Abstract:
BACKGROUND:Chromosomal numerical abnormality (CNA) is a characteristic of breast cancer as with other common solid cancers. Multiple mammary carcinomas are also sometimes encountered in the ipsilateral breast. Deciding whether they are multicentric (arising independently) or multifocal (of the same origin) has been a continued challenge to clinicians and pathologists. METHODS:We experienced two cases of macroscopically distinct double carcinomas in the ipsilateral breast, in which two cancers had a different histopathological morphology. Centromere probes identifying 17 different and specific centromeres were used to obtain the profile of CNA for each tumor, with a microwave-assisted FISH protocol. For comparison, a case of three lesions, two of which had the same and the other different histology was also studied. RESULTS:Contrary to our expectations, in spite of the particular difference in the histopathological picture of these tumors, the CNA profile was the same in one case and different in the other. The gain of chromosome 1 and loss of chromosome 15 are representative features shared by multifocal cases. On the other hand, the multiple cancers with the same histology had mostly the same CNA profile. CONCLUSIONS:CNA profiling is useful to identify the lineage of multiple breast cancers. As shown here, regardless of the histological features, a certain common CNA profile can define the same origin of some multiple cancers.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Nakamura R,Song JP,Isogaki J,Kitayama Y,Sugimura Hdoi
10.1093/jjco/hyg089keywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
463-9issue
9eissn
0368-2811issn
1465-3621journal_volume
33pub_type
杂志文章abstract::Although malignant lymphoma of the breast is a rare disease, we recently experienced a high incidence of central nervous system (CNS) involvement. Thus, we retrospectively reviewed clinical records of 921 patients with breast tumors, treated from 1990 to 2002, to examine CNS involvement. Eight patients were found to h...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/hyg072
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:No risk factor has been confirmed for para-aortic lymph node (PAN) metastasis from gastric cancer. To identify the risk factors and the most frequent route of metastasis to PAN, we analyzed the prospective data from a phase III trial. METHODS:In JCOG9501 comparing D2 and D2 + PAN dissection, 260 patients wi...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1093/jjco/hym067
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Long-term survival and late toxicities of a randomized Phase II study of chemoradiotherapy for esophageal cancer were analyzed. METHODS:Eligible patients were <75 years old and performance status 0-2, and had Stages II-IVA esophageal cancer. For arm A (short-term infusion), cisplatin 70 mg/m(2) Days 1 and 29...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1093/jjco/hys112
更新日期:2012-09-01 00:00:00
abstract:Objective:This study aims to reveal the present situation of changes in physical appearance induced by treatment, the effects of these changes on social activities, and support from medical staff in male cancer patients. Methods:A questionnaire survey was administered to 949 male patients (response rate: 90.1%) visiti...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx069
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the prognostic importance of the sequencing of radiation therapy and chemotherapy after mastectomy in high-risk premenopausal women with breast cancer in addition to other known prognostic factors in the literature. METHODS:In this retrospective study, 176 premenopau...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyg102
更新日期:2003-11-01 00:00:00
abstract::The use of lymphokine activated killer (LAK) cells for adoptive transfer therapy has been reported from number of clinical trials. To our knowledge, however, there has been no report concerning the cell cycle progression of LAK cells. Thus, for the present study we have attempted to examine the LAK cell cycle either b...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported in the literature. Herein, we report the case of a 71-year-old man with a 12-mm carcinoid tumor at the minor duodenal papilla with lymph node metastases. Multidetector-row computed tomography with contrast enhance...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hys185
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1093/jjco/hye129
更新日期:2001-12-01 00:00:00
abstract::To elucidate the relationship between the clinical features and pathologic findings of primary pulmonary lymphoma, we reviewed 24 patients with this disease. The pulmonary lymphomas were divided into four groups: (1) B-cell lymphoma composed of small to medium-sized lymphoid cells (19 cases); (2) B-cell lymphoma compo...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:
更新日期:1995-08-01 00:00:00
abstract::The clinical, hematological and pathological features of the adult T-cell leukemia (ATL)-related diseases and their cell membrane phenotypes in the Nagasaki district, one of the ATL-endemic areas, were delineated to compare them with those of adult T-cell leukemia-lymphoma (ATLL). In addition, the participation of ATL...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:Background:Unexpected multiple primary carcinomas (MPCs) that develop in patients with head and neck carcinomas complicate approaches to their management. We therefore investigated the clinical factors associated with survival outcomes after the treatment of MPCs. Methods:We performed a retrospective review of records...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx178
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to clarify the efficacy and toxicity of hyperfractionated radiation therapy (RT) for patients with nasopharyngeal cancer (NPC). METHODS:Twenty-two patients with NPC treated at our hospital between April 1994 and December 2002 were the subjects of this study. They received hyperfr...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyi041
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:To improve palliative care practice, the need for patients-reported outcome measures is increasing globally. The Integrated Palliative care Outcome Scale (IPOS) is a streamlined outcome scale developed to comprehensively evaluate patients' distress. The goal of this study is to assess the reliability and val...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1093/jjco/hyy203
更新日期:2019-03-01 00:00:00
abstract::The Japan Public Health Center-based prospective Study conducted a baseline survey for 140 000 registered residents aged 40-69 years within 11 public health center areas nationwide in 1990-94. Five- and 10-year follow-up surveys were conducted to update information on lifestyle habits and health conditions. In total, ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu096
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Recent studies reported that hospital procedure volume (i.e. volume of patients per hospital receiving a particular treatment)was directly proportional to cancer survival; however the degree of association might be different according to the primary tumor site, extent of disease and year of diagnosis. We per...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym052
更新日期:2007-07-01 00:00:00
abstract::Thirteen postmortem examinations on neuroblastoma patients were reviewed clinicopathologically. Commonly found metastatic sites were bone, liver and lung. The introduction of massive doses of cyclophosphamide and cisplatinum into chemotherapy protocol markedly reduced the tumor burden: no tumor focus in liver or lung,...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::We encountered a patient with hepatocellular carcinoma (HCC) with peritoneal dissemination and needle tract implantation, both of which were strongly suspected to have been caused by percutaneous needle biopsy. The patient was a 65-year-old man. Partial hepatectomy of subsegment VI had been performed following the dia...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/hyh096
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:A self-administered quantitative food frequency questionnaire (Qx) was developed for a population-based cohort study on cancer in Takayama, Japan. METHODS:The Qx was tested among 58 male and 59 female volunteers. Average daily nutrient intakes for the previous year calculated from the Qx were compared with ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.1.38
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical applications of stereotactic body radiation therapy (SBRT) using the CyberKnife system for pelvic recurrence from rectal cancer with a focus on survival and toxicity. METHODS:Between 2002 and 2006, 23 patients with recurrent rectal cancer were treated with SBRT at our institution....
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyn083
更新日期:2008-10-01 00:00:00
abstract::A 56-year-old housewife was incidentally discovered to have an abnormal shadow in the right B6 area upon a chest X-ray film being taken. A transcutaneous lung biopsy of the mass revealed adenocarcinoma of the lung (WHO classification). A brain computed tomography (CT) scan demonstrated multiple brain metastasis. Follo...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69-year-old woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus. Histologically, small round-...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/27.6.437
更新日期:1997-12-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyl026
更新日期:2006-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym054
更新日期:2007-07-01 00:00:00
abstract::A combined ischiopubic rami resection is extremely rare in the field of gastroenterologic surgery. We report a case of a locally recurrent rectal cancer that was successfully treated by total pelvic exenteration with combined ischiopubic rami resection. A 58-year-old male with locally recurrent rectal cancer and liver...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr169
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Angiosarcoma is an aggressive and malignant neoplasm. Primary hepatic angiosarcoma is extremely rare and accounts for only approximately 5% of all angiosarcomas. Therefore, many doctors do not know enough about this disease; this lack of knowledge motivated us to perform this study. METHODS:We carried out a...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyaa017
更新日期:2020-05-05 00:00:00
abstract:OBJECTIVE:To assess the feasibility and outcome of concurrent chemoradiotherapy (CT-RT) with large regional field and high-dose external beam boost irradiation in thoracic esophageal cancer. METHODS:Patients with clinical stage T1 (submucosal)-4N0-1M0 (UICC 1997) squamous cell carcinoma of the thoracic esophagus were ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hye084
更新日期:2001-08-01 00:00:00
abstract::Some cancer patients suddenly develop severe, excruciating pain that requires rapid management using opioid medication. This study aimed to evaluate the effectiveness of rapid titration using oxycodone injection. Study subjects were advanced cancer patients who experienced severe pain (numeric rating scale ≥7) and nee...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyz145
更新日期:2019-12-18 00:00:00
abstract::In conclusion, a review of the epidemiology and pathology of latent prostatic cancer suggests this tumor to be the probable initial phase of a biological continuum that ends with metastatic cancer. Histological grade and tumor volume are highly correlated, as are histological grade and mitotic index. It has also been ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:Human papillomavirus vaccines are being introduced worldwide and are expected to reduce the incidence of cervical cancer. Here we report a cross-sectional study using a validated human papillomavirus genotyping method to reveal the human papillomavirus prevalence and genotype distribution in Japanese women wi...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu112
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To retrospectively examine the outcomes of hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannomas. METHODS:Twenty-five patients with 26 vestibular schwannomas were treated with hypofractionated stereotactic radiation therapy using a CyberKnife. The vestibular sc...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyt082
更新日期:2013-08-01 00:00:00