Abstract:
BACKGROUND:Ewing sarcoma is a malignant bone tumor mainly affecting teenagers and young adults. Its main driver mutation, the EWS-FLI1 fusion gene, has been identified more than 20 years ago, whereas its other somatic mutations have been just recently reported. METHODS:In this study, we organized the somatic mutations from 216 Ewing sarcoma cases into 216 individual protein-protein interaction networks by using interactome information. These mutation networks were then classified into five different clusters based on their structural similarities. The prognostic effect of mutation genes was evaluated according to their network features. RESULTS:The cases in cluster two exhibited remarkably high metastasis and mortality rates, and STAG2, TP53 and TTN were the three most significantly mutated genes in this cluster. Microarray data demonstrate that the expression of STAG2, TP53 and TTN are down-regulated in the EWS-FLI1-knockdown Ewing sarcoma cells. However, the mutation effect analysis shows that the somatic mutations in TTN are less damaging than those in STAG2 and TP53. The analyses of functional network modules further revealed that STAG2, TP53 and their interacting gene partners participate in the oncogenic-related biological modules such as cell cycle and regulation of transcription from RNA polymerase II promoter while TTN, TP53 and their interacting gene partners constitute the modules less relevant to oncogenesis. The results of Gene Ontology analyses demonstrated that the uniquely mutated genes associated with poor prognosis in Clusters 1, 4 and 5 were distinctively enriched in epidermal growth factor-related functions and phosphoproteins. CONCLUSIONS:Our study identified the highly lethal mutation combination cases and characterized the possible prognostic genes in Ewing sarcoma from a network perceptive.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Zhang Y,Song J,Shi Q,Song X,Shen L,Zhou J,Shao Jdoi
10.1093/jjco/hyz037subject
Has Abstractpub_date
2019-07-01 00:00:00pages
604-613issue
7eissn
0368-2811issn
1465-3621pii
5423808journal_volume
49pub_type
杂志文章abstract::Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69-year-old woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus. Histologically, small round-...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/27.6.437
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:The purpose of the present study is to verify the treatment effects of boron neutron capture therapy (BNCT) in ectopic tumors implanted in the thoracic cavity mimicking malignant pleural mesothelioma (MPM). METHODS:The tumor model was created by implanting murine squamous cell carcinoma cells into the thora...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym022
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:Suboptimal treatment of chemotherapy-induced nausea and vomiting and unsatisfactory response to antiemetic drugs cause impairment of cancer patient's daily functioning. This study was aimed to investigate the association of selected germline polymorphisms with ondansetron and metoclopramide response in Indone...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr117
更新日期:2011-10-01 00:00:00
abstract::Information of prefectural cancer incidence in Japan is an important resource to plan an effective regional cancer control program. In order to obtain accurate prefectural cancer incidence, we have to adjust for both of completeness of regional cancer registries and regional dispersion, simultaneously, Then, we develo...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyz033
更新日期:2019-05-01 00:00:00
abstract::Five cases of recurrent cervical carcinoma with sites of recurrence restricted to the pelvis were treated by intra-arterial infusion of oncostatics via the bilateral internal iliac arteries. One tip of the catheter was positioned in the internal iliac artery, proximal and close to the superior glutea artery, through t...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
abstract::A case of primary malignant lymphoma of the skull base is reported. A 62-year-old man was admitted with headache and diplopia. Computed tomography and magnetic resonance imaging showed an abnormal mass in the right parasellar region. The final diagnosis after surgery was primary malignant lymphoma of the skull base. P...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVE:There have been no previous studies about consultation of the bereaved who have lost a loved one to cancer and ask for medical help. The aim of this study was to investigate their basic characteristics and their psychiatric disorders. METHODS:A retrospective study using clinical and background data obtained ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyq213
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Emotional distress is considered to be higher in patients with head and neck cancer than other types of cancer. The present study aimed to identify predictors of the postoperative levels of depression in patients with head and neck cancer who have undergone surgery. METHODS:Postoperative levels of depression...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu002
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:To evaluate pathological complete response rate and to identify the predictor of response after primary systemic chemotherapy (PST) with weekly docetaxel and epirubicin for locally advanced breast cancer. METHODS:Sixty-three patients with locally advanced breast cancer received three cycles PST on day 1 and...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym172
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Elastography is a technique for detecting the stiffness of tissues. We applied elastography for the diagnosis of prostate cancer and evaluated the usefulness of elastography for prostate biopsy. METHODS:The subjects of this study were 311 patients who underwent elastography during prostate needle biopsy at H...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyp026
更新日期:2009-06-01 00:00:00
abstract::A simple and effective method for concentrating sputum in the preparation of smears for cytodiagnosis of lung cancer was developed. The procedure, which utilizes a fixative consisting of 2,3-dihydroxy-1,4-dithiol-butane, 3,5-ditert-butyl-4-hydroxy-toluene, polyoxyethylene-cetyl-ether, polyethylene glycol 1540, and eth...
journal_title:Japanese journal of clinical oncology
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doi:
更新日期:1985-06-01 00:00:00
abstract:OBJECTIVE:To describe changes in Japanese clinical trial regulations after the implementation of the Clinical Trials Act in April 2018. METHODS:First, how to apply multiple regulations after the enforcement of Clinical Trials Act was described. Second, the changes in the number of clinical trials in the National Cance...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyaa028
更新日期:2020-04-07 00:00:00
abstract::Among 492 patients with esophageal carcinoma who received resective surgery, 102 survived over 5 years. These 5-year survivors were analyzed according to many factors. Females had a better prognosis than males, and patients without lymph-node metastasis had a better 5-year survival rate than those with it. Ten patient...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::A 56-year-old Japanese man in whom a descending colon carcinoma had been resected underwent a high orchitectomy for metastatic epididymis from the colon. Metastatic carcinoma from the digestive organs to the spermatic cord (SC) and/or the intrascrotal contents (ISC) is rare. Fifty-four Japanese patients with metastasi...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:The detection of prostate-specific antigen (PSA) molecular forms such as free PSA and PSA-ACT and the use of PSA molecular ratios, especially the percentage of free to total PSA, have been reported to improve the diagnostic accuracy of prostate cancer in the patients with slightly elevated serum PSA values. ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.6.303
更新日期:1999-06-01 00:00:00
abstract::One hundred and one cases of lung cancer were immunohistochemically studied for stainability with Leu-7 (anti-myelin fiber associated glycoprotein) and OKT-9 (anti-transferrin receptor) monoclonal antibodies. All small cell carcinomas and carcinoid tumors were positively stained by Leu-7, and 22 of 41 differentiated a...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract::In order to determine the significance of androgen receptor (AR) gene mutations for Japanese prostate cancers, we examined the entire coding region, from exon A to H, in 36 primary lesions. Five in stage A, 12 in stage B, six in stage C and 13 in stage D were subjected to PCR-SSCP analysis for genomic DNA and nucleoti...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/27.6.389
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Inconsistency in the prevalence of infection by human papillomavirus (HPV) in lung cancer patients was found between different countries with racial and geographic variations. Our previous reports have indicated that a high-risk HPV 16/18 DNA was frequently detected in Chinese lung cancer patients living in ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyl017
更新日期:2006-05-01 00:00:00
abstract::Hepatectomy for liver metastasis from the colo-rectum and other organs was performed in 77 cases at the National Cancer Center Hospital. The operative procedures included every variety of hepatectomy from extended resection as trisegmentectomy to small resection as partial resection. The operative mortality rate was 3...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:To describe computed tomographic (CT) features of highly enhanced hepatic masses as seen on CT during arterial portography (CTAP) and to survey the varieties of hepatic lesions associated with such findings. METHODS:CTAP files for 400 patients were reviewed, on the basis of which six patients with highly en...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyd113
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate patient-related parameters that determine ovarian cyst formation in women using tamoxifen for breast cancer. METHODS:A retrospective review of tamoxifen-treated women with breast cancer who were followed up in the outpatient clinic at Ankara Oncology Hospital between...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyi165
更新日期:2005-10-01 00:00:00
abstract:BACKGROUNDS:Mutations in the isocitrate dehydrogenase (IDH)1 gene are favourable prognostic factors in newly diagnosed diffuse gliomas, whereas it remains controversial in the recurrent glioblastoma setting. METHODS:A total of 171 patients with newly diagnosed glioblastoma, either 'primary' glioblastoma or 'secondary'...
journal_title:Japanese journal of clinical oncology
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doi:10.1093/jjco/hyaa162
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Vital dye-guided sentinel node biopsy is affordable in most hospitals, but may be of limited accuracy in identifying all sentinel nodes. Leaving sentinel nodes in the axilla may result in a false nodal staging of breast carcinomas. METHODS:From a series of 112 successful sentinel lymph node biopsies with Pa...
journal_title:Japanese journal of clinical oncology
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doi:10.1093/jjco/hyd072
更新日期:2000-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyq019
更新日期:2010-07-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu194
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Duodenal carcinoma is very rare and its culture cell lines have rarely been established. METHODS:Tumor cells separated from a surgically resected primary tumor of duodenal carcinoma were put into culture. The patient was an 81-year-old female and had metastatic lymph nodes. We investigated the biological ch...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.12.596
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:Endobronchial ultrasound with a guide sheath has been a widely used diagnostic procedure for peripheral pulmonary lesions. After sequential sampling with the usual devices, small portions of the collected specimen remain in the guide sheath and these can potentially contribute to diagnosis. We assessed the di...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyv004
更新日期:2015-04-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyz081
更新日期:2019-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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doi:10.1093/jjco/hyf008
更新日期:2002-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu227
更新日期:2015-04-01 00:00:00