient evidence to support this practice and limited data to guide the choice depending on cancer pain pathophysiology, dose titration and starting dose. This survey aimed to clarify the current use of adjuvant analg...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyaa147

    authors： Tagami K,Matsuoka H,Ariyoshi K,Oyamada S,Hiratsuka Y,Kizawa Y,Koyama A,Inoue A

    更新日期：2020-12-16 00:00:00

  • A computer-assisted model for predicting probability of dying within 7 days of hospice admission in patients with terminal cancer.

    abstract：OBJECTIVE:The aim of the present study is to compare the accuracy in using laboratory data or clinical factors, or both, in predicting probability of dying within 7 days of hospice admission in terminal cancer patients. METHODS:We conducted a prospective cohort study of 727 patients with terminal cancer. Three models ...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyp188

    authors： Chiang JK,Cheng YH,Koo M,Kao YH,Chen CY

    更新日期：2010-05-01 00:00:00

  • A case report of adenocarcinoma of the lung in which a partial response was achieved by carboplatin.

    abstract：:A 56-year-old housewife was incidentally discovered to have an abnormal shadow in the right B6 area upon a chest X-ray film being taken. A transcutaneous lung biopsy of the mass revealed adenocarcinoma of the lung (WHO classification). A brain computed tomography (CT) scan demonstrated multiple brain metastasis. Follo...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：

    authors： Akiba T,Saijo N,Miyamoto K,Taguchi J,Taito H,Sakurai M,Tamura T,Sasaki Y,Eguchi K,Shinkai T

    更新日期：1987-06-01 00:00:00

  • Adenocarcinoma and concomitant intraductal papillary adenoma in the pancreas.

    abstract：:A 72-year-old man was found to have a 12 mm solid lesion in the pancreatic tail and an 8 mm cystic lesion in the body of the pancreas by computed tomography carried out during a routine follow-up study of his adult-onset diabetes mellitus. A distal pancreatectomy was performed revealing the pancreas to have an adenoca...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：

    authors： Yoshida J,Ozaki H,Yamamoto J,Kosuge T,Takayasu K,Muramatsu Y,Mukai K

    更新日期：1991-12-01 00:00:00

  • A pooled analysis of primary hepatic angiosarcoma.

    abstract：BACKGROUND:Angiosarcoma is an aggressive and malignant neoplasm. Primary hepatic angiosarcoma is extremely rare and accounts for only approximately 5% of all angiosarcomas. Therefore, many doctors do not know enough about this disease; this lack of knowledge motivated us to perform this study. METHODS:We carried out a...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyaa017

    authors： Zeng D,Cheng J,Gong Z,Chen J,Long H,Zhu B

    更新日期：2020-05-05 00:00:00

  • Thymic epithelial tumor treatment in Japan: analysis of hospital cancer registry and insurance claims data, 2012-2014.

    abstract：INTRODUCTION:Thymic epithelial tumors are a rare type of neoplasm. Accordingly, it is difficult to perform phase III trials in patients with thymic epithelial tumors, and thus, no standard treatment has been established for these tumors. In this study, we aimed to investigate the current status of thymic epithelial tum...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyz167

    authors： Kanemura H,Tamura T,Nishimura N,Kobayashi D,Higashi T

    更新日期：2020-03-09 00:00:00

  • Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.

    abstract：:K-ras mutation is the most common oncogenic alteration in various human cancers including colorectal carcinomas. Point mutations have the potential to activate the K-ras gene if they occur in the critical coding sequences. Almost all of these mutations have been localized in codons 12, 13 and 61. We report a case of c...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyf043

    authors： Miyakura Y,Sugano K,Fukayama N,Konishi F,Nagai H

    更新日期：2002-06-01 00:00:00

  • The prognostic signature of the somatic mutations in Ewing sarcoma: from a network view.

    abstract：BACKGROUND:Ewing sarcoma is a malignant bone tumor mainly affecting teenagers and young adults. Its main driver mutation, the EWS-FLI1 fusion gene, has been identified more than 20 years ago, whereas its other somatic mutations have been just recently reported. METHODS:In this study, we organized the somatic mutations...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyz037

    authors： Zhang Y,Song J,Shi Q,Song X,Shen L,Zhou J,Shao J

    更新日期：2019-07-01 00:00:00

  • Detecting circulating cancer cells using reverse transcriptase-polymerase chain reaction for cytokeratin mRNA in peripheral blood from patients with gastric cancer.

    abstract：BACKGROUND:Cytokeratins (CKs) 19 and 20 have been used as targets for detecting cancer cells. We attempted to detect circulating cancer cells in patients with gastric cancer using a high-sensitivity reverse transcriptase-polymerase chain reaction (RT-PCR) assay for CK transcripts. METHODS:RT-PCR for CK 19 and CK 20 wa...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyd130

    authors： Majima T,Ichikura T,Takayama E,Chochi K,Mochizuki H

    更新日期：2000-11-01 00:00:00

  • Prognosis for resected lung cancer patients with tumors greater than ten centimeters in diameter.

    abstract：:During the period 1962-1986, 43 lung cancer patients, 2.3% of the 1,832 patients who underwent pulmonary resections at the National Cancer Center Hospital, Tokyo, had tumors greater than 10 cm in diameter. These 43 cancers were classified postsurgically according to the 1987 guidelines for TNM classification of malign...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：

    authors： Sano T,Naruke T,Kondo H,Goya T,Tsuchiya R,Suemasu K

    更新日期：1990-12-01 00:00:00

  • The sequencing of radiation therapy and chemotherapy after mastectomy in premenopausal women with breast cancer.

    abstract：OBJECTIVE:The purpose of this study was to evaluate the prognostic importance of the sequencing of radiation therapy and chemotherapy after mastectomy in high-risk premenopausal women with breast cancer in addition to other known prognostic factors in the literature. METHODS:In this retrospective study, 176 premenopau...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyg102

    authors： Cakir S,Gursel B,Meydan D,Yildiz L

    更新日期：2003-11-01 00:00:00

  • Multiple (multicentric and multifocal) cancers in the ipsilateral breast with different histologies: profiles of chromosomal numerical abnormality.

    abstract：BACKGROUND:Chromosomal numerical abnormality (CNA) is a characteristic of breast cancer as with other common solid cancers. Multiple mammary carcinomas are also sometimes encountered in the ipsilateral breast. Deciding whether they are multicentric (arising independently) or multifocal (of the same origin) has been a c...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyg089

    authors： Nakamura R,Song JP,Isogaki J,Kitayama Y,Sugimura H

    更新日期：2003-09-01 00:00:00

  • Docetaxel followed by fluorouracil/epirubicin/cyclophosphamide as neoadjuvant chemotherapy for patients with primary breast cancer.

    abstract：OBJECTIVE:This multicenter, open-label, single-arm, Phase II study assessed the efficacy of a neoadjuvant chemotherapy with docetaxel (75 mg/m(2) q3w) followed by 5-fluorouracil 500 mg/m(2), epirubicin 100 mg/m(2) and cyclophosphamide 500 mg/m(2) q3w in patients with early-stage breast cancer. METHODS:Women with resec...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1093/jjco/hyr081

    authors： Iwata H,Sato N,Masuda N,Nakamura S,Yamamoto N,Kuroi K,Kurosumi M,Tsuda H,Akiyama F,Ohashi Y,Toi M

    更新日期：2011-07-01 00:00:00

  • Chronological observation of epidemiological characteristics of lung cancer in Taiwan with etiological consideration--a 30-year consecutive study.

    abstract：:In order to determine whether the epidemiological characteristics of lung cancer have changed within a certain period of time in Taiwan and to propose some causative factors for its rapid rate of increase we performed chronological and epidemiological studies based on the analysis of: (1) available vital statistics an...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：

    authors： Yang SP,Luh KT,Kuo SH,Lin CC

    更新日期：1984-03-01 00:00:00

  • The first case of primary testicular germ cell tumor containing nephroblastoma as the only one non-germ cell component.

    abstract：:Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is ve...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyr080

    authors： Keskin S,Ekenel M,Başaran M,Aksu C,Kiliçaslan I,Tunç M,Bavbek S

    更新日期：2011-08-01 00:00:00

  • BUBR1 overexpression predicts disease-specific survival after nephroureterectomy in patients with upper tract urothelial carcinoma.

    abstract：OBJECTIVE:To date, there are few reliable markers to distinguish tumors with aggressive characteristics in upper tract urothelial carcinoma. The purpose of this study was to identify a biomarker related to genetic instability (chromosomal instability or microsatellite instability) with prognostic value, in patients wit...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyw060

    authors： Yamamoto Y,Oga A,Akao J,Misumi T,Fuji N,Kobayashi K,Kawai Y,Inoue R,Hirata H,Matsumoto H,Nagao K,Sakano S,Matsuyama H

    更新日期：2016-08-01 00:00:00

  • Vessel-contouring-based pelvic radiotherapy in patients with uterine cervical cancer.

    abstract：OBJECTIVE:The aim of this study was to assess clinically the adequacy of vessel-contouring-based pelvic radiotherapy with regard to nodal coverage for uterine cervical cancer. METHODS:Fifty patients with Stages I-III cervical cancer, treated with vessel-contouring-based three-dimensional radiotherapy since August 2002...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyp029

    authors： Uno T,Isobe K,Ueno N,Kobayashi H,Sanayama Y,Mitsuhashi A,Shozu M,Ito H

    更新日期：2009-06-01 00:00:00

  • A review of changes to and clinical implications of the eighth TNM classification of hepatobiliary and pancreatic cancers.

    abstract：:Hepatobiliary and pancreatic cancers have poor outcomes. Clinical staging is useful for predicting survival and selecting treatment options. The 8th edition of tumor-node metastasis (TNM) was published in 2016 and came into effect from 2018. Regarding liver cancer (hepatocellular carcinoma), tumour size and vascular i...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1093/jjco/hyz150

    authors： Ueno M,Morizane C,Ikeda M,Okusaka T,Ishii H,Furuse J

    更新日期：2019-12-27 00:00:00

  • The cell cycle profile test is a prognostic indicator for breast cancer patients treated with postoperative 5-fluorouracil-based chemotherapy.

    abstract：OBJECTIVE:The cell cycle profile test is suggested to be an independent prognostic indicator for breast cancer patients. To further clarify the prognostic value, we applied this to breast cancer patients treated with postoperative 5-fluorouracil-based chemotherapy. METHODS:A total of 153 breast cancer patients, who we...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyr042

    authors： Kurebayashi J,Kanomata N,Kozuka Y,Moriya T,Kikukawa N,Kawasaki Y,Harada S,Tamura S,Nakayama S,Ishihara H,Noguchi S,Sonoo H

    更新日期：2011-06-01 00:00:00

  • Genetic alterations of androgen receptor gene in Japanese human prostate cancer.

    abstract：:In order to determine the significance of androgen receptor (AR) gene mutations for Japanese prostate cancers, we examined the entire coding region, from exon A to H, in 36 primary lesions. Five in stage A, 12 in stage B, six in stage C and 13 in stage D were subjected to PCR-SSCP analysis for genomic DNA and nucleoti...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/27.6.389

    authors： Watanabe M,Ushijima T,Shiraishi T,Yatani R,Shimazaki J,Kotake T,Sugimura T,Nagao M

    更新日期：1997-12-01 00:00:00

  • Inflammatory pseudotumor of the spleen: a case report.

    abstract：:We report on an inflammatory pseudotumor of the spleen. A 72-year-old woman visited our hospital complaining of nausea. Physical examination and laboratory investigations were unremarkable. Ultrasonography, computed tomography, magnetic resonance imaging and angiography showed a hypovascular splenic mass measuring abo...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyd048

    authors： Noguchi H,Kondo H,Kondo M,Shiraiwa M,Monobe Y

    更新日期：2000-04-01 00:00:00

  • A phase 2 study of abiraterone acetate in Japanese men with metastatic castration-resistant prostate cancer who had received docetaxel-based chemotherapy.

    abstract：OBJECTIVE:In this Phase 2 multicenter study the efficacy and safety of oral abiraterone acetate (1000 mg/once daily) plus prednisolone (5 mg/twice daily) was evaluated in metastatic castration-resistant prostate cancer patients from Japan who had previously received docetaxel-based chemotherapy. METHODS:Men (aged ≥20 ...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1093/jjco/hyu148

    authors： Satoh T,Uemura H,Tanabe K,Nishiyama T,Terai A,Yokomizo A,Nakatani T,Imanaka K,Ozono S,Akaza H

    更新日期：2014-12-01 00:00:00

  • Efficacy of reduced dose of pegfilgrastim in Japanese breast cancer patients receiving dose-dense doxorubicin and cyclophosphamide therapy.

    abstract：BACKGROUND:This retrospective study aimed to evaluate the efficacy of a 3.6-mg dose of pegfilgrastim for primary prophylaxis in Japanese breast cancer patients receiving dose-dense chemotherapy. METHODS:Patients treated with adjuvant or neoadjuvant chemotherapy for early-stage breast cancer at the Tokyo-West Tokushuka...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyw152

    authors： Mizuno Y,Fuchikami H,Takeda N,Iwai M,Sato K

    更新日期：2017-01-01 00:00:00

  • A case of adenocarcinoma of the lung which was successfully treated by chemotherapy with patient survival without recurrence for more than three years.

    abstract：:A 63-year-old man was admitted to the National Cancer Center Hospital on December 20, 1983 for a close examination of the abnormal shadows found in chest roentgenograms. Chest radiographs showed a massive right pleural effusion, a large tumor in the right hilar region and swelling of the left hilar nodes. Transcutaneo...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：

    authors： Akiba T,Saijo N,Miyamoto K,Sakurai M,Tamura T,Sasaki Y,Eguchi K,Shinkai T,Uei Y,Fujiwara Y

    更新日期：1987-06-01 00:00:00

  • Burden on oncologists when communicating the discontinuation of anticancer treatment.

    abstract：OBJECTIVE:Communicating the discontinuation of anticancer treatment to patients is a difficult task. The primary aim of this study was to clarify the level of oncologist-reported burden when communicating about discontinuation of an anticancer treatment. The secondary aims were (i) to identify the sources of burden con...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyr092

    authors： Otani H,Morita T,Esaki T,Ariyama H,Tsukasa K,Oshima A,Shiraisi K

    更新日期：2011-08-01 00:00:00

  • Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study.

    abstract：OBJECTIVE:After approval of bevacizumab in Japan, post-marketing surveillance studies reported on safety. However, few reports have shown the efficacy of bevacizumab as used in daily practice. We evaluated the efficacy and safety of bevacizumab for metastatic colorectal cancer patients in daily practice. METHODS:All u...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyr008

    authors： Sogabe S,Komatsu Y,Yuki S,Kusumi T,Hatanaka K,Nakamura M,Kato T,Miyagishima T,Hosokawa A,Iwanaga I,Sakata Y,Asaka M

    更新日期：2011-04-01 00:00:00

  • Prognostic factors and therapeutic options of radiotherapy in pediatric brain stem gliomas.

    abstract：BACKGROUND:A retrospective analysis was made to clarify the relationship between prognosis, radiation dose and survival of brain stem gliomas. METHODS:From 1983 to 1995, 22 children with brain stem tumors were treated by radiotherapy in the Veterans General Hospital-Taipei. Twelve patients had pathology proof and the ...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/28.8.474

    authors： Liu YM,Shiau CY,Wong TT,Wang LW,Wu LJ,Chi KH,Chen KY,Yen SH

    更新日期：1998-08-01 00:00:00

  • Primary pulmonary lymphoma: relationship between clinical features and pathologic findings in 24 cases. The Japan National Chest Hospital Study Group for Lung Cancer.

    abstract：:To elucidate the relationship between the clinical features and pathologic findings of primary pulmonary lymphoma, we reviewed 24 patients with this disease. The pulmonary lymphomas were divided into four groups: (1) B-cell lymphoma composed of small to medium-sized lymphoid cells (19 cases); (2) B-cell lymphoma compo...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Tamura A,Komatsu H,Yanai N,Homma J,Nagase A,Nemoto E,Hirai T,Hashizume T,Kawata K,Ishikawa S

    更新日期：1995-08-01 00:00:00

  • A randomized phase III study comparing continuation and discontinuation of PD-1 pathway inhibitors for patients with advanced non-small-cell lung cancer (JCOG1701, SAVE study).

    abstract：:The development of PD-1 pathway inhibitors has dramatically altered the treatment of advanced/recurrent non-small-cell lung cancer patients. However, the prognostic significance of their ongoing usage is controversial, especially for patients who have not progressed for a period of time. If discontinuation has no nega...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1093/jjco/hyaa054

    authors： Nomura S,Goto Y,Mizutani T,Kataoka T,Kawai S,Okuma Y,Murakami H,Tanaka K,Ohe Y

    更新日期：2020-07-09 00:00:00

  • Aggressiveness of cancer-care near the end-of-life in Korea.

    abstract：OBJECTIVE:The aim of this study was to examine the appropriateness of chemotherapy and care in Korean cancer patients near the end-of-life. METHODS:We designed a retrospective cohort composed of patients diagnosed as having metastatic cancer and who received palliative chemotherapy at Seoul National University Hospita...

    journal_title：Japanese journal of clinical oncology

    pub_type： 杂志文章

    doi：10.1093/jjco/hyn031

    authors： Keam B,Oh DY,Lee SH,Kim DW,Kim MR,Im SA,Kim TY,Bang YJ,Heo DS

    更新日期：2008-05-01 00:00:00