Phase II trial of UFT activity in pretreated breast cancer patients.

Abstract:

:Seventy metastatic breast adenocarcinoma patients, pretreated with standard hormonotherapy or chemotherapy, received continuous UFT at 10 mg/kg/day, orally, for at least two months. There were one complete response (1.5%), 12 partial responses (17%), one minor response and 37 disease stabilizations. The median duration of response was nine months. A greater efficacy was demonstrated in 29 patients with soft tissue disease, with a rate of 38% objective responses. The major toxicity was gastrointestinal, with 45% of patients developing nausea and vomiting and 30%, diarrhea. Bone marrow toxicity was slight. UFT has shown antitumor activity in our group of pretreated patients, especially these with the cutaneous tumoral and/or inflammatory form of the disease.

journal_name

Jpn J Clin Oncol

authors

Daniels M,Díaz-Rubio E,Guillem V,Montero JM,García-Conde J,Estapé J,Martín M,Herranz C,Ordoñez A,Galán A

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

363-5

issue

6

eissn

0368-2811

issn

1465-3621

journal_volume

23

pub_type

临床试验,杂志文章
  • Burden on oncologists when communicating the discontinuation of anticancer treatment.

    abstract:OBJECTIVE:Communicating the discontinuation of anticancer treatment to patients is a difficult task. The primary aim of this study was to clarify the level of oncologist-reported burden when communicating about discontinuation of an anticancer treatment. The secondary aims were (i) to identify the sources of burden con...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr092

    authors: Otani H,Morita T,Esaki T,Ariyama H,Tsukasa K,Oshima A,Shiraisi K

    更新日期:2011-08-01 00:00:00

  • Disconnection of a venous Port-A-Cath followed by embolization after saline flush: rare case report.

    abstract::A 77-year-old man presented with painful swelling of his Port-A-Cath insertion site soon after flushing with normal saline. No discomfort or abnormality was found during the saline flush. A chest roentgenogram showed that the disconnected catheter had separated from the disc and was absent from its original location. ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/29.12.643

    authors: Lam AW,Chen YM,Yang KY,Tsai CM,Perng RP

    更新日期:1999-12-01 00:00:00

  • Comparison of radiotherapy infrastructure between Korea and Japan.

    abstract:BACKGROUND:Patterns of cancer incidence and radiotherapy use are similar in Korea and Japan, with differences in radiotherapy infrastructure. METHODS:The authors surveyed the megavoltage machines in 91 radiotherapy centers in Korea and published data in Japan. The number of megavoltage machines per center was used as ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz124

    authors: Huh SJ,Nishimura T,Park W,Nakamura K

    更新日期:2019-12-18 00:00:00

  • Second primary osteosarcomas in patients with retinoblastoma.

    abstract:OBJECTIVE:Second primary malignancies have become the leading cause of death in retinoblastoma survivors. Although osteosarcoma is the most common second malignancy, little is known about its clinical and therapeutic features. METHODS:We retrospectively reviewed a database of patients with retinoblastoma and osteosarc...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv140

    authors: Fujiwara T,Fujiwara M,Numoto K,Ogura K,Yoshida A,Yonemoto T,Suzuki S,Kawai A

    更新日期:2015-12-01 00:00:00

  • Cardiac angiosarcoma with cardiac tamponade diagnosed as a ruptured aneurysm of the sinus valsalva.

    abstract::Primary cardiac angiosarcoma is a rare, diagnostically elusive disease with a poor prognosis. In this report, we describe the case of a 56-year-old woman with a right atrial angiosarcoma. The patient presented with impending cardiac tamponade caused by right atrial perforation, but was misdiagnosed as a ruptured aneur...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp044

    authors: Yoshitake I,Hata M,Sezai A,Niino T,Unosawa S,Shimura K,Kasamaki Y,Minami K

    更新日期:2009-09-01 00:00:00

  • Feasibility study of the simultaneous integrated boost (SIB) method for malignant gliomas using intensity-modulated radiotherapy (IMRT).

    abstract:BACKGROUND:Intensity-modulated radiotherapy (IMRT) using the simultaneous integrated boost (SIB) method was designed for treating malignant gliomas. The purpose of this study was to investigate feasibility of this treatment. METHODS:Between December 2000 and November 2002, six patients with malignant gliomas were enro...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyg053

    authors: Suzuki M,Nakamatsu K,Kanamori S,Okumra M,Uchiyama T,Akai F,Nishimura Y

    更新日期:2003-06-01 00:00:00

  • A newly introduced comprehensive consultation fee in the national health insurance system in Japan: a promotive effect of multidisciplinary medical care in the field of radiation oncology--results from a questionnaire survey.

    abstract:OBJECTIVE:The consultation fee for outpatient radiotherapy was newly introduced in the national health insurance system in Japan in April 2012. We conducted a survey on the use of this consultation fee and its effect on clinical practices. METHODS:The health insurance committee of the Japanese Society of Therapeutic R...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt147

    authors: Igaki H,Onishi H,Nakagawa K,Dokiya T,Nemoto K,Shigematsu N,Nishimura Y,Hiraoka M,Japanese Society for Therapeutic Radiology and Oncology Health Insurance Committee.

    更新日期:2013-12-01 00:00:00

  • Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas.

    abstract:OBJECTIVE:The CpG island methylator phenotype is strongly associated with poor survival in neuroblastomas. Neuroblastomas with the CpG island methylator phenotype include almost all neuroblastomas with MYCN amplification, and, even among neuroblastomas without MYCN amplification, have worse prognosis. At the same time,...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt058

    authors: Asada K,Watanabe N,Nakamura Y,Ohira M,Westermann F,Schwab M,Nakagawara A,Ushijima T

    更新日期:2013-06-01 00:00:00

  • Combination chemotherapy for a senile patient with adenoid cystic carcinoma of the esophagus: a case report.

    abstract::Adenoid cystic carcinoma of the esophagus with multiple liver metastases was found in a 77-year-old Japanese female in October, 1991. Combination chemotherapy, including etoposide (VP-16) and tegafur (FT) allowed the patient to survive for approximately a year after the onset of the initial symptoms. During her course...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Matsumoto M,Nomiyama T,Nakae J,Nishikawa H

    更新日期:1993-08-01 00:00:00

  • A clinicopathological study of histiocytosis X.

    abstract::Thirty-five cases of histiocytosis X in the National Children's Hospital were clinicopathologically studied. Fourteen cases were categorized in diffuse histiocytosis X, Letterer-Siwe type (DHX), 19 cases in multifocal eosinophilic granuloma (MEG) and 2 cases in unifocal eosinophilic granuloma (UEG). Nine of 14 DHX die...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Tsunematsu Y,Koide R,Watanabe S,Takahashi H,Morikawa Y,Shimizu K

    更新日期:1984-12-01 00:00:00

  • Long-term outcomes of dynamic conformal arc irradiation combined with neoadjuvant hormonal therapy in Japanese patients with T1c-T2N0M0 prostate cancer: case series study.

    abstract:OBJECTIVE:There are few reports of the outcomes of external beam radiotherapy in Asian males with localized prostate cancer. The aim of this study is to evaluate the long-term outcomes of external beam irradiation using three-dimensional two-dynamic conformal arc therapy, combined with neoadjuvant hormonal therapy, in ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt197

    authors: Ikeda I,Mizowaki T,Norihisa Y,Takayama K,Kamba T,Inoue T,Nakamura E,Kamoto T,Ogawa O,Hiraoka M

    更新日期:2014-02-01 00:00:00

  • Palliative chemotherapy preferences and factors that influence patient choice in incurable advanced cancer.

    abstract:OBJECTIVE:To determine the extent of informed decision-making and treatment preference of Korean patients receiving palliative chemotherapy. METHODS:We assessed 138 patients (median age: 58 years; 73% male) with advanced cancer who had received at least one cycle of chemotherapy. General demographic information, the e...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym147

    authors: Kim MK,Lee JL,Hyun MS,Do YR,Song HS,Kim JG,Bae SH,Ryoo HM,Park KU,Lee KH

    更新日期:2008-01-01 00:00:00

  • Adjuvant chemotherapy for gastric cancer in Japan: present status and suggestions for rational clinical trials.

    abstract::A review of the present status of adjuvant chemotherapy for gastric cancer in Japan has been made. The single use of mitomycin C (MMC) after curative gastrectomy, a multidrug combination of MMC, 5-fluorouracil (5FU) and cytosine arabinoside (CA) (MFC therapy), and a combination of inductive MFC followed by maintenance...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Nakajima T

    更新日期:1990-03-01 00:00:00

  • Proposal for the breakdown of increased cancer healthcare cost and its improvement.

    abstract::Technological progress in the field of cancer treatment can be expected to accelerate in the future, giving hope to such patients. At the same time, there is concern that cancer care will become more expensive. It is indispensable to minimize the economic burden of patients to deliver technological advances in treatme...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyt015

    authors: Koinuma N

    更新日期:2013-04-01 00:00:00

  • Brachytherapy for oral tongue cancer: an analysis of treatment results with various biological markers.

    abstract:OBJECTIVE:Low-dose-rate (LDR) brachytherapy is an effective treatment for tongue cancer. However, little is known about the biological mechanism underlying this therapy, characterized by delivery of continuous exposures of LDR irradiation. It is reported that lower microvessel density (MVD), lower Ki-67 index or higher...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyn050

    authors: Sakata K,Someya M,Nagakura H,Nakata K,Oouchi A,Takagi M,Hareyama M

    更新日期:2008-06-01 00:00:00

  • A case of lateral pelvic lymph node recurrence after TME for submucosal rectal carcinoma successfully treated by lymph node dissection with en bloc resection of the internal iliac vessels.

    abstract::In Japan, lateral lymph node dissection (LLND) is generally performed for the treatment of T3-4 lower rectal carcinoma, and not for T1 lower rectal carcinoma, because of a low positive rate in patients with T1 lesion. We experienced a rare case of lateral pelvic lymph node recurrence after total mesorectal resection f...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyn011

    authors: Hara J,Yamamoto S,Fujita S,Akasu T,Moriya Y

    更新日期:2008-04-01 00:00:00

  • Correlation of biologically effective dose and the tumor control in Stage I (

    abstract:Backgrounds:Stereotactic ablative radiotherapy (SABR) is one of the newly developed innovative radiotherapy and of which optimal dose prescription needs to be standardized. We aimed to investigate the dose-response relationship for patients with SABR. Methods:Fifty-three patients with Stage I non-small cell lung cance...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx172

    authors: Jeon W,Ahn SJ,Kim YC,Oh IJ,Park CK,Jeong JU,Yoon MS,Song JY,Nam TK,Chung WK

    更新日期:2018-02-01 00:00:00

  • Reduced-intensity hematopoietic stem cell transplantation (RIST) for solid malignancies.

    abstract::Reduced intensity stem cell transplantation (RIST) is a new approach of stem cell transplantation, which has shown promising features as reported in multiple phase I and II studies. Elderly patients, who are not eligible for conventional myeloablative hematopoietic stem cell transplantation (HSCT), are now treatable w...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyh139

    authors: Kami M,Makimoto A,Heike Y,Takaue Y

    更新日期:2004-12-01 00:00:00

  • Long-term result of high dose-rate afterloading brachytherapy in squamous cell carcinoma of the cervix: relationship between facility structure and outcome.

    abstract:OBJECTIVE:To compare outcome results for squamous cell carcinoma of the uterine cervix between patients treated in a single facility [single facility therapy: (SFT)] and others combined with external beam irradiation (EBRT) in a small facility and intracavitary brachytherapy in a central facility (combined facilities t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh024

    authors: Okuda T,Itho Y,Ikeda M,Nakamura T,Horikawa Y,Yanagawa S,Ishigaki T

    更新日期:2004-03-01 00:00:00

  • Transformation of fibrolamellar carcinoma to common hepatocellular carcinoma in the recurrent lesions of the rectum and the residual liver: a case report.

    abstract::A 21-year-old man had undergone central bisegmentectomy of the liver due to fibrolamellar carcinoma (FLC). Twice, 24 and 30 months after the first operation, lymph node metastases were removed. We have reported this case previously and this is the second report of the same case. Forty-two months after the second opera...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/29.9.445

    authors: Yamamoto H,Watanabe K,Nagata M,Yano Y,Akai T,Honda I,Watanabe S,Soda H,Matsuzaki O

    更新日期:1999-09-01 00:00:00

  • Hyperfractionated radiation therapy for locoregionally advanced nasopharyngeal cancer.

    abstract:OBJECTIVE:The purpose of this study is to clarify the efficacy and toxicity of hyperfractionated radiation therapy (RT) for patients with nasopharyngeal cancer (NPC). METHODS:Twenty-two patients with NPC treated at our hospital between April 1994 and December 2002 were the subjects of this study. They received hyperfr...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi041

    authors: Isobe K,Uno T,Kawakami H,Ueno N,Aruga T,Yasuda S,Hanazawa T,Okamoto Y,Ito H,Shigematsu N

    更新日期:2005-03-01 00:00:00

  • Attitudes toward participating in Phase I clinical trials: an investigation with patient-family-physician triads.

    abstract:OBJECTIVE:Phase I oncology trials have raised concerns that patients' 'unrealistic' optimism could compromise the validity of informed consent, and that patients often participate in trials to conform to physicians' or family members' recommendations. We aimed to determine whether patients or families-given the same in...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyw135

    authors: Shin DW,Cho J,Kim SY,Yang HK,Cho B,Shin DB,Chun MS,Min YJ,Kim YW,Park JH

    更新日期:2016-12-01 00:00:00

  • Regulatory changes after the enforcement of the new Clinical Trials Act in Japan.

    abstract:OBJECTIVE:To describe changes in Japanese clinical trial regulations after the implementation of the Clinical Trials Act in April 2018. METHODS:First, how to apply multiple regulations after the enforcement of Clinical Trials Act was described. Second, the changes in the number of clinical trials in the National Cance...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa028

    authors: Nakamura K,Shibata T

    更新日期:2020-04-07 00:00:00

  • Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia/lymphoma: a report of the second nationwide study of Japan. The T- and B-Cell Malignancy Study Grou

    abstract::In the present nationwide survey, 1,040 new cases of lymphoid malignancy, in most of which expression of cell surface markers had been determined, and 243 controls for a case-control study on adult T-cell leukemia/lymphoma (ATL) and other types of lymphoid malignancies were enrolled during the two years (1982-84) from...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1985-09-01 00:00:00

  • Radiotherapy in the management of Graves' ophthalmopathy.

    abstract:BACKGROUND:To report the results of radiotherapy for patients with failure, adverse reactions or relative contraindications to the use of steroids or immunosuppressants, by using newly developed quantitative indexes. METHODS:Fourteen female and six male patients with Graves' ophthalmopathy were treated with radiothera...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.6.364

    authors: Sakata K,Hareyama M,Oouchi A,Shidou M,Nagakura H,Morita K,Osanai H,Ohtsuka K,Hinoda Y

    更新日期:1998-06-01 00:00:00

  • The prognostic signature of the somatic mutations in Ewing sarcoma: from a network view.

    abstract:BACKGROUND:Ewing sarcoma is a malignant bone tumor mainly affecting teenagers and young adults. Its main driver mutation, the EWS-FLI1 fusion gene, has been identified more than 20 years ago, whereas its other somatic mutations have been just recently reported. METHODS:In this study, we organized the somatic mutations...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz037

    authors: Zhang Y,Song J,Shi Q,Song X,Shen L,Zhou J,Shao J

    更新日期:2019-07-01 00:00:00

  • A phase II study of irinotecan and capecitabine for patients with unresectable liver-only metastases from colorectal cancer.

    abstract:OBJECTIVE:To assess the resectability rate of patients with initially unresectable liver-only metastases from colorectal cancer (CRC) after treatment with irinotecan/capecitabine. METHODS:Patients received irinotecan (240 mg/m(2)) as a 30 min intravenous infusion on day 1 and capecitabine (1000 mg/m(2)) orally bid for...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp114

    authors: Zhao R,Zhu J,Ji X,Cai J,Wan F,Li Q,Zhong B,Tucker S,Wang D

    更新日期:2010-01-01 00:00:00

  • Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum.

    abstract::The positive correlation between smoking and cancer risk is well estimated in sporadic colorectal cancer, whereas little is known with regard to Lynch syndrome-associated colorectal cancer. A total of 118 familial colorectal cancer patients from the Hereditary Nonpolyposis Colorectal Cancer Registry and Genetic Testin...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu218

    authors: Tanakaya K,Furukawa Y,Nakamura Y,Hirata K,Tomita N,Tamura K,Sugano K,Ishioka C,Yoshida T,Ishida H,Watanabe T,Sugihara K,HNPCC registry and genetic testing project of the Japanese Society for Cancer of the Colon and Rectum.,Yama

    更新日期:2015-03-01 00:00:00

  • Comparative study of assays for prostate-specific antigen molecular forms.

    abstract:BACKGROUND:The detection of prostate-specific antigen (PSA) molecular forms such as free PSA and PSA-ACT and the use of PSA molecular ratios, especially the percentage of free to total PSA, have been reported to improve the diagnostic accuracy of prostate cancer in the patients with slightly elevated serum PSA values. ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/29.6.303

    authors: Kuriyama M,Uno H,Ueno K,Hamamoto Y,Vihn PQ,Ban Y

    更新日期:1999-06-01 00:00:00

  • A case of ovarian cystadenocarcinoma associated with pregnancy.

    abstract::A case of ovarian cystadenocarcinoma associated with pregnancy is reported. The semicystic left ovarian tumor was found in a 28-year-old woman, gravida 2, para 1 at 33 weeks' gestation. A primary Cesarean section, total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by chemotherapy were performed....

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.jjco.a039387

    authors: Sawada M,Yamasaki M,Urabe T,Katayama S,Yamane T

    更新日期:1990-06-01 00:00:00