Adult T-cell leukemia-lymphoma-related diseases in the Nagasaki District.

Abstract:

:The clinical, hematological and pathological features of the adult T-cell leukemia (ATL)-related diseases and their cell membrane phenotypes in the Nagasaki district, one of the ATL-endemic areas, were delineated to compare them with those of adult T-cell leukemia-lymphoma (ATLL). In addition, the participation of ATL virus (ATLV) in the ATL-related diseases was investigated on the basis of a study of ATLV-associated antigen (ATLA) and anti-ATLA antibody. ATLA and/or anti-ATLA antibody could be detected in the ATL-related diseases, including persistent T-lymphocytosis with morphologically abnormal T-lymphocytes, T-cell chronic lymphocytic leukemia (T-CLL) of helper T-cells, T-cell malignant lymphoma of the skin, some seronegative helper T-cell malignant lymphomas and monomorphic T-cell leukemia with round nuclei. These results suggest that those cases in the Nagasaki district, though clinically different from each other, might be the same T-lymphoproliferative disease of possible viral etiology associated with ATLV. On the other hand, persistent T-lymphocytosis seems to be an infectious condition caused by ATLV and partly a preclinical stage of ATLL in view of the clinicohematological features.

journal_name

Jpn J Clin Oncol

authors

Kinoshita K,Amagasaki T,Yamada Y,Ikeda S,Momita S,Toriya K,Kamihira S,Ichimaru M

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

215-30

eissn

0368-2811

issn

1465-3621

journal_volume

13 Suppl 2

pub_type

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